Experts and Doctors on replication origin in Nashville, Tennessee, United States


Locale: Nashville, Tennessee, United States
Topic: replication origin

Top Publications

  1. Kanter D, Kaplan D. Sld2 binds to origin single-stranded DNA and stimulates DNA annealing. Nucleic Acids Res. 2011;39:2580-92 pubmed publisher
    ..Sld2-stimulated annealing may be important for maintaining genome stability during the initiation of DNA replication. ..
  2. Bruck I, Kanter D, Kaplan D. Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem. 2011;286:36414-26 pubmed publisher
    ..Furthermore, origin ssDNA may stimulate the formation of the CMG complex by alleviating inhibitory interactions between Sld2 with Mcm2-7. ..
  3. Vaiskunaite R, Miller A, Davenport L, Mosig G. Two new early bacteriophage T4 genes, repEA and repEB, that are important for DNA replication initiated from origin E. J Bacteriol. 1999;181:7115-25 pubmed
  4. Jiang X, Klimovich V, Arunkumar A, Hysinger E, Wang Y, Ott R, et al. Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex. EMBO J. 2006;25:5516-26 pubmed
    ..A mechanistic model is proposed in which the ternary complex is a key intermediate that directly couples origin DNA unwinding to RPA loading on emerging ssDNA. ..
  5. Huang H, Zhao K, Arnett D, Fanning E. A specific docking site for DNA polymerase {alpha}-primase on the SV40 helicase is required for viral primosome activity, but helicase activity is dispensable. J Biol Chem. 2010;285:33475-84 pubmed publisher
  6. Bruck I, Kaplan D. GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding. J Biol Chem. 2011;286:14157-67 pubmed publisher
    ..Our results are consistent with a model wherein GINS trades places with Sld3 at a replication origin, contributing to the activation of the replication fork helicase. ..
  7. Betous R, Couch F, Mason A, Eichman B, Manosas M, Cortez D. Substrate-selective repair and restart of replication forks by DNA translocases. Cell Rep. 2013;3:1958-69 pubmed publisher
    ..Our findings identify the important substrates of SMARCAL1 in fork repair, suggest that RecG and SMARCAL1 are functional orthologs, and provide a comprehensive model of fork repair by these DNA translocases. ..
  8. Dungrawala H, Bhat K, Le Meur R, Chazin W, Ding X, Sharan S, et al. RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks. Mol Cell. 2017;67:374-386.e5 pubmed publisher
    ..Thus, RADX is essential to achieve the proper balance of RAD51 activity to maintain genome stability. ..
  9. Vujanovic M, Krietsch J, Raso M, Terraneo N, Zellweger R, Schmid J, et al. Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity. Mol Cell. 2017;67:882-890.e5 pubmed publisher
    ..Targeting these fork protection systems represents a promising strategy to potentiate cancer chemotherapy. ..