Experts and Doctors on phosphoadenosine phosphosulfate in Philadelphia, Pennsylvania, United States


Locale: Philadelphia, Pennsylvania, United States
Topic: phosphoadenosine phosphosulfate

Top Publications

  1. Satishchandran C, Hickman Y, Markham G. Characterization of the phosphorylated enzyme intermediate formed in the adenosine 5'-phosphosulfate kinase reaction. Biochemistry. 1992;31:11684-8 pubmed
    ..We have identified a sequence beginning at residue 147 which may reflect a PAPS binding site. This sequence was identified in the carboxy terminal region of 10 reported sequences of proteins of PAPS metabolism. ..
  2. Mazany K, Peng T, Watson C, Tabas I, Williams K. Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. Biochim Biophys Acta. 1998;1407:92-7 pubmed
    ..The human C6ST gene structure has been elucidated and exhibits an intron-less coding region, and the gene has been mapped to human chromosome 11 by radiation hybrid panel mapping. ..
  3. Satishchandran C, Markham G. Mechanistic studies of Escherichia coli adenosine-5'-phosphosulfate kinase. Arch Biochem Biophys. 2000;378:210-5 pubmed
    ..The affinity for Mn(2+) increases 23-fold when the enzyme is phosphorylated. Two Mn(2+) ions bind per subunit when both APS and the ATP analog AMPPNP are present, indicating a potential dual metal ion catalytic mechanism. ..