Experts and Doctors on phosphotransferases in Philadelphia, Pennsylvania, United States


Locale: Philadelphia, Pennsylvania, United States
Topic: phosphotransferases

Top Publications

  1. Herbert T, Hecht N. The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs. Nucleic Acids Res. 1999;27:1747-53 pubmed
    ..Furthermore, association of the non-polysomal derived proteins to exogenous non-specific mRNAs led to their translational repression in vitro. ..
  2. Satishchandran C, Hickman Y, Markham G. Characterization of the phosphorylated enzyme intermediate formed in the adenosine 5'-phosphosulfate kinase reaction. Biochemistry. 1992;31:11684-8 pubmed
    ..We have identified a sequence beginning at residue 147 which may reflect a PAPS binding site. This sequence was identified in the carboxy terminal region of 10 reported sequences of proteins of PAPS metabolism. ..
  3. Gendimenico G, Haugaard N. Adverse effects of hyperbaric oxygen on [3H]uridine incorporation and uridine kinase activity in B104 rat neuroblastoma cells. Mol Cell Biochem. 1990;95:71-6 pubmed
    ..The reduced enzyme activity which appears to account for the depressed [3H]uridine incorporation, may contribute to the lethal effects of oxygen in these cells. ..
  4. Nayak V, Zhao K, Wyce A, Schwartz M, Lo W, Berger S, et al. Structure and dimerization of the kinase domain from yeast Snf1, a member of the Snf1/AMPK protein family. Structure. 2006;14:477-85 pubmed
    ..Taken together, these studies suggest another layer of kinase regulation within the Snf1/AMPK family, and an avenue for development of AMPK-specific activating compounds. ..
  5. He B, Xi F, Zhang X, Zhang J, Guo W. Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. EMBO J. 2007;26:4053-65 pubmed
    ..We propose that Exo70 mediates the assembly of the exocyst complex at the plasma membrane, which is a crucial step in the tethering of post-Golgi secretory vesicles for exocytosis. ..
  6. Liu Y, Tozeren A. Modular composition predicts kinase/substrate interactions. BMC Bioinformatics. 2010;11:349 pubmed publisher
    ..Our method can be used in expanding the currently available drafts of cell signaling pathways and thus will be an important tool in the development of combination drug therapies targeting complex diseases. ..
  7. Leyh T, Taylor J, Markham G. The sulfate activation locus of Escherichia coli K12: cloning, genetic, and enzymatic characterization. J Biol Chem. 1988;263:2409-16 pubmed
    ..The genes are adjacent and are transcribed counterclockwise on the E. coli chromosome in the order cysDNC. cysN and cysC are within the same operon and cysDNC are not in an operon containing cysHIJ. ..
  8. Ahmad M, Jarillo J, Smirnova O, Cashmore A. The CRY1 blue light photoreceptor of Arabidopsis interacts with phytochrome A in vitro. Mol Cell. 1998;1:939-48 pubmed
    ..In vivo labeling studies and specific mutant alleles of CRY1, which interfere with the function of phytochrome, suggest the possible relevance of these findings in vivo. ..
  9. Wang H, Wang M, Wang H, Böcker W, Iliakis G. Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors. J Cell Physiol. 2005;202:492-502 pubmed
    ..The results in aggregate implicate DNA-PK, ATM and possibly other kinases in H2AX phosphorylation. The functional significance and the mechanisms of coordination in space and time of these multiple inputs require further investigation. ..

More Information


  1. Pan J, Lian Z, Wallett S, Wallet S, Feitelson M. The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin. J Gen Virol. 2007;88:3275-85 pubmed
    ..This suggests that URG7 helps to protect virus-infected hepatocytes during chronic hepatitis B virus infection. ..
  2. Orlando K, Zhang J, Zhang X, Yue P, Chiang T, Bi E, et al. Regulation of Gic2 localization and function by phosphatidylinositol 4,5-bisphosphate during the establishment of cell polarity in budding yeast. J Biol Chem. 2008;283:14205-12 pubmed publisher
    ..We propose that phosphatidylinositol 4,5-bisphosphate and Cdc42 act in concert to regulate polarized localization and function of Gic2 during polarized cell growth in the budding yeast. ..
  3. Gibbs J, Liebermann D, Hoffman B. Leukemia suppressor function of Egr-1 is dependent on transforming oncogene. Leukemia. 2008;22:1909-16 pubmed publisher
    ..These findings extend the notion that the molecular nature of genetic lesions responsible for leukemia determines the effectiveness of any given tumor suppressor. ..
  4. Bersenev A, Wu C, Balcerek J, Jing J, Kundu M, Blobel G, et al. Lnk constrains myeloproliferative diseases in mice. J Clin Invest. 2010;120:2058-69 pubmed publisher
    ..Taken together, our data establish Lnk as a bona fide suppressor of MPD in mice and raise the possibility that Lnk dysfunction contributes to the development of hematologic malignancies in humans. ..
  5. Peixoto L, Chen F, Harb O, Davis P, Beiting D, Brownback C, et al. Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses. Cell Host Microbe. 2010;8:208-18 pubmed publisher
    ..These results highlight the value of integrative genomic approaches in prioritizing candidates for functional validation. ..
  6. Marzec M, Liu X, Wong W, Yang Y, Pasha T, Kantekure K, et al. Oncogenic kinase NPM/ALK induces expression of HIF1? mRNA. Oncogene. 2011;30:1372-8 pubmed publisher
    ..These results also provide another rationale to therapeutically target NPM/ALK and STAT3 in ALK+ TCL. ..