Experts and Doctors on transcription factors in Philadelphia, Pennsylvania, United States

Summary

Locale: Philadelphia, Pennsylvania, United States
Topic: transcription factors

Top Publications

  1. Olmedo G, Ninfa E, Stock J, Youngman P. Novel mutations that alter the regulation of sporulation in Bacillus subtilis. Evidence that phosphorylation of regulatory protein SpoOA controls the initiation of sporulation. J Mol Biol. 1990;215:359-72 pubmed
    ..This property of the mutant protein, together with additional genetic information, supports a model for regulation of sporulation initiation by control of the phosphorylation level of SpoOA. ..
  2. Kuzin B, Tillib S, Sedkov Y, Mizrokhi L, Mazo A. The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head. Genes Dev. 1994;8:2478-90 pubmed
    ..These results show that trithorax maintains expression of target genes by interaction with their regulatory regions and that this interaction depends on the presence of at least some of the other trithorax and Polycomb group proteins. ..
  3. Burch J, Davis D. Alternative promoter usage and splicing options result in the differential expression of mRNAs encoding four isoforms of chicken VBP, a member of the PAR subfamily of bZIP transcription factors. Nucleic Acids Res. 1994;22:4733-41 pubmed
  4. Vara Prasad M, Shore S, Dhanasekaran N. Activated mutant of G alpha 13 induces Egr-1, c-fos, and transformation in NIH 3T3 cells. Oncogene. 1994;9:2425-9 pubmed
  5. Megonigal M, Rappaport E, Jones D, Kim C, Nowell P, Lange B, et al. Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias. Proc Natl Acad Sci U S A. 1997;94:11583-8 pubmed
    ..Analysis of additional pediatric cases will determine whether breakpoint distribution deviates from the predilection for 3' distribution in the bcr that has been found in adult cases. ..
  6. Safak M, Gallia G, Ansari S, Khalili K. Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen. J Virol. 1999;73:10146-57 pubmed
    ..Taken together, these data demonstrate that the cellular factor YB-1 and the viral regulatory protein T-antigen interact both physically and functionally and that this interaction modulates transcription from the JCV promoters. ..
  7. Gustafsson M, Pan H, Pinney D, Liu Y, Lewandowski A, Epstein D, et al. Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev. 2002;16:114-26 pubmed
  8. Belletti B, Drakas R, Morrione A, Tu X, Prisco M, Yuan T, et al. Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. Exp Cell Res. 2002;277:107-18 pubmed
    ..In all instances, the increase in Id1 protein expression is paralleled by a corresponding increase in Id1 promoter activity, as measured with a reporter gene. ..
  9. Shewchuk B, Liebhaber S, Cooke N. Specification of unique Pit-1 activity in the hGH locus control region. Proc Natl Acad Sci U S A. 2002;99:11784-9 pubmed
    ..These findings suggest that the structures of the Pit-1 binding sites at HSI specify distinct chromatin-dependent activities essential for LCR-mediated activation of hGH in the developing pituitary. ..

More Information

Publications323 found, 100 shown here

  1. Leatherman J, Levin L, Boero J, Jongens T. germ cell-less acts to repress transcription during the establishment of the Drosophila germ cell lineage. Curr Biol. 2002;12:1681-5 pubmed
  2. Strachan G, Jordan Sciutto K, Rallapalli R, Tuan R, Hall D. The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. J Cell Biochem. 2003;88:557-68 pubmed
    ..These data indicate that the MDMX protein is capable of associating with E2F-1 and negatively regulating its DNA binding ability. ..
  3. Wood J, Nelson V, Ho C, Jansen E, Wang C, Urbanek M, et al. The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. J Biol Chem. 2003;278:26380-90 pubmed
  4. Baby S, Roy A, Mokashi A, Lahiri S. Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1alpha and -1beta in the rat carotid body and glomus cells. Histochem Cell Biol. 2003;120:343-52 pubmed
    ..Thus, the results are consistent with the hypothesis that HIF-1alpha which is present in the glomus cells translocates to the nucleus during exposure to Hx and to CPX in Nx. ..
  5. Lang D, Lu M, Huang L, Engleka K, Zhang M, Chu E, et al. Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature. 2005;433:884-7 pubmed
    ..Thus, a stem cell transcription factor can both determine cell fate and simultaneously maintain an undifferentiated state, leaving a cell poised to differentiate in response to external stimuli. ..
  6. Zhu J, Zhang Y, Joe G, Pompetti R, Emerson S. NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal. Proc Natl Acad Sci U S A. 2005;102:11728-33 pubmed
    ..Thus, NF-Ya is a potent cellular regulator of HSC self-renewal. ..
  7. Alawi F, Lee M. DKC1 is a direct and conserved transcriptional target of c-MYC. Biochem Biophys Res Commun. 2007;362:893-8 pubmed
    ..These data indicate that DKC1 is a direct and conserved transcriptional target of c-MYC, and suggest a biologic basis for DKC1 overexpression in neoplasia. ..
  8. Williams J, Kondo N, Okabe T, Takeshita N, Pilchak D, Koyama E, et al. Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol. 2009;328:315-27 pubmed publisher
    ..Since aggrecan is critical for growth plate function, its deficiency in RAR-mutant mice is likely to have contributed directly to their growth retardation. ..
  9. Stewart A, Seymour R, Pomiankowski A, Plotkin J. The population genetics of cooperative gene regulation. BMC Evol Biol. 2012;12:173 pubmed publisher
  10. Baillat D, Gardini A, Cesaroni M, Shiekhattar R. Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals. Mol Cell Biol. 2012;32:4642-50 pubmed publisher
    ..These results highlight a role for SNAPC1 as a general transcriptional coactivator that functions through elongating RNAPII. ..
  11. Zhang T, Liu J, Zhang J, Thekkethottiyil E, Macatee T, Ismat F, et al. Jun is required in Isl1-expressing progenitor cells for cardiovascular development. PLoS ONE. 2013;8:e57032 pubmed publisher
    ..These data provide a cellular framework for understanding the role of Jun in the pathogenesis of congenital heart disease. ..
  12. Deakyne J, Huang F, Negri J, Tolliday N, Cocklin S, Mazin A. Analysis of the activities of RAD54, a SWI2/SNF2 protein, using a specific small-molecule inhibitor. J Biol Chem. 2013;288:31567-80 pubmed publisher
    ..Thus, the use of SN enabled us to identify important differences in the effect of the RAD54 ATPase and DNA translocation on two major activities of RAD54, BM of Holliday junctions and stimulation of DNA pairing...
  13. Daigle J, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, et al. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity. Acta Neuropathol. 2016;131:605-20 pubmed publisher
    ..Our data emphasizes the importance of stress granules in ALS pathogenesis and identifies Pur-alpha as a novel regulator of SG dynamics. ..
  14. Bitler B, Wu S, Park P, Hai Y, Aird K, Wang Y, et al. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol. 2017;19:962-973 pubmed publisher
    ..Thus, ARID1A mutation inactivates the apoptosis-promoting function of p53 by upregulating HDAC6. Together, these results indicate that pharmacological inhibition of HDAC6 is a therapeutic strategy for ARID1A-mutated cancers. ..
  15. Rao V, Huebner K, Isobe M, ar Rushdi A, Croce C, Reddy E. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science. 1989;244:66-70 pubmed
    ..This suggests the possibility that rearrangements of elk loci may be involved in pathogenesis of certain tumors. ..
  16. Rauscher F, Morris J, Fredericks W, Lopez Guisa J, Balakrishnan C, Jost M, et al. Characterization of monoclonal antibodies directed to the amino-terminus of the WT1, Wilms' tumor suppressor protein. Hybridoma. 1998;17:191-8 pubmed
    ..These WT1-specific MAbs should be useful in characterizing the biochemical and developmental roles of WT1 and in defining the emerging role of WT1 as a diagnostic and/or prognostic marker in mesothelioma, leukemias, and breast cancer. ..
  17. Ryan R, Schultz D, Ayyanathan K, Singh P, Friedman J, Fredericks W, et al. KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol Cell Biol. 1999;19:4366-78 pubmed
    ..We speculate that gene-specific repression may be a consequence of the formation of such complexes, ultimately leading to silenced genes in newly formed heterochromatic chromosomal environments. ..
  18. Tillib S, Petruk S, Sedkov Y, Kuzin A, Fujioka M, Goto T, et al. Trithorax- and Polycomb-group response elements within an Ultrabithorax transcription maintenance unit consist of closely situated but separable sequences. Mol Cell Biol. 1999;19:5189-202 pubmed
    ..Our results show that long-range maintenance of Ultrabithorax expression requires a complex element composed of cooperating modules, each capable of interacting with both positive and negative chromatin regulators. ..
  19. Gripp K, Zackai E, Stolle C. Mutations in the human TWIST gene. Hum Mutat. 2000;15:150-5 pubmed
    ..1998]. The gene deletions and numerous nonsense mutations are suggestive of haploinsufficiency as the disease-causing mechanism. No genotype phenotype correlation was apparent...
  20. Szapary P, Rader D. Pharmacological management of high triglycerides and low high-density lipoprotein cholesterol. Curr Opin Pharmacol. 2001;1:113-20 pubmed
    ..More research is needed to further define the role of fibrates when used alone and in combination with statins in high-risk individuals...
  21. Barak O, Lazzaro M, Cooch N, Picketts D, Shiekhattar R. A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. J Biol Chem. 2004;279:45130-8 pubmed
    ..The human SNF2L+13 null variant is predominant in non-neuronal tissue, whereas the human wild type active SNF2L isoform is expressed in neurons. Thus, like the mouse, active human SNF2L is limited to neurons and a few other tissues. ..
  22. Bulman A, Nelson H. Role of trehalose and heat in the structure of the C-terminal activation domain of the heat shock transcription factor. Proteins. 2005;58:826-35 pubmed
    ..cerevisiae HSF1 transcriptional activity in response to stress might be linked to the combined effects of trehalose and elevated temperatures in modifying the overall structure of HSF1's C-terminal activation domain. ..
  23. Vermitsky J, Earhart K, Smith W, Homayouni R, Edlind T, Rogers P. Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies. Mol Microbiol. 2006;61:704-22 pubmed
    ..C. glabrata provides a promising model for studying the genetic basis of multidrug resistance and its impact on virulence. ..
  24. Zhang Y, Rath N, Hannenhalli S, Wang Z, Cappola T, Kimura S, et al. GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development. 2007;134:189-98 pubmed
  25. Ingvarsdottir K, Edwards C, Lee M, Lee J, Schultz D, Shilatifard A, et al. Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol. 2007;27:7856-64 pubmed
    ..Thus, analysis of lysine demethylation in yeast provides new insight into the physiological roles of jumonji demethylase enzymes. ..
  26. Zhou J, Liu Y, Zhang W, Popov V, Wang M, Pattabiraman N, et al. Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. J Biol Chem. 2010;285:40342-50 pubmed publisher
    ..Thus, DACH1 represses gene transcription through direct DNA binding to the promoter region of target genes by recruiting the transcriptional co-regulator, TCERG1. ..
  27. Morton E, Lamitina T. Caenorhabditis elegans HSF-1 is an essential nuclear protein that forms stress granule-like structures following heat shock. Aging Cell. 2013;12:112-20 pubmed publisher
    ..Our findings suggest that development, stress, and aging pathways may regulate HSF-1 function in distinct ways, and that HSF-1 nuclear stress granule formation is an evolutionarily conserved aspect of HSF-1 regulation in vivo. ..
  28. Herriges M, Swarr D, Morley M, Rathi K, Peng T, Stewart K, et al. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014;28:1363-79 pubmed publisher
    ..These studies reveal that lncRNAs play an important role in foregut and lung endoderm development by regulating multiple aspects of gene transcription, often through regulation of transcription factor expression. ..
  29. Gallia G, Darbinian N, Tretiakova A, Ansari S, Rappaport J, Brady J, et al. Association of HIV-1 Tat with the cellular protein, Puralpha, is mediated by RNA. Proc Natl Acad Sci U S A. 1999;96:11572-7 pubmed
    ..Furthermore, expression of the Puralpha-associated RNA in these cells enhances transcriptional activation of the HIV-1 promoter by Tat and Puralpha. ..
  30. Turner B, Krajewski S, Krajewska M, Takayama S, Gumbs A, Carter D, et al. BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer. J Clin Oncol. 2001;19:992-1000 pubmed
    ..04) and DMFS (P =.02). These findings provide preliminary evidence that BAG-1 represents a potential marker of improved survival in early-stage breast cancer patients, independent of the status of axillary lymph nodes. ..
  31. Kerstetter R, Bollman K, Taylor R, Bomblies K, Poethig R. KANADI regulates organ polarity in Arabidopsis. Nature. 2001;411:706-9 pubmed
  32. Dahl R, Ramirez Bergeron D, Rao S, Simon M. Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 2002;21:2220-30 pubmed
    ..These results demonstrate an important difference between PU.1 and Spi-B. Careful comparison of these Ets factors will delineate important functional domains of PU.1 involved in lymphocyte lineage commitment and/or maturation. ..
  33. Ha A, Riddle R. cBlimp-1 expression in chick limb bud development. Gene Expr Patterns. 2003;3:297-300 pubmed
    ..In addition, cBlimp-1 is expressed in the developing eyes, branchial arches and otic placodes. ..
  34. Lehrke M, Lebherz C, Millington S, Guan H, Millar J, Rader D, et al. Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha. Cell Metab. 2005;1:297-308 pubmed
  35. Igoucheva O, Alexeev V, Scharer O, Yoon K. Involvement of ERCC1/XPF and XPG in oligodeoxynucleotide-directed gene modification. Oligonucleotides. 2006;16:94-104 pubmed
  36. Bunagan M, Cristian L, Degrado W, Gai F. Truncation of a cross-linked GCN4-p1 coiled coil leads to ultrafast folding. Biochemistry. 2006;45:10981-6 pubmed
    ..While stable subdomains or triggering sequences have been shown to be critical to the stability of GCN4 coiled coils, our results suggest that the folding of such a subdomain does not seem to dictate the overall folding kinetics. ..
  37. Gentilella A, Khalili K. BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner. J Biol Chem. 2011;286:9205-15 pubmed publisher
    ..These observations provide the first evidence for an involvement of BAG3 in the ubiquitination and turnover of its partners. ..
  38. Liu Y, Ferguson J, Xue C, Ballantyne R, Silverman I, Gosai S, et al. Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases. Arterioscler Thromb Vasc Biol. 2014;34:902-12 pubmed publisher
    ..Our findings provide novel insights into tissue-level, inflammatory transcriptome regulation in cardiometabolic diseases. These are complementary to more usual approaches limited to interrogation of DNA variations. ..
  39. Barlev N, Candau R, Wang L, Darpino P, Silverman N, Berger S. Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein. J Biol Chem. 1995;270:19337-44 pubmed
    ..In addition, ADA2 physically associated with TBP, but not with TFIIB. These results suggest that the role of ADA2 in transcriptional activation is to promote physical interaction between activation domains and TBP. ..
  40. Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, et al. Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. Cancer Res. 1993;53:5624-8 pubmed
    ..In addition, the AF-6 protein contains the GLGF motif shared with several proteins of vertebrates and invertebrates thought to be involved in signal transduction at special cell-cell junctions. ..
  41. Siddique H, Zou J, Rao V, Reddy E. The BRCA2 is a histone acetyltransferase. Oncogene. 1998;16:2283-5 pubmed
    ..These observations suggest that HAT activity of BRCA2 may play an important role in the regulation of transcription and tumor suppressor function. ..
  42. Ansari S, Safak M, Gallia G, Sawaya B, Amini S, Khalili K. Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity. J Gen Virol. 1999;80 ( Pt 10):2629-38 pubmed
    ..The importance of these findings in light of the proposed mechanism of Tat function is discussed. ..
  43. Hallas C, Pekarsky Y, Itoyama T, Varnum J, Bichi R, Rothstein J, et al. Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. Proc Natl Acad Sci U S A. 1999;96:14418-23 pubmed
    ..These data suggest a similar or complementary function of these proteins in early embryogenesis. ..
  44. Hall C, Nelson D, Ye X, Baker K, DeCaprio J, Seeholzer S, et al. HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. Mol Cell Biol. 2001;21:1854-65 pubmed
    ..Finally, ectopic expression of HIRA in cells caused arrest in S phase and this is consistent with the notion that it is a cyclin-cdk2 substrate that has a role in control of the cell cycle. ..
  45. Shu W, Yang H, Zhang L, Lu M, Morrisey E. Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem. 2001;276:27488-97 pubmed
    ..Together, these studies suggest that Foxp1 and Foxp2 are important regulators of lung epithelial gene transcription. ..
  46. Mullen A, High F, Hutchins A, Lee H, Villarino A, Livingston D, et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science. 2001;292:1907-10 pubmed
    ..These results suggest that a cytokine does not simply induce TH fate choice but instead may act as an essential secondary stimulus that mediates selective survival of a lineage. ..
  47. Shen W, Scearce L, Brestelli J, Sund N, Kaestner K. Foxa3 (hepatocyte nuclear factor 3gamma ) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast. J Biol Chem. 2001;276:42812-7 pubmed
    ..In addition, we investigated the hepatic transcription factor network in Foxa3(-/-) mice and found that the normal activation of HNF-4alpha, HNF-1alpha, and PGC-1 induced by fasting is attenuated in mice lacking Foxa3. ..
  48. Mackler S, Homan Y, Korutla L, Conti A, Blendy J. The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger protein, is regulated by AP1. Neuroscience. 2003;121:355-61 pubmed
    ..Identification of drug induced alterations in gene expression is key to understanding the types of molecular adaptations underlying addiction. ..
  49. Tomescu O, Xia S, Strezlecki D, Bennicelli J, Ginsberg J, Pawel B, et al. Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression. Lab Invest. 2004;84:1060-70 pubmed
    ..These findings of genes regulated by PAX3-FKHR will direct future biological and clinical investigation to important pathways contributing to ARMS tumorigenesis and progression. ..
  50. Muller D, Unterwald E. D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration. J Pharmacol Exp Ther. 2005;314:148-54 pubmed
  51. Proweller A, Tu L, Lepore J, Cheng L, Lu M, Seykora J, et al. Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res. 2006;66:7438-44 pubmed
  52. Abdollahi A. LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions. J Cell Physiol. 2007;210:16-25 pubmed
  53. Liu A, Oliver Krasinski J, Stoffers D. Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1. FEBS Lett. 2006;580:6701-6 pubmed
    ..Understanding the functional roles of PCIF1 domains may have application to therapeutic beta-cell replacement strategies involving PDX-1 for the treatment of diabetes. ..
  54. Miccio A, Wang Y, Hong W, Gregory G, Wang H, Yu X, et al. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 2010;29:442-56 pubmed publisher
    ..These results show that NuRD is a critical co-factor for FOG-1 and underscore the versatile use of NuRD by lineage-specific transcription factors to activate and repress gene transcription in the appropriate cellular and genetic context...
  55. Heyd F, Lynch K. Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. Mol Cell. 2010;40:126-37 pubmed publisher
  56. Wang K, Diskin S, Zhang H, Attiyeh E, Winter C, Hou C, et al. Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature. 2011;469:216-20 pubmed publisher
  57. Xu C, Cole P, Meyers D, Kormish J, Dent S, Zaret K. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science. 2011;332:963-6 pubmed publisher
    ..These studies reveal a functional "prepattern" of chromatin states within multipotent progenitors and potential targets to modulate cell fate induction. ..
  58. Friedman J, Fredericks W, Jensen D, Speicher D, Huang X, Neilson E, et al. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev. 1996;10:2067-78 pubmed
    ..We propose that KAP-1 may be a universal corepressor for the large family of KRAB domain-containing transcription factors. ..
  59. Marsh E, Fulp C, Gomez E, Nasrallah I, Minarcik J, Sudi J, et al. Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Brain. 2009;132:1563-76 pubmed publisher
    ..Given the frequency of ARX mutations in patients with infantile spasms and related disorders, our data unveil a new model for further understanding the pathogenesis of these disorders. ..
  60. Strich R, Surosky R, Steber C, Dubois E, Messenguy F, Esposito R. UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev. 1994;8:796-810 pubmed
    ..Analyses of UME6 mRNA during both nitrogen starvation and meiotic development indicate that its transcription is constitutive, suggesting that regulation of UME6 activity occurs at a post-transcriptional level. ..
  61. Rao V, Reddy E. Delta elk-1, a variant of elk-1, fails to interact with the serum response factor and binds to DNA with modulated specificity. Cancer Res. 1993;53:215-20 pubmed
    ..Therefore, elk-1 appears to fall in the category of genes that encode activators and repressors through the mechanism of differential splicing. ..
  62. Maillard I, Weng A, Carpenter A, Rodriguez C, Sai H, Xu L, et al. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood. 2004;104:1696-702 pubmed
    ..These results suggest a critical role for MAMLs during Notch-mediated cell fate decisions in vivo and indicate that DNMAML1, but not Deltex1, can be used to interfere with the function of multiple Notch family members. ..
  63. Ramos R, Haupt H, Kanetsky P, Donthineni Rao R, Arenas Elliott C, Lackman R, et al. Giant cell tumors: inquiry into immunohistochemical expression of CD117 (c-Kit), microphthalmia transcription factor, tartrate-resistant acid phosphatase, and HAM-56. Arch Pathol Lab Med. 2005;129:360-5 pubmed
    ..Microphthalmia transcription factor (MITF) is necessary for osteoclast gene expression and tartrate-resistant acid phosphatase (TRAP) activation; c-Kit plays a role in regulation of MITF...
  64. Protas M, Weh E, Footz T, Kasberger J, Baraban S, Levin A, et al. Mutations of conserved non-coding elements of PITX2 in patients with ocular dysgenesis and developmental glaucoma. Hum Mol Genet. 2017;26:3630-3638 pubmed publisher
    ..Improved functional annotation of the human genome and transition to sequencing of patient genomes instead of exomes will be required before the magnitude of this class of mutations is fully understood. ..
  65. Schindler U, Menkens A, Beckmann H, Ecker J, Cashmore A. Heterodimerization between light-regulated and ubiquitously expressed Arabidopsis GBF bZIP proteins. EMBO J. 1992;11:1261-73 pubmed
    ..Furthermore, we demonstrate that GBF1, GBF2 and GBF3 heterodimerize and these heterodimers also interact with the G-box, suggesting a potential mechanism for generating additional diversity from these GBF proteins. ..
  66. Martinez R, Venturelli D, Perrotti D, Veronese M, Kastury K, Druck T, et al. Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family. Cancer Res. 1997;57:1180-7 pubmed
    ..Therefore, the regulation of the DR-nm23 gene expression might involve other mechanisms occurring at posttranscriptional and/or translational levels. ..
  67. Kaestner K, Hiemisch H, Schutz G. Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes. Mol Cell Biol. 1998;18:4245-51 pubmed
  68. Tseng H, Biegel J, Brown R. Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes. J Cell Sci. 1999;112 Pt 18:3039-47 pubmed
    ..This result suggests that basonuclin may be a tissue-specific transcription factor for the ribosomal RNA genes. ..
  69. Seo S, McNamara P, Heo S, Turner A, Lane W, Chakravarti D. Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell. 2001;104:119-30 pubmed
    ..We propose that histone masking by INHAT plays a regulatory role in chromatin modification and serves as a novel mechanism of transcriptional regulation. ..
  70. Wang G, Ousley A, Darlington T, Chen D, Chen Y, Fu W, et al. Regulation of the cycling of timeless (tim) RNA. J Neurobiol. 2001;47:161-75 pubmed
    ..Together, these data highlight molecular mechanisms that are critical for behavioral rhythms. ..
  71. Engleka M, Craig E, Kessler D. VegT activation of Sox17 at the midblastula transition alters the response to nodal signals in the vegetal endoderm domain. Dev Biol. 2001;237:159-72 pubmed
    ..Therefore, VegT activation of Sox17alpha plays an important role in establishing a region of endoderm-specific gene expression in vegetal blastomeres. ..
  72. Yu J, Hecht N, Schultz R. Expression of MSY2 in mouse oocytes and preimplantation embryos. Biol Reprod. 2001;65:1260-70 pubmed
    ..Results of these studies are consistent with the proposal that MSY2 functions by stabilizing and/or repressing the translation of maternal mRNAs. ..
  73. Katz J, Perreault N, Goldstein B, Lee C, Labosky P, Yang V, et al. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 2002;129:2619-28 pubmed
    ..All other epithelial cell types are present in the colon of Klf4(-/-) mice. In summary, Klf4 plays a crucial role in colonic epithelial cell differentiation in vivo. ..
  74. Guan H, Li Y, Jensen M, Newgard C, Steppan C, Lazar M. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med. 2002;8:1122-8 pubmed
    ..The 'futile' fuel cycle resulting from expression of GyK in adipocytes is thus a novel mechanism contributing to reduced FFA levels and perhaps insulin sensitization by antidiabetic therapies. ..
  75. Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton T. LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. J Biol Chem. 2003;278:6041-9 pubmed
  76. Wang Q, Hii G, Shusterman S, Mosse Y, Winter C, Guo C, et al. ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas. Cancer Res. 2003;63:1631-5 pubmed
    ..These data suggest that transcriptional regulation of ID2 by the MycN oncoprotein is unlikely to be a seminal molecular event resulting in a highly malignant neuroblastoma phenotype. ..
  77. Shcherbik N, Zoladek T, Nickels J, Haines D. Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90. Curr Biol. 2003;13:1227-33 pubmed
    ..In light of these experiments, we propose that Rsp5p facilitates Mga2p90 release from the ER by promoting polyubiquitination and Npl4p-proteasome-mediated degradation of the interacting Mga2p120 ER bound anchor. ..
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