Experts and Doctors on membrane proteins in Philadelphia, Pennsylvania, United States

Summary

Locale: Philadelphia, Pennsylvania, United States
Topic: membrane proteins

Top Publications

  1. Armstead W. Superoxide generation links protein kinase C activation to impaired ATP-sensitive K+ channel function after brain injury. Stroke. 1999;30:153-9 pubmed
    ..These data suggest, therefore, that O2- generation links PKC activation to impaired KATP channel function after FPI. ..
  2. Lee S, Oe T, Blair I. Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science. 2001;292:2083-6 pubmed
    ..Vitamin C-mediated formation of genotoxins from lipid hydroperoxides in the absence of transition metal ions could help explain its lack of efficacy as a cancer chemoprevention agent. ..
  3. Samulewicz S, Seitz A, Clark L, Heber Katz E. Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears. Wound Repair Regen. 2002;10:215-21 pubmed
    ..Pref-1 is more highly expressed in the MRL wounds, is uniquely found in a condensation of cells within the regenerating tissue of the blastema, and may contribute to the regenerative capacity of the MRL ear wound. ..
  4. Itoh T, Itoh A, Pleasure D. Bcl-2-related protein family gene expression during oligodendroglial differentiation. J Neurochem. 2003;85:1500-12 pubmed
    ..These results provide basic information to guide further studies on the roles for Bcl-2-related family proteins in OLC death. ..
  5. Sarratt K, Chen H, Zutter M, Santoro S, Hammer D, Kahn M. GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood. 2005;106:1268-77 pubmed
    ..These studies establish platelet-collagen responses under physiologic flow as the consequence of a close partnership between 2 structurally distinct receptors and suggest that both receptors play significant hemostatic roles in vivo. ..
  6. Naidoo N. Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders. Sleep Med Rev. 2009;13:195-204 pubmed publisher
  7. Yamagami J, Kacir S, Ishii K, Payne A, Siegel D, Stanley J. Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus. J Immunol. 2009;183:5615-21 pubmed publisher
    ..However, presentation of peptides from Dsg1 by preDsg1-specific B cells may be one step in developing autoimmunity in PF. ..
  8. Lancaster E, Martinez Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology. 2011;77:179-89 pubmed publisher
    ..This review provides an update on these syndromes and autoantigens with special emphasis on clinical diagnosis and treatment. ..
  9. Hsu C, Baumgart T. Spatial association of signaling proteins and F-actin effects on cluster assembly analyzed via photoactivation localization microscopy in T cells. PLoS ONE. 2011;6:e23586 pubmed publisher
    ..The quantitative analysis of sub-diffraction PALM images may provide a starting point for a molecular interpretation of cluster-cluster interactions and of the regulation of T cell signaling MCs by the cytoskeleton. ..

More Information

Publications290 found, 100 shown here

  1. Wang J, Darbinyan A, White M, Darbinian N, Reiss K, Amini S. Involvement of IRS-1 interaction with ADAM10 in the regulation of neurite extension. J Cell Physiol. 2014;229:1039-46 pubmed publisher
    ..Altogether, these observations suggest a role for ADAM10 in the mechanism for IGF1/IRS-1 signaling pathway in sustaining the stability of neuronal processes. ..
  2. Laurent B, Ruitu L, Murn J, Hempel K, Ferrao R, Xiang Y, et al. A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation. Mol Cell. 2015;57:957-70 pubmed publisher
  3. Allman D, Karnell F, Punt J, Bakkour S, Xu L, Myung P, et al. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J Exp Med. 2001;194:99-106 pubmed
  4. Wang H, Kazanietz M. Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J Biol Chem. 2002;277:4541-50 pubmed
    ..In this setting, Tmp21-I serves as an anchoring protein that determines the intracellular localization of these novel phorbol ester receptors. ..
  5. Kazerounian S, Uitto J, Aho S. Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. Exp Dermatol. 2002;11:428-38 pubmed
  6. He Y, Pear W. Notch signalling in B cells. Semin Cell Dev Biol. 2003;14:135-42 pubmed
    ..In this review, we will focus on potential roles of Notch signalling in B lymphopoiesis and also consider how viral proteins may utilize Notch signalling in B cells. ..
  7. Strauss J, Kishida T, Christenson L, Fujimoto T, Hiroi H. START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells. Mol Cell Endocrinol. 2003;202:59-65 pubmed
    ..The roles of StarD4, StarD5, and StarD6 in sterol movement remain to be determined. These genes have tissue-specific patterns of expression that may predict specialized roles. ..
  8. Scarlato M, Ara J, Bannerman P, Scherer S, Pleasure D. Induction of neuropilins-1 and -2 and their ligands, Sema3A, Sema3F, and VEGF, during Wallerian degeneration in the peripheral nervous system. Exp Neurol. 2003;183:489-98 pubmed
    ..Our results suggest the possibility that the neuropilins and their semaphorin ligands serve to guide, rather than to impede, regenerating axons in the adult PNS. ..
  9. Li Y, Rao P, Wen R, Song Y, Muir D, Wallace P, et al. Notch and Schwann cell transformation. Oncogene. 2004;23:1146-52 pubmed
    ..These data suggest that aberrant Notch signaling may contribute to the conversion of benign neurofibromas to MPNSTs. ..
  10. Klein D, Stayrook S, Shi F, Narayan K, Lemmon M. Structural basis for EGFR ligand sequestration by Argos. Nature. 2008;453:1271-5 pubmed publisher
    ..In addition, the structures presented here define requirements for the design of artificial EGF-sequestering proteins that would be valuable anti-cancer therapeutics. ..
  11. Wang J, Gao E, Rabinowitz J, Song J, Zhang X, Koch W, et al. Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol. 2011;300:H859-68 pubmed publisher
    ..We conclude that under catecholamine stress when [Na(+)](i) is high, PLM minimizes [Na(+)](i) overload by relieving its inhibition of Na(+)-K(+)-ATPase and preserves inotropy by simultaneously inhibiting Na(+)/Ca(2+) exchanger. ..
  12. Martinez Lage M, Molina Porcel L, Falcone D, McCluskey L, Lee V, Van Deerlin V, et al. TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation. Acta Neuropathol. 2012;124:285-91 pubmed
    ..We ruled out NIPA1 mutations in 419 additional cases of motor neuron disease. These findings suggest that hereditary spastic paraplegia due to NIPA1 mutations could represent a TDP-43 proteinopathy. ..
  13. Kim H, Kim T, Jeong B, Cho I, Han D, Takegahara N, et al. Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 2013;17:249-60 pubmed publisher
    ..These data demonstrate that Tmem64 is a positive modulator of osteoclast differentiation via SERCA2-dependent Ca(2+) signaling. ..
  14. Deliard S, Panossian S, Mentch F, Kim C, Hou C, Frackelton E, et al. The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry. Obesity (Silver Spring). 2013;21:159-63 pubmed publisher
  15. Jacobson S, Sumaroka A, Luo X, Cideciyan A. Retinal optogenetic therapies: clinical criteria for candidacy. Clin Genet. 2013;84:175-82 pubmed publisher
  16. Burns F, von Kannen S, Guy L, Raper J, Kamholz J, Chang S. DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension. Neuron. 1991;7:209-20 pubmed
    ..Consequently we have named this protein DM-GRASP, since it is an immunoglobulin-like restricted axonal surface protein that is expressed in the dorsal funiculus and ventral midline of the chick spinal cord. ..
  17. Grun J, Brinton M. Separation of functional West Nile virus replication complexes from intracellular membrane fragments. J Gen Virol. 1988;69 ( Pt 12):3121-7 pubmed
    ..Of the five detergents (Tween 20, maltoside, octylglucoside, lubrol PX and sodium deoxycholate) tested, sodium deoxycholate was the most efficient at releasing functional viral replication complexes from intracellular membranes. ..
  18. Lebowitz P, Prendergast G. Functional interaction between RhoB and the transcription factor DB1. Cell Adhes Commun. 1998;6:277-87 pubmed
    ..The results of this study suggest a novel mechanism by which certain Rho proteins may regulate transcription, through sequestration of a transcription factor. ..
  19. Pratico D, Tillmann C, Zhang Z, Li H, Fitzgerald G. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proc Natl Acad Sci U S A. 2001;98:3358-63 pubmed
    ..Furthermore, evidence that COX-1-derived prostanoids contribute to atherogenesis suggests that controlled evaluation of the effects of nonsteroidal anti-inflammatory drugs and/or aspirin on plaque progression in humans is timely. ..
  20. Hong L, Elbl T, Ward J, Franzini Armstrong C, Rybicka K, Gatewood B, et al. MUP-4 is a novel transmembrane protein with functions in epithelial cell adhesion in Caenorhabditis elegans. J Cell Biol. 2001;154:403-14 pubmed
    ..These findings support that MUP-4 is a junctional protein that functions in IF tethering, cell-matrix adherence, and mechanical coupling of tissues...
  21. Tafani M, Karpinich N, Hurster K, Pastorino J, Schneider T, Russo M, et al. Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. J Biol Chem. 2002;277:10073-82 pubmed
    ..It is concluded that the cleaving of PARP in Fas-mediated apoptosis allowed expression of an energy-dependent cell death program that included the translocation of full-length Bid to the mitochondria with induction of the MPT. ..
  22. Prevost N, Woulfe D, Tanaka T, Brass L. Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. Proc Natl Acad Sci U S A. 2002;99:9219-24 pubmed
  23. Liu Z, Shirakawa T, Li Y, Soma A, Oka M, Dotto G, et al. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol. 2003;23:14-25 pubmed
    ..This study provides the first evidence for regulation of Notch/Delta gene expression by an angiogenic growth factor and insight into the critical role of Notch signaling in arteriogenesis and angiogenesis. ..
  24. Hahn P, Lindsten T, Ying G, Bennett J, Milam A, Thompson C, et al. Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis. Invest Ophthalmol Vis Sci. 2003;44:3598-605 pubmed
    ..Future studies will investigate the potential role of Bax and Bak in mediating pathologic photoreceptor death. ..
  25. Stavridi E, Harris K, Huyen Y, Bothos J, Verwoerd P, Stayrook S, et al. Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Structure. 2003;11:1163-70 pubmed
    ..Thus, Mob proteins may regulate their target kinases through electrostatic interactions mediated by conserved charged surfaces. ..
  26. Yang W, Roland I, Godwin A, Xu X. Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells. Oncogene. 2005;24:7991-8002 pubmed
    ..The frequent loss of COX-2 expression suggests in ovarian cancer, unlike in other epithelial cancers, COX-2 expression does not contribute to ovarian cancer malignancy. ..
  27. Willis S, Davidoff C, Schilling J, Wanless A, Doranz B, Rucker J. Virus-like particles as quantitative probes of membrane protein interactions. Biochemistry. 2008;47:6988-90 pubmed publisher
    ..These particles serve as versatile probes for screening crude and purified antibody preparations for receptor specificity, epitope reactivity, and relative binding kinetics. ..
  28. Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, et al. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest. 2010;120:2795-804 pubmed publisher
    ..These studies identify STKs as essential downstream effectors of CCM signaling in development and disease that may regulate both endothelial and epithelial cell junctions. ..
  29. Vass R, Ashbridge E, Geser F, Hu W, Grossman M, Clay Falcone D, et al. Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis. Acta Neuropathol. 2011;121:373-80 pubmed publisher
    ..These findings implicate the FTLD-TDP risk gene TMEM106B in the development of cognitive impairment in ALS. ..
  30. Okegbe T, Dinardo S. The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling. Development. 2011;138:1259-67 pubmed publisher
    ..Because in mammals primordial germ cells also track through endoderm on their way to the genital ridge, our work raises the possibility that conserved mechanisms are employed to regulate germline niche formation...
  31. Zhou Z, Du X, Cai Z, Song X, Zhang H, Mizuno T, et al. Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. J Biol Chem. 2012;287:5317-26 pubmed publisher
    ..These findings provide the structural basis for understanding the function and the regulation of the LINC complex...
  32. Moravcevic K, Oxley C, Lemmon M. Conditional peripheral membrane proteins: facing up to limited specificity. Structure. 2012;20:15-27 pubmed publisher
    ..This broader range of recognition modes presents significant methodological challenges for a full structural understanding. ..
  33. Healey K, Katiyar S, Raj S, Edlind T. CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction. Mol Microbiol. 2012;86:303-13 pubmed publisher
    ..We conclude that membrane sphingolipids modulate echinocandin-Fks interaction. ..
  34. Littman M, Wiley C, Raducha M, Henthorn P. Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs. Mamm Genome. 2013;24:119-26 pubmed publisher
    ..06; 95 % CI = 4.24-19.35). This is the first molecular characterization of an inherited podocytopathy in dogs and may serve as a model for continued studies of complex genetic and environmental interactions in glomerular disease. ..
  35. Duran J, Makarewich C, Sharp T, Starosta T, Zhu F, Hoffman N, et al. Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res. 2013;113:539-52 pubmed publisher
  36. Mueller J, King L, Johnson K, Gao T, Nephew L, Kothari D, et al. Impact of EGF, IL28B, and PNPLA3 polymorphisms on the outcome of allograft hepatitis C: a multicenter study. Clin Transplant. 2016;30:452-60 pubmed publisher
    ..009). Recipient EGF, IL28B, and PNPLA3, and donor IL28B and PNPLA3 genotypes do not predict adverse outcomes in HCV LT recipients. A potential association exists between donor EGF genotype and cirrhosis. ..
  37. Vu H, Rosenbaum S, Capparelli C, Purwin T, Davies M, Berger A, et al. MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma. J Invest Dermatol. 2016;136:453-463 pubmed publisher
    ..Therefore, a decrease in MIG6 may promote the migration and invasiveness of MEK-inhibited mutant NRAS melanoma, especially in response to epidermal growth factor stimulation. ..
  38. Sarafian V, Kim Y, Poole R, Rea P. Molecular cloning and sequence of cDNA encoding the pyrophosphate-energized vacuolar membrane proton pump of Arabidopsis thaliana. Proc Natl Acad Sci U S A. 1992;89:1775-9 pubmed
    ..The lack of sequence identities between the tonoplast H(+)-PPase and any other characterized H+ pump or PPi-dependent enzyme implies a different evolutionary origin for this translocase. ..
  39. Berry G, Mallee J, Blouin J, Antonarakis S. The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene. Cytogenet Cell Genet. 1996;73:77-8 pubmed
    ..1 marker VN02, an expressed sequence tag (EST00541). Through DNA sequence analysis, it was determined that this STS marker if part of the 3' untranslated region of the SLC5A3 gene. ..
  40. Periz G, Fortini M. Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila. EMBO J. 1999;18:5983-93 pubmed
    ..Notch and several other transmembrane proteins are mislocalized in tissue clones homozygous for Ca-P60A mutations, demonstrating a general effect on membrane protein trafficking caused by a deficiency in Ca(2+)-ATPase. ..
  41. Siman R, Reaume A, Savage M, Trusko S, Lin Y, Scott R, et al. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. J Neurosci. 2000;20:8717-26 pubmed
    ..Instead, enhanced amyloidogenic processing of APP likely is critical to the pathogenesis of PS-1-linked FAD. ..
  42. Woulfe D, Jiang H, Mortensen R, Yang J, Brass L. Activation of Rap1B by G(i) family members in platelets. J Biol Chem. 2002;277:23382-90 pubmed
    ..In summary, activation of Rap1 can be stimulated by G(alpha)(i)- and PI3K-dependent mechanisms in platelets and by G(q)- and Ca(2+)-dependent mechanisms, both of which may play a role in promoting platelet activation. ..
  43. Siman R, Velji J. Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network. J Neurochem. 2003;84:1143-53 pubmed
    ..The findings provide further evidence that presenilin-containing complexes are the gamma-secretase, and indicate that presenilins also regulate gamma-secretase assembly. ..
  44. Hingorani S, Petricoin E, Maitra A, Rajapakse V, King C, Jacobetz M, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003;4:437-50 pubmed
    ..Finally, mice with PanINs have an identifiable serum proteomic signature, suggesting a means of detecting the preinvasive state in patients. ..
  45. Zhang Q, Pangrsic T, Kreft M, Krzan M, Li N, Sul J, et al. Fusion-related release of glutamate from astrocytes. J Biol Chem. 2004;279:12724-33 pubmed
  46. Ross D, Rao P, Kadesch T. Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. Mol Cell Biol. 2004;24:3505-13 pubmed
    ..The results presented in this study establish a new target downstream of the Notch-Hes-1 pathway and suggest a dual role for Hes-1 in adipocyte development. ..
  47. Teng Z, Chen J, Chau L, Galunic N, Regan R. Adenoviral transfer of the heme oxygenase-1 gene protects striatal astrocytes from heme-mediated oxidative injury. Neurobiol Dis. 2004;17:179-87 pubmed
    ..These results support the hypothesis that HO-1 protects astrocytes from heme-mediated oxidative injury. Specifically increasing astrocytic HO-1 by gene transfer may have a beneficial effect on hemorrhagic CNS injury. ..
  48. Fei P, Wang W, Kim S, Wang S, Burns T, Sax J, et al. Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell. 2004;6:597-609 pubmed
    ..Thus, Bnip3L, capable of attenuating tumorigenicity, mediates p53-dependent apoptosis under hypoxia, which provides a novel understanding of p53 in tumor suppression. ..
  49. Cohen M, Chen S, Ziyadeh F, Shea E, Hud E, Lautenslager G, et al. Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy. Kidney Int. 2005;68:1554-61 pubmed
    ..The findings causally implicate the increased glycated albumin associated with the diabetic state in the abnormal renal nephrin and VEGF expression found in diabetes, thereby promoting proteinuria and glomerulosclerosis. ..
  50. Hong C, Kwon S, Kim D. Multiple functions of junctin and junctate, two distinct isoforms of aspartyl beta-hydroxylase. Biochem Biophys Res Commun. 2007;362:1-4 pubmed
    ..Here we review recent findings concerning the expressional regulations and the proposed functions of junctin and junctate. ..
  51. Harper D, Theos A, Herman K, Tenza D, Raposo G, Marks M. Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes. J Biol Chem. 2008;283:2307-22 pubmed
    ..These data have important implications for the site and mechanism of fibril formation...
  52. Herrera W, Aleman T, Cideciyan A, Roman A, Banin E, Ben Yosef T, et al. Retinal disease in Usher syndrome III caused by mutations in the clarin-1 gene. Invest Ophthalmol Vis Sci. 2008;49:2651-60 pubmed publisher
    ..USH3A and USH2A share patterns of rod and cone dysfunction and retinal structural abnormalities. Peripheral function measurements showed USH3A to be more rapidly progressive than USH2A. ..
  53. Wang H, Kazanietz M. p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. Mol Biol Cell. 2010;21:1398-408 pubmed publisher
    ..Our study also highlights the relevance of C1 domains in protein-protein interactions in addition to their well-established lipid-binding properties. ..
  54. Shao Y, Aplin A. Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res. 2010;70:6670-81 pubmed publisher
    ..These findings delineate how mutant B-RAF protects melanoma cells from apoptosis and provide insight into possible resistance mechanisms to B-RAF inhibitors. ..
  55. Lee H, Mullins S, Franco Barraza J, Valianou M, Cukierman E, Cheng J. FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer. 2011;11:245 pubmed publisher
    ..Better understanding of the stromal influences that fuel progressive tumorigenic behaviors may allow the effective future use of targeted therapeutics aimed at disrupting specific tumor-stromal interactions. ..
  56. Yu Y, Maguire T, Alwine J. Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1. J Virol. 2012;86:2942-9 pubmed publisher
    ..Our studies suggest that HCMV induces adipocyte-like lipogenesis and overrides normal sterol feedback controls in order to maintain high levels of constitutive lipid synthesis during infection. ..
  57. Seeger Nukpezah T, Golemis E. The extracellular matrix and ciliary signaling. Curr Opin Cell Biol. 2012;24:652-61 pubmed publisher
    ..Further, a growing number of proteins have been determined to possess multiple roles in control of cilia and focal adhesion interactions with the ECM, further coordinating functionality. We summarize and discuss these recent findings. ..
  58. Soboloff J, Rothberg B, Madesh M, Gill D. STIM proteins: dynamic calcium signal transducers. Nat Rev Mol Cell Biol. 2012;13:549-65 pubmed publisher
    ..Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM. ..
  59. George B, Holzman L. Signaling from the podocyte intercellular junction to the actin cytoskeleton. Semin Nephrol. 2012;32:307-18 pubmed publisher
  60. Bønnelykke K, Sleiman P, Nielsen K, Kreiner Møller E, Mercader J, Belgrave D, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet. 2014;46:51-5 pubmed publisher
    ..These results demonstrate the strength of applying specific phenotyping in the search for asthma susceptibility genes. ..
  61. Lindsten T, Ross A, King A, Zong W, Rathmell J, Shiels H, et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell. 2000;6:1389-99 pubmed
    ..Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis. ..
  62. Siegel D. Recombinant monoclonal antibody technology. Transfus Clin Biol. 2002;9:15-22 pubmed
    ..The use of such recombinant methods in transfusion medicine is anticipated to play an important role in the development and production of renewable supplies of low-cost reagents for diagnostic and therapeutic applications. ..
  63. Lai J, Ho W, Yang J, Wang X, Song L, Douglas S. A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes. J Neuroimmunol. 2002;128:101-8 pubmed
    ..Since SP plays an important role in inflammation and viral infections, these studies may have potential applications for therapeutic intervention of inflammation and viral infection of immune cells. ..
  64. Raju G, Dimova N, Klein P, Huang H. SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1. J Biol Chem. 2003;278:428-37 pubmed
    ..These studies define a new mode of regulation for intracellular BMP/Smad1 signaling. ..
  65. Chen J, Regan R. Heme oxygenase-2 gene deletion increases astrocyte vulnerability to hemin. Biochem Biophys Res Commun. 2004;318:88-94 pubmed
    ..These results suggest that heme oxygenase protects astrocytes from heme-mediated oxidative injury and highlight the disparate effect of HO in neurons and astrocytes. ..
  66. Shulby S, Dolloff N, Stearns M, Meucci O, Fatatis A. CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells. Cancer Res. 2004;64:4693-8 pubmed
    ..Finally, fractalkine activates the PI3K/Akt survival pathway in human prostate cancer cells. ..
  67. Shcherbik N, Kee Y, Lyon N, Huibregtse J, Haines D. A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p. J Biol Chem. 2004;279:53892-8 pubmed
    ..They also suggest that the LPKY motif of Mga2p is required for Rsp5p binding and ubiquitination, and Rsp5p regulates Mga2p function by a mechanism that is independent of providing the partial degradation signal. ..
  68. Daniele L, Sauer B, Gallagher S, Pugh E, Philp N. Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice. Am J Physiol Cell Physiol. 2008;295:C451-7 pubmed publisher
    ..Based on these data, we hypothesize that disruption of Mct3 leads to a potentially reversible decrease in subretinal space pH, thereby reducing the magnitude of the light suppressible photoreceptor current. ..
  69. Lynch M, Cernetich Ott A, Weidanz W, Burns J. Prediction of merozoite surface protein 1 and apical membrane antigen 1 vaccine efficacies against Plasmodium chabaudi malaria based on prechallenge antibody responses. Clin Vaccine Immunol. 2009;16:293-302 pubmed publisher
    ..A similar approach to the evaluation of vaccine-induced antibody responses may be useful during clinical trials of Plasmodium falciparum AMA1 and MSP1(42) vaccines. ..
  70. Peixoto L, Chen F, Harb O, Davis P, Beiting D, Brownback C, et al. Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses. Cell Host Microbe. 2010;8:208-18 pubmed publisher
    ..These results highlight the value of integrative genomic approaches in prioritizing candidates for functional validation. ..
  71. Yadla S, Jabbour P, Shenkar R, Shi C, Campbell P, Awad I. Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution. Neurosurg Focus. 2010;29:E4 pubmed publisher
    ..Promising molecular and genetic therapies targeted at identified molecular aberrations are discussed as well. ..
  72. Rausch M, Beer L, Sammel M, Takacs P, Chung K, Shaunik A, et al. A disintegrin and metalloprotease protein-12 as a novel marker for the diagnosis of ectopic pregnancy. Fertil Steril. 2011;95:1373-8 pubmed publisher
    ..Further studies in additional patient populations and in combination with other biomarkers are needed. ..
  73. Moore D, Nygren P, Jo H, Boesze Battaglia K, Bennett J, Degrado W. Affinity of talin-1 for the ?3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. Proc Natl Acad Sci U S A. 2012;109:793-8 pubmed publisher
    ..Instead, the interactions appear to be tuned in such a way that the equilibrium between inactive and active integrin conformations can be readily regulated. ..
  74. Singh J, Cohen S, Mehendiratta V, Mendoza F, Jimenez S, DiMarino A, et al. Effects of scleroderma antibodies and pooled human immunoglobulin on anal sphincter and colonic smooth muscle function. Gastroenterology. 2012;143:1308-1318 pubmed publisher
  75. Pesciotta E, Sriswasdi S, Tang H, Mason P, Bessler M, Speicher D. A label-free proteome analysis strategy for identifying quantitative changes in erythrocyte membranes induced by red cell disorders. J Proteomics. 2012;76 Spec No.:194-202 pubmed publisher
    ..This article is part of a Special Issue entitled: Integrated omics. ..
  76. Yu Y, Pierciey F, Maguire T, Alwine J. PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. PLoS Pathog. 2013;9:e1003266 pubmed publisher
  77. Xia Y, Yan L, Huang B, Liu M, Liu X, Huang C. Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation. J Neurochem. 2014;129:99-106 pubmed publisher
  78. Schill E, Lake J, Tusheva O, Nagy N, Bery S, Foster L, et al. Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. Dev Biol. 2016;409:473-88 pubmed publisher
    ..These data raise concern that ibuprofen may increase Hirschsprung disease risk in some genetically susceptible children. ..
  79. Hwang S, Murga Zamalloa C, Brown N, Basappa J, MCDONNELL S, Mendoza Reinoso V, et al. Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma. Lab Invest. 2017;97:962-970 pubmed publisher
    ..Overall, our data demonstrate that PTBP1 interacts with PKM2 and promotes ALCL oncogenesis by facilitating PKM2-dependent activation of STAT3 within the nucleus. ..
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