Genomes and Genes
Experts and Doctors on cell membrane in Nashville, Tennessee, United States
Locale: Nashville, Tennessee, United States
Topic: cell membrane
Publications134 found, 100 shown here
- Taylor S, Chae H, Rhee S, Exton J. Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins. Nature. 1991;350:516-8 pubmed..We also show that this protein is related to the Gq class of G protein alpha subunits. ..
- Bauman P, Blakely R. Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity. Arch Biochem Biophys. 2002;404:80-91 pubmed..Together our studies document a critical contribution of the hNET C-terminus to transporter trafficking, stability, and function. ..
- Knox C, Belous A, Pierce J, Wakata A, Nicoud I, Anderson C, et al. Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake. Am J Physiol Gastrointest Liver Physiol. 2004;287:G533-40 pubmed..These data indicate that PLC-delta1 exists in liver mitochondria and is involved in regulating mCa2+ uptake through the uniporter. ..
- Harrell P, McCawley L, Fingleton B, McIntyre J, Matrisian L. Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells. Exp Cell Res. 2005;303:308-20 pubmed..Taken together, our findings demonstrate the importance of MMP-7 secretion in relation to its mechanism of action when expressed in a polarized epithelium. ..
- Torres V, Ivie S, McClain M, Cover T. Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin. J Biol Chem. 2005;280:21107-14 pubmed..Reconstitution of toxin activity from two separate domains, as described here for VacA, has rarely been described for pore-forming bacterial toxins, which suggests that VacA is a pore-forming toxin with unique structural properties. ..
- Sparks J, Lu X, Denison M. Genetic analysis of Murine hepatitis virus nsp4 in virus replication. J Virol. 2007;81:12554-63 pubmed publisher..Together, the experiments identify important residues and regions for studies of nsp4 topology, function, and interactions...
- Misra S, Kahlig K, George A. Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia. 2008;49:1535-45 pubmed publisher..Our findings indicate that BFNIS is associated with a range of biophysical defects accompanied by reduced levels of channel protein at the plasma membrane. ..
- Day C, Kenworthy A. Mechanisms underlying the confined diffusion of cholera toxin B-subunit in intact cell membranes. PLoS ONE. 2012;7:e34923 pubmed publisher..By identifying underlying mechanisms that control CTxB dynamics at the cell surface, these findings help to delineate the fundamental properties of toxin-receptor complexes in intact cell membranes. ..
- Turlington M, Noetzel M, Chun A, Zhou Y, Gogliotti R, Nguyen E, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolina. J Med Chem. 2013;56:7976-96 pubmed publisher..PAM 38t (ML254) will be useful to probe the relative contribution of cooperativity and allosteric agonism to the adverse effect liability and neurotoxicity associated with this class of mGlu5 PAMs. ..
- Neel N, Barzik M, Raman D, Sobolik Delmaire T, Sai J, Ham A, et al. VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. J Cell Sci. 2009;122:1882-94 pubmed publisher..These data provide the first demonstration that direct interaction of VASP with CXCR2 is essential for proper CXCR2 function and demonstrate a crucial role for VASP in mediating chemotaxis in leukocytes. ..
- Chinkers M, Garbers D, Chang M, Lowe D, Chin H, Goeddel D, et al. A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature. 1989;338:78-83 pubmed..The ANP receptor/guanylate cyclase represents a new class of mammalian cell-surface receptors which contain an extracellular ligand-binding domain and an intracellular guanylate cyclase catalytic domain. ..
- Liu K, Surendhran K, Nothwehr S, Graham T. P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes. Mol Biol Cell. 2008;19:3526-35 pubmed publisher..These results imply that Drs2p acts independently of coat recruitment to facilitate AP-1/clathrin-coated vesicle budding from the TGN. ..
- Vanoye C, Welch R, Tian C, Sanders C, George A. KCNQ1/KCNE1 assembly, co-translation not required. Channels (Austin). 2010;4:108-14 pubmed
- Harmon C, Abumrad N. Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids. J Membr Biol. 1993;133:43-9 pubmed..This, together with the N-terminal sequence homology, suggested that the adipocyte protein belongs to a family of related intrinsic membrane proteins which include CD36 and PAS IV. ..
- Tilghman R, Hoover R. E-selectin and ICAM-1 are incorporated into detergent-insoluble membrane domains following clustering in endothelial cells. FEBS Lett. 2002;525:83-7 pubmed..Thus, our data suggest that E-selectin and ICAM-1 associate with lipid rafts in human endothelial cells following leukocyte adhesion. ..
- Wang D, Sai J, Richmond A. Cell surface heparan sulfate participates in CXCL1-induced signaling. Biochemistry. 2003;42:1071-7 pubmed..CXCL10 inhibits CXCL1-induced PAK1 activation and chemotaxis by interfering with appropriate binding of CXCL1 to CXCR2 receptor. ..
- Ho R, Leake B, Roberts R, Lee W, Kim R. Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J Biol Chem. 2004;279:7213-22 pubmed..Accordingly, our study indicates functionally important polymorphisms in NTCP exist and that the likelihood of being carriers of such polymorphisms is dependent on ethnicity. ..
- Rohrbough J, Rushton E, Palanker L, Woodruff E, Matthies H, Acharya U, et al. Ceramidase regulates synaptic vesicle exocytosis and trafficking. J Neurosci. 2004;24:7789-803 pubmed..These results indicate that SLAB ceramidase function controls presynaptic terminal sphingolipid composition to regulate vesicle fusion and trafficking, and thus the strength and reliability of synaptic transmission. ..
- SPEED N, Saunders C, Davis A, Owens W, Matthies H, Saadat S, et al. Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding. PLoS ONE. 2011;6:e25169 pubmed publisher..This molecular model, thus, explains how even short-term exposure to "the fast food lifestyle" creates a cycle of disordered eating that cements pathological changes in DA signaling leading to weight gain and obesity. ..
- Small K, Nag S, Mokha S. Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism. Neuroscience. 2013;255:177-90 pubmed publisher..Taken together, the data are consistent with the interpretations that mER activation attenuates ORL1-mediated antinociception through a non-genomic, ERK 2-dependent mechanism in females. ..
- May J, Li L, Qu Z, Huang J. Ascorbate uptake and antioxidant function in peritoneal macrophages. Arch Biochem Biophys. 2005;440:165-72 pubmed..These results suggest that activated macrophages can use ascorbate to lessen self-generated oxidant stress and spare alpha-tocopherol, which may protect these long-lived cells from necrosis or apoptosis. ..
- Henry L, Field J, Adkins E, Parnas M, Vaughan R, Zou M, et al. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. J Biol Chem. 2006;281:2012-23 pubmed..These studies provided evidence for distinct binding sites coordinating SERT antagonists and revealed a close interaction between TM1 and TM3 differentially targeted by stereoisomers of CIT. ..
- Binda F, Dipace C, Bowton E, Robertson S, Lute B, Fog J, et al. Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol Pharmacol. 2008;74:1101-8 pubmed publisher..These data suggest that AMPH activation of CaMKII supports DAT/SYN1A association, resulting in a mode of DAT capable of DA efflux...
- Kaya A, Thaker T, Preininger A, Iverson T, Hamm H. Coupling efficiency of rhodopsin and transducin in bicelles. Biochemistry. 2011;50:3193-203 pubmed publisher..These data suggest that a membrane-like structure is an important contributor to the formation and stability of functional receptor-G protein complexes and can extend the range of studies that investigate properties of these complexes. ..
- Long A, Kim E, Leung H, Woodruff E, An L, Doerge R, et al. Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. J Neurosci. 2008;28:3668-82 pubmed publisher..These data indicate that Fusl regulates assembly of the presynaptic active zone Ca(2+) channel domains required for efficient coupling of the Ca(2+) influx and synaptic vesicle exocytosis during neurotransmission. ..
- Johnson C, Rachakonda G, Kleshchenko Y, Nde P, Madison M, Pratap S, et al. Cellular response to Trypanosoma cruzi infection induces secretion of defensin ?-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013;81:4139-48 pubmed publisher..The mode of activity of human defensin ?-1 against T. cruzi and its function may provide insights for the development of new antiparasitic strategies. ..
- Yu H, Dohn M, Markham N, Coffey R, Reynolds A. p120-catenin controls contractility along the vertical axis of epithelial lateral membranes. J Cell Sci. 2016;129:80-94 pubmed publisher..Importantly, local suppression of contractility by cadherin-bound p120 appears to go beyond regulating cell shape, as loss of this activity also leads to major defects in epithelial lumenogenesis. ..
- Tulsiani D, Abou haila A. Mammalian sperm molecules that are potentially important in interaction with female genital tract and egg vestments. Zygote. 2001;9:51-69 pubmed..An understanding of the expression and modifications of molecules thought to be important in multiple events leading to fertilisation will allow new strategies to block these modifications and alter sperm function. ..
- Gailani D, Ho D, Sun M, Cheng Q, Walsh P. Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential. Blood. 2001;97:3117-22 pubmed
- Enan E. Molecular and pharmacological analysis of an octopamine receptor from American cockroach and fruit fly in response to plant essential oils. Arch Insect Biochem Physiol. 2005;59:161-71 pubmed..Collectively, the data suggest a correlation between cellular changes induced by tested plant essential oils and their toxicity against fruit fly and American cockroach. ..
- Merchant N, Rogers C, Trivedi B, Morrow J, Coffey R. Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005;138:415-21 pubmed..The mechanism of DCA-induced EGFR activation is ligand-dependent and is controlled, at least in part, at the level of AR release from the basolateral cell membrane. ..
- Kroh H, Tans G, Nicolaes G, Rosing J, Bock P. Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation. J Biol Chem. 2007;282:16095-104 pubmed..Further, the Na+ enhancement in MzT activity and exosite I affinity may function in directing the sequential ProT activation pathway by accelerating thrombin formation from the MzT fast form. ..
- BYRD V, Kilkenny D, Dikov M, Reich M, Rocheleau J, Armistead W, et al. Fibroblast growth factor receptor-1 interacts with the T-cell receptor signalling pathway. Immunol Cell Biol. 2003;81:440-50 pubmed..The results suggest that peptide growth factors produced at sites of injury and inflammation can contribute to the outcome of T-cell encounters with antigen. ..
- Milatovic D, Montine T, Aschner M. Measurement of isoprostanes as markers of oxidative stress. Methods Mol Biol. 2011;758:195-204 pubmed publisher..This protocol details current methodology used to quantify these molecules using gas chromatography-mass spectrometry (GC/MS). ..
- Baldridge R, Graham T. Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases. Proc Natl Acad Sci U S A. 2012;109:E290-8 pubmed publisher..Modeling of residues involved in substrate selection suggests a novel P-type ATPase transport pathway at the protein/lipid interface and a potential solution to the giant substrate problem. ..
- Schulz S, Green C, Yuen P, Garbers D. Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell. 1990;63:941-8 pubmed..These results show that a heat-stable enterotoxin receptor responsible for acute diarrhea is a plasma membrane form of guanylyl cyclase. ..
- Dipace C, Sung U, Binda F, Blakely R, Galli A. Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes. Mol Pharmacol. 2007;71:230-9 pubmed..Here, we demonstrate that AMPH stimulation of CAMKII stabilizes an hNET/SYN1A complex. This hNET/SYN1A complex rapidly redistributes, upon AMPH treatment, when mechanisms supported by the transporter's NH2 terminus are eliminated. ..
- Guo L, Chen Z, Cox B, Amarnath V, Epand R, Epand R, et al. Phosphatidylethanolamines modified by ?-ketoaldehyde (?KA) induce endoplasmic reticulum stress and endothelial activation. J Biol Chem. 2011;286:18170-80 pubmed publisher..Thus, ?KA-PE is a potential mediator of the inflammation induced by lipid peroxidation. ..
- Timmons C, Shao Q, Wang C, Liu L, Liu H, Dong X, et al. GB virus type C E2 protein inhibits human immunodeficiency virus type 1 assembly through interference with HIV-1 gag plasma membrane targeting. J Infect Dis. 2013;207:1171-80 pubmed publisher..These findings shed light on a novel mechanism used by GBV-C E2 to inhibit HIV-1 replication and may provide insight into new approaches for suppressing HIV-1 replication. ..
- Mueller S, Schraw W, Richmond A. Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells. J Biol Chem. 1994;269:1973-80 pubmed..Phosphoamino acid analysis indicated that the MGSA-induced receptor phosphorylation was on serine residue(s), suggesting that a serine kinase is activated in response to MGSA binding to the class II IL-8R in non-hematopoietic cells. ..
- May J, Qu Z, Morrow J, Cobb C. Ascorbate-dependent protection of human erythrocytes against oxidant stress generated by extracellular diazobenzene sulfonate. Biochem Pharmacol. 2000;60:47-53 pubmed
- Satoh K, Ichihara K, Landon E, Inagami T, Tang H. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1. J Biol Chem. 2001;276:15761-7 pubmed..In addition, our results indicate that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, a class of cholesterol-lowering drugs, could interrupt Ang II signaling independent of cholesterol lowering in endothelial cells. ..
- Huang F, Matthies H, Speese S, Smith M, Broadie K. Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Nat Neurosci. 2004;7:1070-8 pubmed..The RBO requirement identifies an essential regulatory step in G-protein-coupled, PLC-dependent inositol lipid signaling mediating activation of TRP and TRPL channels during phototransduction. ..
- Goodwin J, Drake K, Rogers C, Wright L, Lippincott Schwartz J, Philips M, et al. Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. J Cell Biol. 2005;170:261-72 pubmed..We propose that a cycle of depalmitoylation and repalmitoylation regulates the time course and sites of Ras signaling by allowing the protein to be released from the cell surface and rapidly redistributed to intracellular membranes. ..
- Apparsundaram S, Schroeter S, Giovanetti E, Blakely R. Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins. J Pharmacol Exp Ther. 1998;287:744-51 pubmed..Together these findings argue for kinase-modulated protein trafficking as a potential route for acute regulation of antidepressant-sensitive NE clearance. ..
- Hobdy Henderson K, Hales C, Lapierre L, Cheney R, Goldenring J. Dynamics of the apical plasma membrane recycling system during cell division. Traffic. 2003;4:681-93 pubmed..These results indicate that critical components of the apical recycling system remain associated on vesicles throughout the cell cycle and may provide a means for rapid re-establishment of plasma membrane components after mitosis. ..
- Sung B, WEAVER A. Cell-cell fusion: a new function for invadosomes. Curr Biol. 2011;21:R121-3 pubmed publisher..Podosomes are cytoskeletal-based structures involved in extracellular matrix remodeling and cellular motility. A new study now implicates podosomes in pore formation during myoblast fusion...
- Chen S, Dell E, Lin F, Sai J, Hamm H. RACK1 regulates specific functions of Gbetagamma. J Biol Chem. 2004;279:17861-8 pubmed..Similarly, RACK1 does not affect signal transduction through the Galpha subunits of G(i), G(s), or G(q). Collectively, these findings suggest a role of RACK1 in regulating specific functions of Gbetagamma. ..
- Buchanan F, Gorden D, Matta P, Shi Q, Matrisian L, DuBois R. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci U S A. 2006;103:1492-7 pubmed..Furthermore, our data implicate a functional role for beta-arrestin 1 as a mediator of cellular migration and metastasis. ..
- Baldridge R, Graham T. Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases. Proc Natl Acad Sci U S A. 2013;110:E358-67 pubmed publisher..This work describes a unique transport mechanism for a P-type ATPase and provides insight into how integral membrane proteins can recognize and transport phospholipid substrate across a lipid bilayer. ..
- Hess J, Ji Q, Carpenter G, Exton J. Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-gamma1. J Biol Chem. 1998;273:20517-24 pubmed..In summary, these data indicate that PLC-gamma is required for growth factor-induced activation of PLD in MEFs. ..
- Denison M, Spaan W, van der Meer Y, Gibson C, Sims A, Prentice E, et al. The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis. J Virol. 1999;73:6862-71 pubmed..This study demonstrates that the putative RNA helicase is closely associated with MHV RNA synthesis and suggests that complexes containing helicase, N, and new viral RNA are the viral replication complexes. ..
- Li L, Sullivan B, Aldrich C, Soloski M, Forman J, Grandea A, et al. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J Immunol. 2004;173:3707-15 pubmed
- Ice R, Wildonger J, Mann R, Hiebert S. Comment on "Nervy links protein kinase A to plexin-mediated semaphorin repulsion". Science. 2005;309:558; author reply 558 pubmed
- Brown M, Burnett P, Denning M, Reynolds A. PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Exp Cell Res. 2009;315:39-49 pubmed publisher..Using Va2 cells and PDGF stimulation, we show for the first time that PDGFR-mediated phosphorylation at this site is dependent on PKCalpha, a conventional PKC isoform implicated previously in disruption of adherens junctions. ..
- Liao H, Carpenter G. Regulated intramembrane cleavage of the EGF receptor. Traffic. 2012;13:1106-12 pubmed publisher..Agonist-initiated cleavage occurs slowly over 3-24 h. Inhibition of calpain protease activity significantly increased the detectable level of ICD fragment. ..
- Knight R, Bader D, Backstrom J. Membrane topology of Bves/Pop1A, a cell adhesion molecule that displays dynamic changes in cellular distribution during development. J Biol Chem. 2003;278:32872-9 pubmed..We therefore hypothesize that the carboxyl terminus regulates the cellular distribution of Bves/Pop1A during coronary vessel development. ..
- Myers S, Leeper L, Chung C. WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient. Mol Biol Cell. 2006;17:4564-75 pubmed..These results suggest that WIPa is required for new pseudopod protrusion and prompt reorientation of cells toward a new gradient by initiating localized bursts of actin polymerization and/or elongation. ..
- Ryan K, Zhou Y, Wente S. The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo. Mol Biol Cell. 2007;18:886-98 pubmed..We conclude that Kap95 serves as a key regulator of NPC assembly into intact NEs. Furthermore, both Kap95 and Ran may provide spatial cues necessary for targeting of vesicular intermediates in de novo NPC assembly. ..
- Wang Z, Han J, David L, Schey K. Proteomics and phosphoproteomics analysis of human lens fiber cell membranes. Invest Ophthalmol Vis Sci. 2013;54:1135-43 pubmed publisher..The results presented herein significantly expand the characterized proteome and phosphoproteome of the human lens fiber cell and provide a valuable reference for future research in studies of lens development and disease. ..
- Nishibe S, Wahl M, Rhee S, Carpenter G. Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. J Biol Chem. 1989;264:10335-8 pubmed..These findings show that the EGF receptor can directly phosphorylate PLC-II in an efficient and selective manner. ..
- Vanoye C, Lossin C, Rhodes T, George A. Single-channel properties of human NaV1.1 and mechanism of channel dysfunction in SCN1A-associated epilepsy. J Gen Physiol. 2006;127:1-14 pubmed
- Chen X, Abair T, Ibanez M, Su Y, Frey M, Dise R, et al. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol. 2007;27:3313-26 pubmed
- Khoshbouei H, Sen N, Guptaroy B, Johnson L, Lund D, Gnegy M, et al. N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. PLoS Biol. 2004;2:E78 pubmed..These data raise the therapeutic possibility of interfering selectively with AMPH-induced DA efflux without altering physiological DA uptake...
- Jin M, Goldenring J. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. Biochim Biophys Acta. 2006;1759:281-95 pubmed..These data suggest that Rab11-FIP1 proteins may play coordinated roles in regulating plasma membrane recycling with regional specificity within the Rab11a-containing recycling system. ..
- McConnell R, Tyska M. Myosin-1a powers the sliding of apical membrane along microvillar actin bundles. J Cell Biol. 2007;177:671-81 pubmed..Thus, in addition to providing a means for amplifying apical surface area, we propose that microvilli function as actomyosin contractile arrays that power the release of BB membrane vesicles into the intestinal lumen...
- McConnell R, Tyska M. Leveraging the membrane - cytoskeleton interface with myosin-1. Trends Cell Biol. 2010;20:418-26 pubmed publisher..These properties put myosins-1 in a unique position to regulate dynamic membrane-cytoskeleton interactions and respond to physical forces during these events. ..
- Bost A, Prentice E, Denison M. Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection. Virology. 2001;285:21-9 pubmed..These results suggest that the membrane populations within the MHV replication complex serve distinct functions both in RNA synthesis and in delivery of replication products to sites of virus assembly. ..
- Brady A, Wang Q, Colbran R, Allen P, Greengard P, Limbird L. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. J Biol Chem. 2003;278:32405-12 pubmed
- Manderfield L, George A. KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex. FEBS J. 2008;275:1336-49 pubmed publisher..The observation that multiple KCNE proteins can co-associate with and modulate KCNQ1 channels to produce biochemically diverse channel complexes has important implications for understanding K(V) channel regulation in human physiology. ..
- Tan C, Brady A, Nickols H, Wang Q, Limbird L. Membrane trafficking of G protein-coupled receptors. Annu Rev Pharmacol Toxicol. 2004;44:559-609 pubmed..The disease consequences of mislocalization of GPCRs also are described. ..
- Danthi P, Coffey C, Parker J, Abel T, Dermody T. Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain. PLoS Pathog. 2008;4:e1000248 pubmed publisher..These results indicate that the phi domain of mu1 plays an important regulatory role in reovirus-induced apoptosis and disease...
- Ho R, Leake B, Urquhart B, Gregor J, Dawson P, Kim R. Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2). J Gastroenterol Hepatol. 2011;26:1740-8 pubmed publisher..Genome sequencing and in vitro studies reveal the presence of multiple functionally relevant variants in SLC10A2 that may influence bile acid homeostasis and physiology. ..
- Wang Y, Cao Z, Newkirk R, Ivy M, Townsel J. Molecular cloning of a cDNA for a putative choline co-transporter from Limulus CNS. Gene. 2001;268:123-31 pubmed
- Madison M, Kleshchenko Y, Nde P, Simmons K, Lima M, Villalta F. Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infect Immun. 2007;75:4780-91 pubmed..cruzi and plays an important role in reducing cellular infection. This is the first report showing that human defensin alpha-1 causes membrane pore formation in a human parasite, leading to trypanosome destruction. ..
- Dise R, Frey M, Whitehead R, Polk D. Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 2008;294:G276-85 pubmed..Our results present a novel mechanism by which the PI3K and Src signaling cascades cooperate to activate Rac and promote intestinal epithelial cell migration downstream of EGFR. ..
- Hallaq H, Wang D, Kunic J, George A, Wells K, Murray K. Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels. Am J Physiol Heart Circ Physiol. 2012;302:H782-9 pubmed publisher..These results demonstrate that the activation of protein kinases can acutely regulate the intracellular distribution and molecular mobility of cardiac Na(+) channels in living cells. ..
- Johnson C, Kleshchenko Y, Ikejiani A, Udoko A, Cardenas T, Pratap S, et al. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS ONE. 2012;7:e40614 pubmed publisher..cruzi through the NTSP domain and that this interaction enhances cellular infection. Thus surface TcCRT is a virulent factor that enhances the pathogenesis of T. cruzi infection through TSP-1, which is up-regulated by the parasite. ..
- Srinivasan K, Wright G, Hames N, Housman M, Roberts A, Aufderheide K, et al. Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses. J Cell Sci. 2013;126:221-33 pubmed publisher..Taken together, these findings suggest that similar components control gradient sensing during FA- and cAMP-mediated motility, but the response of polarized cells is more stable, which ultimately helps maintain their directionality. ..
- Sandhu P, Baba T, Guengerich F. Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity. Arch Biochem Biophys. 1993;306:443-50 pubmed..The recombinant P450 2C10 enzymes did not catalyze (S)-mephenytoin 4'-hydroxylation. ..
- Fueger P, Hess H, Posey K, Bracy D, Pencek R, Charron M, et al. Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse. J Biol Chem. 2004;279:50956-61 pubmed..However, when glucose phosphorylation capacity is increased by HK II overexpression, GLUT4 availability becomes a marked limitation to exercise-stimulated MGU. ..
- Dong J, Yang G, McHaourab H. Structural basis of energy transduction in the transport cycle of MsbA. Science. 2005;308:1023-8 pubmed..These results establish the structural dynamic basis of the power stroke in multidrug-resistant ATP-binding cassette (MDR ABC) transporters...
- Speed N, Matthies H, Kennedy J, Vaughan R, Javitch J, Russo S, et al. Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression. ACS Chem Neurosci. 2010;1:476-81 pubmed publisher..Since Akt2 activation is mediated by insulin, these data further implicate insulin signaling as an important modulator of DAT function and dopaminergic tone. ..
- Baetz N, Goldenring J. Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system. Mol Biol Cell. 2013;24:643-58 pubmed publisher..These findings suggest that Rab11-FIP1 proteins participate in spatially and temporally distinct steps of the recycling process along a complex and dynamic tubular network in which Rab11-FIPs occupy discrete domains. ..
- Ruff Jamison S, McGlade J, Pawson T, Chen K, Cohen S. Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse. J Biol Chem. 1993;268:7610-2 pubmed..We conclude that SHC is a physiological substrate that appears to participate in the in vivo signaling response to EGF. ..
- Davis M, Ireton R, Reynolds A. A core function for p120-catenin in cadherin turnover. J Cell Biol. 2003;163:525-34 pubmed..The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120. ..