Experts and Doctors on reverse transcriptase polymerase chain reaction in Nashville, Tennessee, United States


Locale: Nashville, Tennessee, United States
Topic: reverse transcriptase polymerase chain reaction

Top Publications

  1. Donaldson J, Dempsey P, Reddy S, Bouton A, Coffey R, Hanks S. Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res. 2000;256:168-78 pubmed
    ..Our findings provide novel insight into the normal cellular activities regulated by both Cas and nephrocystin, and raise the possibility that these proteins have a related function in polarized epithelial cells. ..
  2. Zhang M, Mai W, Li C, Cho S, Hao C, Moeckel G, et al. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A. 2004;101:2311-6 pubmed
    ..Reduced PKHD1 levels in pck rat kidneys and its colocalization with polycystins may underlie the pathogenic basis for cystogenesis in polycystic kidney diseases. ..
  3. Wu J, Zhang Y, Wang N, Davis L, Yang G, Wang X, et al. Liver X receptor-alpha mediates cholesterol efflux in glomerular mesangial cells. Am J Physiol Renal Physiol. 2004;287:F886-95 pubmed
    ..These data suggest that LXRalpha may be a potential therapeutic target for treating lipid-related renal glomerular disease. ..
  4. Beqaj S, Flesher R, Walker G, Smith S. Use of the real-time PCR assay in conjunction with MagNA Pure for the detection of mycobacterial DNA from fixed specimens. Diagn Mol Pathol. 2007;16:169-73 pubmed
  5. PLACENCIO V, Sharif Afshar A, Li X, Huang H, Uwamariya C, Neilson E, et al. Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res. 2008;68:4709-18 pubmed publisher
    ..These studies reveal a novel TGF-beta, androgen, and Wnt paracrine signaling axis that enables prostatic regression of the distal ducts after androgen ablation while supporting proximal duct survival. ..
  6. Ruan G, Allen G, Yamazaki S, McMahon D. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol. 2008;6:e249 pubmed publisher
    ..Thus, dopamine and GABA act at the molecular level of PER proteins to play key roles in the organization of the retinal circadian clock. ..
  7. Vilgelm A, Hong S, Washington M, Wei J, Chen H, el Rifai W, et al. Characterization of ?Np73 expression and regulation in gastric and esophageal tumors. Oncogene. 2010;29:5861-8 pubmed publisher
    ..We found that HIC1 negatively regulates ?Np73 transcription in mucosal epithelial cells. This leads to a decrease in ?Np73 protein levels and may normally control the oncogenic potential of the ?Np73 isoform. ..
  8. Talbot H, Griffin M, Chen Q, Zhu Y, Williams J, Edwards K. Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. J Infect Dis. 2011;203:500-8 pubmed publisher
    ..3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations. ..
  9. Van Raay T, Fortino N, Miller B, Ma H, Lau G, Li C, et al. Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin. PLoS ONE. 2011;6:e18650 pubmed publisher
    ..Given the conserved nature of Nkd1, our results shed light on the negative feedback regulation of Wnt signaling through the Nkd1-mediated negative control of nuclear accumulation of β-catenin. ..

More Information

Publications157 found, 100 shown here

  1. Asson Batres M, Smith W. Localization of retinaldehyde dehydrogenases and retinoid binding proteins to sustentacular cells, glia, Bowman's gland cells, and stroma: potential sites of retinoic acid synthesis in the postnatal rat olfactory organ. J Comp Neurol. 2006;496:149-71 pubmed
  2. Barco R, Garcia C, EID J. The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1. PLoS ONE. 2009;4:e5060 pubmed publisher
    ..These findings provide a mechanism by which the SYT-SSX2 chimera may contribute to synovial sarcoma pathogenesis...
  3. Miller E, Bugna J, Libster R, Shepherd B, Scalzo P, Acosta P, et al. Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatrics. 2012;129:e60-7 pubmed publisher
    ..Bronchopulmonary dysplasia and the absence of breastfeeding are risk factors for hospitalization. The results of our study reveal that HRV is the predominant pathogen of respiratory infections in premature infants. ..
  4. Zaynagetdinov R, Sherrill T, Gleaves L, Hunt P, Han W, McLoed A, et al. Chronic NF-κB activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs. Oncotarget. 2016;7:5470-82 pubmed publisher
  5. Coats S, Pabón Peña L, Covington J, Vaughan D. Ligand-specific control of src-suppressed C kinase substrate gene expression. Biochem Biophys Res Commun. 2002;297:1112-20 pubmed
    ..In addition, ectopic expression of recombinant SSeCKS recapitulates attributes of NaB-induced morphogenesis in KNRK cells. The data provide novel evidence that SSeCKS functions in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling. ..
  6. Wang X, Herzog B, Waltner Law M, Hall R, Shiota M, Granner D. The synergistic effect of dexamethasone and all-trans-retinoic acid on hepatic phosphoenolpyruvate carboxykinase gene expression involves the coactivator p300. J Biol Chem. 2004;279:34191-200 pubmed
    ..The functional importance of p300 in the Dex/RA response is illustrated by the observation that selective reduction of this coactivator, but not that of CREB-binding protein, abolishes the synergistic effect in H4IIE cells. ..
  7. Geng Y, Hoke A, Delpire E. The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons. J Biol Chem. 2009;284:14020-8 pubmed publisher
    ..In summary, our study demonstrates redundancy of kinases in the regulation of NKCC1 in dorsal root ganglion neurons. ..
  8. Wang X, Newkirk R, Carre W, Ghose P, Igobudia B, Townsel J, et al. Regulation of ANKRD9 expression by lipid metabolic perturbations. BMB Rep. 2009;42:568-73 pubmed
    ..These findings point to the possibility that ANKRD9 is involved in intracellular lipid accumulation. [BMB reports 2009; 42(9): 568-573]. ..
  9. Kang L, Ayala J, Lee Young R, Zhang Z, James F, Neufer P, et al. Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes. 2011;60:416-26 pubmed publisher
    ..Studies with itga2(-/-) mice provide mechanistic insight for this association by showing that the link between muscle IR and increased collagen can be uncoupled by the absence of collagen-integrin ?(2)?(1) interaction. ..
  10. Sehdev V, Peng D, Soutto M, Washington M, Revetta F, Ecsedy J, et al. The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells. Mol Cancer Ther. 2012;11:763-74 pubmed publisher
    ..001). In conclusion, this study shows frequent overexpression of AURKA and suggests that MLN8237 could be an effective antitumor agent, which can be combined with cisplatin for a better therapeutic outcome in esophageal adenocarcinomas. ..
  11. Milatovic D, Yin Z, Gupta R, Sidoryk M, Albrecht J, Aschner J, et al. Manganese induces oxidative impairment in cultured rat astrocytes. Toxicol Sci. 2007;98:198-205 pubmed
    ..Our results demonstrate that induction of oxidative stress, associated mitochondrial dysfunction, and alterations in GLN/glutamate cycling in astrocytes represent key mechanisms by which Mn exerts its neurotoxicity...
  12. Anderson M, Jodoin J, Lee E, Hales K, Hays T, Lee L. Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. Mol Biol Cell. 2009;20:2709-21 pubmed publisher
  13. Martin C, Bischof L, Bergman B, Hornbuckle L, Hilliker C, Frigeri C, et al. Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. J Biol Chem. 2001;276:25197-207 pubmed
    ..The results provide a framework for the further analysis of the molecular basis for the tissue-restricted expression of the IGRP gene and the identification of key amino acid sequences that determine its biological activity. ..
  14. Menon R, Lombardi S, Fortunato S. IL-18, a product of choriodecidual cells, increases during premature rupture of membranes but fails to turn on the Fas-FasL-mediated apoptosis pathway. J Assist Reprod Genet. 2001;18:276-84 pubmed
    ..IL-18 induced Fas expression in amniochorion; however, it failed to turn on other genes in the Fas-FasL apoptosis pathway including FasL and caspase 8. ..
  15. Apparsundaram S, Ferguson S, Blakely R. Molecular cloning and characterization of a murine hemicholinium-3-sensitive choline transporter. Biochem Soc Trans. 2001;29:711-6 pubmed
    ..The availability of cloned, functional mCHT and its cognate genomic DNA should prove useful for studies of mCHT regulation and should open possibilities for evaluation of CHT dysfunction in murine models. ..
  16. Moseley C, Orenstein M, Phillips J. GH Gene Deletions and IGHD type IA. Rev Endocr Metab Disord. 2002;3:339-46 pubmed
  17. Andrews H, Zhang Y, Trotta N, Broadie K. Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission. Traffic. 2002;3:906-21 pubmed
    ..We conclude that dSec10 has no detectable role in most forms of polarized trafficking/exocytosis, including neurotransmission, but rather is essential for endocrine secretion. ..
  18. Guan Y, Hao C, Cha D, Rao R, Lu W, Kohan D, et al. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med. 2005;11:861-6 pubmed
    ..These studies identify Scnn1g as a PPARgamma target gene in the collecting duct. Activation of this pathway mediates fluid retention associated with TZDs, and suggests amiloride might provide a specific therapy. ..
  19. Roshon M, Ruley H. Hypomorphic mutation in hnRNP U results in post-implantation lethality. Transgenic Res. 2005;14:179-92 pubmed
  20. Ye C, Shu X, Wen W, Pierce L, Courtney R, Gao Y, et al. Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases. Breast Cancer Res Treat. 2008;108:427-34 pubmed
    ..These results do not support the notion that the mitochondrial DNA 4977-bp deletion plays a major role in breast carcinogenesis. ..
  21. Hamid R, Cogan J, Hedges L, Austin E, Phillips J, Newman J, et al. Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele. Hum Mutat. 2009;30:649-54 pubmed publisher
    ..Furthermore, our study illustrates a novel application of lymphoblastoid cell lines in the study of PAH, especially important because the affected site, that is, the lung, is not available for unaffected mutation carriers. ..
  22. Gu Y, Lindner J, Kumar A, Yuan W, Magnuson M. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes. 2011;60:827-37 pubmed publisher
    ..The phosphorylation of AKT-S473, by negatively regulating that of AKT-T308, is essential for maintaining a balance between ?-cell proliferation and cell size in response to proliferative stimuli. ..
  23. Lapierre L, Avant K, Caldwell C, Oztan A, Apodaca G, Knowles B, et al. Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Mol Biol Cell. 2012;23:2302-18 pubmed publisher
    ..These results indicate that Ser-227 phosphorylation of Rab11-FIP2 regulates the composition of both adherens and tight junctions and is intimately involved in the regulation of polarity in epithelial cells. ..
  24. Peng D, Hu T, Schneider B, Chen Z, Xu Z, El Rifai W. Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. PLoS ONE. 2012;7:e46214 pubmed publisher
    ..Taken together, the dysfunction of GPX3 in gastric cancer is mediated by genetic and epigenetic alterations, suggesting impairment of mechanisms that regulate ROS and its possible involvement in gastric tumorigenesis and metastasis. ..
  25. Merrill C, Riesgo Escovar J, Pitts R, Kafatos F, Carlson J, Zwiebel L. Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae. Proc Natl Acad Sci U S A. 2002;99:1633-8 pubmed
  26. Arquitt C, Boyd C, Wright J. Cystic fibrosis transmembrane regulator gene (CFTR) is associated with abnormal enamel formation. J Dent Res. 2002;81:492-6 pubmed
    ..05) in the CF mature enamel. Abnormal enamel mineralization, ion concentrations, and molecular evidence of cftr mRNA expression by odontogenic cells strongly suggest that CFTR plays an important role in enamel formation...
  27. Campbell D, Levitt P. Regionally restricted expression of the transcription factor c-myc intron 1 binding protein during brain development. J Comp Neurol. 2003;467:581-92 pubmed
    ..5 to E14.5; N-myc was absent from the telencephalon by E15.5. The specificity and timing of mibp1 expression in the cerebral cortex suggests a role in maintaining a state of neuronal differentiation in the dorsal telencephalon. ..
  28. Tranguch S, Cheung Flynn J, Daikoku T, Prapapanich V, Cox M, Xie H, et al. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A. 2005;102:14326-31 pubmed
    ..Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation. ..
  29. Eeds A, Hall L, Yadav M, Willis A, Summar S, Putnam A, et al. The frequent observation of evidence for nonsense-mediated decay in RNA from patients with carbamyl phosphate synthetase I deficiency. Mol Genet Metab. 2006;89:80-6 pubmed
    ..This study provides evidence for the high prevalence of RNA instability mutations in genetic disease and underscores the importance of accounting for them in mutation-screening strategies...
  30. Müller I, Knapik E, Hatzopoulos A. Expression of the protein related to Dan and Cerberus gene--prdc--During eye, pharyngeal arch, somite, and swim bladder development in zebrafish. Dev Dyn. 2006;235:2881-8 pubmed
    ..Moreover, the complexity of the prdc expression pattern suggests possible roles in eye development, pharyngeal arch remodeling, somitogenesis, and swim bladder organogenesis...
  31. Chung C, Ely K, McGavran L, Varella Garcia M, Parker J, Parker N, et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol. 2006;24:4170-6 pubmed
    ..High EGFR gene copy number by FISH is frequent in HNSCC and is a poor prognostic indicator. Additional investigation is indicated to determine the biologic significance and implications for EGFR inhibitor therapies in HNSCC. ..
  32. Wu J, Lin X, Xie H. Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system. FEMS Microbiol Lett. 2007;271:214-21 pubmed
    ..Unlike the regulatory mechanism of FimA by FimR, this regulation of the mfa1 gene is accomplished by FimR directly binding to the promoter region of mfa1...
  33. Li H, McCormac M, Estes R, Sefers S, Dare R, Chappell J, et al. Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections. J Clin Microbiol. 2007;45:2105-9 pubmed
    ..The multiplex approach enhances diagnosis through detection of respiratory viral etiologic agents in cases in which the presence of the agent was not suspected and a test was not ordered by the clinicians. ..
  34. Asim M, Chaturvedi R, Hoge S, Lewis N, Singh K, Barry D, et al. Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. J Biol Chem. 2010;285:20343-57 pubmed publisher
    ..A unique AP-1 complex in gastric macrophages contributes to the immune escape of H. pylori. ..
  35. Eby K, Rosenbluth J, Mays D, Marshall C, Barton C, Sinha S, et al. ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy. Mol Cancer. 2010;9:95 pubmed publisher
  36. Son D, Terranova P, Roby K. Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform. Endocrinology. 2010;151:3407-19 pubmed publisher
    ..In addition, like TNF, SAA inhibited cAMP-induced estradiol accumulation and CYP19 levels. These data indicate SAA may play a role in events occurring during the ovulation process. ..
  37. Zhao A, Ohara Imaizumi M, Brissova M, Benninger R, Xu Y, Hao Y, et al. Gαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes. 2010;59:2522-9 pubmed publisher
    ..Gαo is not required for endocrine islet cell differentiation, but it regulates the number of insulin vesicles docked on the β-cell membrane. ..
  38. Gao Q, Ma L, Gao X, Yan W, Williams P, Yin D. TLR4 mediates early graft failure after intraportal islet transplantation. Am J Transplant. 2010;10:1588-96 pubmed publisher
    ..Inhibition of TLR4 activation represents a novel strategy to attenuate early graft failure following intraportal islet transplantation. ..
  39. Lindquist M, Lifland A, Utley T, Santangelo P, Crowe J. Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication. J Virol. 2010;84:12274-84 pubmed publisher
    ..These results suggest that RSV induces a host stress granule response and preferentially replicates in host cells that have committed to a stress response. ..
  40. Blackwell T, Hipps A, Yamamoto Y, Han W, Barham W, Ostrowski M, et al. NF-?B signaling in fetal lung macrophages disrupts airway morphogenesis. J Immunol. 2011;187:2740-7 pubmed publisher
    ..We propose that fetal lung macrophage activation contributes to bronchopulmonary dysplasia by generating a localized inflammatory response that disrupts developmental signals critical for lung formation. ..
  41. Geng F, Tansey W. Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2012;109:6060-5 pubmed publisher
    ..We also find that proteasome subunits are enriched at telomeres and at genes transcribed by RNA polymerase III. Our data suggest that the transcriptionally relevant form of the proteasome is the canonical 26S complex. ..
  42. Novitskiy S, Pickup M, Chytil A, Polosukhina D, Owens P, Moses H. Deletion of TGF-? signaling in myeloid cells enhances their anti-tumorigenic properties. J Leukoc Biol. 2012;92:641-51 pubmed publisher
  43. Gaddy J, Radin J, Loh J, Zhang F, Washington M, Peek R, et al. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect Immun. 2013;81:2258-67 pubmed publisher
    ..Animals infected with the cagA mutant strain had low levels of gastric inflammation and did not develop hypochlorhydria. These results indicate that a high-salt diet potentiates the carcinogenic effects of cagA(+) H. pylori strains. ..
  44. Shattuck Brandt R, Varilek G, Radhika A, Yang F, Washington M, DuBois R. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. Gastroenterology. 2000;118:337-45 pubmed
    ..These results indicate that COX-2 is expressed very early in the pathogenesis of colitis-associated tumors, and that the expression pattern is similar to that seen in tumors from azoxymethane-treated and Min/+ mice. ..
  45. Melo A, R tzler M, Pitts R, Zwiebel L. Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs. Chem Senses. 2004;29:403-10 pubmed publisher
    ..These results are consistent with a role for AaOr7 in olfaction and gustation supporting the hypothesis that AaOr7 and its orthologs may be of general importance to chemosensory processes throughout the lifetime of an insect...
  46. Wang H, Guo Y, Wang D, Kingsley P, Marnett L, Das S, et al. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med. 2004;10:1074-80 pubmed
    ..Besides uncovering a new regulatory mechanism, this study could be clinically relevant to ectopic pregnancy. ..
  47. Smith L, Petrie M, Morrow J, Oates J, Vaughan D. The sterol response element binding protein regulates cyclooxygenase-2 gene expression in endothelial cells. J Lipid Res. 2005;46:862-71 pubmed
  48. Mazei Robison M, Couch R, Shelton R, Stein M, Blakely R. Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology. 2005;49:724-36 pubmed
    ..Interestingly, the A559V variant was previously identified in a subject with bipolar disorder [. Molecular Psychiatry 5, 275], a psychiatric disorder that has a significant number of overlapping symptoms with ADHD. ..
  49. Cha Y, Takahashi S, Wright C. Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus. Dev Biol. 2006;290:246-64 pubmed
    ..Our experiments reveal a two-level suppressive mechanism for restricting the level, range, and duration of Xnr signaling via extracellular inhibition by Xatv/Xlefty coupled with potent indirect transcriptional repression by Xbra. ..
  50. Bonnin A, Peng W, Hewlett W, Levitt P. Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development. Neuroscience. 2006;141:781-94 pubmed
    ..Moreover, all members of the 5-HT1 receptor class are strongly and transiently expressed in the embryonic dorsal thalamus, which suggests a potential role for serotonin in early thalamic development. ..
  51. Carmosino M, Brooks H, Cai Q, Davis L, Opalenik S, Hao C, et al. Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Am J Physiol Renal Physiol. 2007;292:F351-60 pubmed
    ..These findings further suggest distinct regulation of renal transport function by AVP through V1a and V2 receptors in the cortex vs. the medulla. ..
  52. Rojas A, Meherem S, Kim Y, Washington M, Willis J, Markowitz S, et al. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer. 2008;123:14-21 pubmed publisher
  53. Jin R, Lho Y, Connelly L, Wang Y, Yu X, Saint Jean L, et al. The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res. 2008;68:6762-9 pubmed publisher
    ..Thus, the NF-kappaB pathway may be a potential target for therapy against androgen-independent prostate cancer. ..
  54. Sappington R, Sidorova T, Long D, Calkins D. TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest Ophthalmol Vis Sci. 2009;50:717-28 pubmed publisher
    ..RGC apoptosis induced by elevated hydrostatic pressure arises substantially through TRPV1, likely through the influx of extracellular Ca(2+). ..
  55. Meng S, Ryu S, Zhao B, Zhang D, Driever W, McMahon D. Targeting retinal dopaminergic neurons in tyrosine hydroxylase-driven green fluorescent protein transgenic zebrafish. Mol Vis. 2008;14:2475-83 pubmed
    ..This transgenic line provides a useful tool for studying retinal dopaminergic cells in the zebrafish. ..
  56. Wang Z, Yang H, Ramesh A, Roberts L, Zhou L, Lin X, et al. Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Free Radic Biol Med. 2009;47:1221-9 pubmed publisher
    ..These data demonstrate that overexpression of Cu/Zn-SOD and/or catalase is associated with upregulation of AhR and its target genes, such as xenobiotic-metabolizing enzymes. ..
  57. Zhang H, Zhang J, Pope C, Crawford L, Vasavada R, Jagasia S, et al. Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes. 2010;59:143-52 pubmed publisher
    ..In the absence of increased beta-cell proliferation, neogenesis is induced in postpartum FoxM1(Deltapanc) pancreata. Our results suggest that FoxM1 functions downstream of PL to mediate its effects on beta-cell proliferation. ..
  58. Ali S, Williams J, Chen Q, Faouri S, Faori S, Shehabi A, et al. Human metapneumovirus in hospitalized children in Amman, Jordan. J Med Virol. 2010;82:1012-6 pubmed publisher
    ..Longer surveillance studies are needed to better understand the seasonal epidemiology of HMPV and to assess if co-infection with HMPV and RSV leads to more severe illness...
  59. Beckham J, Wilmink G, Opalenik S, Mackanos M, Abraham A, Takahashi K, et al. Microarray analysis of cellular thermotolerance. Lasers Surg Med. 2010;42:752-65 pubmed publisher
    ..5-fold under these conditions despite its role in thermotolerance. The data herein presents genetic pathways which are candidates for further study of pretreatment protocols in laser irradiation. ..
  60. Erdoğan B, Facey C, Qualtieri J, Tedesco J, Rinker E, Isett R, et al. Diagnostic microRNAs in myelodysplastic syndrome. Exp Hematol. 2011;39:915-926.e2 pubmed publisher
    ..Our data utilize both discovery and validation sets and two complementary platforms to identify miRNAs associated with MDS. We have analyzed predicted targets and identified c-Myb and Sufu as potential diagnostic markers of MDS. ..
  61. Yang Y, Thorel F, Boyer D, Herrera P, Wright C. Context-specific ?- to-?-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011;25:1680-5 pubmed publisher
    ..Our findings reveal that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation. ..
  62. Miller E, Gebretsadik T, Carroll K, Dupont W, Mohamed Y, Morin L, et al. Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during 4 consecutive years. Pediatr Infect Dis J. 2013;32:950-5 pubmed publisher
    ..Demographic differences were observed between patients with different viruses, suggesting that host and viral factors play a role in phenotypic expression of viral illness. ..
  63. Saad R, Chen Z, Zhu S, Jia P, Zhao Z, Washington M, et al. Deciphering the unique microRNA signature in human esophageal adenocarcinoma. PLoS ONE. 2013;8:e64463 pubmed publisher
    ..This may provide some clues for the distinct molecular features of EAC to be considered in future studies of the role of miRNAs in EAC and their utility as disease biomarkers. ..
  64. Farrow M, Chumbler N, Lapierre L, Franklin J, Rutherford S, Goldenring J, et al. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc Natl Acad Sci U S A. 2013;110:18674-9 pubmed publisher
    ..The efficacy of DPI and NAC provides proof of concept that chemical attenuation of ROS could serve as a viable strategy for protecting the colonic mucosa of patients with CDI...
  65. Kaikita K, Schoenhard J, Painter C, Ripley R, Brown N, Fogo A, et al. Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition. J Mol Cell Cardiol. 2002;34:617-27 pubmed
    ..While PAI-1 deficiency protects against L -NAME-induced hypertension and perivascular fibrosis, t-PA deficiency does not exacerbate the vascular pathology or hypertension. ..
  66. Ha K, Chen Y, Cai J, Sternberg P. Increased glutathione synthesis through an ARE-Nrf2-dependent pathway by zinc in the RPE: implication for protection against oxidative stress. Invest Ophthalmol Vis Sci. 2006;47:2709-15 pubmed
    ..Induction of the ARE-Nrf2 pathway by zinc provides powerful and prolonged antioxidation and detoxification that may explain the beneficial effects of zinc observed in the treatment of age-related macular degeneration (AMD). ..
  67. Halder S, Cho Y, Datta A, Anumanthan G, Ham A, Carbone D, et al. Elucidating the mechanism of regulation of transforming growth factor ? Type II receptor expression in human lung cancer cell lines. Neoplasia. 2011;13:912-22 pubmed
    ..These results suggest a mechanism for the downregulation of T?RII in lung cancer and that TGF-? tumor suppressor functions may be restored by HDIs in lung cancer patients with the loss of T?RII expression. ..
  68. Wilson A, Liu A, ROLAND J, Adebayo O, Fletcher S, Slaughter J, et al. TR3 modulates platinum resistance in ovarian cancer. Cancer Res. 2013;73:4758-69 pubmed publisher
    ..Moreover, we have described a treatment strategy aimed at overcoming platinum resistance by targeting TR3. ..
  69. Dai C, Krantz S. Increased expression of the INK4a/ARF locus in polycythemia vera. Blood. 2001;97:3424-32 pubmed
    ..Further work to delineate the function of these genes in PV is in progress. (Blood. 2001;97:3424-3432) ..
  70. Atkinson R, Coenen K, Plummer M, Gruen M, Hasty A. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab. 2008;294:E284-90 pubmed
  71. Ghosh A, Akech J, Mukherjee S, Das S. Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells. Biochem Biophys Res Commun. 2002;297:1043-8 pubmed
    ..Biochemical approach also reveals a 1.5-fold stimulation in CPT activity in 11-9-14 cells compared to that of the MCF-12A cells. ..
  72. Brockway S, Denison M. Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication. Virology. 2005;340:209-23 pubmed
    ..This study identifies nsp1 residues important for protein processing, viral RNA synthesis, and viral replication. ..
  73. Saraswati S, Alfaro M, Thorne C, Atkinson J, Lee E, Young P. Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLoS ONE. 2010;5:e15521 pubmed publisher
    ..These results need to be further followed-up to determine if therapeutic inhibition of canonical Wnt may avert adverse remodeling after ischemic injury and its impact on myocardial repair and regeneration. ..
  74. Luan J, Furuta Y, Du J, Richmond A. Developmental expression of two CXC chemokines, MIP-2 and KC, and their receptors. Cytokine. 2001;14:253-63 pubmed
    ..These data suggest that the roles for these chemokines and their receptors during development may be more significant than was initially thought based upon the phenotype of the mice with targeted deletion of CXCR2 and Duffy. ..
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