Experts and Doctors on acetyltransferases in Dallas, Texas, United States

Summary

Locale: Dallas, Texas, United States
Topic: acetyltransferases

Top Publications

  1. McKinsey T, Zhang C, Olson E. Control of muscle development by dueling HATs and HDACs. Curr Opin Genet Dev. 2001;11:497-504 pubmed
    ..We describe the molecules and mechanisms involved in chromatin remodeling during skeletal muscle development. ..
  2. Hou F, Zou H. Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion. Mol Biol Cell. 2005;16:3908-18 pubmed
    ..We propose that EFO1 and EFO2 are targeted to different chromosome structures to help establish or maintain sister-chromatid cohesion. ..
  3. Wong K, Sharma A, Awasthi S, Matlock E, Rogers L, Van Lint C, et al. HIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB. J Biol Chem. 2005;280:9390-9 pubmed
    ..Importantly, these findings suggest that HIV-1 Tat-coactivator interactions may contribute to neurotrophin signaling impairments and neuronal apoptosis associated with HIV-1 infections of the CNS. ..
  4. Wong K, Zhang J, Awasthi S, Sharma A, Rogers L, Matlock E, et al. Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases. J Biol Chem. 2004;279:55667-74 pubmed
  5. Harrod R, Nacsa J, Van Lint C, Hansen J, Karpova T, McNally J, et al. Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription. J Biol Chem. 2003;278:12310-8 pubmed
    ..Our results allude to a mechanism whereby the human immunodeficiency virus type-1 trans-activator might impair tumor suppressor functions in immune/neuronal-derived cells, thus favoring the establishment of neoplasia during AIDS. ..
  6. Cao D, Wang Z, Zhang C, Oh J, Xing W, Li S, et al. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005;25:364-76 pubmed
    ..These findings point to myocardin as a nexus for positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation. ..
  7. Mukherjee S, Keitany G, Li Y, Wang Y, Ball H, Goldsmith E, et al. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science. 2006;312:1211-4 pubmed
    ..The acetylation on MAPKK6 directly competed with phosphorylation, preventing activation of the modified protein. This covalent modification may be used as a general regulatory mechanism in biological signaling. ..
  8. Sakata I, Yang J, Lee C, Osborne Lawrence S, Rovinsky S, Elmquist J, et al. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab. 2009;297:E134-41 pubmed publisher
    ..We also demonstrate that GOAT is the only member of the MBOAT family whose expression is highly enriched within gastric ghrelin cells and whose whole body distribution mirrors that of ghrelin. ..
  9. Li Q, Sudhof T. Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem. 2004;279:10542-50 pubmed
    ..Our data demonstrate that APLPs and APP are processed similarly to act via the same nuclear target, suggesting that BACE 1 cleavage regulates a common function of APP and APLPs in neurons. ..

More Information

Publications17

  1. Moon Y, Shah N, Mohapatra S, Warrington J, Horton J. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J Biol Chem. 2001;276:45358-66 pubmed
    ..The current studies suggest that mouse LCE expression is increased by SREBPs and that the enzyme is a component of the elusive mammalian elongation system that converts palmitic to stearic acid. ..
  2. Hiesberger T, Shao X, Gourley E, Reimann A, Pontoglio M, Igarashi P. Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. J Biol Chem. 2005;280:10578-86 pubmed
    ..Expression of HNF-1alpha in proximal tubules may protect against cystogenesis. ..
  3. Cao X, Sudhof T. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science. 2001;293:115-20 pubmed
    ..This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression. ..
  4. Awasthi S, Sharma A, Wong K, Zhang J, Matlock E, Rogers L, et al. A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions. Mol Cell Biol. 2005;25:6178-98 pubmed
    ..Importantly, these results suggest that p30II functions as a novel retroviral modulator of Myc-TIP60-transforming interactions that may contribute to adult T-cell leukemogenesis. ..
  5. Hou F, Chu C, Kong X, Yokomori K, Zou H. The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. J Cell Biol. 2007;177:587-97 pubmed
    ..Collectively, San may be specifically required for the maintenance of the centromeric cohesion in mitosis. ..
  6. Liang C, Marks G. GABAA receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat: implications for REM sleep control. Brain Res. 2014;1543:58-64 pubmed publisher
    ..Immunoreactive cholinergic boutons were found to be colocalized with GABA(A) receptor subunit protein ?2. This finding implicates a specific subtype and location of GABA(A) receptors in PnO of rat in the control of REM sleep. ..
  7. Cao X, Sudhof T. Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem. 2004;279:24601-11 pubmed
    ..Our data suggest that transcriptional transactivation by APP and Notch may involve distinct mechanisms; whereas the Notch intracellular domain directly functions in the nucleus, the AICD acts indirectly by activating Fe65. ..
  8. Moon Y, Hammer R, Horton J. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. J Lipid Res. 2009;50:412-23 pubmed publisher
    ..These studies demonstrate that reduced ELOVL5 activity leads to hepatic steatosis, and endogenously synthesized PUFAs are key regulators of SREBP-1c activation and fatty acid synthesis in livers of mice. ..