Genomes and Genes
Experts and Doctors on signal transduction in Philadelphia, Pennsylvania, United States
Locale: Philadelphia, Pennsylvania, United States
Topic: signal transduction
Publications347 found, 100 shown here
- Turetsky B, Moberg P. An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia. Am J Psychiatry. 2009;166:226-33 pubmed publisher..This study was designed to test this hypothesis by determining odor detection threshold sensitivities to two odorants that differ in their relative activations of this intracellular cAMP signaling cascade...
- Sengupta R, Burbassi S, Shimizu S, Cappello S, Vallee R, Rubin J, et al. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. J Neurosci. 2009;29:2534-44 pubmed publisher..By this mechanism, opiates could reduce the neuroprotective functions of CXCR4 and exacerbate neuropathology in opiate abusers who are affected by neuroinflammatory/infectious disorders, including neuroAIDS. ..
- Zhuo J, Kruger W, Pratico D. The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia. J Alzheimers Dis. 2010;20:569-76 pubmed publisher..Finally, over-expression of Herp did not result in any significant modification of Abeta levels. We conclude that the Herp protein pathway is unlikely to be directly involved in the pro-amyloidotic effect of HHcy. ..
- Zhou J, Wang C, Wang Z, Dampier W, Wu K, Casimiro M, et al. Attenuation of Forkhead signaling by the retinal determination factor DACH1. Proc Natl Acad Sci U S A. 2010;107:6864-9 pubmed publisher..Attenuation of FOX function by the cell fate determination pathway has broad implications given the diverse role of FOX proteins in cellular biology and tumorigenesis. ..
- Bertozzi C, Schmaier A, Mericko P, Hess P, Zou Z, Chen M, et al. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010;116:661-70 pubmed publisher..These studies identify a nonhemostatic pathway in which platelet CLEC-2 receptors bind lymphatic endothelial PDPN and activate SLP-76 signaling to regulate embryonic vascular development...
- Smith Garvin J, Burns J, Gohil M, Zou T, Kim J, Maltzman J, et al. T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool. Blood. 2010;116:5548-59 pubmed publisher..Furthermore, we show that TCR signals sufficient to promote CD8(+) T-cell differentiation are different from those required to elicit inflammatory cytokine production. ..
- Berger S. Cell signaling and transcriptional regulation via histone phosphorylation. Cold Spring Harb Symp Quant Biol. 2010;75:23-6 pubmed publisher..These results lead to a gathering appreciation of the potential role of signal transduction kinase-mediated direct histone phosphorylation in regulating transcription. ..
- Bang S, Kim S, Dailey M, Chen Y, Moran T, Snyder S, et al. AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase. Proc Natl Acad Sci U S A. 2012;109:616-20 pubmed publisher..Regulation by glucose of phospho-AMPK in hypothalamic cell lines is prevented by blocking AMPK-IPMK binding. These findings imply that IPMK inhibitors will be beneficial in treating obesity and diabetes. ..
- Seeger Nukpezah T, Golemis E. The extracellular matrix and ciliary signaling. Curr Opin Cell Biol. 2012;24:652-61 pubmed publisher..Further, a growing number of proteins have been determined to possess multiple roles in control of cilia and focal adhesion interactions with the ECM, further coordinating functionality. We summarize and discuss these recent findings. ..
- Carito V, Bonuccelli G, Martinez Outschoorn U, Whitaker Menezes D, Caroleo M, Cione E, et al. Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Cell Cycle. 2012;11:3403-14 pubmed publisher..Thus, MSF functions in the metabolic remodeling of the tumor microenvironment by metabolically reprogramming cancer-associated fibroblasts toward glycolytic metabolism. ..
- Fernandes Alnemri T, Kang S, Anderson C, Sagara J, Fitzgerald K, Alnemri E. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol. 2013;191:3995-9 pubmed publisher..These findings define the pathways that lead to rapid NLRP3 activation and identify IRAK1 as a critical mediator of a transcription-independent,inflammasome-dependent early warning response to pathogenic infection. ..
- Kokrashvili Z, Yee K, Ilegems E, Iwatsuki K, Li Y, Mosinger B, et al. Endocrine taste cells. Br J Nutr. 2014;111 Suppl 1:S23-9 pubmed publisher..The present results indicate that a portion of the cephalic-phase rise in circulating GLP-1 levels is mediated by the direct release of GLP-1 from taste cells into the bloodstream. ..
- Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, et al. Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. Br J Cancer. 2014;110:899-907 pubmed publisher..Our data provide novel therapeutic opportunities to mediate cancer cellular death using PL. As such, PL may afford a novel paradigm for both prevention and treatment of malignancy. ..
- Cilenti L, Ambivero C, Ward N, Alnemri E, Germain D, Zervos A. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy. Biochim Biophys Acta. 2014;1843:1295-307 pubmed publisher..Deregulation of this pathway, as it occurs in mnd2 mutant mice, causes mitochondrial dysfunction and mitophagy, and could be responsible for the motor neuron disease and the premature aging phenotype observed in these animals...
- Shenker B, Boesze Battaglia K, Scuron M, Walker L, Zekavat A, DlakiÄ‡ M. The toxicity of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity. Cell Microbiol. 2016;18:223-43 pubmed publisher..Our results provide further insight into the mode of action by which Cdt may function as an immunotoxin and induce cell cycle arrest in target cells such as lymphocytes. ..
- Di Meco A, Joshi Y, Lauretti E, PraticÃ² D. Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice. Mol Psychiatry. 2016;21:403-10 pubmed publisher..We conclude that dexamethasone exposure during pregnancy provides long-lasting protection against the onset and development of the AD-like phenotype by improving cognition and tau pathology. ..
- Rao A. Congenital disorders of platelet function: disorders of signal transduction and secretion. Am J Med Sci. 1998;316:69-76 pubmed..In most patients with inherited platelet dysfunction, the underlying mechanisms remain to be delineated. Future studies of these patients should yield valuable new information on normal platelet mechanisms. ..
- Seghatoleslami M, Roman Blas J, Rainville A, Modaressi R, Danielson K, Tuan R. Progression of chondrogenesis in C3H10T1/2 cells is associated with prolonged and tight regulation of ERK1/2. J Cell Biochem. 2003;88:1129-44 pubmed..Our findings show that the activity of ERK1/2 in chondrogenic cultures of C3H10T1/2 cells is tightly controlled and can cross interact with other signaling activities mediated by BMP-2 to positively regulate chondrogensis. ..
- Germann M, Swain E, Bergman L, Nickels J. Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p. J Biol Chem. 2005;280:4270-8 pubmed..Based on our results, we suggest that sphingolipid-dependent suppression of rvs defects may not work entirely through regulating changes in actin organization. ..
- Wang Z, Shu W, Lu M, Morrisey E. Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol. 2005;25:5022-30 pubmed..Together, these data demonstrate that Wnt7b signals through Fzd1 and -10 and LRP5 and implicate these Wnt coreceptors in the regulation of lung airway and vascular development. ..
- Du A, Hunter C, Murray J, Noble D, Cai C, Evans S, et al. Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 2009;58:2059-69 pubmed publisher..These results demonstrate the requirement for Isl-1 in the maturation, proliferation, and survival of the second wave of hormone-producing islet cells. ..
- Sharma A, Yeow W, Ertel A, Coleman I, Clegg N, Thangavel C, et al. The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression. J Clin Invest. 2010;120:4478-92 pubmed publisher..Together, these data reveal what we believe to be a new paradigm for RB function in controlling prostate tumor progression and lethal tumor phenotypes. ..
- Mazur P, Reynoird N, Khatri P, Jansen P, Wilkinson A, Liu S, et al. SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature. 2014;510:283-7 pubmed publisher..Together, our results elucidate a new role for lysine methylation in integrating cytoplasmic kinase-signalling cascades and establish a pivotal role for SMYD3 in the regulation of oncogenic Ras signalling. ..
- Huebner K, Kastury K, Druck T, Salcini A, Lanfrancone L, Pelicci G, et al. Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2). Genomics. 1994;22:281-7 pubmed..Both SHC1 and GRB2 are in chromosome regions that may be duplicated in some tumor types. ..
- Yang J, Wu J, Kowalska M, Dalvi A, Prevost N, O Brien P, et al. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci U S A. 2000;97:9984-9 pubmed..Therefore, these results provide insights into receptor selectivity among G proteins and a model for understanding platelet function and the effects of psychoactive drugs. ..
- Wagner D, Mullins M. Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev Biol. 2002;245:109-23 pubmed..As has been proposed for the fly orthologue of chordin, short gastrulation, our paradoxical results can be explained by a model whereby Chordin both antagonizes and promotes BMP activity. ..
- Syed F, Rycyzyn M, Westgate L, Clevenger C. A novel and functional interaction between cyclophilin A and prolactin receptor. Endocrine. 2003;20:83-90 pubmed..Hence, the interaction between CypA and the PRLR plays a differential regulatory role in the various signaling pathways leading from the PRLR. ..
- Shimo T, Koyama E, Sugito H, Wu C, Shimo S, Pacifici M. Retinoid signaling regulates CTGF expression in hypertrophic chondrocytes with differential involvement of MAP kinases. J Bone Miner Res. 2005;20:867-77 pubmed..Retinoids appear to have a preeminent role in controlling expression and function of CTGF in hypertrophic and posthypertrophic chondrocytes and do so with differential cooperation and intervention of MAP kinases and BMP signaling. ..
- Dolloff N, Russell M, Loizos N, Fatatis A. Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor. Cancer Res. 2007;67:555-62 pubmed..Therefore, alpha-PDGFR expression may provide select prostate phenotypes with a growth advantage within the bone microenvironment. ..
- Johnson L, Scott P. STAT1 expression in dendritic cells, but not T cells, is required for immunity to Leishmania major. J Immunol. 2007;178:7259-66 pubmed..major and instead stress the importance of STAT1 signaling in DCs for the optimal induction of Th1 responses. ..
- Rafiq K, Hanscom M, Valerie K, Steinberg S, Sabri A. Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis. Circ Res. 2008;102:32-41 pubmed..These results show that Cat.G-induced cardiomyocyte apoptosis involves an increase in EGFR-dependent activation of SHP2 that promotes focal adhesion kinase dephosphorylation and subsequent cardiomyocyte anoikis. ..
- Assoian R, Klein E. Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol. 2008;18:347-52 pubmed publisher..Increasing emphasis is therefore being placed on approaches that use micropatterning to control cell spreading, and deformable substrata to model the compliance of biological tissue. ..
- Tian Y, Sommerville L, Cuneo A, Kelemen S, Autieri M. Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia. Am J Pathol. 2008;173:901-9 pubmed publisher..We propose that through induction of SOCS5 and inhibition of signal transduction, IL-19 expression in VSMCs may represent a novel, protective, autocrine response of VSMCs to inflammatory stimuli. ..
- Hannenhalli S, Kaestner K. The evolution of Fox genes and their role in development and disease. Nat Rev Genet. 2009;10:233-40 pubmed publisher..We summarize the salient features of the evolution of the Fox gene family and highlight the diverse contribution of various Fox subfamilies to developmental processes, from organogenesis to speech acquisition. ..
- Tran T, Utama F, Lin J, Yang N, Sjolund A, Ryder A, et al. Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism. Cancer Res. 2010;70:1711-21 pubmed publisher..52; P < 0.001) but not with Stat5b. Loss of prolactin-Stat5a signaling and concomitant upregulation of BCL6 may represent a regulatory switch facilitating undifferentiated histology and poor prognosis of breast cancer. ..
- Neely R, Brose M, Gray C, McCorkell K, Leibowitz J, Ma C, et al. The RET/PTC3 oncogene activates classical NF-?B by stabilizing NIK. Oncogene. 2011;30:87-96 pubmed publisher..We therefore conclude that RP3 activates classical NF-?B via NIK, NEMO and IKK?. Importantly, our findings reveal a novel mechanism for oncogene-induced NF-?B activation via stabilization of NIK. ..
- Yang L, Conway S, Poethig R. Vegetative phase change is mediated by a leaf-derived signal that represses the transcription of miR156. Development. 2011;138:245-9 pubmed publisher..We conclude that vegetative phase change is initiated by a signal(s) produced by leaf primordia, which acts by repressing the transcription of specific members of the miR156 gene family. ..
- Chung E, Psathas J, Yu D, Li Y, Weiss M, Thomas Tikhonenko A. CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. J Clin Invest. 2012;122:2257-66 pubmed publisher..Thus, CD19 is a major BCR-independent regulator of MYC-driven neoplastic growth in B cell neoplasms. ..
- Tetreault M, Alrabaa R, McGeehan M, Katz J. Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS ONE. 2012;7:e38338 pubmed publisher..Thus, KLF5 and its downstream mediators may provide therapeutic targets and disease markers for IBD or other diseases characterized by injury and disruption of intestinal epithelia. ..
- Swope D, Li J, Radice G. Beyond cell adhesion: the role of armadillo proteins in the heart. Cell Signal. 2013;25:93-100 pubmed publisher..This review will discuss the connection between altered cell adhesion and gene expression and its contribution to disease pathogenesis. ..
- Srinivasula S, Ahmad M, Fernandes Alnemri T, Litwack G, Alnemri E. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A. 1996;93:14486-91 pubmed..On the other hand, Mch4 could be a second upstream protease that is responsible for activation of the same protease cascade in CrmA-insensitive apoptotic pathways. ..
- Ashby B. Co-expression of prostaglandin receptors with opposite effects: a model for homeostatic control of autocrine and paracrine signaling. Biochem Pharmacol. 1998;55:239-46 pubmed..The mechanism is relevant to other autocrine and paracrine mediators including neurotransmitters, which reach transiently high concentrations in the synaptic cleft. ..
- Kline J, Roehrs H, Clevenger C. Functional characterization of the intermediate isoform of the human prolactin receptor. J Biol Chem. 1999;274:35461-8 pubmed..Taken together, differences in signaling and tissue expression suggest that the human intermediate PRLr differs from the long PRLr in physiological function. ..
- Roll R, Bauman E, Bennett J, Abrams C. Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway. J Cell Biol. 2000;150:1461-6 pubmed..Thus, expressed phosphorylated pleckstrin promotes cell spreading that is both matrix and integrin dependent. To our knowledge, this is the first example of a mutated integrin functioning as a dominant negative inhibitor. ..
- Penn R, Pascual R, Kim Y, Mundell S, Krymskaya V, Panettieri R, et al. Arrestin specificity for G protein-coupled receptors in human airway smooth muscle. J Biol Chem. 2001;276:32648-56 pubmed
- Seykora J, Mei L, Dotto G, Stein P. 'Srcasm: a novel Src activating and signaling molecule. J Biol Chem. 2002;277:2812-22 pubmed..Srcasm is capable of interacting with Grb2 and the regulatory subunit of phosphoinositide 3-kinase, p85, in a phosphorylation-dependent manner. The evidence suggests that Srcasm may help promote Src family kinase signaling in cells. ..
- Zhang T, Otevrel T, Gao Z, Ehrlich S, Fields J, Boman B. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res. 2001;61:8664-7 pubmed
- Wang H, Perrault A, Takeda Y, Qin W, Wang H, Iliakis G. Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 2003;31:5377-88 pubmed..A chromatin-based model of DNA DSB rejoining accommodating biochemical and genetic results is presented and deviations between in vitro and in vivo results discussed. ..
- Buxbaum L, Denise H, Coombs G, Alexander J, Mottram J, Scott P. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. J Immunol. 2003;171:3711-7 pubmed..These data indicate that cysteine proteases of L. mexicana are critical in suppressing protective immune responses and that inhibition of CPB may prove to be a valuable immunomodulatory strategy for chronic forms of leishmaniasis. ..
- Perrault R, Wang H, Wang M, Rosidi B, Iliakis G. Backup pathways of NHEJ are suppressed by DNA-PK. J Cell Biochem. 2004;92:781-94 pubmed..Thus, DNA-PK suppresses alternative pathways of end joining by efficiently binding DNA ends and shunting them to D-NHEJ. ..
- Skalet A, Isler J, King L, Harding H, Ron D, Monroe J. Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate. J Biol Chem. 2005;280:39762-71 pubmed..These studies establish a system whereby a terminal or adaptive UPR can be alternatively triggered by physiologic stimuli. ..
- Fu M, Liu M, Sauve A, Jiao X, Zhang X, Wu X, et al. Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol. 2006;26:8122-35 pubmed..DHT-induced prostate cancer cellular contact-independent growth is also blocked by SIRT1, providing a direct functional link between the AR, which is a critical determinant of progression of human prostate cancer, and the sirtuins. ..
- Fikaris A, Lewis A, Abulaiti A, Tsygankova O, Meinkoth J. Ras triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signaling. J Biol Chem. 2006;281:34759-67 pubmed..Our findings also suggest that the frequent mutational activation of Ras in thyroid tumors reflects the ability of Ras-expressing cells to bypass checkpoints and evade apoptosis rather than to simply increase proliferative potential. ..
- Dadke S, Cotteret S, Yip S, Jaffer Z, Haj F, Ivanov A, et al. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol. 2007;9:80-5 pubmed..These results suggest that sumoylation, which has been implicated primarily in processes in the nucleus and nuclear pore, also modulates a key enzyme-substrate signalling complex that regulates metabolism and cell proliferation. ..
- Lefebvre J, Jing L, Becaficco S, Franzini Armstrong C, Granato M. Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation. Proc Natl Acad Sci U S A. 2007;104:2483-8 pubmed
- Chang J, Palanivel V, Kinjyo I, Schambach F, Intlekofer A, Banerjee A, et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science. 2007;315:1687-91 pubmed..These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity. ..
- Kaplan F, Glaser D, Pignolo R, Shore E. A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton. Expert Opin Biol Ther. 2007;7:705-12 pubmed..Effective therapies for FOP, and possibly for a vast array of more common conditions of heterotopic ossification, will be based on blocking activin-like kinase-2, a critical node in the BMP signaling pathway...
- Bhavaraju K, Kim S, Daniel J, Kunapuli S. Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets. Eur J Pharmacol. 2008;580:285-90 pubmed..In contrast, OXSI-2, unlike PKC inhibitors, did not inhibit secretion. Therefore, we conclude that OXSI-2 is not a Syk-selective inhibitor in platelets because of its unexplained non-specific effects. ..
- Cejas P, Walsh M, Pearce E, Han D, Harms G, Artis D, et al. TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood. 2010;115:4750-7 pubmed publisher..Importantly, the data also suggest that a main function of TGF-beta in early Th17 differentiation may be the inhibition of autocrine and paracrine IL-2-mediated suppression of Th17 cell generation. ..
- Burbassi S, Sengupta R, Meucci O. Alterations of CXCR4 function in ?-opioid receptor-deficient glia. Eur J Neurosci. 2010;32:1278-88 pubmed publisher..The data also suggest that the opiate system interferes with normal CXCR4 function in different ways, depending on receptor subtypes. ..
- Okegbe T, Dinardo S. The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling. Development. 2011;138:1259-67 pubmed publisher..Because in mammals primordial germ cells also track through endoderm on their way to the genital ridge, our work raises the possibility that conserved mechanisms are employed to regulate germline niche formation...
- Zuzga D, Pelta Heller J, Li P, Bombonati A, Waldman S, Pitari G. Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer. Int J Cancer. 2012;130:2539-48 pubmed publisher..Reconstitution of physiological cGMP circuitry through VASP, in turn, represents an attractive targeted approach for patients with colorectal cancer. ..
- Rom S, Pacifici M, Passiatore G, Aprea S, Waligórska A, Del Valle L, et al. HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction. Biochim Biophys Acta. 2011;1813:1836-44 pubmed publisher..The Tat/Grb2 interaction affects also viral function by inhibiting the Tat-mediated transactivation of HIV-1 LTR and viral replication in infected primary microglia. ..
- Rao A. Inherited platelet function disorders: overview and disorders of granules, secretion, and signal transduction. Hematol Oncol Clin North Am. 2013;27:585-611 pubmed publisher..Management of these patients needs to be individualized; therapeutic options include platelet transfusions, 1-desamino-8d-arginine vasopressin (DDAVP), recombinant factor VIIa, and antifibrinolytic agents. ..
- Bogusz A, Kovach A, Le L, Feng D, Baxter R, Sohani A. Diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression shows evidence of active B-cell receptor signaling by quantitative immunofluorescence. PLoS ONE. 2017;12:e0172364 pubmed publisher..Our findings suggest that the BCR signaling pathway may be more active in MYC/BCL2 double-expressor DLBCL and may represent a rational therapeutic target in this aggressive DLBCL subgroup. ..
- Wang S, Huo D, Ogundiran T, Ojengbede O, Zheng W, Nathanson K, et al. Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium. Carcinogenesis. 2017;38:789-796 pubmed publisher..914. These results provide new insights on the biological relevance of the mTOR pathway in breast cancer progression and underscore the need for more genetic epidemiology studies of breast cancer in the African Diaspora. ..
- Koyama E, Wu C, Shimo T, Iwamoto M, Ohmori T, Kurisu K, et al. Development of stratum intermedium and its role as a Sonic hedgehog-signaling structure during odontogenesis. Dev Dyn. 2001;222:178-91 pubmed..Given its dynamic and apparently interactive properties, stratum intermedium may help orchestrate progression of odontogenesis from cusp to cervix. ..
- Gao F, Yue T, Shi D, Christopher T, Lopez B, Ohlstein E, et al. p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of PMN accumulation. Cardiovasc Res. 2002;53:414-22 pubmed
- Kannan S. Amplification of extracellular nucleotide-induced leukocyte(s) degranulation by contingent autocrine and paracrine mode of leukotriene-mediated chemokine receptor activation. Med Hypotheses. 2002;59:261-5 pubmed..In turn the leukotriene will act in both autocrine and paracrine manner to amplify the degranulation processes in leukocytes invoked by extracellular nucleotides. ..
- He Y, Pear W. Notch signalling in B cells. Semin Cell Dev Biol. 2003;14:135-42 pubmed..In this review, we will focus on potential roles of Notch signalling in B lymphopoiesis and also consider how viral proteins may utilize Notch signalling in B cells. ..
- Ottey M, Han S, Druck T, Barnoski B, McCorkell K, Croce C, et al. Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant. Br J Cancer. 2004;91:1669-77 pubmed..UVC surviving Fhit -/- cells appear transformed and exhibit >5-fold increased mutation frequency. This increased mutation burden could explain the susceptibility of Fhit-deficient cells in vivo to malignant transformation. ..
- Zajac A, Sun X, Zhang J, Guo W. Cyclical regulation of the exocyst and cell polarity determinants for polarized cell growth. Mol Biol Cell. 2005;16:1500-12 pubmed..We propose that a cyclical regulatory network contributes to the establishment and maintenance of polarized cell growth in yeast. ..
- Sriram U, Biswas C, Behrens E, Dinnall J, Shivers D, Monestier M, et al. IL-4 suppresses dendritic cell response to type I interferons. J Immunol. 2007;179:6446-55 pubmed..This inhibition could explain the increased susceptibility to viral infections observed during Th2-inducing parasitoses. ..
- Shapiro M, Nguyen C, Aghajanian H, Zhang W, Shapiro V. Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms. J Immunol. 2008;181:7055-61 pubmed..Therefore, it can be concluded that inhibition of signaling events involved in T cell activation by LAX occurs through mechanisms both dependent on and independent of its tyrosine phosphorylation. ..
- Sanmiguel J, Olaru F, Li J, Mohr E, Jensen L. Interleukin-1 regulates keratinocyte expression of T cell targeting chemokines through interleukin-1 receptor associated kinase-1 (IRAK1) dependent and independent pathways. Cell Signal. 2009;21:685-94 pubmed publisher..In conclusion IL-1 regulates T cell targeting chemokine production in keratinocytes through IRAK1 dependent and independent pathways. These pathways may contribute to acute and chronic skin inflammation. ..
- Kriete A, Mayo K. Atypical pathways of NF-kappaB activation and aging. Exp Gerontol. 2009;44:250-5 pubmed publisher..Investigation of mechanisms of NF-kappaB in aging as an important marker of cellular stress provides guidance for the development of a systems view of cellular aging. ..
- Zong Y, Panikkar A, Xu J, Antoniou A, Raynaud P, Lemaigre F, et al. Notch signaling controls liver development by regulating biliary differentiation. Development. 2009;136:1727-39 pubmed publisher..These results reconcile previous conflicting reports about the role of Notch during liver development and suggest that Notch acts by coordinating biliary differentiation and morphogenesis. ..
- Solt L, Madge L, May M. NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation. J Biol Chem. 2009;284:27596-608 pubmed publisher..These findings therefore demonstrate that formation of the heterotrimeric IKKalpha-IKKbeta-NEMO holocomplex absolutely requires two intact NEMO-binding domains. ..
- Kambayashi T, LaRosa D, Silverman M, Koretzky G. Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation. Immunol Rev. 2009;232:99-114 pubmed publisher..Deciphering the molecular mechanisms leading to mast cell activation will hopefully bring new ideas for the development of novel therapeutics to control allergic diseases. ..
- Sonawane S, Kim J, Lee M, Lee S, Duff P, Moore D, et al. GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation. 2009;88:1169-77 pubmed publisher..By blocking this interaction with AITRL-Fc, one can sustain the benefit conferred by graft-protective Tregs. ..
- Bryant K, Camacho J, Jasmin J, Wang C, Addya S, Casimiro M, et al. Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate. Int J Biochem Cell Biol. 2011;43:1318-29 pubmed publisher..Thus, Cav-1 Tg mice could serve as a novel model for studying AR-regulated pathways involved in prostate growth and proliferation. ..
- McBride S, Bell A, Jongens T. Behavior in a Drosophila model of fragile X. Results Probl Cell Differ. 2012;54:83-117 pubmed publisher..Sci Transl Med 3(64):64ra61), although the work in studying these interventions in humans is just getting underway as the work in model organisms continues to generate new potential therapeutic targets. ..
- Plotnikova O, Nikonova A, Loskutov Y, Kozyulina P, Pugacheva E, Golemis E. Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis. Mol Biol Cell. 2012;23:2658-70 pubmed publisher..These results define Ca(2+)/CaM as important regulators of AURKA activation in mitotic and nonmitotic signaling. ..
- Wu Q, Wang J, Skubutyte R, Kepler C, Huang Z, Anderson D, et al. Smad3 controls ?-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Arthritis Rheum. 2012;64:3324-33 pubmed publisher..Our findings demonstrate that in healthy NP cells, the TGF?-Smad3 axis serves as a regulator of GlcAT-1 expression. However, an altered responsiveness to TGF? during disc degeneration may compromise GAG synthesis. ..
- Zheng X, Xu C, Smith A, Stratman A, Zou Z, Kleaveland B, et al. Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev Cell. 2012;23:342-55 pubmed publisher..Our studies identify CCM2L as a molecular mechanism by which endothelial cells coordinately regulate vessel stability and growth during cardiovascular development, as well as postnatal vessel growth. ..
- Fujita N, Gogate S, Chiba K, Toyama Y, Shapiro I, Risbud M. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-? (TNF-?) on cells of the nucleus pulposus through co-activation of nuclear factor ?B (NF-?B)/p65 signaling. J Biol Chem. 2012;287:39942-53 pubmed publisher..These findings show that by enhancing the activity of inflammatory cytokines, PHD3 may serve a critical role in degenerative disc disease. ..