Experts and Doctors on schizosaccharomyces pombe proteins in Coventry, Rhode Island, United States

Summary

Locale: Coventry, Rhode Island, United States
Topic: schizosaccharomyces pombe proteins

Top Publications

  1. Goddard A, Ladds G, Forfar R, Davey J. Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits. Fungal Genet Biol. 2006;43:840-51 pubmed
    ..Human G beta subunits complement the loss of Gnr1p, functioning as negative regulators of G alpha signalling in fission yeast. ..
  2. Smith B, Hill C, Godfrey E, Rand D, van den Berg H, Thornton S, et al. Dual positive and negative regulation of GPCR signaling by GTP hydrolysis. Cell Signal. 2009;21:1151-60 pubmed publisher
    ..Analysis of the kinetic model has revealed a dynamic network motif that shows precisely how inclusion of the inactive GTP-bound state for the Galpha produces this unimodal relationship. ..
  3. Meadows J, Shepperd L, Vanoosthuyse V, Lancaster T, Sochaj A, Buttrick G, et al. Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors. Dev Cell. 2011;20:739-50 pubmed publisher
    ..These data demonstrate that at least two distinct pools of PP1, one kinetochore associated and the other motor associated, are needed to silence the spindle checkpoint. ..
  4. Shepperd L, Meadows J, Sochaj A, Lancaster T, Zou J, Buttrick G, et al. Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint. Curr Biol. 2012;22:891-9 pubmed publisher
    ..We now report that phosphorylation of the conserved MELT motifs in Spc7 by Mph1 (Mps1) recruits Bub1 and Bub3 to the kinetochore and that this is required to maintain the SAC signal...

Scientific Experts

Detail Information

Publications4

  1. Goddard A, Ladds G, Forfar R, Davey J. Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits. Fungal Genet Biol. 2006;43:840-51 pubmed
    ..Human G beta subunits complement the loss of Gnr1p, functioning as negative regulators of G alpha signalling in fission yeast. ..
  2. Smith B, Hill C, Godfrey E, Rand D, van den Berg H, Thornton S, et al. Dual positive and negative regulation of GPCR signaling by GTP hydrolysis. Cell Signal. 2009;21:1151-60 pubmed publisher
    ..Analysis of the kinetic model has revealed a dynamic network motif that shows precisely how inclusion of the inactive GTP-bound state for the Galpha produces this unimodal relationship. ..
  3. Meadows J, Shepperd L, Vanoosthuyse V, Lancaster T, Sochaj A, Buttrick G, et al. Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors. Dev Cell. 2011;20:739-50 pubmed publisher
    ..These data demonstrate that at least two distinct pools of PP1, one kinetochore associated and the other motor associated, are needed to silence the spindle checkpoint. ..
  4. Shepperd L, Meadows J, Sochaj A, Lancaster T, Zou J, Buttrick G, et al. Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint. Curr Biol. 2012;22:891-9 pubmed publisher
    ..We now report that phosphorylation of the conserved MELT motifs in Spc7 by Mph1 (Mps1) recruits Bub1 and Bub3 to the kinetochore and that this is required to maintain the SAC signal...