Experts and Doctors on fungal spores in Philadelphia, Pennsylvania, United States


Locale: Philadelphia, Pennsylvania, United States
Topic: fungal spores

Top Publications

  1. Cooper K, Mallory M, Egeland D, Jarnik M, Strich R. Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast. Proc Natl Acad Sci U S A. 2000;97:14548-53 pubmed
    ..The requirement of Ama1p only for meiosis I and spore morphogenesis suggests a function for APC/C(Ama1) specifically adapted to germ cell development. ..
  2. Bungard D, Reed M, Winter E. RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:910-8 pubmed
    ..Our data suggest that Smk1 and Rsc1/2 define parallel pathways that converge to provide signaling information and the expression of gene products, respectively, that are required for spore morphogenesis. ..
  3. McDonald C, Cooper K, Winter E. The Ama1-directed anaphase-promoting complex regulates the Smk1 mitogen-activated protein kinase during meiosis in yeast. Genetics. 2005;171:901-11 pubmed
    ..We propose that this novel mechanism for controlling MAPK activation plays a role in coupling the completion of meiosis II to gamete formation. ..
  4. Strich R, Surosky R, Steber C, Dubois E, Messenguy F, Esposito R. UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev. 1994;8:796-810 pubmed
    ..Analyses of UME6 mRNA during both nitrogen starvation and meiotic development indicate that its transcription is constitutive, suggesting that regulation of UME6 activity occurs at a post-transcriptional level. ..
  5. Krisak L, Strich R, Winters R, Hall J, Mallory M, Kreitzer D, et al. SMK1, a developmentally regulated MAP kinase, is required for spore wall assembly in Saccharomyces cerevisiae. Genes Dev. 1994;8:2151-61 pubmed
    ..We propose that the SMK1 MAP kinase participates in a developmentally regulated signal transduction pathway that coordinates cytodifferentiation events with the transcriptional program. ..
  6. Wagner M, Pierce M, Winter E. The CDK-activating kinase CAK1 can dosage suppress sporulation defects of smk1 MAP kinase mutants and is required for spore wall morphogenesis in Saccharomyces cerevisiae. EMBO J. 1997;16:1305-17 pubmed
    ..These results show that cell cycle progression and morphogenetic pathways can be regulated by a single gene product and suggest mechanisms for coordinating these processes during development. ..
  7. Lindgren A, Bungard D, Pierce M, Xie J, Vershon A, Winter E. The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J. 2000;19:6489-97 pubmed
  8. Schaber M, Lindgren A, Schindler K, Bungard D, Kaldis P, Winter E. CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion. Mol Cell Biol. 2002;22:57-68 pubmed
    ..The early meiotic role of Cak1p, like the postmeiotic role in the Smk1p pathway, is CDC28 independent. The data indicate that Cak1p activates multiple steps in meiotic development through multiple protein kinase targets. ..
  9. Mallory M, Strich R. Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. J Biol Chem. 2003;278:44727-34 pubmed
    ..In addition, these results suggest that Rpd3-Ume1p-Sin3p comprises an interdependent complex required for mediating transcriptional repression. ..

More Information


  1. Schindler K, Winter E. Phosphorylation of Ime2 regulates meiotic progression in Saccharomyces cerevisiae. J Biol Chem. 2006;281:18307-16 pubmed
    ..These data suggest that Ime2p plays a role in controlling the exit from meiosis I and demonstrate that a phospho-modification pathway regulates Ime2p during the different phases of meiotic development. ..
  2. Shin M, Skokotas A, Winter E. The Cdk1 and Ime2 protein kinases trigger exit from meiotic prophase in Saccharomyces cerevisiae by inhibiting the Sum1 transcriptional repressor. Mol Cell Biol. 2010;30:2996-3003 pubmed publisher
    ..These results demonstrate that Sum1 functions as a key meiotic brake through the NDT80 promoter and that Cdk1 and Ime2 trigger exit from meiotic prophase by inhibiting the Sum1 transcriptional repression complex. ..