Experts and Doctors on liver in Philadelphia, Pennsylvania, United States


Locale: Philadelphia, Pennsylvania, United States
Topic: liver

Top Publications

  1. Ciaccio P, Graves P, Bourque D, Glinsmann Gibson B, Halpert J. cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily. Biochim Biophys Acta. 1991;1088:319-22 pubmed
    ..The amino terminal sequence is identical to the first 28 residues of the dog P450IIIA form PBD-1. Southern blot analysis yields restriction patterns consistent with IIIA gene subfamily multiplicity. ..
  2. Pohlmann S, Soilleux E, Baribaud F, Leslie G, Morris L, Trowsdale J, et al. DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proc Natl Acad Sci U S A. 2001;98:2670-5 pubmed
  3. Rankin E, Higgins D, Walisser J, Johnson R, Bradfield C, Haase V. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005;25:3163-72 pubmed
    ..Furthermore, we provide evidence that individual HIF transcription factors may play distinct roles in the development of specific VHL disease manifestations. ..
  4. Blonski W, Reddy K. Evaluation of nonmalignant liver masses. Curr Gastroenterol Rep. 2006;8:38-45 pubmed
    ..An invasive approach is seldom required. This review discusses the various characteristics of the most common benign liver lesions and recommends a practical approach. ..
  5. Hiroki T, Song Y, Liebhaber S, Cooke N. The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatin. Nucleic Acids Res. 2006;34:2154-65 pubmed
    ..These data demonstrate the autonomy of the hDBP locus and suggest that this control is mediated by chromatin-based locus control determinants in close proximity to, and within the transcription unit. ..
  6. Ostrow A, Freeze H, Rychik J. Protein-losing enteropathy after fontan operation: investigations into possible pathophysiologic mechanisms. Ann Thorac Surg. 2006;82:695-700 pubmed
    ..Targeted investigations of these parameters may provide clues as to the mechanism of onset of PLE after Fontan operation. ..
  7. Weiser B, Gonye G, Sykora P, Crumm S, Cahill A. Chronic ethanol feeding causes depression of mitochondrial elongation factor Tu in the rat liver: implications for the mitochondrial ribosome. Am J Physiol Gastrointest Liver Physiol. 2011;300:G815-22 pubmed publisher
    ..In conclusion, chronic ethanol feeding results in a depletion of mitochondrial EF-Tu levels within the liver that is mathematically predicted to be responsible for the impaired mitochondrial protein synthesis seen in alcoholic animals. ..
  8. Joseph S, Ryan S, Pierson S, Renard Rooney D, Thomas A. The effect of mersalyl on inositol trisphosphate receptor binding and ion channel function. J Biol Chem. 1995;270:3588-93 pubmed
    ..This contrasts with the high affinity receptor/active Ca2+ channel induced by thimerosal, suggesting that even closely related thiol agents may interact at different thiol groups. ..
  9. Kozarsky K, Donahee M, Glick J, Krieger M, Rader D. Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol. 2000;20:721-7 pubmed
    ..Thus, stimulation of hepatic SR-BI activity may provide a novel target for therapeutic intervention in atherosclerotic cardiovascular disease. ..

More Information

Publications321 found, 100 shown here

  1. Mastellos D, Papadimitriou J, Franchini S, Tsonis P, Lambris J. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. J Immunol. 2001;166:2479-86 pubmed
    ..These results support a novel role for C5 in liver regeneration and strongly implicate the complement system as an important immunoregulatory component of hepatic homeostasis. ..
  2. Broedl U, Maugeais C, Millar J, Jin W, Moore R, Fuki I, et al. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res. 2004;94:1554-61 pubmed
    ..In light of these results, inhibition of EL has the potential to raise levels of atherogenic lipoproteins in addition to HDL-C levels. ..
  3. Reilly M, Taylor S, Franklin C, Sachais B, Cines D, Williams K, et al. Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model. J Thromb Haemost. 2006;4:2687-94 pubmed
    ..Host-specific factors, such as prothrombotic changes in platelet reactivity and/or endothelial activation, may influence the development of thrombosis in a subset of patients who develop anti-PF4/heparin antibodies. ..
  4. Thatch K, Schwartz M, Yoo E, Mendelson K, Duke D. Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease. J Pediatr Surg. 2008;43:2169-73 pubmed publisher
  5. Mehta G, Rothstein K. Health maintenance issues in cirrhosis. Med Clin North Am. 2009;93:901-15, viii-ix pubmed publisher
    ..There are also specific recommendations geared toward the patient with cirrhosis relating to slowing down the disease process, maintaining quality of life, and improving survival. ..
  6. Xu C, Cole P, Meyers D, Kormish J, Dent S, Zaret K. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science. 2011;332:963-6 pubmed publisher
    ..These studies reveal a functional "prepattern" of chromatin states within multipotent progenitors and potential targets to modulate cell fate induction. ..
  7. Sun Z, Feng D, Everett L, Bugge A, Lazar M. Circadian epigenomic remodeling and hepatic lipogenesis: lessons from HDAC3. Cold Spring Harb Symp Quant Biol. 2011;76:49-55 pubmed publisher
    ..Collectively, these data suggest that the circadian epigenomic remodeling controlled by HDAC3, and largely directed by Rev-erb?, is essential for homeostasis of the lipogenic process in liver. ..
  8. Yang L, Wang W, Qiu W, Guo Z, Bi E, Xu C. A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation. Hepatology. 2017;66:1387-1401 pubmed publisher
    ..Hepatology 2017;66:1387-1401). ..
  9. Di Costanzo L, Drury J, Penning T, Christianson D. Crystal structure of human liver Delta4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis. J Biol Chem. 2008;283:16830-9 pubmed publisher
    ..The locations of disease-linked mutations thought to be responsible for bile acid deficiency are also revealed. ..
  10. Favaro P, Finn J, Siner J, Wright J, High K, Arruda V. Safety of liver gene transfer following peripheral intravascular delivery of adeno-associated virus (AAV)-5 and AAV-6 in a large animal model. Hum Gene Ther. 2011;22:843-52 pubmed publisher
    ..In contrast, AAV-5 exhibited relatively high amounts of vector DNA in tissues other than the liver. Together these data are useful to further define the safety and potential for clinical translation of these AAV vectors. ..
  11. Tulp O, Abdollahi A, Stevens C, Schnitzer Polokoff R. The effects of the intestinal glucosidase inhibitor acarbose on cholesterogenesis in corpulent rats. Comp Biochem Physiol A Comp Physiol. 1991;100:763-8 pubmed
    ..abstract truncated at 250 words) ..
  12. Davis W, Schultz R. Molecular cloning and expression of the mouse translation initiation factor eIF-1A. Nucleic Acids Res. 1998;26:4739-47 pubmed
    ..Each of the promoters is used by the pre-implantation mouse embryo, since we have been able to amplify selectively each of the five individual eIF-1A transcripts initiated from each promoter and start site in the 2-cell mouse embryo. ..
  13. Das Sarma J, Fu L, Hingley S, Lai M, Lavi E. Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis. J Neurovirol. 2001;7:432-6 pubmed
    ..One or more of the sites of these mutations in the MHV-A59 genome are likely to contribute to demyelination and hepatitis. ..
  14. Zelent D, Golson M, Koeberlein B, Quintens R, Van Lommel L, Buettger C, et al. A glucose sensor role for glucokinase in anterior pituitary cells. Diabetes. 2006;55:1923-9 pubmed
  15. Jiang Q, Dibra F, Lee M, Oldenburg R, Uitto J. Overexpression of fetuin-a counteracts ectopic mineralization in a mouse model of pseudoxanthoma elasticum (abcc6(-/-)). J Invest Dermatol. 2010;130:1288-96 pubmed publisher
  16. McClendon A, Dean J, Ertel A, Fu Z, Rivadeneira D, Reed C, et al. RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage. Gastroenterology. 2011;141:1439-50 pubmed publisher
    ..The effects RB and p53 loss are determined by the tissue environment; cell stresses that promote aggressive disease reveal the functions of these tumor suppressors. ..
  17. Narayan S, Master S, Sireci A, Bierl C, Stanley P, Li C, et al. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. PLoS ONE. 2012;7:e35048 pubmed publisher
    ..Most of the interactions appear to be independent of SCHAD's role in the penultimate step of fatty acid oxidation suggesting an organizational, structural or non-enzymatic role for the SCHAD protein. ..
  18. Palladino A, Chen J, Kallish S, Stanley C, Bennett M. Measurement of tissue acyl-CoAs using flow-injection tandem mass spectrometry: acyl-CoA profiles in short-chain fatty acid oxidation defects. Mol Genet Metab. 2012;107:679-83 pubmed publisher
    ..There was more modest accumulation of medium chain species including 3-hydroxyacyl-CoA's consistent with the known chain-length specificity of the SCHAD enzyme. ..
  19. Kung C, Leu J, Basu S, Khaku S, Anokye Danso F, Liu Q, et al. The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction. Cell Rep. 2016;14:2413-25 pubmed publisher
    ..Gene expression analyses and studies with small-molecule inhibitors indicate that the p53 target genes Tnf and Npc1l1 underlie this phenotype. These results shed light on the role of p53 in obesity, metabolism, and inflammation. ..
  20. Susiarjo M, Xin F, Stefaniak M, Mesaros C, Simmons R, Bartolomei M. Bile Acids and Tryptophan Metabolism Are Novel Pathways Involved in Metabolic Abnormalities in BPA-Exposed Pregnant Mice and Male Offspring. Endocrinology. 2017;158:2533-2542 pubmed publisher
    ..Our study has therefore identified two pathways (bile acid and tryptophan metabolism) that potentially underlie BPA-induced maternal and fetal metabolic disease...
  21. Fetzer D, Rodgers S, Harris A, Kono Y, Wasnik A, Kamaya A, et al. Screening and Surveillance of Hepatocellular Carcinoma: An Introduction to Ultrasound Liver Imaging Reporting and Data System. Radiol Clin North Am. 2017;55:1197-1209 pubmed publisher
    ..It is anticipated that US LI-RADS will improve the performance of ultrasound for HCC screening and surveillance and unify management recommendations...
  22. Flubacher M, Bear S, Tsichlis P. Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis. J Virol. 1994;68:7709-16 pubmed
  23. Lee H, Ogawa H, Fujioka M, Gerton G. Guanidinoacetate methyltransferase in the mouse: extensive expression in Sertoli cells of testis and in microvilli of caput epididymis. Biol Reprod. 1994;50:152-62 pubmed
  24. Yang Y, Wilson J. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science. 1996;273:1862-4 pubmed
    ..Thus, CD40L-dependent activation of T cells occurs through signaling of CD40 in the antigen-presenting cell to enhance requisite costimulatory pathways that include B7. ..
  25. Sund N, Ang S, Sackett S, Shen W, Daigle N, Magnuson M, et al. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol. 2000;20:5175-83 pubmed
    ..This is the first example of such functional dichotomy for a tissue specification transcription factor. ..
  26. Kishida T, Kostetskii I, Zhang Z, Martinez F, Liu P, Walkley S, et al. Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J Biol Chem. 2004;279:19276-85 pubmed
    ..These observations suggest that the Mln64 START domain is largely dispensable for sterol metabolism in mice. ..
  27. DeAngelis R, Markiewski M, Taub R, Lambris J. A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology. 2005;42:1148-57 pubmed
    ..In conclusion, high fat in the diet impairs liver regeneration and predisposes steatotic livers to increased injury through IkappaBalpha overexpression and subsequent NF-kappaB inhibition. ..
  28. Matsuzaki Y, Nakano A, Jiang Q, Pulkkinen L, Uitto J. Tissue-specific expression of the ABCC6 gene. J Invest Dermatol. 2005;125:900-5 pubmed
    ..The results have implications for mutation detection strategies in PXE by RT-PCR, and they further support the notion that PXE is a primary metabolic disorder...
  29. Qi Y, Nie Z, Lee Y, Singhal N, Scherer P, Lazar M, et al. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes. 2006;55:3083-90 pubmed
    ..Together, these results provide strong support for an important role of resistin in insulin resistance and diabetes associated with genetic or diet-induced obesity. ..
  30. Cherala G, Shapiro B, D mello A. Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat. Drug Metab Dispos. 2007;35:1057-63 pubmed
    ..In summary, perinatal LPDs produced transient alterations in activities of select hepatic P450s and resulted in a gender- and diet-dependent long-term alteration in hexobarbital pharmacodynamics. ..
  31. Boden G, Salehi S, Cheung P, Homko C, Song W, Loveland Jones C, et al. Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue. Obesity (Silver Spring). 2013;21:1208-14 pubmed publisher
  32. Krishnaiah S, Wu G, Altman B, Growe J, Rhoades S, Coldren F, et al. Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism. Cell Metab. 2017;25:961-974.e4 pubmed publisher
    ..These results provide the first comprehensive views of circadian liver and cell-autonomous metabolism. ..
  33. Benau D, Schumacher W, McGuire E, Fitzpatrick McElligott S, Storey B, Roth S. Light microscopic localization of glycosyltransferase activities in cells and tissues. J Histochem Cytochem. 1990;38:23-30 pubmed
    ..With the appropriate sugar donor and acceptor, this assay should detect any transferase, other than the glucosyltransferases, that utilizes UDP sugars. ..
  34. Yimlamai D, Christodoulou C, Galli G, Yanger K, Pepe Mooney B, Gurung B, et al. Hippo pathway activity influences liver cell fate. Cell. 2014;157:1324-38 pubmed publisher
  35. Zaret K. From Endoderm to Liver Bud: Paradigms of Cell Type Specification and Tissue Morphogenesis. Curr Top Dev Biol. 2016;117:647-69 pubmed publisher
  36. Costanzi C, Pehrson J. Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. Nature. 1998;393:599-601 pubmed
    ..Here we show that an mH2A1 subtype is preferentially concentrated in the inactive X chromosome of female mammals. Our results link X inactivation with a major alteration of the nucleosome, the primary structural unit of chromatin. ..
  37. Cox J, Kim N, Traish A, Christianson D. Arginase-boronic acid complex highlights a physiological role in erectile function. Nat Struct Biol. 1999;6:1043-7 pubmed
    ..Therefore, human penile arginase is a potential target for therapeutic intervention in the treatment of erectile dysfunction. ..
  38. Nazarian L, Park J, Halpern E, Parker L, Johnson P, Lev Toaff A, et al. Size of colorectal liver metastases at abdominal CT: comparison of precontrast and postcontrast studies. Radiology. 1999;213:825-30 pubmed
    ..To investigate whether measurements of hepatic metastases from colorectal carcinoma before contrast material administration are significantly different statistically from measurements after contrast material administration...
  39. Agrawal A, Shapiro B. Neonatal phenobarbital imprints overexpression of cytochromes P450 with associated increase in tumorigenesis and reduced life span. FASEB J. 2005;19:470-2 pubmed
  40. Vakoc C, Mandat S, Olenchock B, Blobel G. Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell. 2005;19:381-91 pubmed
    ..Both the presence of HP1gamma and H3K9 methylation are dependent upon elongation by RNA polymerase II. These findings demonstrate novel roles for H3K9 methylation and HP1gamma in transcription activation. ..
  41. Bell P, Moscioni A, McCarter R, Wu D, Gao G, Hoang A, et al. Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver. Mol Ther. 2006;14:34-44 pubmed
    ..It appears that AAV vectors alone do not contribute to the formation of tumors in these strains of mice although the expression of LacZ alone or in combination with vector may be problematic...
  42. Teff K. Visceral nerves: vagal and sympathetic innervation. JPEN J Parenter Enteral Nutr. 2008;32:569-71 pubmed publisher
    ..In conclusion, the vagus nerve, part of the parasympathetic nervous system, plays a critical role in the regulation of blood glucose levels and is an often overlooked factor contributing to glucose homeostasis. ..
  43. Juskeviciute E, Vadigepalli R, Hoek J. Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat. BMC Genomics. 2008;9:527 pubmed publisher
  44. Jin Y, Duan L, Lee S, Kloosterboer H, Blair I, Penning T. Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism. J Biol Chem. 2009;284:10013-22 pubmed publisher
  45. Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga M, Kaminski M, et al. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog. 2009;5:e1000313 pubmed publisher
  46. Markiewski M, DeAngelis R, Strey C, Foukas P, Gerard C, Gerard N, et al. The regulation of liver cell survival by complement. J Immunol. 2009;182:5412-8 pubmed publisher
    ..In conclusion, this study documents functions of complement proteins as prosurvival factors that, through their interactions with cytokines, inhibit apoptotic signaling in proliferating cells of epithelial origin. ..
  47. You S, Liao X, Weiss R, Lazar M. The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo. Mol Endocrinol. 2010;24:1359-67 pubmed publisher
    ..Thus, the NCoR interaction with HDAC3 modulates expression of both positively- and negatively-regulated genes by TH in vivo. ..
  48. Wang Z, Zhou Q, Kruh G, Gallo J. Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011;39:2155-61 pubmed publisher
    ..The findings confirmed that both Abcc2 and Abcc3 significantly influenced the PK properties of MTX, and depending on the MTX dose and strain, alternate elimination pathways were elicited and saturable...
  49. Wan M, Leavens K, Hunter R, Koren S, von Wilamowitz Moellendorff A, Lu M, et al. A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition. Cell Metab. 2013;18:99-105 pubmed publisher
  50. Joseph S, Lin C, Pierson S, Thomas A, Maranto A. Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells. J Biol Chem. 1995;270:23310-6 pubmed
    ..We conclude that the WB cell contains both type-I and type-III IP3R isoforms and that a proportion of these receptors exist as heterotetramers. ..
  51. Du K, Peng Y, Greenbaum L, Haber B, Taub R. HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a possible cause of increased EIIIB expression in proliferating liver. Mol Cell Biol. 1997;17:4096-104 pubmed
    ..Changes in fibronectin forms may be important in modifying liver architecture during the proliferative response, thus providing a potential mechanism by which SR proteins may participate in cellular growth control. ..
  52. Armstead V, Opentanova I, Minchenko A, Lefer A. Tissue factor expression in vital organs during murine traumatic shock: role of transcription factors AP-1 and NF-kappaB. Anesthesiology. 1999;91:1844-52 pubmed
    ..The purpose of this study was to investigate TF expression in vital organs and to determine possible regulatory mechanisms of TF expression in the lung during traumatic shock in rats...
  53. Leu J, Crissey M, Leu J, Ciliberto G, Taub R. Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol Cell Biol. 2001;21:414-24 pubmed
  54. Hudes G, Haas N, Yeslow G, Gillon T, Gunnarsson P, Ellman M, et al. Phase I clinical and pharmacologic trial of intravenous estramustine phosphate. J Clin Oncol. 2002;20:1115-27 pubmed
    ..High-dose IV EMP can be administered safely as a weekly short infusion to patients with HRPC. High peak concentrations of active metabolites after IV EMP may provide an advantage over oral EMP in antimicrotubule drug combinations. ..
  55. Leu J, Crissey M, Craig L, Taub R. Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation. Mol Cell Biol. 2003;23:1251-9 pubmed
    ..These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways. ..
  56. Tremblay K, Zaret K. Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev Biol. 2005;280:87-99 pubmed
  57. Bathori G, Csordás G, Garcia Perez C, Davies E, Hajnoczky G. Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC). J Biol Chem. 2006;281:17347-58 pubmed
    ..Thus, the VDAC gating is dependent on the physiological concentrations of cations, allowing the OMM to control the passage of ions and some small molecules. The OMM barrier is likely to decrease during the calcium signal. ..
  58. Vonderheide R, Flaherty K, Khalil M, Stumacher M, Bajor D, Hutnick N, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol. 2007;25:876-83 pubmed
    ..Further studies of repeated doses of CP-870,893 alone and in combination with other antineoplastic agents are warranted. ..
  59. Pellizzon M, Billheimer J, Bloedon L, Szapary P, Rader D. Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models. J Am Coll Nutr. 2007;26:66-75 pubmed
    ..The combined data suggest that the lipid lowering effect of flax is not hepatic mediated and may be at the level of cholesterol absorption and/or bile acid reabsorption. ..
  60. Liu Y, Millar J, Cromley D, Graham M, Crooke R, Billheimer J, et al. Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice. Biochim Biophys Acta. 2008;1781:97-104 pubmed publisher
    ..Our findings indicate that the majority of TG destined for secretion by liver is synthesized by DGAT2 and suggests that DGAT2 may be a therapeutic target for treatment of hypertriglyceridemia, hepatic steatosis and obesity. ..
  61. Thangavel C, Shapiro B. Inherent sexually dimorphic expression of hepatic CYP2C12 correlated with repressed activation of growth hormone-regulated signal transduction in male rats. Drug Metab Dispos. 2008;36:1884-95 pubmed publisher
  62. Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner K. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metab. 2009;10:55-62 pubmed publisher
    ..Collectively, these results provide genetic evidence supporting a role for CRTC2 in the transcriptional response to fasting, but indicate only a limited contribution of this cofactor to the maintenance of glucose homeostasis. ..
  63. Wan M, Leavens K, Saleh D, Easton R, Guertin D, Peterson T, et al. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab. 2011;14:516-27 pubmed publisher
    ..These data show that insulin signaling through Akt2 promotes anabolic lipid metabolism independent of Foxa2 or FoxO1 and through pathways additional to the mTORC1-dependent activation of SREBP1c. ..
  64. Harbut M, Patel B, Yeung B, McNamara C, Bright A, Ballard J, et al. Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. Proc Natl Acad Sci U S A. 2012;109:21486-91 pubmed publisher
    ..Collectively, these data suggest ER quality control as a vulnerability of protozoan parasites, and that SPP inhibition may represent a suitable transmission blocking antimalarial strategy and potential pan-protozoan drug target. ..
  65. Anguela X, Sharma R, Doyon Y, Miller J, Li H, Haurigot V, et al. Robust ZFN-mediated genome editing in adult hemophilic mice. Blood. 2013;122:3283-7 pubmed publisher
    ..These results broaden the therapeutic potential of AAV/ZFN-mediated genome editing in the liver and could expand this strategy to other nonreplicating cell types. ..
  66. Ma D, Liu T, Chang L, Rui C, Xiao Y, Li S, et al. The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis. J Biol Chem. 2015;290:31003-12 pubmed publisher
    ..These results illustrate an unexpected mechanism through which the biological clock regulates cholesterol homeostasis through its regulation of non-rhythmic genes in the liver. ..
  67. Carter R, Avadhani N. Cloning and characterization of the mouse cytochrome c oxidase subunit IV gene. Arch Biochem Biophys. 1991;288:97-106 pubmed
    ..The unique features of the gene, as well as its characteristics common to other nuclear genes coding for different mitochondrial proteins, have been discussed. ..
  68. Randolph R, Ross A. Vitamin A status regulates hepatic lecithin: retinol acyltransferase activity in rats. J Biol Chem. 1991;266:16453-7 pubmed
  69. Velchik M, Roth G, Wegener W, Alavi A. Bronchobiliary fistula detected by cholescintigraphy. J Nucl Med. 1991;32:136-8 pubmed
    ..The procedure was complicated by the development of a subphrenic abscess that required percutaneous biliary drainage...
  70. Gonatas J, Mezitis S, Stieber A, Fleischer B, Gonatas N. MG-160. A novel sialoglycoprotein of the medial cisternae of the Golgi apparatus [published eeratum appears in J Biol Chem 1989 Mar 5;264(7):4264]. J Biol Chem. 1989;264:646-53 pubmed
    ..Alternatively, resident neuronal Golgi sialoglycoproteins may acquire sialic acid in trans elements of the apparatus and then shuttle back in medial cisternae. ..
  71. Masters B, Kelly E, Quaife C, Brinster R, Palmiter R. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc Natl Acad Sci U S A. 1994;91:584-8 pubmed
    ..This proves that these widely expressed MTs are not essential for development but that they do protect against cadmium toxicity. These mice provide a means for testing other proposed functions of MT in vivo. ..
  72. Matsuura T, Ross A. Regulation of hepatic lecithin: retinol acyltransferase activity by retinoic acid. Arch Biochem Biophys. 1993;301:221-7 pubmed
    ..We conclude that retinoic acid, an important end product of retinol metabolism, regulates a key aspect of hepatic retinol metabolism through its regulatory activity on liver LRAT. ..
  73. Bazel S, Andrejko K, Chen J, Deutschman C. Hepatic gene expression and cytokine responses to sterile inflammation: comparison with cecal ligation and puncture sepsis in the rat. Shock. 1999;11:347-55 pubmed
    ..This differed significantly from observations after CLP. We conclude that CLP-induced alterations in hepatic gene expression may reflect differences in IL-6 activity. ..
  74. Zaret K. Liver specification and early morphogenesis. Mech Dev. 2000;92:83-8 pubmed
    ..The initial stages of hepatogenesis are therefore beginning to be understood, and serve as a paradigm for the development of other tissues from the endoderm. ..
  75. Cho H, Mu J, Kim J, Thorvaldsen J, Chu Q, Crenshaw E, et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science. 2001;292:1728-31 pubmed
    ..These data establish Akt2 as an essential gene in the maintenance of normal glucose homeostasis. ..
  76. Raper S, Yudkoff M, Chirmule N, Gao G, Nunes F, Haskal Z, et al. A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. Hum Gene Ther. 2002;13:163-75 pubmed
    ..The low levels of gene transfer detected in this trial suggest that at the doses tested, significant metabolic correction did not occur. ..
  77. Wallace K, Pack M. Unique and conserved aspects of gut development in zebrafish. Dev Biol. 2003;255:12-29 pubmed
  78. Veronese M, Gillen L, Burke J, Dorval E, Hauck W, Pequignot E, et al. Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice. J Clin Pharmacol. 2003;43:831-9 pubmed
  79. Bort R, Martinez Barbera J, Beddington R, Zaret K. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development. 2004;131:797-806 pubmed
    ..Other endodermal transcription factors may also function morphogenetically rather than by directly regulating tissue-specific programs. ..
  80. Lian Z, Liu J, Li L, Li X, Tufan N, Wu M, et al. Human S15a expression is upregulated by hepatitis B virus X protein. Mol Carcinog. 2004;40:34-46 pubmed
    ..Hence, HBxAg upregulated the expression of S15a, the latter of which participates in the development of HCC, perhaps by altering the integrity of translation. ..
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    ..IX variants did not trigger antibody formation to F.IX in mice tolerant to F.IX-WT. These studies demonstrate that F.IX variants provide a promising strategy to improve the efficacy for a variety of gene-based therapies for hemophilia B. ..
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    ..We demonstrate that intestinal-specific LXR agonism promotes macrophage RCT in vivo and that macrophage LXR itself plays an important, but not predominant, role in promoting RCT in response to an LXR agonist. ..
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