Experts and Doctors on animals in Nashville, Tennessee, United States

Summary

Locale: Nashville, Tennessee, United States
Topic: animals

Top Publications

  1. Magnuson M, Shelton K. An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. J Biol Chem. 1989;264:15936-42 pubmed
    ..Analysis of the pattern of RNA splicing in tissues containing beta cells indicates that the splice acceptor site utilized in producing hepatic glucokinase mRNA is also utilized in the beta cell...
  2. Qi Z, Hao C, Salter K, Redha R, Breyer M. Type II cAMP-dependent protein kinase regulates electrogenic ion transport in rabbit collecting duct. Am J Physiol. 1999;276:F622-8 pubmed
    ..These results suggest PKA type II is the major isozyme regulating electrogenic ion transport in the rabbit collecting duct. ..
  3. Hallahan D, Geng L, Qu S, Scarfone C, Giorgio T, Donnelly E, et al. Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell. 2003;3:63-74 pubmed
    ..Radiation-guided drug delivery to tumor blood vessels is a novel paradigm for targeted drug delivery. ..
  4. Li X, Ong D. Cellular retinoic acid-binding protein II gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus. J Biol Chem. 2003;278:35819-25 pubmed
    ..The ability of E2 to induce expression of CRABP(II) suggests that it can enhance the activity of RA, directly affecting expression of retinoid-responsive genes. ..
  5. Ryther R, Flynt A, Harris B, Phillips J, Patton J. GH1 splicing is regulated by multiple enhancers whose mutation produces a dominant-negative GH isoform that can be degraded by allele-specific small interfering RNA (siRNA). Endocrinology. 2004;145:2988-96 pubmed
    ..Importantly, we show here that small interfering RNAs can be used to specifically degrade exon 3-skipped transcripts, potentially a new avenue of therapeutic intervention in isolated GH deficiency II and other dominant disorders. ..
  6. Jiao Y, Robison A, Bass M, Colbran R. Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization. J Neurochem. 2008;105:1746-60 pubmed publisher
    ..In combination, these data show that densin splice variants have distinct functional characteristics suggesting multiple roles during neuronal development. ..
  7. Yang S, Wei S, Pozzi A, Capdevila J. The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Arch Biochem Biophys. 2009;489:82-91 pubmed publisher
  8. Tanjore H, Cheng D, Degryse A, Zoz D, Abdolrasulnia R, Lawson W, et al. Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. J Biol Chem. 2011;286:30972-80 pubmed publisher
    ..Dissecting pathways involved in ER stress-induced EMT may lead to new treatment strategies to limit fibrosis. ..
  9. Vishnivetskiy S, Lee R, Zhou X, Franz A, Xu Q, Xu H, et al. Functional role of the three conserved cysteines in the N domain of visual arrestin-1. J Biol Chem. 2017;292:12496-12502 pubmed publisher
    ..Thus, these three conserved cysteines play a role in the domain rotation but not in the C-tail release. ..

More Information

Publications925 found, 100 shown here

  1. Knittle T, Doyle K, Tamkun M. Immunolocalization of the mNav2.3 Na+ channel in mouse heart: upregulation in myometrium during pregnancy. Am J Physiol. 1996;270:C688-96 pubmed
    ..These data provide perhaps the most dramatic example of NaC regulation. The acute and transient upregulation in myometrium during gestation suggests the Nav2.3 channel plays a role in uterine function at term...
  2. Chu C, Sindelar D, Neal D, Allen E, Donahue E, Cherrington A. Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. J Clin Invest. 1997;99:1044-56 pubmed
    ..Lastly, the gluconeogenic effects of EPI markedly decreased (60-80%) its overall glycogenolytic action on the liver. ..
  3. Adkins E, Barker E, Blakely R. Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Mol Pharmacol. 2001;59:514-23 pubmed
    ..These findings support a critical role for TMD I residues in defining shared aspects of SERT substrate and antagonist recognition. ..
  4. Spector S, Munjal I, Schmidt D. Endogenous morphine and codeine. Possible role as endogenous anticonvulsants. Brain Res. 2001;915:155-60 pubmed
    ..These studies suggest that the endogenous alkaloids morphine and codeine are involved in the modulation of convulsions and that morphine and/or codeine may act as an endogenous anticonvulsant. ..
  5. Cheng H, Harris R. Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways. J Biol Chem. 2002;277:45638-43 pubmed
    ..05). Therefore, these studies indicate that p38 stimulates COX-2 expression in cTALH and macula densa by transcriptional regulation predominantly via a NF-kappaB-dependent pathway and by post-transcriptional increases in mRNA stability. ..
  6. Zhang D, Zhou T, Ruan G, McMahon D. Circadian rhythm of Period1 clock gene expression in NOS amacrine cells of the mouse retina. Brain Res. 2005;1050:101-9 pubmed
    ..The results demonstrate circadian rhythms in Per1 promoter activation in nitric oxide (NO) and GABA secreting amacrine cells, and suggest that NO and GABA could be controlled by circadian clock mechanisms in the mammalian retina. ..
  7. Chen S, Lin F, Hamm H. RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation. J Biol Chem. 2005;280:33445-52 pubmed
    ..These data thus demonstrate that RACK1 can regulate the activity of a G betagamma effector by competing for its binding to the signal transfer region of G betagamma. ..
  8. Mann J, Backlund M, Buchanan F, Daikoku T, Holla V, Rosenberg D, et al. Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. Cancer Res. 2006;66:6649-56 pubmed
    ..These data indicate that PGDH may serve a tumor suppressor function in colorectal cancer and provide a possible COX-2-independent way to target PGE(2) to inhibit cancer progression. ..
  9. Acuff H, Sinnamon M, Fingleton B, Boone B, Levy S, Chen X, et al. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res. 2006;66:7968-75 pubmed
    ..The use of the Hu/Mu ProtIn chip allows us to distinguish tumor- and host-derived proteases and guides the further analysis of the significance of these genes in tumor progression. ..
  10. West J, Harral J, Lane K, Deng Y, Ickes B, Crona D, et al. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol. 2008;295:L744-55 pubmed publisher
    ..This model should be useful to the research community in examining early molecular and physical events in the development of PAH and as a platform to validate potential treatments. ..
  11. Walters M, Blobaum A, Kingsley P, Felts A, Sulikowski G, Marnett L. The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives. Bioorg Med Chem Lett. 2009;19:3271-4 pubmed publisher
    ..Thus, although the 2'-methyl group is a major determinant of time-dependent cyclooxygenase inhibition, the geometry of the benzylidene double bond plays a role as well. ..
  12. Lee H, Joo M, Abdolrasulnia R, Young D, Choi I, Ware L, et al. Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Biol Chem. 2010;285:39655-62 pubmed publisher
    ..In vitro citrullination assay showed that incubation of purified PAD2 and IKK? proteins in the presence of Ca(2+) citrullinated IKK?. These results demonstrate that PAD2 interacts with IKK? and suppresses NF-?B activity. ..
  13. Buck J, McKinley E, Hight M, Fu A, Tang D, Smith R, et al. Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline. J Nucl Med. 2011;52:107-14 pubmed publisher
  14. Erreger K, Davis A, Poe A, Greig N, Stanwood G, Galli A. Exendin-4 decreases amphetamine-induced locomotor activity. Physiol Behav. 2012;106:574-8 pubmed publisher
    ..Our findings implicate GLP-1R signaling as a novel modulator of psychostimulant-induced behavior and therefore a potential therapeutic target for psychostimulant abuse...
  15. Gaddy J, Radin J, Loh J, Zhang F, Washington M, Peek R, et al. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect Immun. 2013;81:2258-67 pubmed publisher
    ..Animals infected with the cagA mutant strain had low levels of gastric inflammation and did not develop hypochlorhydria. These results indicate that a high-salt diet potentiates the carcinogenic effects of cagA(+) H. pylori strains. ..
  16. LePage D, Metcalf J, Bordenstein S, On J, Perlmutter J, Shropshire J, et al. Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature. 2017;543:243-247 pubmed publisher
  17. Ross J, Fong P, Cavener D. Correlated evolution of the cis-acting regulatory elements and developmental expression of the Drosophila Gld gene in seven species from the subgroup melanogaster. Dev Genet. 1994;15:38-50 pubmed publisher
    ..Together these data suggest the absence or presence of the TTAGA elements may be responsible for variation in the absence or presence of GLD in the ejaculatory duct among species...
  18. Sasaki H, Hogan B. HNF-3 beta as a regulator of floor plate development. Cell. 1994;76:103-15 pubmed
    ..Ectopic dorsal neuronal differentiation and abnormal dorsal axonal projections are also seen. These results suggest that HNF-3 beta is an important regulator of floor plate development in vivo. ..
  19. Thomas J. Antigen-specific responses in autoimmunity and tolerance. Immunol Res. 2001;23:235-44 pubmed
    ..This essay reviews our current understanding of escape pathways for anti-insulin B cells. ..
  20. Tulsiani D. Glycan-modifying enzymes in luminal fluid of the mammalian epididymis: an overview of their potential role in sperm maturation. Mol Cell Endocrinol. 2006;250:58-65 pubmed
    ..In this article, I have attempted to summarize and present an overview on the potential role of these glycan-modifying enzymes in sperm maturation. ..
  21. Gupta A, Wang Y, Browne C, Kim S, Case T, Paul M, et al. Neuroendocrine differentiation in the 12T-10 transgenic prostate mouse model mimics endocrine differentiation of pancreatic beta cells. Prostate. 2008;68:50-60 pubmed
    ..This study indicates that a pathway similar to pancreatic beta-cell differentiation is involved in NE differentiation of prostate cancer. ..
  22. Ryzhov S, Solenkova N, Goldstein A, Lamparter M, Fleenor T, Young P, et al. Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Circ Res. 2008;102:356-63 pubmed
    ..Our results suggest a role for adenosine in vasculogenesis and its potential use to stimulate engraftment in cell-based therapies. ..
  23. Stobart C, Lee A, Lu X, Denison M. Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity. J Virol. 2012;86:4801-10 pubmed publisher
  24. Engers D, Frist A, Lindsley C, Hong C, Hopkins C. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective M. Bioorg Med Chem Lett. 2013;23:3248-52 pubmed publisher
  25. Moses H, Serra R. Regulation of differentiation by TGF-beta. Curr Opin Genet Dev. 1996;6:581-6 pubmed
    ..Drosophila and transgenic mouse models are now providing useful insights into mechanisms of TGF-beta action in vivo. ..
  26. Browning R, Leite Browning M. Effect of ergotamine and ergonovine on thermal regulation and cardiovascular function in cattle. J Anim Sci. 1997;75:176-81 pubmed
    ..Results indicated that individual ergot alkaloids administered i.v. induced signs of fescue toxicosis in cattle. ..
  27. Huang S, Qiu Y, Stein R, Brandt S. p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein. Oncogene. 1999;18:4958-67 pubmed
    ..The dependence of their interaction in MEL cells on addition of a differentiation inducer suggests, further, that this TAL1-p300 complex may have an important role in terminal erythroid differentiation. ..
  28. Picklo M, Olson S, Markesbery W, Montine T. Expression and activities of aldo-keto oxidoreductases in Alzheimer disease. J Neuropathol Exp Neurol. 2001;60:686-95 pubmed
    ..These results suggest that in brain regions involved in AD, neurons and glia utilize different mechanisms to detoxify HNE, and that increased ALDH activity is a protective response of cerebral cortex to AD. ..
  29. Gerrish K, Van Velkinburgh J, Stein R. Conserved transcriptional regulatory domains of the pdx-1 gene. Mol Endocrinol. 2004;18:533-48 pubmed
    ..Our data suggests that pdx-1 transcription is also regulated by factors acting upon conserved area IV sequences. ..
  30. Roberts R, Lin P. Structural and functional optical imaging of angiogenesis in animal models. Methods Enzymol. 2004;386:105-22 pubmed
  31. Parker M, Roberts R, Enriquez M, Zhao X, Takahashi T, Pat Cerretti D, et al. Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway. Biochem Biophys Res Commun. 2004;323:17-23 pubmed
    ..These results suggest that ephrin-B1 internalization is an active receptor-mediated process that utilizes the clathrin-mediated endocytic pathway. ..
  32. Yankeelov T, Niermann K, Huamani J, Kim D, Quarles C, Fleischer A, et al. Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging. J Ultrasound Med. 2006;25:487-97 pubmed
    ..Microbubble contrast-enhanced sonography can effectively depict intratumoral heterogeneity in preclinical xenograft models when voxel-by-voxel analysis is performed, and this analysis correlates with similar DCE-MRI measurements. ..
  33. Bernardo A, Harrison F, McCord M, Zhao J, Bruchey A, Davies S, et al. Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. Neurobiol Aging. 2009;30:1777-91 pubmed publisher
    ..These results suggest that GD3 synthase may be a novel therapeutic target to combat the cognitive deficits, amyloid plaque formation, and neurodegeneration that afflict Alzheimer's patients. ..
  34. Manderfield L, George A. KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex. FEBS J. 2008;275:1336-49 pubmed publisher
    ..The observation that multiple KCNE proteins can co-associate with and modulate KCNQ1 channels to produce biochemically diverse channel complexes has important implications for understanding K(V) channel regulation in human physiology. ..
  35. Wei J, O BRIEN D, Vilgelm A, Piazuelo M, Correa P, Washington M, et al. Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology. 2008;134:1412-23 pubmed publisher
    ..Our findings implicate p73 in H pylori-induced apoptosis and more generally suggest that the p53 family may play a role in the epithelial cell response to H pylori infection. ..
  36. Sheffler D, Conn P. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology. 2008;55:419-27 pubmed publisher
    ..Together, these data provide further evidence that allosteric compounds can differentially modulate the coupling of a single receptor to independent signaling pathways or act in a system-dependent manner. ..
  37. Yang L, Edwards C, Mundy G. Gr-1+CD11b+ myeloid-derived suppressor cells: formidable partners in tumor metastasis. J Bone Miner Res. 2010;25:1701-6 pubmed publisher
    ..They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis. ..
  38. LUTHER J, Brown N. The renin-angiotensin-aldosterone system and glucose homeostasis. Trends Pharmacol Sci. 2011;32:734-9 pubmed publisher
    ..We review these findings in the context of pharmacological strategies interrupting the RAAS to highlight the potential application of these strategies to the prevention of diabetes progression. ..
  39. Snyder J, Kearns C, Appel B. Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. 2012;7:15 pubmed publisher
    ..Notch signaling promotes glia cell formation from neural precursors in vertebrate embryos. Our data indicate that Fbxw7 helps attenuate Notch signaling during zebrafish neural development thereby limiting the number of OPCs. ..
  40. Liu Y, Hawkins O, Su Y, Vilgelm A, Sobolik T, Thu Y, et al. Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-?B impairs this drug-induced senescence. EMBO Mol Med. 2013;5:149-66 pubmed publisher
    ..Altogether, these data demonstrate that induction of senescence, coupled with immune surveillance, can limit melanoma growth. ..
  41. Schulz S, Green C, Yuen P, Garbers D. Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell. 1990;63:941-8 pubmed
    ..These results show that a heat-stable enterotoxin receptor responsible for acute diarrhea is a plasma membrane form of guanylyl cyclase. ..
  42. Jensen R, Thompson M, Jetton T, Szabo C, van der Meer R, Helou B, et al. BRCA1 is secreted and exhibits properties of a granin. Nat Genet. 1996;12:303-8 pubmed
    ..As a regulated secretory protein, BRCA1 appears to function by a mechanism not previously described for tumour suppressor gene products. ..
  43. Beck C, Fahlke C, George A. Molecular basis for decreased muscle chloride conductance in the myotonic goat. Proc Natl Acad Sci U S A. 1996;93:11248-52 pubmed
    ..These results provide a molecular basis for the decreased chloride conductance in myotonic muscle...
  44. Ohi R, Feoktistova A, McCann S, Valentine V, Look A, Lipsick J, et al. Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. Mol Cell Biol. 1998;18:4097-108 pubmed
    ..Collectively, these results suggest that Cdc5 family members participate in a novel pathway to regulate G2/M progression. ..
  45. Jain N, Qi H, Catania K, Kaas J. Anatomic correlates of the face and oral cavity representations in the somatosensory cortical area 3b of monkeys. J Comp Neurol. 2001;429:455-68 pubmed
  46. Halseth A, Bracy D, Wasserman D. Functional limitations to glucose uptake in muscles comprised of different fiber types. Am J Physiol Endocrinol Metab. 2001;280:E994-9 pubmed
  47. Shin O, Couvillon A, Exton J. Arfophilin is a common target of both class II and class III ADP-ribosylation factors. Biochemistry. 2001;40:10846-52 pubmed
    ..Our findings suggest that both class II and III ARFs may influence the same cellular pathways through arfophilin as a common downstream effector. ..
  48. Qi Z, Hao C, Langenbach R, Breyer R, Redha R, Morrow J, et al. Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J Clin Invest. 2002;110:61-9 pubmed
    ..In contrast, the pressor effect of Ang II is blunted by COX1 inhibition. These results suggest that, rather than having similar cardiovascular effects, the activities of COX1 and COX2 are functionally antagonistic. ..
  49. Wang Z, Chen J, Wang S, Moeckel G, Harris R. Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol. 2003;14:3147-54 pubmed
    ..These studies indicate that functional EGFR activity is an essential component of the kidney's ability to recover from acute injury and that EGFR may regulate genes involved in growth, repair, and cell survival in the kidney...
  50. Liu K, Yang T, Viswanathan P, Roden D. New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant. Circulation. 2005;112:3239-46 pubmed
    ..This not only represents a new mechanism in the drug-induced long-QT syndrome but also strongly supports the concept that variable cell surface expression contributes to clinical variability in the LQT3 phenotype. ..
  51. Cheng N, Chytil A, Shyr Y, Joly A, Moses H. Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Cancer Res. 2007;67:4869-77 pubmed
    ..Furthermore, this co-xenograft model represents a unique context to study stromal TGF-beta and HGF signaling in mammary tumorigenesis. ..
  52. Torres T, Catlin R, Chan R, Fujimoto Y, Sasaki N, Printz R, et al. Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. Diabetes. 2009;58:78-86 pubmed publisher
    ..During a hyperglycemic clamp, glucose production was suppressed and glucose incorporation into glycogen was normal. Alteration of hepatic GK activity in ZDF rats has profound effects on plasma glucose and hepatic glucose flux. ..
  53. Olivares Villagómez D, Mendez Fernandez Y, Parekh V, Lalani S, Vincent T, Cheroutre H, et al. Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Proc Natl Acad Sci U S A. 2008;105:17931-6 pubmed publisher
    ..Also, TL deficiency accelerated colitis in a genetic model of inflammatory bowel disease. These findings reveal an important regulatory role of TL in controlling IEL function and intestinal inflammation. ..
  54. Parekh V, Lalani S, Kim S, Halder R, Azuma M, Yagita H, et al. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J Immunol. 2009;182:2816-26 pubmed publisher
    ..Collectively, our findings reveal a critical role for the PD-1/PD-L costimulatory pathway in the alphaGalCer-mediated induction of iNKT cell anergy that can be targeted for the development of immunotherapies. ..
  55. Choe K, Przybysz A, Strange K. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol Cell Biol. 2009;29:2704-15 pubmed publisher
    ..These findings define the mechanism of SKN-1 accumulation in the cell nucleus and provide a new mechanistic framework for understanding how phosphorylation signals are integrated to regulate stress resistance and longevity. ..
  56. Hawkins N, Martin M, Frankel W, Kearney J, Escayg A. Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus. Neurobiol Dis. 2011;41:655-60 pubmed publisher
  57. Marjoram L, Wright C. Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus. Development. 2011;138:475-85 pubmed publisher
  58. Rollins Smith L, Ramsey J, Pask J, Reinert L, Woodhams D. Amphibian immune defenses against chytridiomycosis: impacts of changing environments. Integr Comp Biol. 2011;51:552-62 pubmed publisher
    ..We also briefly review what is known about the impacts of temperature, environmental chemicals, and stress on the host-pathogen interactions and suggest future directions for research. ..
  59. Tanjore H, Blackwell T, Lawson W. Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2012;302:L721-9 pubmed publisher
    ..However, many questions remain regarding the role of ER stress in initiation and progression of lung fibrosis, including whether ER stress or the UPR could be targeted for therapeutic benefit. ..
  60. Wang N, Frank G, Ding R, Tan Z, Rachakonda A, Pandolfi P, et al. Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2. PLoS ONE. 2012;7:e35632 pubmed publisher
    ..The angiotensin II-AT(2)-PLZF-GATA4 signal may further augment Ang II induced pathological effects on cardiomyocytes. ..
  61. Purushothaman G, Marion R, Li K, Casagrande V. Gating and control of primary visual cortex by pulvinar. Nat Neurosci. 2012;15:905-12 pubmed publisher
    ..Excitation of lateral pulvinar after LGN lesion activated supra-granular layer V1 neurons. Thus, lateral pulvinar is able to powerfully control and gate information outflow from V1. ..
  62. Lubinski A, Page T. The Optic Lobes Regulate Circadian Rhythms of Olfactory Learning and Memory in the Cockroach. J Biol Rhythms. 2016;31:161-9 pubmed publisher
    ..The data suggest that the optic lobes contain the circadian clock(s) that regulate learning and memory processes via inhibition of neural processes in the brain. ..
  63. Tvorogov D, Carpenter G. EGF-dependent association of phospholipase C-gamma1 with c-Cbl. Exp Cell Res. 2002;277:86-94 pubmed
    ..The data, therefore, show an EGF-inducible direct association of PLC-gamma1 with c-Cbl in vivo that is mediated by the SH3 domain of PLC-gamma1. ..
  64. Cai S, Horne D. Transport of 5-formyltetrahydrofolate into primary cultured rat astrocytes. Arch Biochem Biophys. 2003;410:161-6 pubmed
    ..It is concluded that astrocytes have a system for the uptake of 5-FTHF and folate analogs which is carrier mediated, this system is sensitive to energy inhibitors and alcohol exposure. ..
  65. Moore M, DiCostanzo C, Dardevet D, Lautz M, Farmer B, Neal D, et al. Portal infusion of a selective serotonin reuptake inhibitor enhances hepatic glucose disposal in conscious dogs. Am J Physiol Endocrinol Metab. 2004;287:E1057-63 pubmed
  66. Katada A, Vos J, Swelstad B, Zealear D. A sequential double labeling technique for studying changes in motoneuronal projections to muscle following nerve injury and reinnervation. J Neurosci Methods. 2006;155:20-7 pubmed
    ..These results suggest that sequential double labeling of TB and FR is a valuable method for long-term muscle reinnervation studies. ..
  67. Zhao H, Wang S, Cheng H, Zhang M, Takahashi T, Fogo A, et al. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol. 2006;17:2664-9 pubmed
    ..In summary, eNOS(-/-) db/db mice provide the most robust model of type II DN that has been described to date and support a role for deficient eNOS-derived NO production in the pathogenesis of DN. ..
  68. Horiguchi M, Huang M, Meltzer H. The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J Pharmacol Exp Ther. 2011;338:605-14 pubmed publisher
    ..These results suggest 5-HT(7) antagonism may contribute to the efficacy of some atypical APDs in the treatment of cognitive impairment in schizophrenia and may itself have some benefit in this regard. ..
  69. Kennedy M, Limbird L. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. J Biol Chem. 1993;268:8003-11 pubmed
    ..Alternatively, this shared structural motif may play a role in not yet investigated pathways, such as receptor expression, turnover, and localization. ..
  70. Rose K, Winfrey V, Hoffman L, Hall D, Furuta T, Greenstein D. The POU gene ceh-18 promotes gonadal sheath cell differentiation and function required for meiotic maturation and ovulation in Caenorhabditis elegans. Dev Biol. 1997;192:59-77 pubmed
    ..Taken together, these observations indicate that ceh-18 is a crucial determinant of sheath cell differentiation, a function required for normal meiotic maturation and ovulation. ..
  71. Koizumi T, Roselli R, Parker R, Hermo Weiler C, Banerjee M, Newman J. Clearance of filtered fluid from the lung during exercise: role of hyperpnea. Am J Respir Crit Care Med. 2001;163:614-8 pubmed
    ..We conclude that hyperpnea is a major mechanism of interstitial liquid clearance during exercise, and may be largely responsible for preventing pulmonary edema that might occur at the high microvascular pressures of strenuous exercise. ..
  72. Price R, Weiner D, Chang M, Sanders Bush E. RNA editing of the human serotonin 5-HT2C receptor alters receptor-mediated activation of G13 protein. J Biol Chem. 2001;276:44663-8 pubmed
    ..Thus, RNA editing represents a novel mechanism for regulating the pattern of activation of heterotrimeric G-proteins, molecular switches that control an enormous variety of biological processes. ..
  73. Fu C, Bardhan S, Cetateanu N, Wamil B, Wang Y, Yan H, et al. Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis. Clin Cancer Res. 2001;7:4182-94 pubmed
    ..These results and the immunohistochemistry data suggest a therapeutic potential for the CM101 target protein HP59 both as a drug target and as a vaccine against pathoangiogenesis. ..
  74. Fan G, Lapierre L, Goldenring J, Richmond A. Differential regulation of CXCR2 trafficking by Rab GTPases. Blood. 2003;101:2115-24 pubmed
    ..Our data suggest that the intracellular trafficking of CXCR2 is differentially regulated by Rab proteins. ..
  75. Wu J, Zhang Y, Wang N, Davis L, Yang G, Wang X, et al. Liver X receptor-alpha mediates cholesterol efflux in glomerular mesangial cells. Am J Physiol Renal Physiol. 2004;287:F886-95 pubmed
    ..These data suggest that LXRalpha may be a potential therapeutic target for treating lipid-related renal glomerular disease. ..
  76. Nagdas S, Winfrey V, Olson G. Tyrosine phosphorylation generates multiple isoforms of the mitochondrial capsule protein, phospholipid hydroperoxide glutathione peroxidase (PHGPx), during hamster sperm capacitation. Biol Reprod. 2005;72:164-71 pubmed
    ..These data suggest that the tyrosine-phosphorylation of PHGPx may represent an important event in the signaling pathway(s) associated with capacitation and could potentially affect mitochondrial function. ..
  77. Hackett T, Karmos G, Schroeder C, Ulbert I, Sterbing D Angelo S, D Angelo W, et al. Neurosurgical access to cortical areas in the lateral fissure of primates. J Neurosci Methods. 2005;141:103-13 pubmed
    ..Since, these techniques could be adapted for exploration of areas within other sulci, the approach represents an important advance in efforts to elucidate the functional organization of the primate cerebral cortex. ..
  78. de la Mothe L, Blumell S, Kajikawa Y, Hackett T. Thalamic connections of the auditory cortex in marmoset monkeys: core and medial belt regions. J Comp Neurol. 2006;496:72-96 pubmed
    ..The results indicate that parallel subcortical pathways target the core and medial belt regions and that RM and CM represent functionally distinct areas within the medial belt auditory cortex. ..
  79. Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, et al. Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells. Diabetes. 2006;55:3264-70 pubmed
    ..These results suggest that downregulation of Hnf6 expression in beta-cells during development is essential to achieve a mature, glucose-responsive beta-cell. ..
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