Genomes and Genes
Experts and Doctors on murine hepatitis virus in Philadelphia, Pennsylvania, United States
Locale: Philadelphia, Pennsylvania, United States
Topic: murine hepatitis virus
- Roth Cross J, Bender S, Weiss S. Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia. J Virol. 2008;82:9829-38 pubmed publisher..These findings suggest that secretion of IFN-beta by macrophages and microglia plays a role in protecting the host from MHV infection of the central nervous system. ..
- Navas S, Weiss S. Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism. J Virol. 2003;77:4972-8 pubmed..Thus, the JHM genetic background plays a dominant role over the spike in the determination of hepatotropism. ..
- Roth Cross J, Martinez Sobrido L, Scott E, Garcia Sastre A, Weiss S. Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels. J Virol. 2007;81:7189-99 pubmed..These findings show that MHV employs unique strategies to circumvent the IFN-alpha/beta response at multiple steps...
- Zhao L, Birdwell L, Wu A, Elliott R, Rose K, Phillips J, et al. Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus. J Virol. 2013;87:8408-18 pubmed publisher..Thus, RNase L activation during MHV infection is cell type specific and correlates with relatively high levels of expression of OAS genes, which are necessary but not sufficient for induction of an effective RNase L antiviral response. ..
- Das Sarma J, Fu L, Hingley S, Lai M, Lavi E. Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis. J Neurovirol. 2001;7:432-6 pubmed..One or more of the sites of these mutations in the MHV-A59 genome are likely to contribute to demyelination and hepatitis. ..
- Zhao L, Jha B, Wu A, Elliott R, Ziebuhr J, Gorbalenya A, et al. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe. 2012;11:607-16 pubmed publisher..Thus, RNase L is a critical cellular factor for protection against viral infection of the liver and the resulting hepatitis. ..
- Roth Cross J, Stokes H, Chang G, Chua M, Thiel V, Weiss S, et al. Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2. J Virol. 2009;83:3743-53 pubmed publisher..This novel phenotype suggests a strategy to investigate the function of the MHV-A59 ns2 protein involving the search for organ-specific proteins or RNAs that react differentially to wild-type and mutant ns2 proteins. ..
- Zhao L, Rose K, Elliott R, Van Rooijen N, Weiss S. Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus. J Virol. 2011;85:10058-68 pubmed publisher..Our results further support the notion that viral tissue tropism is determined in part by postentry events, including the early type I interferon response. ..
- Cowley T, Weiss S. Murine coronavirus neuropathogenesis: determinants of virulence. J Neurovirol. 2010;16:427-34 pubmed publisher..SD. Further data suggest that neither the internal (I) protein nor nonstructural proteins ns4, and ns2 are significant contributors to neurovirulence. ..
- Phillips J, Weiss S. Pathogenesis of neurotropic murine coronavirus is multifactorial. Trends Pharmacol Sci. 2011;32:2-7 pubmed publisher..We propose that the extreme neurovirulence of JHM.SD is multifactorial and might include as yet unidentified neuron-specific spread mechanisms. ..
- Zhang R, Jha B, Ogden K, Dong B, Zhao L, Elliott R, et al. Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity. Proc Natl Acad Sci U S A. 2013;110:13114-9 pubmed publisher..Thus, VP3-CTD is a 2',5'-PDE able to functionally substitute for ns2 in MHV infection. Remarkably, therefore, two disparate RNA viruses encode proteins with homologous 2',5'-PDEs that antagonize activation of innate immunity. ..
- Shindler K, Kenyon L, Dutt M, Hingley S, Das Sarma J. Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus. J Virol. 2008;82:8882-6 pubmed publisher..In contrast, MHV-2, a nondemyelinating MHV strain, does not induce ON. Results reveal a reproducible virus-induced ON model important for the evaluation of novel therapies...
- Scott E, Branigan P, Del Vecchio A, Weiss S. Chemokine expression during mouse-hepatitis-virus-induced encephalitis: contributions of the spike and background genes. J Neurovirol. 2008;14:5-16 pubmed publisher..Chemokine mRNA patterns were in general agreement. Thus, chemokine patterns correspond with the cellular infiltrate, and the spike protein influences levels of macrophage, but not T-cell, chemokines...
- Matthews A, Weiss S, Paterson Y. Murine hepatitis virus--a model for virus-induced CNS demyelination. J Neurovirol. 2002;8:76-85 pubmed..Here we review this field in the context of the immune response to MHV in the liver and the CNS focusing on studies that have been published in the past 5 years...
- Phillips J, Chua M, Rall G, Weiss S. Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation, and virus-induced immunopathology in the central nervous system. Virology. 2002;301:109-20 pubmed..Despite this robust and viral-specific immune response to S(4)R infection, infection of RAG1-/- mice suggested that immune-mediated pathology also contributes to the high neurovirulence of S(4)R...
- Qiu Z, Hingley S, Simmons G, Yu C, Das Sarma J, Bates P, et al. Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry. J Virol. 2006;80:5768-76 pubmed