Experts and Doctors on cell cycle proteins in Nashville, Tennessee, United States


Locale: Nashville, Tennessee, United States
Topic: cell cycle proteins

Top Publications

  1. Ohi M, Vander Kooi C, Rosenberg J, Ren L, Hirsch J, Chazin W, et al. Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Mol Cell Biol. 2005;25:451-60 pubmed
    ..These structural and functional data provide a basis for understanding the role of Prp19p as a key architectural component of the NTC. ..
  2. Kanteti R, Dhanasingh I, El Hashani E, Riehm J, Stricker T, Nagy S, et al. C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype. Cancer Biol Ther. 2016;17:91-103 pubmed publisher
    ..Taken together, these studies provide evidence in support of C. elegans as initial in vivo model to study nicotine and its effects on oncogenic mutations identified in humans. ..
  3. Morrell J, Tomlin G, Rajagopalan S, Venkatram S, Feoktistova A, Tasto J, et al. Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB. Curr Biol. 2004;14:579-84 pubmed
    ..Our results suggest that the Sid4p-Cdc11p complex organizes a signaling hub on the SPB and that this hub coordinates cell and nuclear division. ..
  4. Lenferink A, Simpson J, Shawver L, Coffey R, Forbes J, Arteaga C. Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice. Proc Natl Acad Sci U S A. 2000;97:9609-14 pubmed
    ..These data suggest that increased signaling by ErbB receptors up-regulates MAPK activity, which, in turn, phosphorylates and destabilizes p27, thus contributing to dysregulated cell cycle progression. ..
  5. Ohi R, McCollum D, Hirani B, Den Haese G, Zhang X, Burke J, et al. The Schizosaccharomyces pombe cdc5+ gene encodes an essential protein with homology to c-Myb. EMBO J. 1994;13:471-83 pubmed
    ..This evidence suggests that cdc5+ might encode a transcription factor whose activity is required for cell cycle progression and growth during G2. ..
  6. Wolfe B, McDonald W, Yates J, Gould K. Phospho-regulation of the Cdc14/Clp1 phosphatase delays late mitotic events in S. pombe. Dev Cell. 2006;11:423-30 pubmed
    ..These findings point to a simple regulatory circuit that couples Cdk1 activation with its inactivation mediated through phosphorylation-dependent regulation of Clp1/Flp1 phosphatase activity. ..
  7. Liu Y, Bertram C, Shi Q, Zinkel S. Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress. Cell Death Differ. 2011;18:841-52 pubmed publisher
    ..These results establish a direct role for the BH3-only Bcl-2 family member, Bid, acting at the level of the damage sensor complex to amplify the Atr-directed cellular response to replicative DNA damage. ..
  8. Snyder J, Kearns C, Appel B. Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. 2012;7:15 pubmed publisher
    ..Notch signaling promotes glia cell formation from neural precursors in vertebrate embryos. Our data indicate that Fbxw7 helps attenuate Notch signaling during zebrafish neural development thereby limiting the number of OPCs. ..
  9. Myers J, Zhao R, Xu X, Ham A, Cortez D. Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Res. 2007;67:6685-90 pubmed
    ..Thus, ATRIP is a CDK2 substrate, and CDK2-dependent phosphorylation of S224 regulates the ability of ATR-ATRIP to promote cell cycle arrest in response to DNA damage. ..

More Information


  1. Coats S, Pabón Peña L, Covington J, Vaughan D. Ligand-specific control of src-suppressed C kinase substrate gene expression. Biochem Biophys Res Commun. 2002;297:1112-20 pubmed
    ..In addition, ectopic expression of recombinant SSeCKS recapitulates attributes of NaB-induced morphogenesis in KNRK cells. The data provide novel evidence that SSeCKS functions in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling. ..
  2. O Rear L, Longobardi L, Torello M, Law B, Moses H, Chiarelli F, et al. Signaling cross-talk between IGF-binding protein-3 and transforming growth factor-(beta) in mesenchymal chondroprogenitor cell growth. J Mol Endocrinol. 2005;34:723-37 pubmed
    ..Collectively, these results demonstrate cross-talk between the IGFBP-3-dependent STAT-1 signaling and the TGF-beta-dependent ERK pathway that regulates MCC proliferation. ..
  3. Shin I, Rotty J, Wu F, Arteaga C. Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry. J Biol Chem. 2005;280:6055-63 pubmed
  4. Gould K, Feoktistova A, Fleig U. A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition. Mol Gen Genet. 1998;259:437-48 pubmed
    ..Overexpression of suc1+ suppresses the effects of T167 E overproduction by restoring sufficient amounts of suc1p to the cell to allow passage through mitosis. ..
  5. Morrell J, Morphew M, Gould K. A mutant of Arp2p causes partial disassembly of the Arp2/3 complex and loss of cortical actin function in fission yeast. Mol Biol Cell. 1999;10:4201-15 pubmed
    ..Analysis of the mutant Arp2 protein demonstrated defects in ATP and Arp3p binding, suggesting a possible model for disruption of the complex. ..
  6. McDonald N, Vander Kooi C, Ohi M, Gould K. Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis. Dev Cell. 2015;35:725-36 pubmed publisher
    ..F-BAR oligomerization is also critical for Fer and RhoGAP4 physiological function, demonstrating its broad importance to F-BAR proteins that function without membrane bending. ..
  7. Huang S, Qiu Y, Shi Y, Xu Z, Brandt S. P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL. EMBO J. 2000;19:6792-803 pubmed
    ..These results reveal a novel mechanism by which TAL1 activity is regulated and implicate acetylation of this transcription factor in promotion of erythroid differentiation. ..
  8. McConnell J, Gomez R, McCorvey L, Law B, Wadzinski B. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. Oncogene. 2007;26:6021-30 pubmed
    ..These results indicate TIP is a novel inhibitory regulator of PP2A and implicate a role for TIP.PP2A complexes within the ATM/ATR signaling pathway controlling DNA replication and repair. ..
  9. Nichols C, Sanders Bush E. Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta and ILAD-1, a novel gene with homology to arrestins. J Neurochem. 2004;90:576-84 pubmed
    ..The genes thus far found to be responsive to LSD are beginning to give a more complete picture of the complex intracellular events initiated by hallucinogens. ..
  10. Furge K, Cheng Q, Jwa M, Shin S, Song K, Albright C. Regions of Byr4, a regulator of septation in fission yeast, that bind Spg1 or Cdc16 and form a two-component GTPase-activating protein with Cdc16. J Biol Chem. 1999;274:11339-43 pubmed
    ..A region of Byr4 that bound Spg1, SBS4, and the region that bound Cdc16, Cdc16-binding site, was necessary and sufficient to form Cdc16-dependent Spg1GAP activity that was similar to that of wild-type Byr4 with Cdc16. ..
  11. Law B, Chytil A, Dumont N, Hamilton E, Waltner Law M, Aakre M, et al. Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells. Mol Cell Biol. 2002;22:8184-98 pubmed
    ..Together, these results indicate that rapamycin and TGF-beta cooperate to inhibit the proliferation of nontransformed cells and cancer cells by acting in concert to inhibit Cdk2 activity. ..
  12. Couch F, Bansbach C, Driscoll R, Luzwick J, Glick G, Betous R, et al. ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev. 2013;27:1610-23 pubmed publisher
    ..Thus, phosphorylation of SMARCAL1 is one mechanism by which ATR prevents fork collapse, promotes the completion of DNA replication, and maintains genome integrity. ..
  13. Biswas S, Shi Q, Wernick A, Aiello A, Zinkel S. The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice. Cell Death Differ. 2013;20:869-77 pubmed publisher
    ..Loss of Bid thus inhibits T-cell tumorigenesis by increasing clearance of damaged cells, and preventing propagation of deleterious mutations. ..
  14. Nam E, Cortez D. ATR signalling: more than meeting at the fork. Biochem J. 2011;436:527-36 pubmed publisher
    ..We discuss how to incorporate these new insights into a model of ATR regulation and point out the significant gaps in our understanding of this essential genome-maintenance pathway. ..
  15. Eblen S, Fautsch M, Anders R, Leof E. Conditional binding to and cell cycle-regulated inhibition of cyclin-dependent kinase complexes by p27Kip1. Cell Growth Differ. 1995;6:915-25 pubmed
    ..The results suggest an interplay between the acquisition of quiescence, cdk activity, and G1 traverse. ..
  16. Bruck I, Kaplan D. Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth. J Biol Chem. 2009;284:28823-31 pubmed publisher
    ..We conclude that DDK phosphorylation of Mcm2 is required for cell growth. ..
  17. Ye C, Cai Q, Dai Q, Shu X, Shin A, Gao Y, et al. Expression patterns of the ATM gene in mammary tissues and their associations with breast cancer survival. Cancer. 2007;109:1729-35 pubmed
    ..35-0.92 and HR=0.70, 95% CI: 0.43-1.13, respectively). The ATM gene expression was down-regulated in breast cancer tissues and a high ATM gene expression level in breast cancer tissue was associated with a favorable prognosis. ..
  18. Sitaram P, Anderson M, Jodoin J, Lee E, Lee L. Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis. Development. 2012;139:2945-54 pubmed publisher
    ..We present a model in which Lis-1 and asun cooperate to regulate dynein localization and centrosome positioning during Drosophila spermatogenesis...
  19. Muraoka R, Lenferink A, Law B, Hamilton E, Brantley D, Roebuck L, et al. ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol Cell Biol. 2002;22:2204-19 pubmed
    ..These results suggest that p27(+/-) mammary epithelium may be more susceptible to oncogene-induced tumorigenesis, whereas p27-null glands, due to severely impaired cyclin D1/Cdk4 function, are more resistant to transformation. ..
  20. Morrell J, Nichols C, Gould K. The GIN4 family kinase, Cdr2p, acts independently of septins in fission yeast. J Cell Sci. 2004;117:5293-302 pubmed
    ..Our data indicate that Cdr2p functions at two positions within the cell at discrete cell cycle stages to influence the timing of mitotic entry and cytokinesis, respectively...
  21. Cho Y, Liang P. Killin is a p53-regulated nuclear inhibitor of DNA synthesis. Proc Natl Acad Sci U S A. 2008;105:5396-401 pubmed publisher
    ..These results support Killin as a missing link between p53 activation and S phase checkpoint control designed to eliminate replicating precancerous cells, should they escape G(1) blockade mediated by p21. ..
  22. Ohi M, Gould K. Characterization of interactions among the Cef1p-Prp19p-associated splicing complex. RNA. 2002;8:798-815 pubmed
    ..Further, our data indicate that a mutation in the U-box of Prp19p disrupts these numerous protein interactions causing Cef1p degradation and Ntc instability. ..
  23. Govindan J, Cheng H, Harris J, Greenstein D. Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Curr Biol. 2006;16:1257-68 pubmed
    ..elegans, highlighting contrasts and parallels between MSP signaling in C. elegans and luteinizing hormone signaling in mammals. ..
  24. Clifford D, Wolfe B, Roberts Galbraith R, McDonald W, Yates J, Gould K. The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1. J Cell Biol. 2008;181:79-88 pubmed publisher
    ..Our evidence indicates that Clp1/Flp1 must interact with the Mid1 scaffold to ensure the fidelity of Schizosaccharomyces pombe cytokinesis. ..
  25. Cortez D, Glick G, Elledge S. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A. 2004;101:10078-83 pubmed
    ..Thus, the MCM complex is a platform for multiple DNA damage-dependent regulatory signals that control DNA replication. ..
  26. Nam E, Zhao R, Cortez D. Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. J Biol Chem. 2011;286:37320-7 pubmed publisher
    ..Furthermore, our data indicate that the essential function of ATR for cell viability is linked to its function in promoting proper replication in the context of replication stress and is independent of G(2) checkpoint activity. ..
  27. Nozaki K, Ogawa M, Williams J, Lafleur B, Ng V, Drapkin R, et al. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology. 2008;134:511-22 pubmed publisher
    ..We now sought to characterize more definitively the pathway for emergence of SPEM...
  28. Soutto M, Peng D, Razvi M, Ruemmele P, Hartmann A, Roessner A, et al. Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas. Cancer. 2010;116:4033-42 pubmed publisher
    ..Taken together, their findings demonstrated that both epigenetic and genetic mechanisms were involved in silencing CHFR expression in EACs. ..
  29. Carnahan R, Gould K. The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe. J Cell Biol. 2003;162:851-62 pubmed
    ..We propose a model in which Cdc15p plays a critical role in recruiting and coordinating the pathways essential for the assembly of medially located F-actin filaments and construction of the CAR. ..
  30. Lovejoy C, Xu X, Bansbach C, Glick G, Zhao R, Ye F, et al. Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A. 2009;106:19304-9 pubmed publisher
    ..CINP interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress, and G2 checkpoint integrity. ..
  31. Ruan G, Allen G, Yamazaki S, McMahon D. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol. 2008;6:e249 pubmed publisher
    ..Thus, dopamine and GABA act at the molecular level of PER proteins to play key roles in the organization of the retinal circadian clock. ..
  32. Bruck I, Kanter D, Kaplan D. Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem. 2011;286:36414-26 pubmed publisher
    ..Furthermore, origin ssDNA may stimulate the formation of the CMG complex by alleviating inhibitory interactions between Sld2 with Mcm2-7. ..
  33. Burns C, Ohi R, Mehta S, O TOOLE E, Winey M, Clark T, et al. Removal of a single alpha-tubulin gene intron suppresses cell cycle arrest phenotypes of splicing factor mutations in Saccharomyces cerevisiae. Mol Cell Biol. 2002;22:801-15 pubmed
  34. Lovejoy C, Lock K, Yenamandra A, Cortez D. DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol. 2006;26:7977-90 pubmed
    ..Therefore, DDB1 prevents DNA lesions from accumulating in replicating human cells, in part by regulating Cdt1 degradation. ..
  35. Harris J, Govindan J, Yamamoto I, Schwartz J, Kaverina I, Greenstein D. Major sperm protein signaling promotes oocyte microtubule reorganization prior to fertilization in Caenorhabditis elegans. Dev Biol. 2006;299:105-21 pubmed
    ..We propose that MSP-dependent microtubule reorganization promotes meiotic spindle assembly by facilitating the search and capture of microtubules by meiotic chromatin following NEBD. ..
  36. Venkatram S, Jennings J, Link A, Gould K. Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring. Mol Biol Cell. 2005;16:3052-63 pubmed
    ..Our results suggest that the Mto2p and the EMTOC are critical for anchoring the cytokinetic actin ring to the medial region of the cell and for proper coordination of mitosis with cytokinesis. ..
  37. Clément A, Solnica Krezel L, Gould K. The Cdc14B phosphatase contributes to ciliogenesis in zebrafish. Development. 2011;138:291-302 pubmed publisher
    ..This first study of a loss of function of a Cdc14 family member in a vertebrate organism reveals a new role for Cdc14B in ciliogenesis and consequently in a number of developmental processes. ..
  38. Wu D, Yang H, Xiang W, Zhou L, Shi M, Julies G, et al. Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res. 2005;46:1380-7 pubmed
  39. Nam E, Zhao R, Glick G, Bansbach C, Friedman D, Cortez D. Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J Biol Chem. 2011;286:28707-14 pubmed publisher
    ..Our results suggest that, like ATM and DNA-PK, phosphorylation regulates ATR, and phospho-peptide specific antibodies to Thr-1989 provide a proximal marker of ATR activation. ..
  40. Johnson A, Collier S, Ohi M, Gould K. Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function. J Biol Chem. 2012;287:25741-8 pubmed publisher
    ..Thus, Dma1 forms an obligate dimer via its RING domain, which is essential for efficient transfer of ubiquitin to its substrate(s). This study further supports the mechanistic paradigm that many RING E3 ligases function as RING dimers. ..
  41. Broadus M, Gould K. Multiple protein kinases influence the redistribution of fission yeast Clp1/Cdc14 phosphatase upon genotoxic stress. Mol Biol Cell. 2012;23:4118-28 pubmed publisher
    ..This work advances our understanding of pathways influencing Clp1 localization and may provide insight into mechanisms controlling Cdc14B phosphatases in higher eukaryotes. ..
  42. Lee Y, Dimitrova Y, Schneider G, Ridenour W, Bhattacharya S, Soss S, et al. Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition. Biochemistry. 2008;47:10921-32 pubmed publisher
    ..A series of structure-based SIP mutations showed reduced S100A6 binding affinity, setting the stage for direct functional analysis of S100A6-SIP interactions...
  43. Mordes D, Nam E, Cortez D. Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A. 2008;105:18730-4 pubmed publisher
    ..Thus, Dpb11 is a functional ortholog of human TopBP1, and the Mec1/ATR activation mechanism is conserved from yeast to humans. ..
  44. Boyd A, Shakhtour B, Shyr Y. Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases. J Am Acad Dermatol. 2008;58:750-4 pubmed publisher
    ..Further evaluation of this expression may prove useful in delineating the biologic behavior of these tumors and warrants additional research. ..
  45. Liu Y, Vaithiyalingam S, Shi Q, Chazin W, Zinkel S. BID binds to replication protein A and stimulates ATR function following replicative stress. Mol Cell Biol. 2011;31:4298-309 pubmed publisher
    ..We propose a model in which BID associates with RPA and stimulates the recruitment and/or stabilization of ATR-ATRIP to the DNA damage sensor complex. ..
  46. Mehta S, Gould K. Identification of functional domains within the septation initiation network kinase, Cdc7. J Biol Chem. 2006;281:9935-41 pubmed
    ..We found that a region adjacent to the kinase domain is responsible for Spg1 association and identified an overlapping but distinct SPB localization domain. In addition Cdc7 associates with itself and exists as a dimer in vivo. ..
  47. Gunasekaran U, Gannon M. Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY). 2011;3:565-75 pubmed
    ..Further studies are needed in order to identify potential beta cell targets for preventing or slowing the progression of diabetes that occurs with age. ..
  48. McDonald W, Ohi R, Smelkova N, Frendewey D, Gould K. Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing. Mol Cell Biol. 1999;19:5352-62 pubmed
    ..These data raise the possibility that the cdc5p complex is an intermediate in the assembly or disassembly of an active S. pombe spliceosome. ..
  49. Snider C, Willet A, Chen J, ArpaÄŸ G, Zanic M, Gould K. Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis. J Cell Biol. 2017;216:3041-3050 pubmed publisher
    ..Our results suggest that proper PM lipid composition is important to stabilize the central position of the CR and resist myosin V-based forces to promote the fidelity of cell division. ..
  50. Warren E, Huang H, Fanning E, Chazin W, Eichman B. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem. 2009;284:24662-72 pubmed publisher
  51. Xu X, Vaithiyalingam S, Glick G, Mordes D, Chazin W, Cortez D. The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol. 2008;28:7345-53 pubmed publisher
    ..Thus, the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling. ..
  52. Ball H, Cortez D. ATRIP oligomerization is required for ATR-dependent checkpoint signaling. J Biol Chem. 2005;280:31390-6 pubmed
    ..Thus, the ATR-ATRIP complex exists in higher order oligomeric states within cells and ATRIP oligomerization is essential for its function. ..
  53. Song K, Mach K, Chen C, Reynolds T, Albright C. A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis. J Cell Biol. 1996;133:1307-19 pubmed
    ..A slower migrating byr4 protein was found in cells with a mutation in the beta-tubulin gene, which arrests cells at the metaphase-anaphase transition. ..
  54. Muraoka R, Lenferink A, Simpson J, Brantley D, Roebuck L, Yakes F, et al. Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function. J Cell Biol. 2001;153:917-32 pubmed
    ..Therefore, p27 is required for mammary gland development in a dose-dependent fashion and positively regulates cyclin D-Cdk4 function in the mammary gland. ..
  55. McCollum D, Balasubramanian M, Pelcher L, Hemmingsen S, Gould K. Schizosaccharomyces pombe cdc4+ gene encodes a novel EF-hand protein essential for cytokinesis. J Cell Biol. 1995;130:651-60 pubmed
    ..We find that Cdc4 protein forms a complex with a 200-kD protein which can be cross-linked to UTP, a property common to myosin heavy chains. Together these results suggest that Cdc4p may be a novel myosin light chain. ..
  56. Stein S, Thomas E, Herzog B, Westfall M, Rocheleau J, Jackson R, et al. NDRG1 is necessary for p53-dependent apoptosis. J Biol Chem. 2004;279:48930-40 pubmed
    ..This report further supports the notion that p53 controls a network of genes that are required for its apoptotic function. ..
  57. Ball H, Myers J, Cortez D. ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell. 2005;16:2372-81 pubmed
    ..These data suggest that binding to RPA-ssDNA is not the essential function of ATRIP in ATR-dependent checkpoint signaling and ATR has an important function in properly localizing the ATR-ATRIP complex. ..
  58. Burns C, Ohi R, Krainer A, Gould K. Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proc Natl Acad Sci U S A. 1999;96:13789-94 pubmed
    ..These data provide evidence that eukaryotic cells require CDC5 proteins for pre-mRNA splicing. ..
  59. Yoon H, Feoktistova A, Chen J, Jennings J, Link A, Gould K. Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function. J Biol Chem. 2006;281:32284-93 pubmed
    ..Phosphorylation of Hcn1 occurs at a single Cdk1 site in vitro and in vivo. Mutation of this site to alanine, but not aspartic acid, compromises APC/C function and leads to a specific defect in the completion of cell division. ..
  60. Robertson P, Warren E, Zhang H, Friedman D, Lary J, Cole J, et al. Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem. 2008;283:3338-48 pubmed
  61. Bruck I, Kaplan D. GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding. J Biol Chem. 2011;286:14157-67 pubmed publisher
    ..Our results are consistent with a model wherein GINS trades places with Sld3 at a replication origin, contributing to the activation of the replication fork helicase. ..
  62. Chen J, Lu L, Ohi M, Creamer K, English C, Partridge J, et al. Cdk1 phosphorylation of the kinetochore protein Nsk1 prevents error-prone chromosome segregation. J Cell Biol. 2011;195:583-93 pubmed publisher
    ..Our findings establish new roles for Cdk1 and the Nsk1-Dlc1 complex in regulating the k-MT interface and chromosome segregation. ..
  63. Hinton C, Fitzgerald L, Thompson M. Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1. Exp Cell Res. 2007;313:1735-44 pubmed
    ..These findings implicate Akt in upstream events leading to BRCA1 nuclear localization and function. ..
  64. Scheving L, Buchanan R, Krause M, Zhang X, Stevenson M, Russell W. Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2007;293:G552-9 pubmed
    ..Thus 10(-6) M dexamethasone exerts a time-dependent and redundant inhibitory effect on EGFr-mediated proliferative signaling in hepatocytes, targeting not only the ErbB proteins but also their various positive and negative effectors. ..
  65. Gould K, Burns C, Feoktistova A, Hu C, Pasion S, Forsburg S. Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity. Genetics. 1998;149:1221-33 pubmed
    ..An S. pombe homolog of the replicative DNA helicase DNA2 of S. cerevisiae suppresses cdc24. These results suggest that Cdc24p plays a role in the progression of normal DNA replication and is required to maintain genomic integrity. ..
  66. Johnson A, Gould K. Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase. EMBO J. 2011;30:341-54 pubmed publisher