Genomes and Genes
Experts and Doctors on amino acid sequence in Dallas, Texas, United States
Locale: Dallas, Texas, United States
Topic: amino acid sequence
Publications274 found, 100 shown here
- Ichtchenko K, Nguyen T, Sudhof T. Structures, alternative splicing, and neurexin binding of multiple neuroligins. J Biol Chem. 1996;271:2676-82 pubmed..Thus, neuroligins constitute a multigene family of brain-specific proteins with distinct isoforms that may have overlapping functions in mediating recognition processes between neurons. ..
- Liu Z, Galindo R, Wasserman S. A role for CKII phosphorylation of the cactus PEST domain in dorsoventral patterning of the Drosophila embryo. Genes Dev. 1997;11:3413-22 pubmed..Taken together, these data indicate that wild-type axis formation requires CKII-catalyzed phosphorylation of the Cactus PEST domain. ..
- Simmons A, Puschel A, McPherson J, Overhauser J, Lovett M. Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval. Biochem Biophys Res Commun. 1998;242:685-91 pubmed..The known functions of semaphorins and the interesting pattern of expression for Semaf suggest that haploinsufficiency for SEMAF may disrupt normal brain development and might lead to some of the features of Cri-du-chat...
- Liu X, Li P, Widlak P, Zou H, Luo X, Garrard W, et al. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A. 1998;95:8461-6 pubmed..DFF40 also triggered chromatin condensation when incubated with nuclei. These data suggest that DFF40 is sufficient to trigger both DNA fragmentation and chromatin condensation during apoptosis. ..
- Espenshade P, Cheng D, Goldstein J, Brown M. Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. J Biol Chem. 1999;274:22795-804 pubmed..Espenshade, P. J., Slaughter, C. A., Jaen, J. C., Brown, M. S., and Goldstein, J. L. (1999), J. Biol. Chem., 274, 22805-22812), we develop an in vitro assay to characterize the activity of purified recombinant S1P. ..
- Chen Z, Hutchison M, Cobb M. Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. J Biol Chem. 1999;274:28803-7 pubmed..These results suggest that TAO proteins lie in stress-sensitive kinase cascades and define a mechanism by which these kinases may organize downstream targets. ..
- Wang D, Chang P, Wang Z, Sutherland L, Richardson J, Small E, et al. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001;105:851-62 pubmed..Myocardin is the founding member of a class of muscle transcription factors and provides a mechanism whereby SRF can convey myogenic activity to cardiac muscle genes. ..
- Quill T, Ren D, Clapham D, Garbers D. A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001;98:12527-31 pubmed..It is possible, therefore, that two independent alpha subunits, different from other known voltage-gated channels, regulate sperm motility. ..
- Ye S, Cech A, Belmares R, Bergstrom R, Tong Y, Corey D, et al. The structure of a Michaelis serpin-protease complex. Nat Struct Biol. 2001;8:979-83 pubmed..The serine residue C-terminal to the scissile peptide bond is found in a closer than usual interaction with His 57 at the active site of trypsin. ..
- Barker S, Wang J, Sierra D, Ross E. RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. Genomics. 2001;78:223-9 pubmed..At least two mRNAs that include the exon that encodes the N-terminal region unique to RGSZ1 were found in brain and a few other tissues, but not retina. RGS20 thus can account for multiple G(z)-selective GAPs in different tissues. ..
- Christich A, Kauppila S, Chen P, Sogame N, Ho S, Abrams J. The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Curr Biol. 2002;12:137-40 pubmed..skl is potentially a fourth IAP antagonist in the "Reaper region" and a new candidate transducer of apoptotic damage signaling in Drosophila. ..
- Kasus Jacobi A, Ou J, Bashmakov Y, Shelton J, Richardson J, Goldstein J, et al. Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem. 2003;278:32380-9 pubmed
- Zhou J, Mateos F, Ober R, Ward E. Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis. J Mol Biol. 2005;345:1071-81 pubmed..These studies define the molecular basis for the marked difference in binding specificity between human and rodent FcRn, and give insight into how human FcRn recognizes IgGs. ..
- Lambracht Washington D, Moore Y, Wonigeit K, Lindahl K. Structure and expression of MHC class Ib genes of the central M region in rat and mouse: M4, M5, and M6. Immunogenetics. 2008;60:131-45 pubmed publisher..M6, and the inversion of RT1.M5 in the rat. This demonstrates substantial evolutionary dynamics in this region despite conservation of the class I gene sequences themselves. ..
- Guo J, Cheng P, Liu Y. Functional significance of FRH in regulating the phosphorylation and stability of Neurospora circadian clock protein FRQ. J Biol Chem. 2010;285:11508-15 pubmed publisher..Furthermore, we showed that the rapid FRQ degradation in the absence of FRH is independent of FWD-1, the ubiquitin E3 ligase of FRQ under normal conditions, thus uncovering an alternative pathway for FRQ degradation...
- Renthal N, Guidry P, Shanmuganad S, Renthal W, Stroynowski I. Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide. Immunogenetics. 2011;63:57-64 pubmed publisher..Collectively, these studies demonstrate that H2-Q5(k), and its homologous class I-like H2(b) gene may play tissue-specific roles in regulating immune surveillance. ..
- Burnaevskiy N, Fox T, Plymire D, Ertelt J, Weigele B, Selyunin A, et al. Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. Nature. 2013;496:106-9 pubmed publisher..Taken together, these findings show a previously unrecognized pathogenic mechanism for the site-specific elimination of N-myristoyl protein modification...
- Zhong D, Blount P. Phosphatidylinositol is crucial for the mechanosensitivity of Mycobacterium tuberculosis MscL. Biochemistry. 2013;52:5415-20 pubmed publisher..tuberculosis but not E. coli, is sufficient for gating of the M. tuberculosis MscL channel within a physiological range of membrane tension. ..
- Yu F, Sun H, Janmey P, Yin H. Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin. J Biol Chem. 1992;267:14616-21 pubmed..We propose that the sequences identified in gelsolin may represent a consensus for PPI binding in a variety of proteins. ..
- Mehta K, Chen W, Goldstein J, Brown M. The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor. J Biol Chem. 1991;266:10406-14 pubmed..D., Brown, M.S., Bilheimer, D.W., and Goldstein, J.L. (1991) J. Biol. Chem. 266, 10415-10419). ..
- Zhang J, Cousens L, Barr P, Sprang S. Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta. Proc Natl Acad Sci U S A. 1991;88:3446-50 pubmed..Analysis of the three-dimensional structure in light of functional studies of bFGF suggests that the receptor binding site and the positively charged heparin binding site correspond to adjacent but separate loci on the beta-barrel. ..
- Chen W, Andres D, Goldstein J, Russell D, Brown M. cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1. Cell. 1991;66:327-34 pubmed..The rat beta subunit shows 37% sequence identity with the protein encoded by the yeast DPR1/RAM1 gene, indicating that DPR1/RAM1 is the yeast counterpart of the peptide-binding subunit of the mammalian farnesyltransferase. ..
- Archer B, Ozcelik T, Jahn R, Francke U, Sudhof T. Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990;265:17267-73 pubmed..A PstI restriction fragment length polymorphism was identified at the SYB2 locus. ..
- Herring B, Nunnally M, Gallagher P, Stull J. Molecular characterization of rat skeletal muscle myosin light chain kinase. Am J Physiol. 1989;256:C399-404 pubmed..Thus rat skeletal muscle contains a single myosin light chain kinase isoform, which is distinct from the cardiac, smooth, and nonmuscle forms...
- Hardy D, Garbers D. A sperm membrane protein that binds in a species-specific manner to the egg extracellular matrix is homologous to von Willebrand factor. J Biol Chem. 1995;270:26025-8 pubmed..The unique domain structure of zonadhesin suggests multiple functions, one of which is to mediate sperm adhesion to the zona pellucida. ..
- Fülle H, Vassar R, Foster D, Yang R, Axel R, Garbers D. A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proc Natl Acad Sci U S A. 1995;92:3571-5 pubmed..These observations suggest that GC-D may function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors. ..
- Porcella S, Popova T, Hagman K, Penn C, Radolf J, Norgard M. A mgl-like operon in Treponema pallidum, the syphilis spirochete. Gene. 1996;177:115-21 pubmed..The existence of a mgl operon in T. pallidum thus may have important implications with respect to T. pallidum survival, tissue dissemination, and sensory transduction during virulence expression. ..
- Ayi T, Tsan J, Hwang L, Bowcock A, Baer R. Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. Oncogene. 1998;17:2143-8 pubmed..These data suggest that BRCA1 and BARD1 have co-evolved to participate in a common pathway of tumor suppression. ..
- Soyombo A, Yi W, Hofmann S. Structure of the human palmitoyl-protein thioesterase-2 gene (PPT2) in the major histocompatibility complex on chromosome 6p21.3. Genomics. 1999;56:208-16 pubmed..These polymorphisms (and a microsatellite discovered within PPT2) will aid in the further delineation of the possible role of PPT2 in lysosomal storage disorders of unknown etiology. ..
- Sevrioukov E, He J, Moghrabi N, Sunio A, Kramer H. A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila. Mol Cell. 1999;4:479-86 pubmed..Furthermore, a defect in endocytic trafficking was visualized in developing photoreceptor cells. These results provide direct evidence that eye color mutations of the granule group also disrupt vesicular trafficking to lysosomes. ..
- Rodriguez A, Oliver H, Zou H, Chen P, Wang X, Abrams J. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol. 1999;1:272-9 pubmed..These findings establish dark as an important apoptosis effector in Drosophila and raise profound evolutionary considerations concerning the relationship between mitochondrial components and the apoptosis-promoting machinery. ..
- Han Y, Kodadek T. Peptides selected to bind the Gal80 repressor are potent transcriptional activation domains in yeast. J Biol Chem. 2000;275:14979-84 pubmed..This peptide library-based approach should be generally useful for probing the chemical relationship of different binding interactions or functions of a given native domain. ..
- Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, et al. APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol Biol Cell. 2001;12:3839-51 pubmed..Surprisingly, with Ubc4 as the E2 enzyme, Zn(2+) ions alone are sufficient to catalyze the ubiquitination of cyclin B1. Therefore, the Zn(2+) ions of the RING finger family of ubiquitin ligases may be directly involved in catalysis. ..
- Pei J, Grishin N. Breaking the singleton of germination protease. Protein Sci. 2002;11:691-7 pubmed..Our analysis helps localize the active site of GPRs and provides insight into the catalytic mechanisms of a superfamily of putative metal-regulated proteases. ..
- Christerson L, Gallagher E, Vanderbilt C, Whitehurst A, Wells C, Kazempour R, et al. p115 Rho GTPase activating protein interacts with MEKK1. J Cell Physiol. 2002;192:200-8 pubmed..Here we have identified an MEKK1 binding partner that offers a connection between this protein kinase and the machinery regulating cytoskeletal reorganization. ..
- Ginalski K, Kinch L, Rychlewski L, Grishin N. BOF: a novel family of bacterial OB-fold proteins. FEBS Lett. 2004;567:297-301 pubmed
- Trosky J, Mukherjee S, Burdette D, Roberts M, McCarter L, Siegel R, et al. Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus. J Biol Chem. 2004;279:51953-7 pubmed
- Shin O, Han W, Wang Y, Sudhof T. Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. J Biol Chem. 2005;280:1641-51 pubmed
- Qi Y, Grishin N. Structural classification of thioredoxin-like fold proteins. Proteins. 2005;58:376-88 pubmed..Considering these structurally similar domains together sheds new light on the relationships between sequence, structure, function and evolution of thioredoxins. ..
- Sevrioukov E, Moghrabi N, Kuhn M, KRAMER H. A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila. Mol Biol Cell. 2005;16:2301-12 pubmed
- Ferguson A, Labunskyy V, Fomenko D, Arac D, Chelliah Y, Amezcua C, et al. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem. 2006;281:3536-43 pubmed..A physiological role for Sep15 and SelM as thiol-disulfide oxidoreductases and their contribution to the quality control pathways of the endoplasmic reticulum are discussed. ..
- Kang J, Gocke C, Yu H. Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity. BMC Biochem. 2006;7:5 pubmed..Our studies further suggest that sumoylation motifs containing a phosphorylated serine or an acidic residue at the +5 position might be more efficiently sumoylated. ..
- Kim S, Sprung R, Chen Y, Xu Y, Ball H, Pei J, et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell. 2006;23:607-18 pubmed..The combined data sets offer a rich source for further characterization of the contribution of this modification to cellular physiology and human diseases. ..
- Chook Y, Süel K. Nuclear import by karyopherin-?s: recognition and inhibition. Biochim Biophys Acta. 2011;1813:1593-606 pubmed publisher..This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import. ..
- Sanders C, Smith D. LUMP is a putative double-stranded RNA binding protein required for male fertility in Drosophila melanogaster. PLoS ONE. 2011;6:e24151 pubmed publisher..We show that one dsRNA binding domains (dsRBD) is essential for LUMP function in male fertility. These findings reveal LUMP is a novel factor required for late stages of male germline differentiation. ..
- Liao J, Li H, Zeng W, Sauer D, Belmares R, Jiang Y. Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science. 2012;335:686-90 pubmed publisher..Based on the symmetry of NCX_Mj and its ability to catalyze bidirectional ion-exchange reactions, we propose a structure model for the inward-facing NCX_Mj...
- Gething M, Sambrook J. Protein folding in the cell. Nature. 1992;355:33-45 pubmed
- Perin M, Fried V, Slaughter C, Sudhof T. The structure of cytochrome b561, a secretory vesicle-specific electron transport protein. EMBO J. 1988;7:2697-703 pubmed..This result agrees well with the putative function of this unique cytochrome and with the notion that this protein is localized to large dense-core synaptic vesicles. ..
- Cseh K, Beutler B. Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein. J Biol Chem. 1989;264:16256-60 pubmed..This incompletely processed form of the molecule also begins with a leucine residue. Although secreted as a soluble product, it is biologically inactive in the L-929 cell cytotoxicity assay. ..
- Camp L, Verkruyse L, Afendis S, Slaughter C, Hofmann S. Molecular cloning and expression of palmitoyl-protein thioesterase. J Biol Chem. 1994;269:23212-9 pubmed
- Kobe B, Deisenhofer J. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature. 1993;366:751-6 pubmed..A possible ribonuclease-binding region incorporates the surface formed by the parallel beta-sheet and the beta alpha loops. ..
- Horazdovsky B, Davies B, Seaman M, McLaughlin S, Yoon S, Emr S. A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Mol Biol Cell. 1997;8:1529-41 pubmed..On the basis of these and other observations, we propose that the Vps17p protein complex may participate in the intracellular trafficking of the Vps10p-sorting receptor, as well as other later-Golgi proteins. ..
- Mineo C, Ying Y, Chapline C, Jaken S, Anderson R. Targeting of protein kinase Calpha to caveolae. J Cell Biol. 1998;141:601-10 pubmed..Caveolae appear to be a membrane site where PKC enzymes are organized to carry out essential regulatory functions as well as to modulate signal transduction at the cell surface. ..
- Stepp S, Schatzle J, Bennett M, Kumar V, Mathew P. Gene structure of the murine NK cell receptor 2B4: presence of two alternatively spliced isoforms with distinct cytoplasmic domains. Eur J Immunol. 1999;29:2392-9 pubmed..The genomic clone of 2B4 reveals that the two cDNA clones are products of alternative splicing. Since they differ only in a portion of the cytoplasmic domain, it is likely that they transduce different signals. ..
- Zhang C, McKinsey T, Lu J, Olson E. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001;276:35-9 pubmed..These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. ..
- Amarneh B, Vik S. Mutagenesis of subunit N of the Escherichia coli complex I. Identification of the initiation codon and the sensitivity of mutants to decylubiquinone. Biochemistry. 2003;42:4800-8 pubmed..These mutants also showed enhanced inhibition by decylubiquinone, indicating that subunit N interacts with quinones. The mutation associated with LHON, G391S, had little effect on these functions. ..
- Arai S, Miyazaki T. Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. EMBO J. 2005;24:1863-73 pubmed..We also show that MBT-1 appears to influence myelopoiesis by transiently enhancing p57(KIP2) expression levels. ..
- Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122:421-34 pubmed..Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene. ..
- Zhao Y, Tong C, Jiang J. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature. 2007;450:252-8 pubmed..Hence, by employing multiple Arg clusters as inhibitory elements counteracted by differential phosphorylation, SMO acts as a rheostat to translate graded HH signals into distinct responses. ..
- Rybkin I, Kim M, Bezprozvannaya S, Qi X, Richardson J, Plato C, et al. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. J Cell Biol. 2007;179:527-37 pubmed..These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues. ..
- Kao L, Megraw T. Centrocortin cooperates with centrosomin to organize Drosophila embryonic cleavage furrows. Curr Biol. 2009;19:937-42 pubmed publisher..Together, these findings show that the C terminus of CNN coordinates cleavage furrow formation through binding to CEN, thereby providing a molecular link between the centrosome and cleavage furrow assembly. ..
- Mues G, Griggs R, Hartung A, Whelan G, Best L, Srivastava A, et al. From ectodermal dysplasia to selective tooth agenesis. Am J Med Genet A. 2009;149A:2037-41 pubmed publisher..We also present a new mutation in the EDA gene which causes selective tooth agenesis and demonstrates the phenotype variation that can be encountered in the ectodermal dysplasia syndrome (HED) with the highest prevalence worldwide. ..
- Hasemann C, Capra J. Mutational analysis of the cross-reactive idiotype of the A strain mouse. J Immunol. 1991;147:3170-9 pubmed..Furthermore, the idiotopes studied surround the Ag-binding site and clearly involve multiple interactions in several of the L and H chain CDR...
- McCauliffe D, Zappi E, Lieu T, Michalak M, Sontheimer R, Capra J. A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule". J Clin Invest. 1990;86:332-5 pubmed..These homologies suggest that this Ro protein has a very basic cellular function(s) which may in part involve calcium binding. ..
- McPhaul M, Noble J, Simpson E, Mendelson C, Wilson J. The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen. J Biol Chem. 1988;263:16358-63 pubmed..These findings establish that the cDNA clone encodes chicken ovarian aromatase and demonstrate that this protein can catalyze the three successive oxidation reactions necessary to form estrogen from androgen. ..
- Bassel Duby R, Hernandez M, Yang Q, Rochelle J, Seldin M, Williams R. Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994;14:4596-605 pubmed
- Petrenko A, Lazaryeva V, Geppert M, Tarasyuk T, Moomaw C, Khokhlatchev A, et al. Polypeptide composition of the alpha-latrotoxin receptor. High affinity binding protein consists of a family of related high molecular weight polypeptides complexed to a low molecular weight protein. J Biol Chem. 1993;268:1860-7 pubmed..In addition, the receptor is found in a less tight association with synaptotagmin but not with other polypeptides. ..
- Estabrook R, Shet M, Fisher C, Jenkins C, Waterman M. The interaction of NADPH-P450 reductase with P450: an electrochemical study of the role of the flavin mononucleotide-binding domain. Arch Biochem Biophys. 1996;333:308-15 pubmed
- Xu S, Cobb M. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J Biol Chem. 1997;272:32056-60 pubmed..The data are consistent with a model in which MEKK1-JNK/SAPK binding facilitates the receipt of signals from upstream inputs and localizes JNK/SAPK to intracellular targets of the pathway. ..
- Kim M, Repp A, Smith D. LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster. Genetics. 1998;150:711-21 pubmed..These findings provide direct evidence that odorant-binding proteins are required for normal chemosensory behavior in Drosophila and may partially determine the chemical specificity of olfactory neurons in vivo. ..
- Lee R, Sawin E, Chalfie M, Horvitz H, Avery L. EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in caenorhabditis elegans. J Neurosci. 1999;19:159-67 pubmed..Our data suggest that phosphate ions imported into glutamatergic neurons through transporters such as EAT-4 and BNPI are required specifically for glutamatergic neurotransmission. ..
- Zwirner N, Dole K, Stastny P. Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes. Hum Immunol. 1999;60:323-30 pubmed..Moreover, the expression of MICA on the surface of endothelial cells makes this polymorphic molecule a possible target during the immune response of graft rejection in organ transplantation. ..
- Dobrosotskaya I, James G. MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures. Biochem Biophys Res Commun. 2000;270:903-9 pubmed..In agreement with this observation, a significant portion of a GFP fusion of MAGI-1b localizes to the basolateral membrane of polarized MDCK cells. ..
- Vik S, Long J, Wada T, Zhang D. A model for the structure of subunit a of the Escherichia coli ATP synthase and its role in proton translocation. Biochim Biophys Acta. 2000;1458:457-66 pubmed..The results of these studies, in conjunction with information about subunits b and c, can be incorporated into a model for the mechanism of proton translocation in the Escherichia coli ATP synthase. ..
- Patterson C, Schaub T, Coleman E, Davis E. Developmental regulation of FKBP65. An ER-localized extracellular matrix binding-protein. Mol Biol Cell. 2000;11:3925-35 pubmed..Taken together, these results support an ER-localized FKBP65-tropoelastin interaction that occurs specifically during growth and development of tissues. ..
- Krishna S, Zhou T, Daugherty M, Osterman A, Zhang H. Structural basis for the catalysis and substrate specificity of homoserine kinase. Biochemistry. 2001;40:10810-8 pubmed..Therefore, we propose that the catalytic mechanism of HSK does not involve a catalytic base for activating the phosphoryl acceptor hydroxyl but instead is mediated via a transition state stabilization mechanism...
- Chen Z, Singer W, Wells C, Sprang S, Sternweis P. Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF. J Biol Chem. 2003;278:9912-9 pubmed..This suggests that the rgRGS domain may serve a structural or allosteric role in the regulation of the nucleotide exchange activity of p115RhoGEF on Rho by Galpha(13). ..
- Karthikeyan S, Zhou Q, Mseeh F, Grishin N, Osterman A, Zhang H. Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch. Structure. 2003;11:265-73 pubmed..The invariant residues Asn36 and Glu86 are implicated in the catalysis. ..
- Rand T, Ginalski K, Grishin N, Wang X. Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci U S A. 2004;101:14385-9 pubmed
- Bembenek J, Kang J, Kurischko C, Li B, Raab J, Belanger K, et al. Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeast. Cell Cycle. 2005;4:961-71 pubmed..Our results suggest a requirement for Crm1p-dependent nuclear export of Cdc14p in coordinating mitotic exit and cytokinesis in budding yeast. ..
- Qi W, Tang Z, Yu H. Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell. 2006;17:3705-16 pubmed..Our results suggest that phosphorylation of Bub1 at T609 by Cdk1 creates a docking site for the PBD of Plk1 and facilitates the kinetochore recruitment of Plk1. ..
- Chiu Y, Sun Q, Chen Z. E1-L2 activates both ubiquitin and FAT10. Mol Cell. 2007;27:1014-23 pubmed..Silencing of E1-L2 expression by RNAi blocks the formation of FAT10 conjugates in cells. Deletion of E1-L2 in mice caused embryonic lethality, suggesting that E1-L2 plays an important role in embryogenesis. ..
- Karakuzu O, Wang D, Cameron S. MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans. Development. 2009;136:943-53 pubmed publisher..However, unlike the mes mutants, mig-32 and spat-3 mutants are fertile, suggesting that PRC1 function is not absolutely required in the germline for essential functions of PRC2. ..
- DEREBE M, Zeng W, Li Y, Alam A, Jiang Y. Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc Natl Acad Sci U S A. 2011;108:592-7 pubmed publisher..Furthermore, structural insight from our CNG mimics allows us to pinpoint equivalent interactions in CNG channels through structure-based mutagenesis that have previously not been predicted using NaK or K(+) channel models. ..
- Kim S, Sun H, Tomchick D, Yu H, Luo X. Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Proc Natl Acad Sci U S A. 2012;109:6549-54 pubmed publisher..Our results indicate that CTD is a part of an extensive kinetochore-binding interface of Mad1, and rationalize graded kinetochore targeting of Mad1 during checkpoint signaling. ..
- Jia D, Gomez T, Billadeau D, Rosen M. Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Mol Biol Cell. 2012;23:2352-61 pubmed publisher..We propose that multivalency enables FAM21 to sense the density of retromer on membranes, allowing coordination of SHRC recruitment, and consequent actin polymerization, with retromer sorting domain organization/maturation. ..
- Hofmann S, Topham M, Hsieh C, Francke U. cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. Genomics. 1991;9:656-69 pubmed..Of particular interest is an Alu-associated poly-d(GA) sequence located in an intron in the middle of the gene, and two stretches of acidic amino acids in the coding region of exon 1 that vary in length among different individuals. ..
- Craft C, Lolley R, Seldin M, Lee R. Rat pineal gland phosducin: cDNA isolation, nucleotide sequence, and chromosomal assignment in the mouse. Genomics. 1991;10:400-9 pubmed..In keeping with a proposed role of retinal phosducin in down-regulation of the photo-transduction cascade, a modulatory role in signal transduction is proposed for pineal phosducin. ..
- Orr E, Bewley G, Orr W. cDNA and deduced amino acid sequence of Drosophila catalase. Nucleic Acids Res. 1990;18:3663 pubmed
- Wright W, Sassoon D, Lin V. Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD. Cell. 1989;56:607-17 pubmed..Myogenin and MyoD thus form part of a gene family regulating myogenesis, and together with myd may constitute a set of factors that interact to regulate the determination and differentiation of muscle cells. ..