Genomes and Genes
Experts and Doctors on signal transduction in Pittsburgh, Pennsylvania, United States
Locale: Pittsburgh, Pennsylvania, United States
Topic: signal transduction
Publications336 found, 100 shown here
- Alcorn J, Crowe C, Kolls J. TH17 cells in asthma and COPD. Annu Rev Physiol. 2010;72:495-516 pubmed publisher..Recently, the T lymphocyte subset T(H)17 was shown to play a role in regulating neutrophilic and macrophage inflammation in the lung, suggesting a potential role for T(H)17 cells in severe, steroid-insensitive asthma and COPD. ..
- Volonte D, Galbiati F. Caveolin-1, cellular senescence and pulmonary emphysema. Aging (Albany NY). 2009;1:831-5 pubmed..We propose caveolin-1 as a key player of a novel signaling pathway that links cigarette smoke to premature senescence of lung fibroblasts and development of pulmonary emphysema. ..
- Guo N, Li X, Mann M, Funderburgh M, Du Y, Funderburgh J. Hyaluronan synthesis mediates the fibrotic response of keratocytes to transforming growth factor beta. J Biol Chem. 2010;285:32012-9 pubmed publisher..These results suggest that newly synthesized cell-associated HA acts as an extracellular enhancer of wound healing and fibrosis in keratocytes by augmenting a limited subset of the cellular responses to TGF?. ..
- Thomas L, Salter R. Activation of macrophages by P2X7-induced microvesicles from myeloid cells is mediated by phospholipids and is partially dependent on TLR4. J Immunol. 2010;185:3740-9 pubmed publisher..We suggest that phospholipids delivered by MV may be mediators of sterile inflammation in a number of diseases. ..
- Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, et al. Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest. 2011;121:3645-56 pubmed publisher..These findings suggest that TIM-1 may be a novel therapeutic target for modulating the immune response and provide insight into the signals involved in the generation and induction of Bregs. ..
- Steinman R, Robinson A, Feghali Bostwick C. Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts. PLoS ONE. 2012;7:e48560 pubmed publisher..To our knowledge, we are the first to report that roscovitine modulates matrix protein transcription. Roscovitine may thus be a viable treatment option for SSc and other fibrosing diseases. ..
- Taylor B, Darville T, Ferrell R, Ness R, Haggerty C. Racial variation in toll-like receptor variants among women with pelvic inflammatory disease. J Infect Dis. 2013;207:940-6 pubmed publisher..Among women with PID, TLR variants that increase inflammation are associated with African American race and may mediate the relationship between race and endometritis and/or UGTI. ..
- Mallampalli R, Glasser J, Coon T, Chen B. Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. Cell Cycle. 2013;12:663-73 pubmed publisher..These observations indicate molecular interplay between Aurora B and calmodulin in telophase and suggest that calmodulin acts as a checkpoint sensor for chromosomal segregation errors during mitosis. ..
- Gamper A, Rofougaran R, Watkins S, Greenberger J, Beumer J, Bakkenist C. ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage. Nucleic Acids Res. 2013;41:10334-44 pubmed publisher..Our data reveal that, unexpectedly, ATR kinase inhibitors may be more potent cellular radiosensitizers than ATM kinase inhibitors, and that this is associated with a novel role for ATR in G1 phase cells. ..
- Toocheck C, Clister T, Shupe J, Crum C, Ravindranathan P, Lee T, et al. Mouse Spermatogenesis Requires Classical and Nonclassical Testosterone Signaling. Biol Reprod. 2016;94:11 pubmed publisher..Collectively, these observations indicate that classical and nonclassical testosterone signaling regulate overlapping and distinct functions that are required for the maintenance of spermatogenesis and male fertility. ..
- Zou H, Thomas S, Yan Z, Grandis J, Vogt A, Li L. Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J. 2009;23:425-32 pubmed publisher..These findings are consistent with the view that RHBDF1 is critically involved in a GPCR ligand-stimulated process leading to the activation of latent EGFR ligands...
- Zahid M, Phillips B, Albers S, Giannoukakis N, Watkins S, Robbins P. Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice. PLoS ONE. 2010;5:e12252 pubmed publisher..In order to identify peptide(s) able to transduce heart tissue, biopanning was performed in cell culture and in vivo with a M13 phage peptide display library...
- Pedulla M, Ford M, Houtz J, Karthikeyan T, Wadsworth C, Lewis J, et al. Origins of highly mosaic mycobacteriophage genomes. Cell. 2003;113:171-82 pubmed..While the role of phages as vehicles of toxin genes is well established, these observations suggest a much broader involvement of phages in bacterial virulence and the host response to bacterial infections...
- Zhang X, Yang J, Li Y, Liu Y. Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells. Am J Physiol Renal Physiol. 2005;288:F16-26 pubmed..These results suggest a novel regulatory mechanism controlling c-met expression by TGF-beta1 in renal epithelial cells, in which both Smad and Sp proteins participate and cooperate in activating c-met gene transcription. ..
- Tsung A, McCoy S, Klune J, Geller D, Billiar T, Hefeneider S. A novel inhibitory peptide of Toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice. Shock. 2007;27:364-9 pubmed publisher..These results demonstrated the therapeutic potential of peptide P13 to limit an LPS-induced inflammatory response and enhance survival in murine models of inflammation...
- Bielefeldt K, Davis B. Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice. Am J Physiol Gastrointest Liver Physiol. 2008;294:G130-8 pubmed..Considering the importance of acid in dyspeptic symptoms and gastroesophageal reflux, TRPV1 or ASIC3 may be an attractive target for treatment strategies in patients who do not respond to acid suppressive therapy...
- Hu K, Mars W, Liu Y. Novel actions of tissue-type plasminogen activator in chronic kidney disease. Front Biosci. 2008;13:5174-86 pubmed..These new findings have radically changed our conception of tPA in renal fibrogenesis and represent a paradigm shift towards uncovering its cytokine function. ..
- Block E, Klarlund J. Wounding sheets of epithelial cells activates the epidermal growth factor receptor through distinct short- and long-range mechanisms. Mol Biol Cell. 2008;19:4909-17 pubmed publisher..One pathway signals at a distance from wounds through release of ATP, and another pathway acts locally and is independent on ATP signaling. ..
- Mastroberardino P, Hoffman E, Horowitz M, Betarbet R, Taylor G, Cheng D, et al. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol Dis. 2009;34:417-31 pubmed publisher..Thus, we have discovered a novel mitochondrial iron transport system that goes awry in PD, and which may provide a new target for therapeutic intervention. ..
- ARTIM D, Kullmann F, Daugherty S, Wu H, de Groat W. Activation of the nitric oxide-cGMP pathway reduces phasic contractions in neonatal rat bladder strips via protein kinase G. Am J Physiol Renal Physiol. 2009;297:F333-40 pubmed publisher..These results suggest that the NO-cGMP-PKG pathway may be involved in inhibitory control of the neonatal rat bladder. ..
- Dagda R, Zhu J, Chu C. Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models. Mitochondrion. 2009;9:289-98 pubmed publisher..Converging mechanisms from different model systems support the concept of common pathways in parkinsonian neurodegeneration that may be amenable to future therapeutic interventions. ..
- Dai C, Stolz D, Kiss L, Monga S, Holzman L, Liu Y. Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol. 2009;20:1997-2008 pubmed publisher..These results suggest that targeting hyperactive Wnt/beta-catenin signaling may represent a novel therapeutic strategy for proteinuric kidney diseases. ..
- Gold M, Gebhart G. Nociceptor sensitization in pain pathogenesis. Nat Med. 2010;16:1248-57 pubmed publisher..Accordingly, we focus here on nociceptors: their excitability, their heterogeneity and their role in initiating and maintaining pain. ..
- Kang R, Tang D, Lotze M, Zeh H. RAGE regulates autophagy and apoptosis following oxidative injury. Autophagy. 2011;7:442-4 pubmed..These findings provide insight into how crosstalk between apoptosis and autophagy is mediated via ROS signaling with a process involving RAGE. ..
- Bonacci G, Baker P, Salvatore S, Shores D, Khoo N, Koenitzer J, et al. Conjugated linoleic acid is a preferential substrate for fatty acid nitration. J Biol Chem. 2012;287:44071-82 pubmed publisher..These results affirm that metabolic and inflammatory reactions yield electrophilic products that can modulate adaptive cell signaling mechanisms. ..
- Knowles L, Zewe J, Malik G, Parwani A, Gingrich J, Pilch J. CLT1 targets bladder cancer through integrin ?5?1 and CLIC3. Mol Cancer Res. 2013;11:194-203 pubmed publisher..On the basis of its affinity for bladder tumor tissue and strong antitumor effects, we propose that CLT1 could be useful for targeting bladder cancer. ..
- Ota K, Liu R, Voleti B, Maldonado Avilés J, Duric V, Iwata M, et al. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nat Med. 2014;20:531-5 pubmed publisher..Taken together, these postmortem and preclinical findings identify REDD1 as a critical mediator of the atrophy of neurons and depressive behavior caused by chronic stress exposure. ..
- Law N, Donaubauer E, Zeleznik A, Hunzicker Dunn M. How Protein Kinase A Activates Canonical Tyrosine Kinase Signaling Pathways To Promote Granulosa Cell Differentiation. Endocrinology. 2017;158:2043-2051 pubmed publisher..Thus, for the two central signaling pathways that regulate gene expression in GCs, FSH via PKA intersects canonical RTK-regulated signaling by modulating the activity of PPs...
- Shiraha H, Glading A, Chou J, Jia Z, Wells A. Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain. Mol Cell Biol. 2002;22:2716-27 pubmed..These data point to a novel mechanism of negative control of calpain activation, direct phosphorylation by PKA. ..
- Wang D, Dai C, Li Y, Liu Y. Canonical Wnt/?-catenin signaling mediates transforming growth factor-?1-driven podocyte injury and proteinuria. Kidney Int. 2011;80:1159-1169 pubmed publisher..These studies suggest that Wnt/?-catenin signaling may be exploited as a therapeutic target for the treatment of proteinuric kidney diseases. ..
- Jung K, Chen K, Kretzler M, Wu C. TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells. J Am Soc Nephrol. 2007;18:66-73 pubmed
- Levina V, Nolen B, Marrangoni A, Cheng P, Marks J, Szczepanski M, et al. Role of eotaxin-1 signaling in ovarian cancer. Clin Cancer Res. 2009;15:2647-56 pubmed publisher..Furthermore, CCL11 could be used as a biomarker and a prognostic factor of relapse-free survival in ovarian cancer. ..
- Varum S, Momcilovic O, Castro C, Ben Yehudah A, Ramalho Santos J, Navara C. Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain. Stem Cell Res. 2009;3:142-56 pubmed publisher..These results demonstrate that modulation of mitochondrial function results in increased pluripotency of the cell population, and sheds new light on the mechanisms and signaling pathways modulating hESC pluripotency. ..
- Samarasinghe R, Witchell S, DeFranco D. Cooperativity and complementarity: synergies in non-classical and classical glucocorticoid signaling. Cell Cycle. 2012;11:2819-27 pubmed publisher..Using NPCs as a cellular model, we speculate on the components of this non-classical pathway and the mechanisms whereby a number of cytoplasmic and nuclear signaling events may be integrated. ..
- Puri N, Pitman R, Mulnix R, Erickson T, Iness A, Vitali C, et al. Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides. Cancer Lett. 2014;343:14-23 pubmed publisher..Additionally, T-oligo decreases tumor size and inhibits angiogenesis through decreased VEGF signaling and increased TSP-1 expression. ..
- Tourkova I, Liu L, Sutjarit N, Larrouture Q, Luo J, Robinson L, et al. Adrenocorticotropic hormone and 1,25-dihydroxyvitamin D3 enhance human osteogenesis in vitro by synergistically accelerating the expression of bone-specific genes. Lab Invest. 2017;97:1072-1083 pubmed publisher..Our results point to the importance of ACTH in bone maintenance and that extra skeletal (renal) 1,25(OH)2D is required for bone mineralization despite 1?-hydroxylase expression by osteoblasts...
- Zhao A, Huan J, Gupta S, Pal R, Sahu A. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci. 2002;5:727-8 pubmed..These results indicate that a PI3K-PDE3B-cAMP pathway interacting with the Janus kinase 2 (Jak2)-Stat3 pathway constitutes a critical component of leptin signaling in the hypothalamus. ..
- Balkundi D, Ziegler J, Watchko J, Craven C, Trucco M. Regulation of FasL/Fas in human trophoblasts: possible implications for chorioamnionitis. Biol Reprod. 2003;69:718-24 pubmed..These mechanisms may be important in perpetuating inflammation in the placental microenvironment and may contribute to the pathogenesis of chorioamnionitis. ..
- Dai C, Stolz D, Bastacky S, St Arnaud R, Wu C, Dedhar S, et al. Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol. 2006;17:2164-75 pubmed..These results also illustrate that the integrin and slit diaphragm signals in podocytes are intrinsically coupled through an ILK-dependent mechanism. ..
- Burguera B, Brunetto A, Garcia Ocana A, Teijeiro R, Esplen J, Thomas T, et al. Leptin increases proliferation of human steosarcoma cells through activation of PI(3)-K and MAPK pathways. Med Sci Monit. 2006;12:BR341-9 pubmed..Our data support the hypothesis that leptin may increase bone mass by stimulating osteoblast proliferation through activation of the P1 (3)-K and MAPK signaling pathways. ..
- Kamagate A, Dong H. FoxO1 integrates insulin signaling to VLDL production. Cell Cycle. 2008;7:3162-70 pubmed
- Cherra S, Kulich S, Uechi G, Balasubramani M, Mountzouris J, Day B, et al. Regulation of the autophagy protein LC3 by phosphorylation. J Cell Biol. 2010;190:533-9 pubmed publisher..These data demonstrate a role for phosphorylation in regulating LC3 activity. ..
- Ganguly S, Bishop A, Xu W, Ghosh S, Nickerson K, Lanni F, et al. Zap1 control of cell-cell signaling in Candida albicans biofilms. Eukaryot Cell. 2011;10:1448-54 pubmed publisher..In addition, our results indicate that Zap1 is a positive regulator of farnesol accumulation...
- Dorritie K, McCubrey J, Johnson D. STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. Leukemia. 2014;28:248-57 pubmed publisher..This review summarizes our current understanding of STAT protein involvement in normal hematopoiesis and leukemogenesis, as well as recent advances in the development and testing of novel STAT inhibitors. ..
- Chen R, Hou W, Zhang Q, Kang R, Fan X, Tang D. Emerging role of high-mobility group box 1 (HMGB1) in liver diseases. Mol Med. 2013;19:357-66 pubmed publisher..The importance of HMGB1 activation in various forms of liver disease in relation to liver damage, steatosis, inflammation, fibrosis, tumorigenesis and regeneration is discussed in this review. ..
- Kikuchi A, Pradhan Sundd T, Singh S, Nagarajan S, Loizos N, Monga S. Platelet-Derived Growth Factor Receptor Î± Contributes to Human Hepatic Stellate Cell Proliferation and Migration. Am J Pathol. 2017;187:2273-2287 pubmed publisher..Our findings support a distinct contribution of PDGFRÎ± signaling to HSC proliferation and migration and provide evidence that inhibition of PDGFRÎ± signaling could alter the pathogenesis ofÂ hepatic fibrosis. ..
- Xiao X, Fischbach S, Zhang T, Chen C, Sheng Q, Zimmerman R, et al. SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes. Diabetes. 2017;66:2646-2658 pubmed publisher..Together, our data suggest that chronic pancreatitis may trigger TGFβ1-mediated β-cell EMT to lead to CPRD, which could substantially be prevented by sustained expression of FoxO1 in β-cells. ..
- Celil A, Campbell P. BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem. 2005;280:31353-9 pubmed..In addition to Runx2, other signaling components may be necessary to regulate Osx during osteoblast lineage progression. ..
- Hochbaum D, Hong K, Barila G, Ribeiro Neto F, Altschuler D. Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis. J Biol Chem. 2008;283:4464-8 pubmed
- Zhang M, Lin L, Lee S, Mo L, Cao J, Ifedigbo E, et al. Deletion of caveolin-1 protects hyperoxia-induced apoptosis via survivin-mediated pathways. Am J Physiol Lung Cell Mol Physiol. 2009;297:L945-53 pubmed publisher..We also demonstrate that deletion of cav-1 protects hyperoxia-induced apoptosis via modulation of survivin expression. ..
- Li H, Su X, Yan X, Wasserloos K, Chao W, Kaynar A, et al. Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice. Anesthesiology. 2010;113:619-29 pubmed publisher..The role of TLR4-MyD88 signaling in ventilator-induced lung injury remains incompletely understood...
- Li H, Li Q, Liu P, Liu Y, Li J, Wasserloos K, et al. WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2012;47:528-35 pubmed publisher..These findings support a role for WISP1 as an endogenous signal that acts through TLR4 signaling to increase alveolar-capillary permeability in VILI. ..
- Loughner C, Bruford E, McAndrews M, Delp E, Swamynathan S, Swamynathan S. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Hum Genomics. 2016;10:10 pubmed publisher..Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members. ..
- Campbell G. Distalization of the Drosophila leg by graded EGF-receptor activity. Nature. 2002;418:781-5 pubmed..This similarity between proximodistal patterning in vertebrates and flies supports previous suggestions of an evolutionary relationship between appendages/body-wall outgrowths in animals. ..
- Li J, Rao H, Burkin D, Kaufman S, Wu C. The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. Dev Biol. 2003;261:209-19 pubmed..These results suggest that MIBP functions in the control of myogenic differentiation by regulating alpha7beta1 integrin-mediated cell interactions with laminin matrix and intracellular signaling through paxillin. ..
- Kreiss C, Toegel S, Bauer A. Alpha2-adrenergic regulation of NO production alters postoperative intestinal smooth muscle dysfunction in rodents. Am J Physiol Gastrointest Liver Physiol. 2004;287:G658-66 pubmed
- Pflug B, Zheng H, Udan M, D Antonio J, Marshall F, Brooks J, et al. Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor. Cancer Lett. 2007;246:139-48 pubmed..Collectively, these data support the therapeutic targeting of the ET(A) receptor as a novel treatment strategy for RCC. ..
- Raman K, Sappington P, Yang R, Levy R, Prince J, Liu S, et al. The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2006;291:G556-65 pubmed..Circulating IL-10 levels were higher in rage(-/-) compared with rage(+/+) mice. These results suggest that activation of RAGE-dependent signaling is a key factor leading to gut mucosal barrier dysfunction after HS/R. ..
- Yin W, Signore A, Iwai M, Cao G, Gao Y, Johnnides M, et al. Preconditioning suppresses inflammation in neonatal hypoxic ischemia via Akt activation. Stroke. 2007;38:1017-24 pubmed..Suppression of inflammatory responses may contribute to PC neuroprotection against neonatal H-I brain injury. This effect is mediated in part via upregulating PI3-K/Akt activity. ..
- Iyer A, Tran K, Borysenko C, Cascio M, Camacho C, Blair H, et al. Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity. J Cell Physiol. 2007;211:748-58 pubmed..This transient interaction with the receptor on the cell surface is in marked contrast to other EGFR ligands which cause EGFR transit through, and signaling from intracellular locales in addition to cell surface signaling. ..
- Chu T, Peters D. Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions. Physiol Genomics. 2008;34:185-92 pubmed publisher..These immortal data provide a resource for further analyses of the molecular mechanisms underlying the biological response to LSS and contribute to the expanding collection of publicly available SAGE data. ..
- Wertz J, Bauer P. Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cells. Biochem Biophys Res Commun. 2008;375:557-61 pubmed publisher..Taken together, our findings establish caveolin-1 as an important regulator of downstream signaling and membrane targeting of BMPRII in vascular smooth muscle cells. ..
- Zhang G, Liu X, Farkas A, Parwani A, Lathrop K, Lenzner D, et al. Estrogen receptor beta functions through nongenomic mechanisms in lung cancer cells. Mol Endocrinol. 2009;23:146-56 pubmed publisher..In conclusion, our results suggest that that proliferative effects of estrogen in lung cancer cells is mediated primarily, if not exclusively, by the nongenomic action of ERbeta. ..
- Burke S, Collier J, Scott D. cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP. FASEB J. 2009;23:2855-65 pubmed publisher..We conclude that cAMP and glucose signaling converge on a complex containing ChREBP, HNF4alpha, and CBP, and that cAMP acts by disrupting this transcriptional complex assembled by glucose-derived signals. ..
- Qiu W, Wang X, Leibowitz B, Liu H, Barker N, Okada H, et al. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc Natl Acad Sci U S A. 2010;107:20027-32 pubmed publisher..These results suggest that effective chemoprevention of colon cancer by NSAIDs lies in the elimination of stem cells that are inappropriately activated by oncogenic events through induction of apoptosis. ..
- Park B, Lee S, Stolz D, Lee Y, Lee B. Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells. J Biol Chem. 2011;286:20087-99 pubmed publisher..Taken together, the combination of HRG and TGZ may provide a basis for the development of a novel strategy in the treatment of apoptosis-resistant and/or hormone-refractory breast cancer. ..
- Kang R, Tang D, Schapiro N, Loux T, Livesey K, Billiar T, et al. The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics. Oncogene. 2014;33:567-77 pubmed publisher..Moreover, our observations provide a novel mechanism within the tumor microenvironment by which necrosis and inflammation promote tumor progression. ..
- Kang R, Zhang Q, Hou W, Yan Z, Chen R, Bonaroti J, et al. Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. Gastroenterology. 2014;146:1097-107 pubmed publisher..These findings indicate a role for the innate immune response in tissue damage. ..
- Jiang M, Klein M, Zanger U, Mohammad M, CAVE M, Gaikwad N, et al. Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. J Hepatol. 2016;64:44-52 pubmed publisher..The induced STS facilitates the conversion of inactive estrogen sulfates to active estrogens, which in return attenuates the NF-ÎºB-mediated inflammation. ..
- Overacre A, VIGNALI D. T(reg) stability: to be or not to be. Curr Opin Immunol. 2016;39:39-43 pubmed publisher..In this review, we will discuss how T(reg) stability is defined and the mechanisms utilized to maintain stability. ..
- Morse D, Pischke S, Zhou Z, Davis R, Flavell R, Loop T, et al. Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem. 2003;278:36993-8 pubmed..For the first time, the effect of CO is shown to be mediated via the JNK signaling pathway and the transcription factor AP-1. ..
- Song J, Lee Y. Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. J Biol Chem. 2005;280:26845-55 pubmed..Taken together, our data demonstrate that cross-talk between JIP3 and JIP1 is mediated through SEK1-JNK2 and Akt1. ..
- Jin Y, Kim H, Ifedigbo E, Lau L, Choi A. Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. Am J Respir Cell Mol Biol. 2005;33:297-302 pubmed..Taken together, our data demonstrate that Cyr61 expression provides cytoprotection in hyperoxia-induced pulmonary epithelial cell death and that this effect was in part mediated via the Akt signaling pathway. ..
- Elbing K, McCartney R, Schmidt M. Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. Biochem J. 2006;393:797-805 pubmed..Finally, we showed that the Snf1 kinase domain isolated from bacteria as a GST fusion protein can be activated in vitro and shows substrate specificity in the absence of its beta and gamma subunits. ..
- Duerr R, Taylor K, Brant S, Rioux J, Silverberg M, Daly M, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006;314:1461-3 pubmed..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease. ..
- Fujita T, Epperly M, Zou H, Greenberger J, Wan Y. Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells. Mol Biol Cell. 2008;19:5446-55 pubmed publisher..The present results unveil a new function for the TGF-beta pathway in the regulation of APC to mediate chromatid separation during mitosis. ..
- Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, et al. Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol. 2009;182:572-80 pubmed..Blocking this novel signaling axis may present a novel therapeutic target for posttrauma inflammation...
- Gribar S, Sodhi C, Richardson W, Anand R, Gittes G, Branca M, et al. Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. J Immunol. 2009;182:636-46 pubmed..Thus, the reciprocal nature of TLR4 and TLR9 signaling within the neonatal intestine plays a role in the development of NEC and provides novel therapeutic approaches to this disease. ..
- Vilardaga J, Bünemann M, Feinstein T, Lambert N, Nikolaev V, Engelhardt S, et al. GPCR and G proteins: drug efficacy and activation in live cells. Mol Endocrinol. 2009;23:590-9 pubmed publisher..The direct measurement of ligand efficacy at the level of the receptor by Förster resonance energy transfer is also now possible and allows intrinsic efficacies of clinical drugs to be linked with the effect of receptor polymorphisms. ..
- Khader S, Gaffen S, Kolls J. Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol. 2009;2:403-11 pubmed publisher..Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa. ..
- Chen F, Ellis E, Strom S, Shneider B. ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes. Pediatr Res. 2010;67:183-7 pubmed publisher..Overall, these findings support the hypothesis that FIC1 enhances FXR signaling via a PKCzeta-dependent signaling pathway. ..
- Cardinal J, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry K, et al. Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 2010;77:101-9 pubmed publisher..Hence, oral HW is an effective antioxidant and antiinflammatory agent that prevented CAN, improved survival of rat renal allografts, and may be of therapeutic value in the setting of transplantation. ..
- Schopfer F, Cole M, Groeger A, Chen C, Khoo N, Woodcock S, et al. Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions. J Biol Chem. 2010;285:12321-33 pubmed publisher..Administration of this class of signaling mediators to ob/ob mice revealed that NO(2)-FA lower insulin and glucose levels without inducing adverse side effects such as the increased weight gain induced by TZDs. ..