Genomes and Genes
Experts and Doctors on action potentials in Houston, Texas, United States
Locale: Houston, Texas, United States
Topic: action potentials
- Weragoda R, Ferrer E, Walters E. Memory-like alterations in Aplysia axons after nerve injury or localized depolarization. J Neurosci. 2004;24:10393-401 pubmed..This commonality suggests that relatively simple, accessible axons may offer an opportunity to define fundamental plasticity mechanisms that were important in the evolution of memory. ..
- Chen X, DeAngelis G, Angelaki D. Diverse spatial reference frames of vestibular signals in parietal cortex. Neuron. 2013;80:1310-21 pubmed publisher..Our findings reveal distinct spatial reference frames for representing vestibular signals and pose new challenges for understanding the respective roles of these areas in potentially diverse vestibular functions. ..
- Schulte J, Fehrmann E, Tekook M, Kranick D, Fels B, Li N, et al. Cardiac expression of the CREM repressor isoform CREM-IbÎ”C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016;111:15 pubmed publisher..Since CREM repressors are inducible by chronic Î²-adrenergic stimulation our results suggest that the inhibition of CRE-dependent transcription contributes to the formation of an arrhythmogenic substrate in chronic heart disease. ..
- Nargeot R, Baxter D, Byrne J. Correlation between activity in neuron B52 and two features of fictive feeding in Aplysia. Neurosci Lett. 2002;328:85-8 pubmed..These results suggest that activity in B52 may contribute to switching between ingestion-like and rejection-like BMPs by regulating both phase transition and termination of BMPs. ..
- Li Q, Guan X, Yen K, Zhang J, Yan J. The single transmembrane segment determines the modulatory function of the BK channel auxiliary ? subunit. J Gen Physiol. 2016;147:337-51 pubmed publisher..Our findings provide insights into the structure-function relationship of the ?1 subunit in understanding its potent modulatory effects on BK channels. ..
- Pang J, Gao F, Wu S. Light-evoked excitatory and inhibitory synaptic inputs to ON and OFF alpha ganglion cells in the mouse retina. J Neurosci. 2003;23:6063-73 pubmed..This detailed physiological analysis complements the existing anatomical results and provides new insights on the functional roles of individual synapses in the inner mammalian retina. ..
- Tian L, Kawai R, Crow T. Serotonin-immunoreactive CPT interneurons in Hermissenda: identification of sensory input and motor projections. J Neurophysiol. 2006;96:327-35 pubmed..Our results show that CPT neurons are polysensory interneurons that contribute to reflexive foot contractions in Hermissenda. ..
- Wang Y, Iliescu B, Ma J, Josic K, Dragoi V. Adaptive changes in neuronal synchronization in macaque V4. J Neurosci. 2011;31:13204-13 pubmed publisher..Thus, adaptive synchronization between the spiking activity of individual neurons and their local population can enhance temporally insensitive, rate-based-coding schemes for sensory discrimination. ..
- Salek R, Claussen C, Perez A, Dafny N. Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats. Eur J Pharmacol. 2012;679:60-7 pubmed publisher..However, following MPD rechallenge of these 14 units, 11 units (79%) exhibited an increase in their firing rate which is interpreted as sensitization. In conclusion, all PFC units modified their neural baseline activity. ..
- Kapur A, Yeckel M, Johnston D. Hippocampal mossy fiber activity evokes Ca2+ release in CA3 pyramidal neurons via a metabotropic glutamate receptor pathway. Neuroscience. 2001;107:59-69 pubmed..These results provide insight into the mechanisms and conditions of Ca2+ release in CA3 neurons and demonstrate the powerful influence mossy fiber input can have on these neurons. ..
- Ocker G, Josic K, Shea Brown E, Buice M. Linking structure and activity in nonlinear spiking networks. PLoS Comput Biol. 2017;13:e1005583 pubmed publisher..Our findings open new avenues to investigating how single-neuron nonlinearities-including those of different cell types-combine with connectivity to shape population activity and function. ..
- Li X, Nandedkar S, Zhou P. Modified motor unit number index: A simulation study of the first dorsal interosseous muscle. Med Eng Phys. 2016;38:115-20 pubmed publisher..The current simulation study demonstrated both the advantages and limitations of the standard and modified MUNIX techniques, which can help guide appropriate application and interpretation of MUNIX measurements. ..
- Haggerty D, Glykos V, Adams N, LeBeau F. Bidirectional modulation of hippocampal gamma (20-80 Hz) frequency activity in vitro via alpha(?)- and beta(?)-adrenergic receptors (AR). Neuroscience. 2013;253:142-54 pubmed publisher..These results suggest that NA is able to differentially modulate on-going gamma frequency oscillatory activity that could result in either increased or decreased information flow through the hippocampus. ..
- Zhang T, Placzek A, Dani J. In vitro identification and electrophysiological characterization of dopamine neurons in the ventral tegmental area. Neuropharmacology. 2010;59:431-6 pubmed publisher..We conclude that whole-cell patch clamp recording in combination with immunohistochemical detection of TH expression can guarantee positive but not negative DA identification in the VTA. ..
- Kubota Y, Putkey J, Shouval H, Waxham M. IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin. J Neurophysiol. 2008;99:264-76 pubmed..We examined the relative impact of these Ng-induced effects in the induction of synaptic plasticity. ..
- Li D, Chen S, Pan H. Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. J Neurochem. 2010;113:530-42 pubmed publisher..Collectively, our findings suggest that adenosine inhibits the excitability of PVN pre-sympathetic neurons through A(1) receptor-mediated opening of K(ATP) channels. ..
- Susuki K, Chang K, Zollinger D, Liu Y, Ogawa Y, Eshed Eisenbach Y, et al. Three mechanisms assemble central nervous system nodes of Ranvier. Neuron. 2013;78:469-82 pubmed publisher..Our results demonstrate that ECM, paranodal, and axonal cytoskeletal mechanisms ensure robust CNS nodal Na? channel clustering. ..
- Yin S, Luo J, Qian A, Du J, Yang Q, Zhou S, et al. Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. J Clin Invest. 2013;123:3941-51 pubmed publisher..These findings also suggest that selective TRPV1 antagonists are potential therapeutic drugs for treating retinoid-induced sensory hypersensitivity. ..
- Dragomir A, Akay Y, Akay M. Modeling carbachol-induced hippocampal network synchronization using hidden Markov models. J Neural Eng. 2010;7:056012 pubmed publisher..These findings, coupled with the documented cholinergic neurotransmission deficits in the 3xTG mice model, may be highly relevant for the case of AD...
- Yu X, Yoganarasimha D, Knierim J. Backward shift of head direction tuning curves of the anterior thalamus: comparison with CA1 place fields. Neuron. 2006;52:717-29 pubmed
- Kubota Y, Putkey J, Waxham M. Neurogranin controls the spatiotemporal pattern of postsynaptic Ca2+/CaM signaling. Biophys J. 2007;93:3848-59 pubmed..These analyses suggest that Ng regulates the encounter rate between Ca(2+) saturated CaM and its downstream targets during postsynaptic Ca(2+) transients. ..
- Law S, Conneely O, DeMayo F, O Malley B. Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992;6:2129-35 pubmed..Unlike Nur77, Nurr1 appears to be predominantly located in brain tissue, suggesting a primary role for this putative transcription factor in regulation of gene expression in the central nervous system. ..
- Qian J, Noebels J. Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse. J Neurosci. 2006;26:6089-95 pubmed..The ability to examine release dynamics with zinc fluorescence detection will facilitate exploration of the molecular pharmacology and plasticity of exocytosis at many CNS synapses. ..
- White J, Lin T, Brown A, Arancillo M, Lackey E, Stay T, et al. An optimized surgical approach for obtaining stable extracellular single-unit recordings from the cerebellum of head-fixed behaving mice. J Neurosci Methods. 2016;262:21-31 pubmed publisher..The surgical principles we present for accessing the cerebellum can be easily adapted to examine the function of neurons in other brain regions. ..
- Im S, Takle K, Jo J, Babcock D, Ma Z, Xiang Y, et al. Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. elife. 2015;4:e10735 pubmed publisher..Our results highlight a conserved role for Tachykinin signaling in regulating nociception and the power of Drosophila for genetic dissection of nociception. ..
- Zhang Y, Vilaythong A, Yoshor D, Noebels J. Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma. J Neurosci. 2004;24:5239-48 pubmed..We suggest that presynaptic release defects shared by these mutants lead to postsynaptic LVA excitability increases in thalamic pacemaker neurons that favor rebound bursting and absence epilepsy. ..
- Barnwell L, Lugo J, Lee W, Willis S, Gertz S, Hrachovy R, et al. Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation. Epilepsia. 2009;50:1741-51 pubmed publisher..2 channels is associated with enhanced susceptibility to convulsant stimulation, supporting the concept that Kv4.2 deficiency may contribute to aberrant network excitability and regulate seizure threshold. ..
- Noebels J. Single locus mutations in mice expressing generalized spike-wave absence epilepsies. Ital J Neurol Sci. 1995;16:107-11 pubmed..The reproducibility of these defined genetic models may facilitate age-dependent antiepileptic drug discovery by defining novel targets for therapy at different developmental stages of the seizure disorder. ..
- Di Pasquale E, Keegan K, Noebels J. Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer. J Neurophysiol. 1997;77:621-31 pubmed..This defect could lower the threshold for aberrant thalamocortical spike wave oscillations in vivo, and may contribute to the mechanism of one form of inherited absence epilepsy...
- Dufer M, Haspel D, Krippeit Drews P, Aguilar Bryan L, Bryan J, Drews G. Oscillations of membrane potential and cytosolic Ca(2+) concentration in SUR1(-/-) beta cells. Diabetologia. 2004;47:488-498 pubmed publisher..We examined how this gene deletion interferes with stimulus-secretion coupling. We tested the influence of metabolic inhibition and galanin, whose mode of action is controversial...
- Colbert C, Johnston D. Protein kinase C activation decreases activity-dependent attenuation of dendritic Na+ current in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1998;79:491-5 pubmed
- Xia R, Yosef N, Ubogu E. Clinical, electrophysiological and pathologic correlations in a severe murine experimental autoimmune neuritis model of Guillain-Barré syndrome. J Neuroimmunol. 2010;219:54-63 pubmed publisher..The high induction rates, as well as pathologic similarities with AIDP make sm-EAN a robust model to study the pathogenesis of human peripheral nerve inflammation using objective outcome measures. ..
- Huang Y, Stern M. In vivo properties of the Drosophila inebriated-encoded neurotransmitter transporter. J Neurosci. 2002;22:1698-708 pubmed..These data raise the possibility that Ine negatively regulates neuronal sodium channels, and thus that the substrate neurotransmitter of Ine positively regulates sodium channels. ..
- Verstreken P, Bellen H. Neuroscience. The meaning of a mini. Science. 2001;293:443-4 pubmed
- Bernard C, Anderson A, Becker A, Poolos N, Beck H, Johnston D. Acquired dendritic channelopathy in temporal lobe epilepsy. Science. 2004;305:532-5 pubmed..Kinase inhibition partly reversed dendritic excitability to control levels. Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE. ..
- Bellen H, Lu Y, Beckstead R, Bhat M. Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and glia. Trends Neurosci. 1998;21:444-9 pubmed..Caspr/paranodin might play an important role in barrier formation, and link neuronal membrane components with the axonal cytoskeletal network. ..
- Maksimovic S, Nakatani M, Baba Y, Nelson A, Marshall K, Wellnitz S, et al. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature. 2014;509:617-21 pubmed publisher..Thus, the Merkel cell-neurite complex is an unique sensory structure composed of two different receptor cell types specialized for distinct elements of discriminative touch. ..
- Broussard J, Yang K, Levine A, Tsetsenis T, Jenson D, Cao F, et al. Dopamine Regulates Aversive Contextual Learning and Associated In Vivo Synaptic Plasticity in the Hippocampus. Cell Rep. 2016;14:1930-9 pubmed publisher..The results indicate that dopamine-receptor signaling during an aversive contextual task regulates aversive memory retention and regulates associated synaptic mechanisms in the hippocampus that likely underlie learning. ..
- Lauver A, Yuan L, Jeromin A, Nadin B, Rodriguez J, Davies H, et al. Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression. J Neurochem. 2006;99:1207-23 pubmed..Our results establish a specific role for native Kv4.2 transcripts in forming and maintaining I(SA) current at characteristic levels in hippocampal pyramidal neurons. ..
- Froudarakis E, Berens P, Ecker A, Cotton R, Sinz F, Yatsenko D, et al. Population code in mouse V1 facilitates readout of natural scenes through increased sparseness. Nat Neurosci. 2014;17:851-7 pubmed publisher..Our results argue for a functional benefit of sparsification that could be a general principle governing the structure of the population activity throughout cortical microcircuits. ..
- Chin J, Liu R, Cleary L, Eskin A, Byrne J. TGF-beta1-induced long-term changes in neuronal excitability in aplysia sensory neurons depend on MAPK. J Neurophysiol. 2006;95:3286-90 pubmed
- Sun Y, Wu C, Renger J, Uebele V, Lu H, Beierlein M. GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons. J Neurosci. 2012;32:7782-90 pubmed publisher..Our results show that GABA-evoked depolarizations can interact with T-type Ca(2+) channels to powerfully control spike generation in TRN neurons. ..
- Fotowat H, Fayyazuddin A, Bellen H, Gabbiani F. A novel neuronal pathway for visually guided escape in Drosophila melanogaster. J Neurophysiol. 2009;102:875-85 pubmed publisher..These pathways exhibit very different patterns of sensory activity and are associated with two distinct motor programs. ..
- Chun Jen Lin C, Summerville J, Howlett E, Stern M. The metabotropic glutamate receptor activates the lipid kinase PI3K in Drosophila motor neurons through the calcium/calmodulin-dependent protein kinase II and the nonreceptor tyrosine protein kinase DFak. Genetics. 2011;188:601-13 pubmed publisher..CaMKII, but not PI3K, requires DFak activity for these increases. We conclude that the activation of PI3K by DmGluRA is mediated by CaMKII and DFak. ..
- Peron S, Krapp H, Gabbiani F. Influence of electrotonic structure and synaptic mapping on the receptive field properties of a collision-detecting neuron. J Neurophysiol. 2007;97:159-77 pubmed..Our results illustrate how interactions between the distribution of synaptic inputs and the electrotonic properties of neurons contribute to shaping their receptive fields. ..
- Hansen B, Chelaru M, Dragoi V. Correlated variability in laminar cortical circuits. Neuron. 2012;76:590-602 pubmed publisher..Contrary to expectation that the output cortical layers encode stimulus information most accurately, we found that the input network offers superior discrimination performance compared to the output networks...
- Crow T, Tian L. Morphological characteristics and central projections of two types of interneurons in the visual pathway of Hermissenda. J Neurophysiol. 2002;87:322-32 pubmed..These results indicate that there is at least one additional interneuron in the higher-order visual circuit between type I interneurons and pedal motor neurons responsible for the generation of phototactic locomotion in Hermissenda...
- Maruko I, Zhang B, Tao X, Tong J, Smith E, Chino Y. Postnatal development of disparity sensitivity in visual area 2 (v2) of macaque monkeys. J Neurophysiol. 2008;100:2486-95 pubmed publisher..This reduction in disparity sensitivity of V2 and V1 neurons is likely to limit binocular depth perception during the first several weeks of a monkey's life. ..
- Gabbiani F, Krapp H. Spike-frequency adaptation and intrinsic properties of an identified, looming-sensitive neuron. J Neurophysiol. 2006;96:2951-62 pubmed..Spike-frequency adaptation is likely to play an important role in tuning the LGMD and in shaping the variability of its responses to visual looming stimuli. ..
- Wu X, McNeil B, Xu J, Fan J, Xue L, Melicoff E, et al. Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal. Nat Neurosci. 2009;12:1003-1010 pubmed publisher..Our findings provide a unifying mechanism for the initiation of various forms of endocytosis that are critical in maintaining exocytosis. ..
- Losavio B, Iyer V, Patel S, Saggau P. Acousto-optic laser scanning for multi-site photo-stimulation of single neurons in vitro. J Neural Eng. 2010;7:045002 pubmed publisher..Our laser scanning systems can produce the sophisticated spatio-temporal patterns of synaptic input that are necessary to investigate single-neuron dendritic physiology. ..
- Cao X, Byun H, Chen S, Cai Y, Pan H. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. J Neurochem. 2010;114:1460-75 pubmed publisher..Increased BDNF activity in these neurons likely contributes to the reduction in Kv channel function through TrkB receptor stimulation in painful diabetic neuropathy. ..
- Barrows C, McCabe M, Chen H, Swann J, Weston M. PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network. J Neurosci. 2017;37:8595-8611 pubmed publisher..Moreover, given the robustness of homeostatic plasticity, these diverse effects on connection types may be necessary to cause network phenotypes such as increased synchrony. ..
- Weng H, Dougherty P. Response properties of dorsal root reflexes in cutaneous C fibers before and after intradermal capsaicin injection in rats. Neuroscience. 2005;132:823-31 pubmed..The role of C fiber DRRs in normal sensory transmission and during hyperalgesia is discussed. ..
- Sun Y, Pita Almenar J, Wu C, Renger J, Uebele V, Lu H, et al. Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons. J Neurosci. 2013;33:2048-59 pubmed publisher..Our study demonstrates fast and precise synaptic E-I signaling mediated by ACh, suggesting novel computational mechanisms for the cholinergic control of neuronal activity in thalamic circuits. ..
- Namiranian K, Lloyd E, Crossland R, Marrelli S, Taffet G, Reddy A, et al. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Am J Physiol Regul Integr Comp Physiol. 2010;299:R461-9 pubmed publisher..There was no sign of TREK-1-like currents in CVSMCs from WT mice, and there were no major differences in currents between the genotypes. We conclude that regulation of arterial diameter is not altered in mice lacking TREK-1. ..
- Nadin B, Pfaffinger P. Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells. J Neurosci. 2010;30:8551-65 pubmed publisher..Overall, DPP6 expression seems to be critical for the expression of a high-frequency electrophysiological phenotype in CG cells by increasing leak conductance, A-type current levels and kinetics, and Na(+) current amplitude. ..
- Davis R. Olfactory learning. Neuron. 2004;44:31-48 pubmed..Molecular genetic studies of olfactory learning in Drosophila have revealed numerous molecules that function within the third order olfactory neurons for normal olfactory learning. ..
- Weng H, Chen J, Cata J. Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. Neuroscience. 2006;138:1351-60 pubmed
- Wu S, Cheng C, Lanz R, Wang T, Respress J, Ather S, et al. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013;25:417-26 pubmed publisher..Collectively, our results reveal that COUP-TFII confers atrial identity through direct binding and by modulating expression of a broad spectrum of genes that have an impact on atrial development and function. ..
- Selcher J, Weeber E, Christian J, Nekrasova T, Landreth G, Sweatt J. A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. Learn Mem. 2003;10:26-39 pubmed..Overall, our data indicate that the progressive increase in spiking observed during TBS represents a form of physiologic temporal integration that is dependent on ERK MAPK activity. ..
- Sabbahi M, Sengul Y. Cervical multisegmental motor responses in healthy subjects. Spinal Cord. 2012;50:432-9 pubmed publisher..Experimental design...
- Yoganarasimha D, Rao G, Knierim J. Lateral entorhinal neurons are not spatially selective in cue-rich environments. Hippocampus. 2011;21:1363-74 pubmed publisher..These data strongly support the notion that the MEC and LEC convey fundamentally different types of information to the hippocampus, in terms of their spatial firing characteristics, under various environmental and behavioral conditions. ..