Experts and Doctors on zygote in Philadelphia, Pennsylvania, United States


Locale: Philadelphia, Pennsylvania, United States
Topic: zygote

Top Publications

  1. Ayabe T, Kopf G, Schultz R. Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs. Development. 1995;121:2233-44 pubmed
    ..Results of these experiments suggest that although ryanodine receptors are present and functional, release of Ca2+ from this store is not essential for sperm-induced egg activation. ..
  2. Zhang Y, Lindblom T, Chang A, Sudol M, Sluder A, Golemis E. Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1. Gene. 2000;257:33-43 pubmed
    ..These results parallel the arrest phenotypes associated with global disruption of zygotic gene expression, suggesting that Dim1 proteins maintain an essential function in gene expression in higher eukaryotes. ..
  3. Mintzer K, Lee M, Runke G, Trout J, Whitman M, Mullins M. Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development. 2001;128:859-69 pubmed
    ..In total, our work strongly supports the role of Laf/Alk8 as a type I BMP receptor required for the specification of ventral cell fates. ..
  4. Buffone M, Schindler K, Schultz R. Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos. Cell Cycle. 2009;8:3904-13 pubmed
    ..These data suggest that CDC14B is a negative regulator of the 1-to-2-cell transition and of zygotic genome activation in mouse embryogenesis. ..
  5. Ma P, Lin S, Bartolomei M, Schultz R. Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol Reprod. 2010;83:1027-35 pubmed publisher
    ..Taken together, our results support a role for MTA2 within the NuRD complex in genomic imprinting. ..
  6. Abrams E, Zhang H, Marlow F, KAPP L, Lu S, Mullins M. Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. Cell. 2012;150:521-32 pubmed publisher
    ..Our studies provide insight into the machinery required for karyomere fusion and suggest that specialized proteins are necessary for proper nuclear division in large dividing blastomeres...
  7. Ma J, Svoboda P, Schultz R, Stein P. Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression. Biol Reprod. 2001;64:1713-21 pubmed
  8. Hawes S, Gie Chung Y, Latham K. Genetic and epigenetic factors affecting blastomere fragmentation in two-cell stage mouse embryos. Biol Reprod. 2001;65:1050-6 pubmed
  9. Fedoriw A, Stein P, Svoboda P, Schultz R, Bartolomei M. Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Science. 2004;303:238-40 pubmed
    ..Our results suggest that CTCF protects the H19 DMD from de novo methylation during oocyte growth and is required for normal preimplantation development. ..

More Information


  1. Ghiselli G. SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells. Mol Cancer. 2006;5:52 pubmed
    ..Collectively the data support the view that SMC3 deficiency affects chromosomal stability leading to the activation of p53-dependent mitotic checkpoint. ..