Experts and Doctors on organic anion transporters in Memphis, Tennessee, United States
Locale: Memphis, Tennessee, United States
Topic: organic anion transporters
Ramsey L, Panetta J, Smith C, Yang W, Fan Y, Winick N, et al
. Genome-wide study of methotrexate clearance replicates SLCO1B1. Blood. 2013;121:898-904 pubmed publisher
..This study is registered at http://www.clinicaltrials.gov as NCT00005585 and NCT00005596. ..
Jackowski S, Alix J. Cloning, sequence, and expression of the pantothenate permease (panF) gene of Escherichia coli. J Bacteriol. 1990;172:3842-8 pubmed
..The predicted topological profile of pantothenate permease is similar to that of other membrane carriers that catalyze cation-dependent symport. ..
Ramsey L, Bruun G, Yang W, Treviño L, Vattathil S, Scheet P, et al
. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012;22:1-8 pubmed publisher
..8% of SLCO1B1's effects (1.9% of total variation) and had larger effect sizes than common NS variants. Our results show that rare variants are likely to have an important effect on pharmacogenetic phenotypes. ..
Lancaster C, Bruun G, Peer C, Mikkelsen T, Corydon T, Gibson A, et al
. OATP1B1 polymorphism as a determinant of erythromycin disposition. Clin Pharmacol Ther. 2012;92:642-50 pubmed publisher
..0072). These results suggest that impairment of OATP1B1 function can alter erythromycin metabolism, independent of changes in CYP3A4 activity. ..
Zimmerman E, Hu S, Roberts J, Gibson A, Orwick S, Li L, et al
. Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013;19:1458-66 pubmed publisher
..These findings signify a unique role for OATP1B1 and OATP1B3 in the elimination of sorafenib-glucuronide and suggest a role for these transporters in the in vivo handling of glucuronic acid conjugates of drugs. ..
Sprowl J, Ong S, Gibson A, Hu S, Du G, Lin W, et al
. A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016;7:10880 pubmed publisher
Cunningham T, Dorrington R, Cooper T. The UGA4 UASNTR site required for GLN3-dependent transcriptional activation also mediates DAL80-responsive regulation and DAL80 protein binding in Saccharomyces cerevisiae. J Bacteriol. 1994;176:4718-25 pubmed
..We demonstrate here that the GATA-containing sites upstream of UGA4 required for optimal GLN3-dependent transcriptional activation also mediate DAL80 protein binding in vitro and DAL80-responsive regulation in vivo. ..
Treviño L, Shimasaki N, Yang W, Panetta J, Cheng C, Pei D, et al
. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol. 2009;27:5972-8 pubmed publisher
..4; P = .03 to .004). A genome-wide interrogation identified inherited variations in a plausible, yet heretofore low-priority candidate gene, SLCO1B1, as important determinants of methotrexate's pharmacokinetics and clinical effects. ..