Experts and Doctors on zebrafish in Philadelphia, Pennsylvania, United States


Locale: Philadelphia, Pennsylvania, United States
Topic: zebrafish

Top Publications

  1. Morton E, Lamitina T. A suite of MATLAB-based computational tools for automated analysis of COPAS Biosort data. Biotechniques. 2010;48:xxv-xxx pubmed publisher
    ..The MATLAB code is freely available at our web site ( ..
  2. Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, et al. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest. 2010;120:2795-804 pubmed publisher
    ..These studies identify STKs as essential downstream effectors of CCM signaling in development and disease that may regulate both endothelial and epithelial cell junctions. ..
  3. Liu H, Lee N, Tsai T, Ho S. Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to mediate lipid and glucose metabolism. Biochim Biophys Acta. 2010;1801:1330-40 pubmed publisher
    ..We propose that local over-production of phosphatidic acid (PA) by excess PLD promotes membrane curvature, which affects Golgi membrane structure and secretory processes, contributing to impairment of lipid and glucose metabolism. ..
  4. Langdon Y, Mullins M. Maternal and zygotic control of zebrafish dorsoventral axial patterning. Annu Rev Genet. 2011;45:357-77 pubmed publisher
  5. Legant W, Shao L, Grimm J, Brown T, Milkie D, Avants B, et al. High-density three-dimensional localization microscopy across large volumes. Nat Methods. 2016;13:359-65 pubmed publisher
    ..We also demonstrate super-resolution correlative imaging with protein-specific photoactivable fluorophores, providing a mutually compatible, single-platform alternative to correlative light-electron microscopy over large volumes. ..
  6. Kelly C, Chin A, Leatherman J, Kozlowski D, Weinberg E. Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish. Development. 2000;127:3899-911 pubmed
    ..This work demonstrates that a maternal gene controlling localization of (beta)-catenin in dorsal nuclei is necessary for dorsal yolk syncytial layer gene activity and formation of the organizer in the zebrafish. ..
  7. Motta Mena L, Reade A, Mallory M, Glantz S, Weiner O, Lynch K, et al. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol. 2014;10:196-202 pubmed publisher
    ..Our approach provides a powerful new tool for optogenetic control of gene expression in space and time...
  8. Protas M, Weh E, Footz T, Kasberger J, Baraban S, Levin A, et al. Mutations of conserved non-coding elements of PITX2 in patients with ocular dysgenesis and developmental glaucoma. Hum Mol Genet. 2017;26:3630-3638 pubmed publisher
    ..Improved functional annotation of the human genome and transition to sequencing of patient genomes instead of exomes will be required before the magnitude of this class of mutations is fully understood. ..
  9. Elkouby Y, Mullins M. Coordination of cellular differentiation, polarity, mitosis and meiosis - New findings from early vertebrate oogenesis. Dev Biol. 2017;430:275-287 pubmed publisher
    ..Here, we review these advances mostly from the zebrafish and mouse. We discuss oogenesis concepts across established model organisms, and construct an inclusive paradigm for early oocyte differentiation in vertebrates. ..

More Information

Publications156 found, 100 shown here

  1. Connors S, Tucker J, Mullins M. Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues. Dev Biol. 2006;293:191-202 pubmed
    ..Thus, fine modulation of BMP signaling levels through the negative and positive actions of Chordin and Tolloid, respectively, patterns tail tissues. ..
  2. Zhang Y, Duc A, Rao S, Sun X, Bilbee A, Rhodes M, et al. Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Dev Cell. 2013;24:411-25 pubmed publisher
    ..Accordingly, circumstances that tip the balance of these paralogs in favor of Rpl22 (e.g., Rpl22l1 knockdown or Rpl22 overexpression) result in repression of Smad1 and blockade of HSC emergence...
  3. Arif E, Rathore Y, Kumari B, Ashish F, Wong H, Holzman L, et al. Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. J Biol Chem. 2014;289:9502-18 pubmed publisher
    ..Collectively, these results support the conclusion that inhibiting Neph1 signaling is therapeutically significant in preventing podocyte damage from glomerular injury. ..
  4. Panzer J, Gibbs S, Dosch R, Wagner D, Mullins M, Granato M, et al. Neuromuscular synaptogenesis in wild-type and mutant zebrafish. Dev Biol. 2005;285:340-57 pubmed
    ..Identification of the underlying genetic defects in these mutants will extend our understanding of the cellular and molecular mechanisms that underlie the formation and function of neuromuscular and other synapses. ..
  5. Padmanabhan A, Lee J, Ismat F, Lu M, Lawson N, Kanki J, et al. Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proc Natl Acad Sci U S A. 2009;106:22305-10 pubmed publisher
    ..Development of a zebrafish model of von Recklinghausen neurofibromatosis will allow for structure-function analysis and genetic screens in this tractable vertebrate system. ..
  6. Lakhina V, Marcaccio C, Shao X, Lush M, Jain R, Fujimoto E, et al. Netrin/DCC signaling guides olfactory sensory axons to their correct location in the olfactory bulb. J Neurosci. 2012;32:4440-56 pubmed publisher
    ..These findings implicate Netrins as the only known attractants for olfactory sensory neurons, first drawing OR111-7-expressing axons into the bulb and then into the ventromedially positioned central zone protoglomerulus. ..
  7. Arif E, Kumari B, Wagner M, Zhou W, Holzman L, Nihalani D. Myo1c is an unconventional myosin required for zebrafish glomerular development. Kidney Int. 2013;84:1154-65 pubmed publisher
    ..Thus, our results demonstrate that Myo1c is necessary for podocyte morphogenesis. ..
  8. Yee N, Yusuff S, Pack M. Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Genesis. 2001;30:137-40 pubmed
  9. Xu H, Leinwand S, Dell A, Fried Cassorla E, Raper J. The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing. J Neurosci. 2010;30:7423-33 pubmed publisher
    ..They support a model in which ADCY8 is an essential component of a signaling pathway that opposes repellent signaling. Finally, they demonstrate that ADCY8 helps regulate retinal sensitivity to midline guidance cues...
  10. Marsden K, Granato M. In Vivo Ca(2+) Imaging Reveals that Decreased Dendritic Excitability Drives Startle Habituation. Cell Rep. 2015;13:1733-40 pubmed publisher
  11. Sun Z, Gitler A. Discovery and characterization of three novel synuclein genes in zebrafish. Dev Dyn. 2008;237:2490-5 pubmed publisher
  12. Shen Q, Little S, Xu M, Haupt J, Ast C, Katagiri T, et al. The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J Clin Invest. 2009;119:3462-72 pubmed publisher
  13. Cui S, Leyva Vega M, Tsai E, Eauclaire S, Glessner J, Hakonarson H, et al. Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene. Gastroenterology. 2013;144:1107-1115.e3 pubmed publisher
    ..Based on genetic analysis of patients with BA and zebrafish, GPC1 appears to be a BA susceptibility gene. These findings also support a role for Hedgehog signaling in the pathogenesis of BA. ..
  14. Maegawa S, Varga M, Weinberg E. FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer. Development. 2006;133:3265-76 pubmed
  15. Kapoor A, Sekar R, Hansen N, Fox Talbot K, Morley M, Pihur V, et al. An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval. Am J Hum Genet. 2014;94:854-69 pubmed publisher
    ..These results suggest that focused studies of proteins within the cardiomyocyte ID are likely to provide insights into QT prolongation and its associated disorders. ..
  16. McAleer M, Duffy K, Davidson W, Kari G, Dicker A, Rodeck U, et al. Antisense inhibition of cyclin D1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos. Int J Radiat Oncol Biol Phys. 2006;66:546-51 pubmed
    ..These results are consistent with the hypothesis that inhibition of cyclin D1 is sufficient to account for the radiosensitizing action of flavopiridol in the zebrafish embryo vertebrate model. ..
  17. Graziotto J, Inglehearn C, Pack M, Pierce E. Decreased levels of the RNA splicing factor Prpf3 in mice and zebrafish do not cause photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2008;49:3830-8 pubmed publisher
    ..These models suggest that RP18 is not a result of haploinsufficiency but instead arises from a toxic gain of function caused by missense mutations in PRPF3. ..
  18. Turro E, Greene D, Wijgaerts A, Thys C, Lentaigne C, Bariana T, et al. A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Sci Transl Med. 2016;8:328ra30 pubmed publisher
    ..Similar studies of platelets and MKs may reveal the mechanism underlying the severe bleeding frequently observed in cancer patients treated with next-generation SFK inhibitors. ..
  19. Escobar Aguirre M, Zhang H, Jamieson Lucy A, Mullins M. Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning. PLoS Genet. 2017;13:e1006983 pubmed publisher
    ..To our knowledge, this is also the first study to use genome editing to unravel the module-dependent function of a cytoskeletal linker. ..
  20. Wallace K, Pack M. Unique and conserved aspects of gut development in zebrafish. Dev Biol. 2003;255:12-29 pubmed
  21. Petrella J, Cohen C, Gaetz J, Bergelson J. A zebrafish coxsackievirus and adenovirus receptor homologue interacts with coxsackie B virus and adenovirus. J Virol. 2002;76:10503-6 pubmed
    ..In contrast, CAR residues contacting the south edge of the canyon are not conserved, suggesting that receptor interaction with the viral "puff region" is not essential for attachment. ..
  22. Matthews R, Plumb Rudewiez N, Lorent K, Gissen P, Johnson C, Lemaigre F, et al. Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6. Development. 2005;132:5295-306 pubmed
    ..Furthermore, they show that tissue-specific roles for genes that regulate trafficking of intracellular proteins have been modified during vertebrate evolution. ..
  23. Chalasani S, Sabol A, Xu H, Gyda M, Rasband K, Granato M, et al. Stromal cell-derived factor-1 antagonizes slit/robo signaling in vivo. J Neurosci. 2007;27:973-80 pubmed
    ..These results demonstrate that endogenous levels of SDF1 antagonize the repellent effects of slit/robo signaling in vivo and that this antagonism is important during axonal pathfinding. ..
  24. Downes G, Granato M. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Dev Biol. 2004;270:232-45 pubmed
    ..Taken together, our results demonstrate that AChE is dispensable for its proposed non-classical roles in muscle fiber formation and sensory neuron development, but is crucial for regulating the stability of neuromuscular synapses. ..
  25. Nguyen V, Trout J, Connors S, Andermann P, Weinberg E, Mullins M. Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development. 2000;127:1209-20 pubmed
  26. Zeller J, Granato M. The zebrafish diwanka gene controls an early step of motor growth cone migration. Development. 1999;126:3461-72 pubmed
  27. Duffy K, McAleer M, Davidson W, Kari L, Kari C, Liu C, et al. Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids. Nucleic Acids Res. 2005;33:4914-21 pubmed
  28. Li Y, Allende M, Finkelstein R, Weinberg E. Expression of two zebrafish orthodenticle-related genes in the embryonic brain. Mech Dev. 1994;48:229-44 pubmed
    ..However, there are a number of interesting differences between the forebrain and midbrain regions which express the genes in the two species. ..
  29. Yee N, Gong W, Huang Y, Lorent K, Dolan A, Maraia R, et al. Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. PLoS Biol. 2007;5:e312 pubmed
    ..These data show that functional interactions between Pol III subunits have been conserved during eukaryotic evolution and support the utility of zebrafish as a model vertebrate for analysis of Pol III function...
  30. Clifton J, Lucumi E, Myers M, Napper A, Hama K, Farber S, et al. Identification of novel inhibitors of dietary lipid absorption using zebrafish. PLoS ONE. 2010;5:e12386 pubmed publisher
    ..These findings support the utility of zebrafish screening assays to identify novel compounds that target complex physiological processes. ..
  31. Fogelgren B, Lin S, Zuo X, Jaffe K, Park K, Reichert R, et al. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet. 2011;7:e1001361 pubmed publisher
    ..Our work supports a model in which the exocyst is required for the ciliary localization of polycystin-2, thus allowing for polycystin-2 function in cellular processes. ..
  32. Taku A, Marcaccio C, Ye W, Krause G, Raper J. Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target. Development. 2016;143:123-32 pubmed publisher
  33. Lefebvre J, Ono F, Puglielli C, Seidner G, Franzini Armstrong C, Brehm P, et al. Increased neuromuscular activity causes axonal defects and muscular degeneration. Development. 2004;131:2605-18 pubmed
    ..Together, our results provide compelling evidence that during pathfinding, myotomal muscle cells communicate extensively with extending motor axons through en passant synaptic contacts. ..
  34. Kozlowski D, Whitfield T, Hukriede N, Lam W, Weinberg E. The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Dev Biol. 2005;277:27-41 pubmed
    ..Determination of eya gene function during zebrafish organogenesis will facilitate understanding the molecular etiology of human vestibular and hearing disorders. ..
  35. Tuz K, Bachmann Gagescu R, O Day D, Hua K, Isabella C, Phelps I, et al. Mutations in CSPP1 cause primary cilia abnormalities and Joubert syndrome with or without Jeune asphyxiating thoracic dystrophy. Am J Hum Genet. 2014;94:62-72 pubmed publisher
    ..In summary, CSPP1 mutations are a major cause of the Joubert-Jeune phenotype in humans; however, the mechanism by which these mutations lead to both JBTS and JATD remains unknown. ..
  36. Dosch R, Wagner D, Mintzer K, Runke G, Wiemelt A, Mullins M. Maternal control of vertebrate development before the midblastula transition: mutants from the zebrafish I. Dev Cell. 2004;6:771-80 pubmed
    ..These mutants exhibit phenotypes not previously observed in zygotic mutant screens. This collection of maternal-effect mutants provides the basis for a molecular genetic analysis of the maternal control of embryogenesis in vertebrates. ..
  37. Mindnich R, Adamski J. Zebrafish 17beta-hydroxysteroid dehydrogenases: an evolutionary perspective. Mol Cell Endocrinol. 2009;301:20-6 pubmed publisher
    ..These findings reflect on two aspects: (1) the evolutionary origin of steroid-specific enzymes and (2) a possible conservation of steroid hormone function in invertebrates through currently unknown mechanisms. ..
  38. Liu X, Li Y, Shinton S, Rhodes J, Tang L, Feng H, et al. Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. J Immunol. 2017;199:1706-1715 pubmed publisher
    ..This confirmed a conserved role for CD79 in B cell development and differentiation, without the requirement of a pre-B cell stage in zebrafish. ..
  39. Hand N, Master Z, Eauclaire S, Weinblatt D, Matthews R, Friedman J. The microRNA-30 family is required for vertebrate hepatobiliary development. Gastroenterology. 2009;136:1081-90 pubmed publisher
    ..One of these, the biliary miRNA miR-30a, is required for biliary development in zebrafish. This is the first demonstration of a functional role for miRNA in hepatic organogenesis. ..
  40. Ko Y, Yi H, Qiu C, Huang S, Park J, Ledó N, et al. Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease. Am J Hum Genet. 2017;100:940-953 pubmed publisher
    ..Our analysis shows that gene-expression changes driven by genetic variation in the kidney can highlight potential new target genes for CKD development. ..
  41. Schmid B, Fürthauer M, Connors S, Trout J, Thisse B, Thisse C, et al. Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development. 2000;127:957-67 pubmed
  42. Zhang J, Lefebvre J, Zhao S, Granato M. Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice. Nat Neurosci. 2004;7:1303-9 pubmed
    ..Our results demonstrate a new role for MuSK homologs in axonal pathway selection. ..
  43. Jing L, Gordon L, Shtibin E, Granato M. Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development. PLoS ONE. 2010;5:e8843 pubmed publisher
  44. Seiler C, Pack M. Transgenic labeling of the zebrafish pronephric duct and tubules using a promoter from the enpep gene. Gene Expr Patterns. 2011;11:118-21 pubmed publisher
    ..We established a stable transgenic line using this promoter fragment that has specific GFP expression in pronephric ducts and tubules starting at 20h post-fertilization. ..
  45. O Hara F, Beck E, Barr L, Wong L, Kessler D, Riddle R. Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer. Development. 2005;132:3163-73 pubmed
    ..We propose that Lmx1b.1- and Lmx1b.2-mediated regulation of wnt1, wnt3a, wnt10b, pax8 and fgf8 maintains cell survival in the isthmocerebellar region. ..
  46. Li Q, Frank M, Akiyama M, Shimizu H, Ho S, Thisse C, et al. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Dis Model Mech. 2011;4:777-85 pubmed publisher
  47. Abrams E, Zhang H, Marlow F, KAPP L, Lu S, Mullins M. Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. Cell. 2012;150:521-32 pubmed publisher
    ..Our studies provide insight into the machinery required for karyomere fusion and suggest that specialized proteins are necessary for proper nuclear division in large dividing blastomeres. ..
  48. Ho S, Lorent K, Pack M, Farber S. Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure. Cell Metab. 2006;3:289-300 pubmed
    ..These data indicate that ffr is required for both Golgi structure and vesicular trafficking, and ultimately lipid transport. ..
  49. Andermann P, Weinberg E. Expression of zTlxA, a Hox11-like gene, in early differentiating embryonic neurons and cranial sensory ganglia of the zebrafish embryo. Dev Dyn. 2001;222:595-610 pubmed
    ..Expression of the gene is also observed in several non-neural tissues, including the pharyngeal arches, budding gill filaments, outgrowing semicircular protrusions in the otic vesicle, and in the pectoral fin buds. ..
  50. Davidson W, Ren Q, Kari G, Kashi O, Dicker A, Rodeck U. Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. Cell Cycle. 2008;7:1224-30 pubmed
    ..In summary, this study highlights off-target effects of the pharmacological p53 inhibitor PFTalpha related to inhibition of p73 function and essential roles of p73 at early but not later stages of zebrafish development. ..
  51. Marlow F, Mullins M. Bucky ball functions in Balbiani body assembly and animal-vegetal polarity in the oocyte and follicle cell layer in zebrafish. Dev Biol. 2008;321:40-50 pubmed publisher
    ..Finally, the expansion of animal identity in oocytes and somatic follicle cells suggests that somatic cell fate and oocyte polarity are interdependent. ..
  52. Seiler C, Abrams J, Pack M. Characterization of zebrafish intestinal smooth muscle development using a novel sm22?-b promoter. Dev Dyn. 2010;239:2806-12 pubmed publisher
  53. Choi S, Chacon Heszele M, Huang L, McKenna S, Wilson F, Zuo X, et al. Cdc42 deficiency causes ciliary abnormalities and cystic kidneys. J Am Soc Nephrol. 2013;24:1435-50 pubmed publisher
    ..Abnormalities in this pathway result in deranged ciliogenesis and polycystic kidney disease...
  54. Schill E, Lake J, Tusheva O, Nagy N, Bery S, Foster L, et al. Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. Dev Biol. 2016;409:473-88 pubmed publisher
    ..These data raise concern that ibuprofen may increase Hirschsprung disease risk in some genetically susceptible children. ..
  55. McAleer M, Davidson C, Davidson W, Yentzer B, Farber S, Rodeck U, et al. Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers. Int J Radiat Oncol Biol Phys. 2005;61:10-3 pubmed
    ..Zebrafish embryos may thus provide a rapid, facile system to screen novel agents ultimately intended for human use in the context of therapeutic or accidental radiation exposure. ..
  56. Holloway B, Gomez de la Torre Canny S, Ye Y, Slusarski D, Freisinger C, Dosch R, et al. A novel role for MAPKAPK2 in morphogenesis during zebrafish development. PLoS Genet. 2009;5:e1000413 pubmed publisher
    ..We postulate that a p38 MAPKAPK2 kinase cascade modulates the activity of F-actin at the yolk cell margin circumference allowing the gradual closure of the blastopore as epiboly progresses. ..
  57. Mei W, Lee K, Marlow F, Miller A, Mullins M. hnRNP I is required to generate the Ca2+ signal that causes egg activation in zebrafish. Development. 2009;136:3007-17 pubmed publisher
    ..Our studies therefore reveal an important new role of hnrnp I in regulating the fundamental process of IP(3)-mediated Ca(2+) release at egg activation. ..
  58. Banerjee S, Isaacman Beck J, Schneider V, Granato M. A novel role for Lh3 dependent ECM modifications during neural crest cell migration in zebrafish. PLoS ONE. 2013;8:e54609 pubmed publisher
    ..Together these data suggest that Lh3-Collagen18A1 dependent ECM modifications regulate the transition of trunk neural crest cells from a non-segmental sheet like migration mode to a segmental stream migration mode. ..
  59. Chin A, Tsang M, Weinberg E. Heart and gut chiralities are controlled independently from initial heart position in the developing zebrafish. Dev Biol. 2000;227:403-21 pubmed
  60. Zoeller J, Pimtong W, Corby H, Goldoni S, Iozzo A, Owens R, et al. A central role for decorin during vertebrate convergent extension. J Biol Chem. 2009;284:11728-37 pubmed publisher
    ..The morphant and overexpression phenotype represent a convergent extension defect. Our results indicate a central function for Decorin during early embryogenesis. ..
  61. Hashiguchi M, Mullins M. Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development. 2013;140:1970-80 pubmed publisher
    ..Thus, DV and AP patterning are intimately coordinated to allow cells to acquire both positional and temporal information simultaneously. ..
  62. Wagner D, Dosch R, Mintzer K, Wiemelt A, Mullins M. Maternal control of development at the midblastula transition and beyond: mutants from the zebrafish II. Dev Cell. 2004;6:781-90 pubmed
    ..These mutants provide powerful tools to dissect the maternal and paternal control of vertebrate embryogenesis. ..
  63. Leskow F, Holloway B, Wang H, Mullins M, Kazanietz M. The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci U S A. 2006;103:5373-8 pubmed
    ..Our results reveal a crucial role for chn1 in early development and implicate Rac as a key regulator of morphogenetic movements during zebrafish epiboly. ..
  64. Yee N, Lorent K, Pack M. Exocrine pancreas development in zebrafish. Dev Biol. 2005;284:84-101 pubmed
    ..By contrast, analyses of mind bomb mutants and jagged morpholino-injected larvae suggest that Notch signaling principally regulates ductal differentiation of bipotential exocrine progenitors. ..
  65. ROSENBERG A, Wolman M, Franzini Armstrong C, Granato M. In vivo nerve-macrophage interactions following peripheral nerve injury. J Neurosci. 2012;32:3898-909 pubmed publisher
    ..Thus, live cell imaging defines novel cellular and functional interactions between injured nerves and immune cells. ..
  66. Grosser T, Yusuff S, Cheskis E, Pack M, Fitzgerald G. Developmental expression of functional cyclooxygenases in zebrafish. Proc Natl Acad Sci U S A. 2002;99:8418-23 pubmed
    ..Both zCOX isoforms are genetically and functionally homologous to their mammalian orthologs. The zebrafish affords a tractable model system for the study of COX biology and development. ..
  67. Dore L, Amigo J, Dos Santos C, Zhang Z, Gai X, Tobias J, et al. A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A. 2008;105:3333-8 pubmed publisher
    ..These results reveal a miRNA locus that is required for erythropoiesis and uncover a new regulatory axis through which GATA-1 controls this process. ..
  68. Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan A, et al. Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genet. 2008;4:e1000240 pubmed publisher
    ..Furthermore, they support a recently proposed model in which replication origins licensed by excess Mcm2-7 are required for the survival of human cells exposed to replication stress. ..
  69. Cui S, Capecci L, Matthews R. Disruption of planar cell polarity activity leads to developmental biliary defects. Dev Biol. 2011;351:229-41 pubmed publisher
    ..Our results demonstrate that PCP plays an important role in vertebrate biliary development, interacting with other factors known to be involved in biliary morphogenesis. ..
  70. Hu G, Goll M, Fisher S. ?C31 integrase mediates efficient cassette exchange in the zebrafish germline. Dev Dyn. 2011;240:2101-7 pubmed publisher
    ..Recombination was achieved at high efficiency in both somatic cells and in the germline. We demonstrate an effective approach to RMCE, increasing the repertoire of tools available to manipulate the zebrafish genome. ..
  71. Bremer J, Skinner J, Granato M. A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. PLoS ONE. 2017;12:e0178854 pubmed publisher
    ..Thus, we established a technically simple assay to rapidly identify valuable entry points into pathways critical for vertebrate peripheral nerve regeneration. ..
  72. Mintzer K, Lee M, Runke G, Trout J, Whitman M, Mullins M. Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development. 2001;128:859-69 pubmed
    ..In total, our work strongly supports the role of Laf/Alk8 as a type I BMP receptor required for the specification of ventral cell fates. ..
  73. Little S, Mullins M. Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development. 2004;131:5825-35 pubmed
    ..Our results support a model in which zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning. ..
  74. Palaisa K, Granato M. Analysis of zebrafish sidetracked mutants reveals a novel role for Plexin A3 in intraspinal motor axon guidance. Development. 2007;134:3251-7 pubmed
    ..We propose that axonal repulsion via Plexin A3 is a major driving force for intraspinal motor growth cone guidance. ..
  75. Wolman M, Jain R, Liss L, Granato M. Chemical modulation of memory formation in larval zebrafish. Proc Natl Acad Sci U S A. 2011;108:15468-73 pubmed publisher
  76. Cui S, Eauclaire S, Matthews R. Interferon-gamma directly mediates developmental biliary defects. Zebrafish. 2013;10:177-83 pubmed publisher
    ..These results support an importance of IFN? in mediating biliary defects, and also demonstrate the feasibility of direct injection of intact protein into developing zebrafish larvae. ..
  77. Pashos E, Park J, Leach S, Fisher S. Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish. Dev Biol. 2013;381:471-81 pubmed publisher
    ..We also identified a novel enhancer that mediates initiation of ptf1a expression in the pancreas, through which the signals that specify the ventral pancreas are expected to exert their action. ..
  78. Varga M, Maegawa S, Bellipanni G, Weinberg E. Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo. Mech Dev. 2007;124:775-91 pubmed
  79. Lightcap C, Kari G, Arias Romero L, Chernoff J, Rodeck U, Williams J. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS ONE. 2009;4:e6025 pubmed publisher
    ..Collectively, these results suggest that LC8 facilitates nuclear import of Pak1 and that this function is indispensable during vertebrate development. ..
  80. Banerjee S, Gordon L, Donn T, Berti C, Moens C, Burden S, et al. A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration. Development. 2011;138:3287-96 pubmed publisher
    ..We propose that a Wnt11r-MuSK dependent, PCP-like pathway restricts neural crest cells to their segmental path. ..
  81. Schneider V, Granato M. Genomic structure and embryonic expression of zebrafish lysyl hydroxylase 1 and lysyl hydroxylase 2. Matrix Biol. 2007;26:12-9 pubmed
  82. Davuluri G, Seiler C, Abrams J, Soriano A, Pack M. Differential effects of thin and thick filament disruption on zebrafish smooth muscle regulatory proteins. Neurogastroenterol Motil. 2010;22:1100-e285 pubmed publisher
    ..These in vivo findings provide new information regarding the activation and stability of smooth muscle regulatory proteins in zebrafish larvae and their role in intestinal peristalsis in this model organism. ..
  83. Berton O, Hahn C, Thase M. Are we getting closer to valid translational models for major depression?. Science. 2012;338:75-9 pubmed publisher
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