Experts and Doctors on pyridazines in Memphis, Tennessee, United States
Locale: Memphis, Tennessee, United States
Kaneda K, Kita H. Synaptically released GABA activates both pre- and postsynaptic GABA(B) receptors in the rat globus pallidus. J Neurophysiol. 2005;94:1104-14 pubmed
..Together, we infer that both pre- and postsynaptic GABA(B) receptors may play crucial roles in the control of GP neuronal activity. ..
Hashimoto K, Kita H. Slow oscillatory activity of rat globus pallidus neurons in vitro. Eur J Neurosci. 2006;23:443-53 pubmed
Zhao Y, Hammoudeh D, Yun M, Qi J, White S, Lee R. Structure-based design of novel pyrimido[4,5-c]pyridazine derivatives as dihydropteroate synthase inhibitors with increased affinity. ChemMedChem. 2012;7:861-70 pubmed publisher
..This study clearly demonstrates that compounds lacking the N-methyl substitution exhibit increased inhibition of DHPS, but the beneficial effects of optimizing the side chain length are less apparent. ..
Kita H, Chiken S, Tachibana Y, Nambu A. Origins of GABA(A) and GABA(B) receptor-mediated responses of globus pallidus induced after stimulation of the putamen in the monkey. J Neurosci. 2006;26:6554-62 pubmed
Li C, Tripathi P, Armstrong W. Differences in spike train variability in rat vasopressin and oxytocin neurons and their relationship to synaptic activity. J Physiol. 2007;581:221-40 pubmed
..For example, the increased firing variability that precedes bursting in OT neurons during lactation could be related to significant changes in synaptic activity. ..
Blundon J, Roy N, Teubner B, Yu J, Eom T, Sample K, et al
. Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling. Science. 2017;356:1352-1356 pubmed publisher
..We conclude that, in adult mice, disrupting adenosine signaling in the thalamus rejuvenates plasticity in the auditory cortex and improves auditory perception. ..