Experts and Doctors on helper inducer t lymphocytes in Pittsburgh, Pennsylvania, United States


Locale: Pittsburgh, Pennsylvania, United States
Topic: helper inducer t lymphocytes

Top Publications

  1. Singh N, Sun H. Iron overload and unique susceptibility of liver transplant recipients to disseminated disease due to opportunistic pathogens. Liver Transpl. 2008;14:1249-55 pubmed publisher
    ..Studies to assess iron homeostasis and the mechanisms by which iron overload contributes to the pathogenesis of opportunistic infections in liver transplant recipients are warranted. ..
  2. Ragni M, Wu W, Liang X, Hsieh C, Cortese Hassett A, Lu L. Factor VIII-pulsed dendritic cells reduce anti-factor VIII antibody formation in the hemophilia A mouse model. Exp Hematol. 2009;37:744-54 pubmed publisher
    ..These findings suggest F.VIII-pulsed DCre reduce anti-F.VIII antibody formation in hemophilia A mice by induction of regulatory T-cell-mediated hyporesponsiveness of T-helper cells to F.VIII. ..
  3. Gaffen S. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 2009;9:556-67 pubmed publisher
  4. Serbina N, Lazarevic V, Flynn J. CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection. J Immunol. 2001;167:6991-7000 pubmed
    ..tuberculosis is imperative for the design of successful vaccination strategies. ..
  5. Tagmyer T, Craigo J, Cook S, Issel C, Montelaro R. Envelope-specific T-helper and cytotoxic T-lymphocyte responses associated with protective immunity to equine infectious anemia virus. J Gen Virol. 2007;88:1324-36 pubmed
  6. Dubin P, Kolls J. Th17 cytokines and mucosal immunity. Immunol Rev. 2008;226:160-71 pubmed publisher
    ..In this review, we summarize the current state of this literature and present possible applications of Th17-targeted immunotherapy in the treatment and prevention of infection. ..
  7. Khader S, Gaffen S, Kolls J. Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol. 2009;2:403-11 pubmed publisher
    ..Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa. ..
  8. Fourcade J, Sun Z, Kudela P, Janjic B, Kirkwood J, El Hafnawy T, et al. Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire. J Immunol. 2010;184:6709-18 pubmed publisher
    ..They also suggest that TA-specific Treg expansion may be better impaired by therapies aimed at depleting CD4+CD25high Tregs and preventing the peripheral conversion of CD4+CD25- T cells. ..
  9. de Souza A, Oriss T, O Malley K, Ray A, Kane L. T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc Natl Acad Sci U S A. 2005;102:17113-8 pubmed
    ..These results constitute evidence that TIM-1 directly couples to phosphotyrosine-dependent intracellular signaling pathways. ..

More Information


  1. Pillemer B, Xu H, Oriss T, Qi Z, Ray A. Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Eur J Immunol. 2007;37:2082-9 pubmed
    ..Thus, up-regulation of SOCS3 expression may be a useful therapeutic approach in diseases where inhibition of Treg is desirable. ..
  2. Krishnamoorthy N, Oriss T, Paglia M, Fei M, Yarlagadda M, Vanhaesebroeck B, et al. Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat Med. 2008;14:565-73 pubmed publisher
    ..Collectively, these results highlight the importance of the c-Kit-PI3 kinase-IL-6 signaling axis in DCs in regulating T cell responses. ..
  3. Mathers A, Janelsins B, Rubin J, Tkacheva O, Shufesky W, Watkins S, et al. Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses. J Immunol. 2009;182:921-33 pubmed
    ..Overall, our data demonstrate that human epidermal smiLCs induce Th17 responses by mechanisms different from those previously described and highlight the need to target clinical treatments based on these variations. ..
  4. Gaffen S. The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr Rheumatol Rep. 2009;11:365-70 pubmed
    ..This article discusses the history of the discovery of Th17 cells, the potential mechanisms of action of IL-17 in autoimmunity, and perspectives for IL-17-targeted cytokine therapy. ..
  5. Guglani L, Khader S. Th17 cytokines in mucosal immunity and inflammation. Curr Opin HIV AIDS. 2010;5:120-7 pubmed publisher
    ..In this review, we have summarized the recent advances in our understanding of Th17 cytokines and how they contribute to immunity versus inflammation at mucosal sites. ..
  6. Tse H, Thayer T, Steele C, Cuda C, Morel L, Piganelli J, et al. NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity. J Immunol. 2010;185:5247-58 pubmed publisher
    ..These data validate the role of superoxide in shaping Th responses and as a signaling intermediate to modulate Th17 and Th1 T cell responses...