Experts and Doctors on plasmids in Providence, Rhode Island, United States

Summary

Locale: Providence, Rhode Island, United States
Topic: plasmids

Top Publications

  1. Yeung K, Janosch P, McFerran B, Rose D, Mischak H, Sedivy J, et al. Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol. 2000;20:3079-85 pubmed
    ..The properties of RKIP reveal the specific sequestration of interacting components as a novel motif in the cell's repertoire for the regulation of signaling pathways. ..
  2. Vila Sanjurjo A, Squires C, Dahlberg A. Isolation of kasugamycin resistant mutants in the 16 S ribosomal RNA of Escherichia coli. J Mol Biol. 1999;293:1-8 pubmed
    ..Despite the universal conservation and functional importance of these residues, the results presented here show that the identity of the bases is not critical for ribosomal function. ..
  3. Yeung K, Rose D, Dhillon A, Yaros D, Gustafsson M, Chatterjee D, et al. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol. 2001;21:7207-17 pubmed
    ..Since the MAPK and NF-kappaB pathways have physiologically distinct roles, the function of RKIP may be, in part, to coordinate the regulation of these pathways. ..
  4. Davis E, Musch M, Goldstein L. Transfection of an inducible trout anion exchanger (AE1) into HEK-EcR cells. J Exp Zool. 2002;293:46-57 pubmed
    ..These results demonstrate the inducible expression of new anion transport membrane protein in HEK-293 cells. This is the first expression of trAE1 in a mammalian system. ..
  5. Chatterjee D, Bai Y, Wang Z, Beach S, Mott S, Roy R, et al. RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem. 2004;279:17515-23 pubmed
  6. Gee G, Tsomaia N, Mierke D, Atwood W. Modeling a sialic acid binding pocket in the external loops of JC virus VP1. J Biol Chem. 2004;279:49172-6 pubmed
    ..Molecular dynamics simulations were then used to build and confirm a model of the interaction between VP1 and the sialic acid component of the JCV receptor. ..
  7. Wang X, Tang X, Li M, Marshall J, Mao Z. Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival. J Biol Chem. 2005;280:16705-13 pubmed
    ..This study identifies the transcription factor MEF2 as a target of cAMP-PKA pathway and demonstrates that PKA phosphorylation of MEF2 is a key step in modulating its DNA binding activity and ability to promote neuronal survival. ..
  8. Zhang P, Chan J, Dragoi A, Gong X, Ivanov S, Li Z, et al. Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. EMBO Rep. 2005;6:531-7 pubmed
    ..Thus, our study identifies T(alpha)1 as a unique activator of the TRAF6 signal pathway and provides a cohesive interpretation of the molecular basis of the therapeutic utility of T(alpha)1. ..
  9. Mulcahy L, Vaslet C, Nillni E. Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides. J Biol Chem. 2005;280:39818-26 pubmed
  10. Zhou X, Li D, Resnick M, Behar J, Wands J, Cao W. Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells. J Pharmacol Exp Ther. 2011;339:218-27 pubmed publisher
    ..We conclude that a low dose of H(2)O(2) increases cell proliferation. H(2)O(2)-induced increase in cell proliferation may depend on sequential activation of ERK2 MAPK, NF-?B1 p50, and NOX5-S. ..

Detail Information

Publications10

  1. Yeung K, Janosch P, McFerran B, Rose D, Mischak H, Sedivy J, et al. Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol. 2000;20:3079-85 pubmed
    ..The properties of RKIP reveal the specific sequestration of interacting components as a novel motif in the cell's repertoire for the regulation of signaling pathways. ..
  2. Vila Sanjurjo A, Squires C, Dahlberg A. Isolation of kasugamycin resistant mutants in the 16 S ribosomal RNA of Escherichia coli. J Mol Biol. 1999;293:1-8 pubmed
    ..Despite the universal conservation and functional importance of these residues, the results presented here show that the identity of the bases is not critical for ribosomal function. ..
  3. Yeung K, Rose D, Dhillon A, Yaros D, Gustafsson M, Chatterjee D, et al. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol. 2001;21:7207-17 pubmed
    ..Since the MAPK and NF-kappaB pathways have physiologically distinct roles, the function of RKIP may be, in part, to coordinate the regulation of these pathways. ..
  4. Davis E, Musch M, Goldstein L. Transfection of an inducible trout anion exchanger (AE1) into HEK-EcR cells. J Exp Zool. 2002;293:46-57 pubmed
    ..These results demonstrate the inducible expression of new anion transport membrane protein in HEK-293 cells. This is the first expression of trAE1 in a mammalian system. ..
  5. Chatterjee D, Bai Y, Wang Z, Beach S, Mott S, Roy R, et al. RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem. 2004;279:17515-23 pubmed
  6. Gee G, Tsomaia N, Mierke D, Atwood W. Modeling a sialic acid binding pocket in the external loops of JC virus VP1. J Biol Chem. 2004;279:49172-6 pubmed
    ..Molecular dynamics simulations were then used to build and confirm a model of the interaction between VP1 and the sialic acid component of the JCV receptor. ..
  7. Wang X, Tang X, Li M, Marshall J, Mao Z. Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival. J Biol Chem. 2005;280:16705-13 pubmed
    ..This study identifies the transcription factor MEF2 as a target of cAMP-PKA pathway and demonstrates that PKA phosphorylation of MEF2 is a key step in modulating its DNA binding activity and ability to promote neuronal survival. ..
  8. Zhang P, Chan J, Dragoi A, Gong X, Ivanov S, Li Z, et al. Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. EMBO Rep. 2005;6:531-7 pubmed
    ..Thus, our study identifies T(alpha)1 as a unique activator of the TRAF6 signal pathway and provides a cohesive interpretation of the molecular basis of the therapeutic utility of T(alpha)1. ..
  9. Mulcahy L, Vaslet C, Nillni E. Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides. J Biol Chem. 2005;280:39818-26 pubmed
  10. Zhou X, Li D, Resnick M, Behar J, Wands J, Cao W. Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells. J Pharmacol Exp Ther. 2011;339:218-27 pubmed publisher
    ..We conclude that a low dose of H(2)O(2) increases cell proliferation. H(2)O(2)-induced increase in cell proliferation may depend on sequential activation of ERK2 MAPK, NF-?B1 p50, and NOX5-S. ..