Experts and Doctors on zebrafish in Memphis, Tennessee, United States
Locale: Memphis, Tennessee, United States
Nelson D. A second CYP26 P450 in humans and zebrafish: CYP26B1. Arch Biochem Biophys. 1999;371:345-7 pubmed
..The importance of the CYP26A1 P450 in mouse and zebrafish development flags the CYP26B1 gene as a potential developmental gene. ..
Geng X, Speirs C, Lagutin O, Inbal A, Liu W, Solnica Krezel L, et al
. Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008;15:236-47 pubmed publisher
..These results identify Six3 as a direct regulator of Shh expression and reveal a crossregulatory loop between Shh and Six3 in the ventral forebrain. ..
Cheepala S, Bao J, Nachagari D, Sun D, Wang Y, Zhong T, et al
. Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression. J Biol Chem. 2013;288:22207-18 pubmed publisher
..Altogether, our studies provide the first evidence for a conserved domain in CL3 of ABCC4 that is crucial in ensuring its proper plasma membrane localization. ..
Lagutin O, Zhu C, Kobayashi D, Topczewski J, Shimamura K, Puelles L, et al
. Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev. 2003;17:368-79 pubmed
..Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate. ..
Liu J, Lessman C. Soluble tubulin complexes, gamma-tubulin, and their changing distribution in the zebrafish (Danio rerio) ovary, oocyte and embryo. Comp Biochem Physiol B Biochem Mol Biol. 2007;147:56-73 pubmed
Wu G, Diaz A, Paugh B, Rankin S, Ju B, Li Y, et al
. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014;46:444-450 pubmed publisher
..This comprehensive analysis provides insights into the unique and shared pathways driving pediatric HGG within and outside the brainstem. ..
Damm E, Clements W. Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nat Cell Biol. 2017;19:457-467 pubmed publisher
..Preventing association of the NC with the DA leads to loss of HSCs. Our results define NC as key cellular components of the HSC specification niche that can be profiled to identify unknown HSC specification signals. ..
Genthe J, Min J, Farmer D, Shelat A, Grenet J, Lin W, et al
. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem Biol. 2017;12:2436-2447 pubmed publisher
Stankiewicz P, Khan T, Szafranski P, Slattery L, Streff H, Vetrini F, et al
. Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. Am J Hum Genet. 2017;101:503-515 pubmed publisher
..Taken together, our data demonstrate the pathogenic role of BPTF haploinsufficiency in syndromic neurodevelopmental anomalies and extend the clinical spectrum of human disorders caused by ablation of chromatin remodeling complexes. ..