Experts and Doctors on zebrafish in Nashville, Tennessee, United States

Summary

Locale: Nashville, Tennessee, United States
Topic: zebrafish

Top Publications

  1. Park H, Mehta A, Richardson J, Appel B. olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Dev Biol. 2002;248:356-68 pubmed
    ..One possibility consistent with these data is that Hedgehog signaling, partly by inducing olig2 expression, specifies neural precursor cells that have potential for primary motor neuron or oligodendrocyte fate. ..
  2. Shin J, Park H, Topczewska J, Mawdsley D, Appel B. Neural cell fate analysis in zebrafish using olig2 BAC transgenics. Methods Cell Sci. 2003;25:7-14 pubmed
    ..Combined with recent advances in live embryo image analysis, this strategy has the potential to greatly advance the investigation of neural cell behavior during development. ..
  3. Latimer A, Jessen J. Hgf/c-met expression and functional analysis during zebrafish embryogenesis. Dev Dyn. 2008;237:3904-15 pubmed publisher
    ..Similar to mouse, knockdown of zebrafish Met reduces liver size. Our results suggest a role for Met during endoderm specification and indicate that mechanisms of liver development are conserved between mammals and bony fish. ..
  4. Meng S, Ryu S, Zhao B, Zhang D, Driever W, McMahon D. Targeting retinal dopaminergic neurons in tyrosine hydroxylase-driven green fluorescent protein transgenic zebrafish. Mol Vis. 2008;14:2475-83 pubmed
    ..This transgenic line provides a useful tool for studying retinal dopaminergic cells in the zebrafish. ..
  5. Sarmah B, Wente S. Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway. Proc Natl Acad Sci U S A. 2010;107:19921-6 pubmed publisher
    ..We propose that IP6K2 activity is required at the level or downstream of Smoothened but upstream of the transcription activator Gli1. ..
  6. Liu D, Wang W, Melville D, Cha Y, Yin Z, Issaeva N, et al. Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly. Dev Dyn. 2011;240:1613-25 pubmed publisher
    ..These functions provide further insight into Lzap activity that may contribute not only to development, but also to tumor formation. ..
  7. Topczewska J, Topczewski J, Solnica Krezel L, Hogan B. Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. Mech Dev. 2001;100:343-7 pubmed
    ..Early expression of foxc1a in the paraxial mesoderm is modified in chordino, swirl, somitabun, and spadetail mutants. ..
  8. Cha Y, Solnica Krezel L, DuBois R. Fishing for prostanoids: deciphering the developmental functions of cyclooxygenase-derived prostaglandins. Dev Biol. 2006;289:263-72 pubmed
  9. Solnica Krezel L. Gastrulation in zebrafish -- all just about adhesion?. Curr Opin Genet Dev. 2006;16:433-41 pubmed
    ..Whereas some signaling pathways are required for a subset of these behaviors, other molecules, such as E-cadherin or Galpha12 and Galpha13 proteins, appear to have a widespread role in different gastrulation cell behaviors...

More Information

Publications112 found, 100 shown here

  1. Qu X, Jia H, Garrity D, Tompkins K, Batts L, Appel B, et al. Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol. 2008;317:486-96 pubmed publisher
    ..Together, our studies reveal an essential role of ndrg4 in regulating proliferation and growth of cardiomyocytes, suggesting that ndrg4 may function downstream of tbx5 during heart development and growth. ..
  2. Latimer A, Jessen J. Extracellular matrix assembly and organization during zebrafish gastrulation. Matrix Biol. 2010;29:89-96 pubmed publisher
    ..These results provide a framework for uncovering the interrelationship between ECM structure and cellular processes regulating convergence and extension such as directed migration and mediolateral/radial intercalation. ..
  3. Jao L, Appel B, Wente S. A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization. Development. 2012;139:1316-26 pubmed publisher
    ..We propose that defective GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors. ..
  4. Ni T, Lu J, Zhu M, Maddison L, Boyd K, Huskey L, et al. Conditional control of gene function by an invertible gene trap in zebrafish. Proc Natl Acad Sci U S A. 2012;109:15389-94 pubmed
    ..Furthermore, because FT1 is based on the promiscuous Tol2 transposon, it should be applicable to many organisms. ..
  5. Lin C, Erkek S, Tong Y, Yin L, Federation A, Zapatka M, et al. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. 2016;530:57-62 pubmed publisher
    ..Our integrated analysis of enhancer elements in a large series of primary tumour samples reveals insights into cis-regulatory architecture, unrecognized dependencies, and cellular origins. ..
  6. Chopra S, Stroud D, Watanabe H, Bennett J, Burns C, Wells K, et al. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res. 2010;106:1342-50 pubmed publisher
    ..These findings identify a novel and possibly nonelectrogenic role for cardiac sodium channels in heart development. ..
  7. Fekany K, Yamanaka Y, Leung T, Sirotkin H, Topczewski J, Gates M, et al. The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development. 1999;126:1427-38 pubmed
  8. Latimer A, Dong X, Markov Y, Appel B. Delta-Notch signaling induces hypochord development in zebrafish. Development. 2002;129:2555-63 pubmed
    ..We propose that Delta signaling from paraxial mesoderm diversifies midline cell fate by inducing a subset of neighboring midline precursors to develop as hypochord, rather than as notochord. ..
  9. Park H, Appel B. Delta-Notch signaling regulates oligodendrocyte specification. Development. 2003;130:3747-55 pubmed
    ..Our data provide evidence that Notch signaling maintains subsets of ventral spinal cord precursors during neuronal birth and, acting with other temporally and spatially restricted factors, specifies them for oligodendrocyte fate. ..
  10. Zhang C, Song Y, Thompson D, Madonna M, Millhauser G, Toro S, et al. Pineal-specific agouti protein regulates teleost background adaptation. Proc Natl Acad Sci U S A. 2010;107:20164-71 pubmed publisher
  11. Williams B, Cantrell V, Mundell N, Bennett A, Quick R, Jessen J. VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. J Cell Sci. 2012;125:2141-7 pubmed publisher
    ..Our findings implicate matrix metalloproteinases as downstream effectors of PCP and suggest a broadly applicable mechanism whereby VANGL2 affects diverse morphogenetic processes. ..
  12. Samuel A, Rubinstein A, Azar T, Ben Moshe Livne Z, Kim S, Inbal A. Six3 regulates optic nerve development via multiple mechanisms. Sci Rep. 2016;6:20267 pubmed publisher
    ..Hence, the new zebrafish model for Six3 loss of function furthers our understanding of the mechanisms governing optic nerve development and Six3-mediated eye and forebrain malformations. ..
  13. Wilm T, Solnica Krezel L. Essential roles of a zebrafish prdm1/blimp1 homolog in embryo patterning and organogenesis. Development. 2005;132:393-404 pubmed
    ..Our studies reveal essential roles for prdm1 in limiting the function of the gastrula organizer and regulating cell fate specification and morphogenetic processes in precise correspondence with its intricate expression pattern. ..
  14. Latimer A, Appel B. Notch signaling regulates midline cell specification and proliferation in zebrafish. Dev Biol. 2006;298:392-402 pubmed
    ..Together, our results indicate that Notch signaling regulates allocation of appropriate numbers of different midline cells by different mechanisms. ..
  15. Dohn M, Mundell N, Sawyer L, Dunlap J, Jessen J. Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Dev Biol. 2013;383:39-51 pubmed publisher
    ..Together, our results demonstrate that zebrafish Vangl2/Prickle1a and non-canonical Wnt/Frizzled signaling have opposing effects on ECM organization underlying PCP and gastrulation cell movements...
  16. Patterson M, Barske L, Van Handel B, Rau C, Gan P, Sharma A, et al. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017;49:1346-1353 pubmed publisher
    ..Our results corroborate the relevance of MNDCMs in heart regeneration. Moreover, they imply that intrinsic heart regeneration is not limited nor uniform in all individuals, but rather is a variable trait influenced by multiple genes. ..
  17. Inbal A, Kim S, Shin J, Solnica Krezel L. Six3 represses nodal activity to establish early brain asymmetry in zebrafish. Neuron. 2007;55:407-15 pubmed
    ..Our data reveal a Six3-dependent mechanism for establishment of correct brain laterality and provide an entry point to understanding the genetic regulation of Nodal signaling in the brain. ..
  18. Wang W, Melville D, Montero Balaguer M, Hatzopoulos A, Knapik E. Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. Dev Biol. 2011;360:173-85 pubmed publisher
  19. Bennett J, Stroud D, Becker J, Roden D. Proliferation of embryonic cardiomyocytes in zebrafish requires the sodium channel scn5Lab. Genesis. 2013;51:562-74 pubmed publisher
  20. Jao L, Wente S, Chen W. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci U S A. 2013;110:13904-9 pubmed publisher
    ..This CRISPR/Cas9 system represents a highly effective and scalable gene knockout method in zebrafish and has the potential for applications in other model organisms. ..
  21. Speirs C, Jernigan K, Kim S, Cha Y, Lin F, Sepich D, et al. Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development. 2010;137:1327-37 pubmed publisher
  22. Hufnagel R, Arno G, Hein N, Hersheson J, Prasad M, Anderson Y, et al. Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes. J Med Genet. 2015;52:85-94 pubmed publisher
  23. Koteiche H, Claxton D, Mishra S, Stein R, McDonald E, McHaourab H. Species-Specific Structural and Functional Divergence of α-Crystallins: Zebrafish αBa- and Rodent αA(ins)-Crystallin Encode Activated Chaperones. Biochemistry. 2015;54:5949-58 pubmed publisher
    ..These results emphasize the role of sequence divergence as an evolutionary strategy to tune chaperone function to the requirements of the tissues and organisms in which they are expressed. ..
  24. Wang W, Huang C, Lu Y, Hsin J, Prabhakar V, Cheng C, et al. Heart-targeted overexpression of Nip3a in zebrafish embryos causes abnormal heart development and cardiac dysfunction. Biochem Biophys Res Commun. 2006;347:979-87 pubmed
    ..These results showed that myocyte apoptosis is a universal pathogenic factor for congenital heart failure using zebrafish as a model organism. ..
  25. Granero Molto F, Sarmah S, O Rear L, Spagnoli A, Abrahamson D, Saus J, et al. Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development. J Biol Chem. 2008;283:20495-504 pubmed publisher
    ..Moreover, this phenotype is mediated by Gpbp but not GpbpDelta26/CERT, suggesting that Gpbp is an important factor for normal skeletal muscle and brain development. ..
  26. Zeng X, Zheng X, Xiang Y, Cho H, Jessen J, Zhong T, et al. Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish. Dev Biol. 2009;328:363-76 pubmed publisher
    ..These results provide the first evidence that function of Pld1 in the developing notochord is essential for vascular development in vertebrates. ..
  27. Topczewski J, Sepich D, Myers D, Walker C, Amores A, Lele Z, et al. The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension. Dev Cell. 2001;1:251-64 pubmed
  28. Doll C, Burkart J, Hope K, Halpern M, Gamse J. Subnuclear development of the zebrafish habenular nuclei requires ER translocon function. Dev Biol. 2011;360:44-57 pubmed publisher
    ..Our results show that in the absence of sec61al1, an excess of precursor cells for the LsDh exit the ventricular region and differentiate, resulting in formation of bilaterally symmetric habenular nuclei. ..
  29. Snelson C, Burkart J, Gamse J. Formation of the asymmetric pineal complex in zebrafish requires two independently acting transcription factors. Dev Dyn. 2008;237:3538-44 pubmed publisher
    ..Careful analysis shows that flh is not required for tbx2b transcription and double mutants exhibit an additive phenotype. We conclude that Flh and Tbx2b regulate separate programs of pineal and parapineal development. ..
  30. Taylor R, Hsieh Y, Gamse J, Chuang C. Making a difference together: reciprocal interactions in C. elegans and zebrafish asymmetric neural development. Development. 2010;137:681-91 pubmed publisher
    ..Although the molecular details are divergent, both organisms use iterative cell-cell communication to establish left-right neuronal identity. ..
  31. de Borsetti N, Dean B, Bain E, Clanton J, Taylor R, Gamse J. Light and melatonin schedule neuronal differentiation in the habenular nuclei. Dev Biol. 2011;358:251-61 pubmed publisher
    ..We conclude that light and melatonin schedule the differentiation of neurons and the formation of neural processes in the habenular nuclei. ..
  32. Wei C, Salichos L, Wittgrove C, Rokas A, Patton J. Transcriptome-wide analysis of small RNA expression in early zebrafish development. RNA. 2012;18:915-29 pubmed publisher
    ..Beside miRNAs, we also identified a large and unexpectedly diverse set of piRNAs expressed during early development. ..
  33. Topczewska J, Topczewski J, Shostak A, Kume T, Solnica Krezel L, Hogan B. The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. Genes Dev. 2001;15:2483-93 pubmed
    ..Therefore, zebrafish foxc1a plays an essential and conserved role in somite formation, regulating both the expression of paraxis and the A/P patterning of somite primordia. ..
  34. de Caestecker M, Bottomley M, Bhattacharyya S, Payne T, Roberts A, Yelick P. The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochem Biophys Res Commun. 2002;293:1556-65 pubmed
    ..These results expand the signaling repertoire of zAlk8 by demonstrating an ability to participate in two distinct TGF-beta subfamily signaling pathways. ..
  35. Jessen J, Topczewski J, Bingham S, Sepich D, Marlow F, Chandrasekhar A, et al. Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nat Cell Biol. 2002;4:610-5 pubmed
    ..We propose Trilobite/Stbm mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis. ..
  36. Zannino D, Appel B. Olig2+ precursors produce abducens motor neurons and oligodendrocytes in the zebrafish hindbrain. J Neurosci. 2009;29:2322-33 pubmed publisher
    ..These studies, therefore, reveal both common and independent roles for olig2 in development of somatic motor neurons and oligodendrocytes of the hindbrain. ..
  37. Lin F, Chen S, Sepich D, Panizzi J, Clendenon S, Marrs J, et al. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. J Cell Biol. 2009;184:909-21 pubmed publisher
    ..These results provide the first in vivo evidence that Galpha(12/13) regulate epiboly through two distinct mechanisms: limiting E-cadherin activity and modulating the organization of the actin cytoskeleton. ..
  38. Williams C, Kim S, Ni T, Mitchell L, Ro H, Penn J, et al. Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev Biol. 2010;341:196-204 pubmed publisher
    ..Collectively, these studies suggest that arterial endothelial cells are specified and formed via repressing venous cell fate at the lateral plate mesoderm by Hh signaling during vasculogenesis. ..
  39. Latimer A, Shin J, Appel B. her9 promotes floor plate development in zebrafish. Dev Dyn. 2005;232:1098-104 pubmed
    ..We show that, instead, her9 is a downstream effector of Nodal signaling for floor plate specification. ..
  40. Melville D, Montero Balaguer M, Levic D, Bradley K, Smith J, Hatzopoulos A, et al. The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Dis Model Mech. 2011;4:763-76 pubmed publisher
  41. Wu S, de Borsetti N, Bain E, Bulow C, Gamse J. Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development. Dev Biol. 2014;385:13-22 pubmed publisher
    ..We propose that the Mediator complex is responsible for subtle but significant changes in transcriptional timing and amplitude that are essential for coordinating the development of neurons in the epithalamus. ..
  42. Park H, Shin J, Appel B. Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development. 2004;131:5959-69 pubmed
    ..Our studies show that spatial and temporal differences in Hh signaling within a common population of neural precursors can contribute to cell fate diversification. ..
  43. Hong C, Yu P. Applications of small molecule BMP inhibitors in physiology and disease. Cytokine Growth Factor Rev. 2009;20:409-18 pubmed publisher
    ..We also discuss several potential applications for small molecule BMP inhibitors, including stem cell manipulation, and the therapeutic modification of bone remodeling, heterotopic ossification, and iron homeostasis. ..
  44. Carlin D, Sepich D, Grover V, Cooper M, Solnica Krezel L, Inbal A. Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling. Development. 2012;139:2614-24 pubmed publisher
    ..We further find that Six3 promotes ventral telencephalic fates through transient regulation of foxg1a expression and repression of the Wnt/?-catenin pathway. ..
  45. Müller I, Melville D, Tanwar V, Rybski W, Mukherjee A, Shoemaker M, et al. Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm. Dis Model Mech. 2013;6:332-41 pubmed publisher
    ..These results implicate, for the first time, regulators of BMP signaling in human AF, providing mechanistic insights into the pathogenesis of the disease and identifying potential new therapeutic targets. ..
  46. Marlow F, Topczewski J, Sepich D, Solnica Krezel L. Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr Biol. 2002;12:876-84 pubmed
    ..Furthermore, elongation and orientation of the cell body are independent properties that require both cell-autonomous and nonautonomous Rok2 function. ..
  47. Lin F, Sepich D, Chen S, Topczewski J, Yin C, Solnica Krezel L, et al. Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. J Cell Biol. 2005;169:777-87 pubmed
    ..These findings provide the first evidence that Galpha(12) and Galpha(13) have overlapping and essential roles in distinct cell behaviors that drive vertebrate gastrulation. ..
  48. Shin J, Poling J, Park H, Appel B. Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development. 2007;134:1911-20 pubmed
  49. Zhang C, Forlano P, Cone R. AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metab. 2012;15:256-64 pubmed publisher
    ..This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation. ..
  50. Jessen J, Solnica Krezel L. Identification and developmental expression pattern of van gogh-like 1, a second zebrafish strabismus homologue. Gene Expr Patterns. 2004;4:339-44 pubmed
    ..Injection of synthetic vangl1 RNA partially suppressed the gastrulation defect in trilobite mutant embryos, suggesting that Vangl1 and Trilobite/Vangl2 have similar biochemical activities. ..
  51. Lang M, Lapierre L, Frotscher M, Goldenring J, Knapik E. Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nat Genet. 2006;38:1198-203 pubmed
    ..As SEC23A lesions cause the cranio-lenticulo-sutural dysplasia syndrome, crusher provides the first vertebrate model system that links the biology of endoplasmic reticulum to Golgi trafficking with a clinically relevant dysmorphology. ..
  52. Kim S, Speirs C, Solnica Krezel L, Ess K. Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin. Dis Model Mech. 2011;4:255-67 pubmed publisher
    ..The finding of a non-cell-autonomous function of mutant cells might help explain the formation of brain hamartomas and cortical malformations in human TSC...
  53. Kim S, Scott S, Bennett M, Carson R, Fessel J, Brown H, et al. Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency. PLoS Genet. 2013;9:e1003563 pubmed publisher
    ..Altered mTORC1 signaling and maternal nutritional status may play critical roles in MADD disease progression and suggest novel treatment approaches that may ameliorate disease severity. ..
  54. Sebag J, Zhang C, Hinkle P, Bradshaw A, Cone R. Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science. 2013;341:278-81 pubmed publisher
  55. Solnica Krezel L, Eaton S. Embryo morphogenesis: getting down to cells and molecules. Development. 2003;130:4229-33 pubmed
  56. Appel B, Marasco P, McClung L, Latimer A. lunatic fringe regulates Delta-Notch induction of hypochord in zebrafish. Dev Dyn. 2003;228:281-6 pubmed
  57. Müller I, Knapik E, Hatzopoulos A. Expression of the protein related to Dan and Cerberus gene--prdc--During eye, pharyngeal arch, somite, and swim bladder development in zebrafish. Dev Dyn. 2006;235:2881-8 pubmed
    ..Moreover, the complexity of the prdc expression pattern suggests possible roles in eye development, pharyngeal arch remodeling, somitogenesis, and swim bladder organogenesis...
  58. Panizzi J, Jessen J, Drummond I, Solnica Krezel L. New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia. Development. 2007;134:921-31 pubmed
    ..Our studies in zebrafish embryos have identified new, essential roles for this RhoGEF in ciliated epithelia during vertebrate development...
  59. Jia H, King I, Chopra S, Wan H, Ni T, Jiang C, et al. Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proc Natl Acad Sci U S A. 2007;104:14008-13 pubmed
    ..Hence, our studies suggest that Grl regulates embryonic heart growth via opposing Gata5, at least in part through their protein interactions in modulating gene expression. ..
  60. Thatcher E, Bond J, Paydar I, Patton J. Genomic organization of zebrafish microRNAs. BMC Genomics. 2008;9:253 pubmed publisher
    ..The largest of these families (the miR-430 family) contains 72 members largely clustered in two main locations along chromosome 4. Thus far, most zebrafish miRNAs exhibit tissue specific patterns of expression. ..
  61. Becker J, Robinson T, Sachidanandan C, Kelly A, Coy S, Peterson R, et al. In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovasc Res. 2012;93:463-70 pubmed publisher
    ..We believe this in vivo reporter line will offer a unique approach to the identification of novel chemical or genetic regulators of myocardial hypertrophy and heart failure. ..
  62. Kim S, Kowalski M, Carson R, Bridges L, Ess K. Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish. Dis Model Mech. 2013;6:925-33 pubmed publisher
  63. Solnica Krezel L, Driever W. The role of the homeodomain protein Bozozok in zebrafish axis formation. Int J Dev Biol. 2001;45:299-310 pubmed
    ..Notably, Bozozok appears to function by repressing transcription of target genes such as swr (bmp2b) gene, and as such is the earliest acting repressor that the nascent dorsal axis is using to antagonize ventral influences...
  64. Roberts R, Appel B. Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish. Dev Dyn. 2009;238:1638-48 pubmed publisher
    ..We conclude that PrkCi function and planar divisions are necessary for asymmetric, self-renewing division of spinal cord precursors. ..
  65. Taylor R, Qi J, Talaga A, Ma T, Pan L, Bartholomew C, et al. Asymmetric inhibition of Ulk2 causes left-right differences in habenular neuropil formation. J Neurosci. 2011;31:9869-78 pubmed publisher
    ..This work describes a regulatory mechanism for neuronal process extension that may be conserved in other developmental contexts in addition to the epithalamus. ..
  66. Flynt A, Li N, Thatcher E, Solnica Krezel L, Patton J. Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate. Nat Genet. 2007;39:259-63 pubmed
    ..Through regulation of su(fu), miR-214 enables precise specification of muscle cell types by sharpening cellular responses to Hedgehog. ..
  67. Van Raay T, Coffey R, Solnica Krezel L. Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol. 2007;309:151-68 pubmed
    ..Finally, reducing Nkd1 function in slb mutants suppressed the axial mesendoderm C&E defect. These data indicate that zebrafish Nkd1 and Nkd2 function to limit both canonical and non-canonical Wnt signaling. ..
  68. Snelson C, Santhakumar K, Halpern M, Gamse J. Tbx2b is required for the development of the parapineal organ. Development. 2008;135:1693-702 pubmed publisher
    ..We conclude that tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration. ..
  69. Flynt A, Thatcher E, Burkewitz K, Li N, Liu Y, Patton J. miR-8 microRNAs regulate the response to osmotic stress in zebrafish embryos. J Cell Biol. 2009;185:115-27 pubmed publisher
    ..Ultimately, disruption of miR-8 family member function leads to an inability to respond to osmotic stress and blocks the ability to properly traffic and/or cluster transmembrane glycoproteins at the apical surface of ionocytes. ..
  70. Sepich D, Usmani M, Pawlicki S, Solnica Krezel L. Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movements. Development. 2011;138:543-52 pubmed publisher
    ..Wnt/PCP signaling influences the polarity of the microtubule cytoskeleton and, conversely, microtubules are required for the asymmetric distribution of Wnt/PCP pathway components. ..
  71. Wu S, Shin J, Sepich D, Solnica Krezel L. Chemokine GPCR signaling inhibits β-catenin during zebrafish axis formation. PLoS Biol. 2012;10:e1001403 pubmed publisher
    ..Our study delineates a novel negative, Gsk3β-independent control mechanism of β-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation. ..
  72. Cheng A, Thisse B, Thisse C, Wright C. The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. Development. 2000;127:1049-61 pubmed
    ..We propose that the induction of lefty/Xatv in the left LPM by nodal/Xnr1 provides an efficient self-regulating mechanism to downregulate nodal/Xnr1 expression and ensure a transient 'left' signal within the embryo. ..
  73. Zeng X, Wilm T, Sepich D, Solnica Krezel L. Apelin and its receptor control heart field formation during zebrafish gastrulation. Dev Cell. 2007;12:391-402 pubmed
    ..Our results implicate GPCR signaling in movements of discrete cell populations that establish organ rudiments during vertebrate gastrulation. ..
  74. Sarmah B, Winfrey V, Olson G, Appel B, Wente S. A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Proc Natl Acad Sci U S A. 2007;104:19843-8 pubmed
    ..However, coincident knockdown of Ipk1 and IFT88 or IFT57 had synergistic perturbations. With GFP-Ipk1 enriched in centrosomes and basal bodies, we propose that Ipk1 plays a previously uncharacterized role in ciliary function. ..
  75. Coyle R, Latimer A, Jessen J. Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling. Exp Cell Res. 2008;314:2150-62 pubmed publisher
    ..Together, our results support the notion that pathways regulating pericellular proteolysis and cell polarity converge to promote efficient cell migration. ..
  76. McFarland K, Topczewska J, Weidinger G, Dorsky R, Appel B. Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum. Dev Biol. 2008;318:162-71 pubmed publisher
    ..Specifically, we propose that Hedgehog limits the range of Wnt signaling, which is necessary for olig2(+) neuron development. ..
  77. Li N, Flynt A, Kim H, Solnica Krezel L, Patton J. Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites. Nucleic Acids Res. 2008;36:4277-85 pubmed publisher
    ..This finding underscores the challenge that prediction algorithms face and emphasizes the need to experimentally validate predicted MREs. ..
  78. Fidler A, Vanacore R, Chetyrkin S, Pedchenko V, Bhave G, Yin V, et al. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Proc Natl Acad Sci U S A. 2014;111:331-6 pubmed publisher
    ..Collectively, our findings establish that the triad-a collagen IV scaffold with sulfilimine cross-links, peroxidasin, and hypohalous acids-is a primordial innovation of the ECM essential for organogenesis and tissue evolution. ..
  79. Thatcher E, Flynt A, Li N, Patton J, Patton J. MiRNA expression analysis during normal zebrafish development and following inhibition of the Hedgehog and Notch signaling pathways. Dev Dyn. 2007;236:2172-80 pubmed
  80. Li M, Maddison L, Crees Z, Chen W. Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish. Zebrafish. 2013;10:170-6 pubmed publisher
    ..Our data indicate that CDK4 inhibition contributes to the limited β-cell replication in larval zebrafish. To our knowledge, this is the first example of genetically induced β-cell replication in zebrafish. ..
  81. Becker J, Chatterjee S, Robinson T, Bennett J, Pan kov D, Galindo C, et al. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014;141:335-45 pubmed publisher
  82. Sepich D, Myers D, Short R, Topczewski J, Marlow F, Solnica Krezel L. Role of the zebrafish trilobite locus in gastrulation movements of convergence and extension. Genesis. 2000;27:159-73 pubmed
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