Genomes and Genes
Experts and Doctors on hippocampus in Philadelphia, Pennsylvania, United States
Locale: Philadelphia, Pennsylvania, United States
Publications167 found, 100 shown here
- Wood M, Kaplan M, Brensinger C, Guo W, Abel T. Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory. Hippocampus. 2005;15:610-21 pubmed..Our results suggest a novel role for ubiquitin C-terminal hydrolase enzymes in mammals in spatial learning and working memory. ..
- Yu W, Solowska J, Qiang L, Karabay A, Baird D, Baas P. Regulation of microtubule severing by katanin subunits during neuronal development. J Neurosci. 2005;25:5573-83 pubmed
- Wolf J, Finkel L, Contreras D. Sublinear summation of afferent inputs to the nucleus accumbens in the awake rat. J Physiol. 2009;587:1695-704 pubmed publisher..These results suggest that sublinear integration of afferent input from the PFC and HC is the dominant mode of integration of Nacb cells in the awake animal, which has implications for corticostriatal models of psychiatric dysfunction. ..
- Lu B, Su Y, Das S, Liu J, Xia J, Ren D. The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell. 2007;129:371-83 pubmed..Thus, NALCN, a nonselective cation channel, forms the background Na(+) leak conductance and controls neuronal excitability. ..
- Singh H, Li M, Hall L, Chen S, Sukur S, Lu R, et al. MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain. Neuroscience. 2016;317:76-107 pubmed publisher..The interaction of MaxiK channel with GAT3 opens the possibility of a role of MaxiK channel in GABA homeostasis and signaling. ..
- Marchenko O, Das S, Yu J, Novak I, Rodionov V, Efimova N, et al. A minimal actomyosin-based model predicts the dynamics of filopodia on neuronal dendrites. Mol Biol Cell. 2017;28:1021-1033 pubmed publisher..The model predicts the response of the system to each of these experimental perturbations, supporting the hypothesis that our actomyosin-driven mechanism controls dendritic filopodia dynamics. ..
- Crino P, Jin H, Shumate M, Robinson M, Coulter D, Brooks Kayal A. Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Epilepsia. 2002;43:211-8 pubmed..Upregulation of EAAT3/EAAC1 in hippocampal and neocortical epilepsy may be an important modulator of extracellular glutamate concentrations and may occur as a response to recurrent seizures in these cell types. ..
- Murchison C, Zhang X, Zhang W, Ouyang M, Lee A, Thomas S. A distinct role for norepinephrine in memory retrieval. Cell. 2004;117:131-43 pubmed..These findings may be relevant to symptoms in several neuropsychiatric disorders as well as the treatment of cardiac failure with beta blockers. ..
- Ances B, Vitaliani R, Taylor R, Liebeskind D, Voloschin A, Houghton D, et al. Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain. 2005;128:1764-77 pubmed
- Balu D, Lucki I. Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology. Neurosci Biobehav Rev. 2009;33:232-52 pubmed publisher..Finally, this review discusses the potential of using hippocampal neurogenesis as a therapeutic target for these disorders. ..
- Schneider J, Kidd S, Anderson D. Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus. Toxicol Lett. 2013;217:75-81 pubmed publisher..These data suggest potential epigenetic effects of developmental Pb exposure on DNA methylation mediated at least in part through dysregulation of methyltransferases. ..
- Knobelman D, Hen R, Lucki I. Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) autoreceptors in different brain regions of the mouse. J Pharmacol Exp Ther. 2001;298:1083-91 pubmed
- Pan Z, Kao T, Horvath Z, Lemos J, Sul J, Cranstoun S, et al. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci. 2006;26:2599-613 pubmed..This includes the historical period when myelin also evolved. ..
- Ortinski P, Dong J, Mungenast A, Yue C, Takano H, Watson D, et al. Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nat Neurosci. 2010;13:584-91 pubmed publisher..Thus, reactive astrocytosis could generate local synaptic perturbations, leading to broader functional deficits associated with neurologic disease. ..
- Gerber A, Bale T. Antiinflammatory treatment ameliorates HPA stress axis dysfunction in a mouse model of stress sensitivity. Endocrinology. 2012;153:4830-7 pubmed..The specificity of these effects in a stress-sensitive genotype highlights the importance of utilizing a model of stress dysregulation in the examination of factors that may translate to neuropsychiatric disease. ..
- Snyder M, Adelman A, Gao W. Gestational methylazoxymethanol exposure leads to NMDAR dysfunction in hippocampus during early development and lasting deficits in learning. Neuropsychopharmacology. 2013;38:328-40 pubmed publisher..These changes may be involved in disease initiation and cognitive impairment in the early stage of SZ. ..
- Jones S, Korobova F, Svitkina T. Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments. J Cell Biol. 2014;205:67-81 pubmed publisher..We propose that stable actin filaments play a structural role for formation of the AIS diffusion barrier, whereas dynamic actin may promote AIS coat remodeling. ..
- Ramirez L, Goukasian N, Porat S, Hwang K, Eastman J, Hurtz S, et al. Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy. Neurobiol Aging. 2016;39:82-9 pubmed publisher..To our knowledge, this is the first report of the effect of ABCA7 and MS4A6A on neurodegeneration. ..
- Jin L, Wang H, Friedman E. Stimulated D(1) dopamine receptors couple to multiple Galpha proteins in different brain regions. J Neurochem. 2001;78:981-90 pubmed..The results indicate that in addition to the D(1)/G(s)/adenylyl cyclase system, brain D(1)-like dopamine receptor sites activate phospholipase C through Galpha(q) protein. ..
- Harvey J. Role of the serotonin 5-HT(2A) receptor in learning. Learn Mem. 2003;10:355-62 pubmed..It was concluded that the 5-HT2A receptor demonstrates constitutive activity, and that variations in this activity can produce profound alterations in cognitive states...
- Rioux L, Arnold S. The expression of retinoic acid receptor alpha is increased in the granule cells of the dentate gyrus in schizophrenia. Psychiatry Res. 2005;133:13-21 pubmed..Understanding the basis for this and how it affects downstream molecular pathways associated with hippocampal plasticity may provide insight into the dysfunctional connectivity of schizophrenia. ..
- Qiang L, Yu W, Andreadis A, Luo M, Baas P. Tau protects microtubules in the axon from severing by katanin. J Neurosci. 2006;26:3120-9 pubmed..These results, which validate our hypothesis, also suggest a potential explanation for why axonal microtubules deteriorate in neuropathies involving the dissociation of tau from the microtubules. ..
- Davis J, Kenney J, Gould T. Hippocampal alpha4beta2 nicotinic acetylcholine receptor involvement in the enhancing effect of acute nicotine on contextual fear conditioning. J Neurosci. 2007;27:10870-7 pubmed..The present results suggest a critical role for alpha4beta2 nAChRs in the dorsal hippocampus for mediating the enhancing effect of nicotine on contextual fear conditioning. ..
- Schrlau M, Dun N, Bau H. Cell electrophysiology with carbon nanopipettes. ACS Nano. 2009;3:563-8 pubmed publisher..In addition to their superior injection capabilities reported previously, CNPs are capable of multifunctionality, enabling, for example, concurrent intracellular injection and electrical measurements without damaging cells. ..
- Lai M, Hughes E, Peng X, Zhou L, Gleichman A, Shu H, et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009;65:424-34 pubmed publisher..To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures...
- Turner J, Castellano L, Blendy J. Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline. Nicotine Tob Res. 2011;13:41-6 pubmed publisher..These findings suggest receptor upregulation as a mechanism for its efficacy as a smoking cessation therapy. ..
- Vecsey C, Wimmer M, Havekes R, Park A, Perron I, Meerlo P, et al. Daily acclimation handling does not affect hippocampal long-term potentiation or cause chronic sleep deprivation in mice. Sleep. 2013;36:601-7 pubmed publisher..Here, we examine whether acclimation handling, performed as in our sleep deprivation studies, alters sleep/wake behavior, stress, or forms of hippocampal synaptic plasticity that are impaired by sleep deprivation...
- Wisse L, Butala N, Das S, Davatzikos C, Dickerson B, Vaishnavi S, et al. Suspected non-AD pathology in mild cognitive impairment. Neurobiol Aging. 2015;36:3152-3162 pubmed publisher..Subthreshold levels of cerebral amyloidosis are unlikely to play a role in SNAP-MCI, but pathologies involving the hippocampus and cerebrovascular disease may underlie the neurodegeneration and cognitive impairment in this group. ..
- Nakatsu Y, Tyndale R, DeLorey T, Durham Pierre D, Gardner J, McDanel H, et al. A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature. 1993;364:448-50 pubmed..The human homologue of the region deleted in p(cp) mice is associated with Angelman syndrome. Thus, p(cp) mice may be useful in defining the region containing the gene(s) for this syndrome. ..
- Lin R, Matesic D, McKenzie R, Devlin T, Von Lubitz D. Neuroprotective activity of dimer of 16,16'-dimethyl-15-dehydroprostaglandin B1 (di-Calciphor) in cerebral ischemia. Brain Res. 1993;606:130-4 pubmed..The lack of adverse side effects may facilitate the potential therapeutic use of this drug in preventing neuronal damage caused by stroke. ..
- Brooks Kayal A, Shumate M, Jin H, Lin D, Rikhter T, Holloway K, et al. Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells. J Neurosci. 1999;19:8312-8 pubmed..These data demonstrate that specific GABAR subunit mRNAs exhibit coordinated control of expression in individual DGCs, which has significant impact on inhibitory function. ..
- Galvin J, Uryu K, Lee V, Trojanowski J. Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Proc Natl Acad Sci U S A. 1999;96:13450-5 pubmed..Our findings broaden the concept of neurodegenerative "synucleinopathies" by implicating betaS and gammaS, in addition to alphaS, in the onset/progression of PD and DLB. ..
- Buono R, Ferraro T, O Connor M, Sperling M, Ryan S, Scattergood T, et al. Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy. Epilepsia. 2001;42:782-4 pubmed..10). These data suggest that this IL-1beta promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry. ..
- Wang L, Liu X, Lenox R. Transcriptional regulation of mouse MARCKS promoter in immortalized hippocampal cells. Biochem Biophys Res Commun. 2002;292:969-79 pubmed..The discovery of the activator function of the MARCKS distal promoter region, and its potential interaction with multiple Sp proteins may provide a new clue to the understanding of Macs transcriptional regulation in brain. ..
- Li D, Wang F, Lai M, Chen Y, Zhang J. A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C. J Neurosci. 2005;25:1914-23 pubmed..Thus, the PP2calpha-Ca2+ channel complex is responsible for rapid dephosphorylation of Ca2+ channels and may contribute to regulation of synaptic transmission in neurons. ..
- Fenik V, Ogawa H, Davies R, Kubin L. Carbachol injections into the ventral pontine reticular formation activate locus coeruleus cells in urethane-anesthetized rats. Sleep. 2005;28:551-9 pubmed..Our goal was to determine whether carbachol injections into the ventral nucleus pontis oralis elicits comparable effects...
- Vitaliani R, Mason W, Ances B, Zwerdling T, Jiang Z, Dalmau J. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005;58:594-604 pubmed..Recognition of this disorder is important because despite the severity of the symptoms, patients usually recover. The location and function of the isolated antigen suggest that the disorder is directly mediated by antibodies...
- Qiu C, Johnson B, Tallent M. K+ M-current regulates the transition to seizures in immature and adult hippocampus. Epilepsia. 2007;48:2047-58 pubmed..This selective function of M-channels likely contributes to the transient window of vulnerability to seizures that occurs with BFNC. ..
- Kidd S, Anderson D, Schneider J. Postnatal lead exposure alters expression of forebrain p75 and TrkA nerve growth factor receptors. Brain Res. 2008;1195:113-9 pubmed publisher..The significance of these effects on the septo-hippocampal and striatal functioning remains to be studied. ..
- Qiang L, Yu W, Liu M, Solowska J, Baas P. Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules. Mol Biol Cell. 2010;21:334-44 pubmed publisher..Collectively, these results indicate that bFGF enhances axonal branch formation by augmenting the severing of microtubules through both a spastin-based mode and a katanin-based mode. ..
- Onksen J, Brown E, Blendy J. Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect. Neuropsychopharmacology. 2011;36:960-9 pubmed publisher..Furthermore, attenuated capacity for synaptic remodeling may underlie these behaviors. ATR deletion may serve as a valuable model to study the various proposed roles of newborn neurons in the hippocampus. ..
- Risbud R, Porter B. Changes in microRNA expression in the whole hippocampus and hippocampal synaptoneurosome fraction following pilocarpine induced status epilepticus. PLoS ONE. 2013;8:e53464 pubmed publisher..The loss of microRNAs enriched in the synaptoneurosomal fraction implies a dramatic change in translational regulation in synapses 48 hours after status epilepticus. ..
- Gundersen B, Briand L, Onksen J, LeLay J, Kaestner K, Blendy J. Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator ?. J Neurosci. 2013;33:13673-85 pubmed publisher..The current results suggest that activation of CREM? may provide a means to accelerate the therapeutic efficacy of current antidepressant treatment. ..
- Klinman E, Holzbaur E. Comparative analysis of axonal transport markers in primary mammalian neurons. Methods Cell Biol. 2016;131:409-24 pubmed publisher..Ultimately, the ideal cargo to investigate depends on the question being asked and the limitations of individual microscopes available for imaging. ..
- Karpowicz R, Haney C, Mihaila T, Sandler R, Petersson E, Lee V. Selective imaging of internalized proteopathic Î±-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies. J Biol Chem. 2017;292:13482-13497 pubmed publisher..Further, lysosomal processing of transmitted seeds may represent a new therapeutic target to combat the spread of synucleinopathies. ..
- Saykin A, Shtasel D, Gur R, Kester D, Mozley L, Stafiniak P, et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch Gen Psychiatry. 1994;51:124-31 pubmed..Neuropsychological evaluations before treatment permit differentiation of primary deficits from changes secondary to medication or chronicity. This is essential for developing a neurobehavioral perspective on schizophrenia. ..
- Skorupa A, Fisher K, Wilson J, Parente M, Wolfe J. Sustained production of beta-glucuronidase from localized sites after AAV vector gene transfer results in widespread distribution of enzyme and reversal of lysosomal storage lesions in a large volume of brain in mucopolysaccharidosis VII mice. Exp Neurol. 1999;160:17-27 pubmed
- Graves L, Dalvi A, Lucki I, Blendy J, Abel T. Behavioral analysis of CREB alphadelta mutation on a B6/129 F1 hybrid background. Hippocampus. 2002;12:18-26 pubmed..These studies underscore the importance of controlling for genetic background in the behavioral analysis of knockout and transgenic mice. ..
- Daley J, Gechman L, Skipworth J, Rall G. Poliovirus replication and spread in primary neuron cultures. Virology. 2005;340:10-20 pubmed
- Ang C, Carlson G, Coulter D. Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy. J Neurosci. 2006;26:11850-6 pubmed..This dysregulated temporoammonic pathway is critically positioned to mediate generation and/or propagation of seizure activity in the hippocampus. ..
- Tuzun E, Rossi J, Karner S, Centurion A, Dalmau J. Adenylate kinase 5 autoimmunity in treatment refractory limbic encephalitis. J Neuroimmunol. 2007;186:177-80 pubmed..Detection of antibodies to AK5 in LE patients carries a poor prognosis, and suggests the prompt use of aggressive immunosuppression...
- Royo N, Lebold D, Magge S, Chen I, Hauspurg A, Cohen A, et al. Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function. Neuroscience. 2007;148:359-70 pubmed..We propose that a deeper understanding of the factors that link neuronal survival to recovery of function will be important for future studies of potentially therapeutic agents. ..
- Lu B, Su Y, Das S, Wang H, Wang Y, Liu J, et al. Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature. 2009;457:741-4 pubmed publisher..These findings identify NALCN as the cation channel activated by substance P receptor, and suggest that UNC-80 and Src family kinases, rather than a G protein, are involved in the coupling from receptor to channel. ..
- Pluta J, Avants B, Glynn S, Awate S, Gee J, Detre J. Appearance and incomplete label matching for diffeomorphic template based hippocampus segmentation. Hippocampus. 2009;19:565-71 pubmed publisher..Thus, this approach does not require expert neuroanatomical training and is viable for high-throughput studies of both the normal and the highly atrophic hippocampus. ..
- Balu D, Carlson G, Talbot K, Kazi H, Hill Smith T, Easton R, et al. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus. 2012;22:230-40 pubmed publisher..Taken together, these results implicate the Akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia. ..
- O Donnell L, Conway S, Rose R, Nicolas E, Slifker M, Balachandran S, et al. STAT1-independent control of a neurotropic measles virus challenge in primary neurons and infected mice. J Immunol. 2012;188:1915-23 pubmed publisher..Moreover, the canonical IFN-?-triggered STAT1 gene expression profile was not induced in STAT1-deficient neurons, suggesting that IFN-? regulates neuronal STAT1-independent pathways to control viral replication. ..
- Leach P, Poplawski S, Kenney J, Hoffman B, Liebermann D, Abel T, et al. Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory. Learn Mem. 2012;19:319-24 pubmed publisher..Therefore, Gadd45b may be a novel therapeutic target for the cognitive deficits associated with many neurodevelopmental, neurological, and psychiatric disorders. ..
- Hawk J, Bookout A, Poplawski S, Bridi M, Rao A, Sulewski M, et al. NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors. J Clin Invest. 2012;122:3593-602 pubmed publisher..Blocking NR4A signaling interfered with the ability of HDAC inhibitors to enhance memory. These results demonstrate that the Nr4a gene family contributes to memory formation and is a promising target for improving cognitive function. ..
- Miller J, Neufang M, Solway A, Brandt A, Trippel M, Mader I, et al. Neural activity in human hippocampal formation reveals the spatial context of retrieved memories. Science. 2013;342:1111-4 pubmed publisher..Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded. ..
- Kutlu M, Gould T. Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory. Physiol Behav. 2016;155:162-71 pubmed publisher..Understanding how nicotine alters learning and memory will advance basic understanding of the neural substrates of learning and aid in understanding mental disorders that involve cognitive and learning deficits. ..
- Yousem D, Geckle R, Bilker W, McKeown D, Doty R. Posttraumatic olfactory dysfunction: MR and clinical evaluation. AJNR Am J Neuroradiol. 1996;17:1171-9 pubmed..MR imaging shows abnormalities in patients with posttraumatic olfactory dysfunction at a very high rate (88%), predominantly in the olfactory bulbs and tracts and the inferior frontal lobes. ..
- Barak O, Lazzaro M, Lane W, Speicher D, Picketts D, Shiekhattar R. Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J. 2003;22:6089-100 pubmed..Furthermore, we show that hNURF potentiates neurite outgrowth in cell culture. Taken together, our data suggess a role for an ISWI complex in neuronal growth. ..
- Browne K, Leoni M, Iwata A, Chen X, Smith D. Acute treatment with MgSO4 attenuates long-term hippocampal tissue loss after brain trauma in the rat. J Neurosci Res. 2004;77:878-83 pubmed..These data also show that the previously reported broad efficacy of MgSO(4) or NPS 1506 observed shortly after brain trauma could not be detected 8 months post-injury. ..
- Gliebus G, Lippa C. The influence of beta-blockers on delayed memory function in people with cognitive impairment. Am J Alzheimers Dis Other Demen. 2007;22:57-61 pubmed..These data support the notion that common medications used in cognitively impaired elderly patients can worsen cognition and that careful selection of medications may help to maximize retrieval of newly formed memories. ..
- Gonzalez M, Susarla B, Fournier K, Sheldon A, Robinson M. Constitutive endocytosis and recycling of the neuronal glutamate transporter, excitatory amino acid carrier 1. J Neurochem. 2007;103:1917-31 pubmed..As one defines the machinery required for constitutive trafficking of EAAC1, it may be possible to determine how intracellular signals regulate EAAC1 cell surface expression. ..
- Porter B, Lund I, Varodayan F, Wallace R, Blendy J. The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis. Neuroscience. 2008;152:829-36 pubmed publisher..Together these data suggest that the increase in ICER mRNA following SE may have a role in suppressing the severity of epilepsy. ..
- Hoshaw B, Hill T, Crowley J, Malberg J, Khawaja X, Rosenzweig Lipson S, et al. Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission. Eur J Pharmacol. 2008;594:109-16 pubmed publisher..Thus, IGF-I administration initiates a long-lasting cascade of neurochemical effects involving increased serotonin levels that results in antidepressant-like behavioral effects. ..
- Kollins K, Hu J, Bridgman P, Huang Y, Gallo G. Myosin-II negatively regulates minor process extension and the temporal development of neuronal polarity. Dev Neurobiol. 2009;69:279-98 pubmed publisher..Together, these data indicate that myosin II negatively regulates MP extension, and the developmental time course for axonogenesis. ..
- Gao Y, Glenn A, SCHUG R, Yang Y, Raine A. The neurobiology of psychopathy: a neurodevelopmental perspective. Can J Psychiatry. 2009;54:813-23 pubmed
- Lee E, Warmann G, Dhir R, Ahima R. Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. J Neurosci. 2011;31:14361-6 pubmed publisher..These findings demonstrate that metabolic syndrome modulates the outcome of seizures and brain injury. ..
- Hodes G, Brookshire B, Hill Smith T, Teegarden S, Berton O, Lucki I. Strain differences in the effects of chronic corticosterone exposure in the hippocampus. Neuroscience. 2012;222:269-80 pubmed publisher..In addition, differences in the inflammatory response of matrix metalloproteinases (MMPs) may also contribute to these strain differences in resistance to the deleterious effects of CORT to the brain. ..
- Lovatt D, Ruble B, Lee J, Dueck H, Kim T, Fisher S, et al. Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue. Nat Methods. 2014;11:190-6 pubmed publisher..The TIVA methodology is, to our knowledge, the first noninvasive approach for capturing mRNA from live single cells in their natural microenvironment. ..
- Cohen A, Lin D, Coulter D. Protracted postnatal development of inhibitory synaptic transmission in rat hippocampal area CA1 neurons. J Neurophysiol. 2000;84:2465-76 pubmed..By the third postnatal week, mIPSCs have matured kinetically but retain distinct responses to modulatory drugs, possibly reflecting continued immaturity in synaptic structure and function persisting through adolescence...
- Greger J, Katz R, Taganov K, Rall G, Skalka A. Transduction of terminally differentiated neurons by avian sarcoma virus. J Virol. 2004;78:4902-6 pubmed..The transduction efficiency of the ASV vector was found to be intermediate between the relatively high and low efficiencies obtained with human immunodeficiency virus type 1 and murine leukemia virus vectors, respectively...
- Talbot K, Eidem W, Tinsley C, Benson M, Thompson E, Smith R, et al. Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J Clin Invest. 2004;113:1353-63 pubmed..Such changes may contribute to the cognitive deficits common in schizophrenia. ..
- Sung S, Yang H, Uryu K, Lee E, Zhao L, Shineman D, et al. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. Am J Pathol. 2004;165:2197-206 pubmed
- Porter B, Zhang G, Celix J, Hsu F, Raol Y, Telfeian A, et al. Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients. Neurobiol Dis. 2005;18:484-91 pubmed..Patient-specific GABAAR expression might contribute to variability in anti-epileptic drug efficacy, side-effect profiles, and seizure susceptibility. ..
- Ouyang M, Zhang L, Zhu J, Schwede F, Thomas S. Epac signaling is required for hippocampus-dependent memory retrieval. Proc Natl Acad Sci U S A. 2008;105:11993-7 pubmed publisher..These findings demonstrate that cAMP signaling through Epac (as well as PKA) plays an essential role in cognition. ..
- Bevers M, Ingleton L, Che D, Cole J, Li L, Da T, et al. RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia. Exp Neurol. 2010;224:170-7 pubmed publisher..These findings represent the first in vivo evidence that reducing expression of an individual calpain isoform can decrease post-ischemic neuronal death and preserve hippocampal function. ..