Experts and Doctors on cattle in Philadelphia, Pennsylvania, United States

Summary

Locale: Philadelphia, Pennsylvania, United States
Topic: cattle

Top Publications

  1. Bashir M, Abrams W, Tucker T, Sellinger B, Budarf M, Emanuel B, et al. Molecular cloning and characterization of the bovine and human tuftelin genes. Connect Tissue Res. 1998;39:13-24; discussion 63-7 pubmed
    ..The human tuftelin gene was localized to chromosome 1q21 by in situ hybridization. ..
  2. Baglia F, Badellino K, Li C, Lopez J, Walsh P. Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin. J Biol Chem. 2002;277:1662-8 pubmed
    ..Thus, factor XI binds to the GP Ib-IX-V complex, promoting its activation by thrombin. ..
  3. Dunaief J, King A, Esumi N, Eagen M, Dentchev T, Sung C, et al. Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo. Curr Eye Res. 2002;24:392-6 pubmed
    ..Disruption of the PP1-pRb interaction may influence retinoblastoma tumorigenesis as well as RPE cell proliferation and survival. ..
  4. O Connell G, Vresilovic E, Elliott D. Comparison of animals used in disc research to human lumbar disc geometry. Spine (Phila Pa 1976). 2007;32:328-33 pubmed
  5. Kieba I, Fong K, Tang H, Hoffman K, Speicher D, Klickstein L, et al. Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity. Cell Microbiol. 2007;9:2689-99 pubmed
  6. Cohn H, Harris D, Pesant S, Pfeiffer M, Zhou R, Koch W, et al. Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. Am J Physiol Heart Circ Physiol. 2008;295:H1695-704 pubmed publisher
    ..This is the first study to suggest that VSM alpha(1D)ARs are a GRK2 substrate in vivo. ..
  7. Tian A, Baumgart T. Sorting of lipids and proteins in membrane curvature gradients. Biophys J. 2009;96:2676-88 pubmed publisher
    ..The sorting of Cholera toxin subunit B is rationalized by statistical models. We discuss the implications of our findings for intracellular sorting mechanisms. ..
  8. Rosano J, Tousi N, Scott R, Krynska B, Rizzo V, PRABHAKARPANDIAN B, et al. A physiologically realistic in vitro model of microvascular networks. Biomed Microdevices. 2009;11:1051-7 pubmed publisher
    ..This microfluidic system can provide novel insight into characterization of drug delivery particles and dynamic flow conditions in microvascular networks. ..
  9. Wang J, Han X, Saha S, Xu T, Rai R, Zhang F, et al. Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo. Chem Biol. 2011;18:121-30 pubmed publisher

More Information

Publications114 found, 100 shown here

  1. Driscoll T, Nerurkar N, Jacobs N, Elliott D, Mauck R. Fiber angle and aspect ratio influence the shear mechanics of oriented electrospun nanofibrous scaffolds. J Mech Behav Biomed Mater. 2011;4:1627-36 pubmed publisher
  2. Han W, Nerurkar N, Smith L, Jacobs N, Mauck R, Elliott D. Multi-scale structural and tensile mechanical response of annulus fibrosus to osmotic loading. Ann Biomed Eng. 2012;40:1610-21 pubmed publisher
    ..Moreover, because the composition and structure is altered as a consequence of progressive disk degeneration, quantification of these interactions is critical for study of the AF pathogenesis of degeneration and tissue engineering ..
  3. Matunis M, Michael W, Dreyfuss G. Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. Mol Cell Biol. 1992;12:164-71 pubmed
    ..Overall, K represents a novel type of hnRNA-binding protein. It is likely that K and J play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. ..
  4. Gibson C, Golub E, Ding W, Shimokawa H, Young M, Termine J, et al. Identification of the leucine-rich amelogenin peptide (LRAP) as the translation product of an alternatively spliced transcript. Biochem Biophys Res Commun. 1991;174:1306-12 pubmed
    ..Analysis of the structure of LRAP suggests that the polypeptide might exhibit interesting properties relative to hydroxy apatite crystal formation. ..
  5. Croul S, Mezitis S, Stieber A, Chen Y, Gonatas J, Goud B, et al. Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus. J Histochem Cytochem. 1990;38:957-63 pubmed
    ..The antiserum to MG-160 represents a reliable reagent for immunohistochemical visualization of the Golgi apparatus in brain and several other human tissues obtained at autopsy, fixed with Bouin's, and embedded in paraffin. ..
  6. Ciaccio P, Tew K. cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. Biochim Biophys Acta. 1994;1186:129-32 pubmed
    ..Northern blots revealed that dihydrodiol dehydrogenase(s) were markedly induced in HT29 colon cells by treatment with the Michael acceptor agent ethacrynic acid. ..
  7. Danielson K, Fazzio A, Cohen I, Cannizzaro L, Eichstetter I, Iozzo R. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. Genomics. 1993;15:146-60 pubmed
    ..This study provides the molecular basis for discerning the transcriptional control of the decorin gene and offers the opportunity to investigate genetic disorders linked to this important human gene. ..
  8. Ohnishi T. Iron-sulfur clusters/semiquinones in complex I. Biochim Biophys Acta. 1998;1364:186-206 pubmed
    ..A brief introduction of EPR technique was also described in Appendix A of this mini-review. ..
  9. Fisher A, Dodia C, Manevich Y, Chen J, Feinstein S. Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase. J Biol Chem. 1999;274:21326-34 pubmed
    ..These results identify a new GSH peroxidase that is not a selenoenzyme and can reduce phospholipid hydroperoxides. Thus, this enzyme may be an important component of cellular antioxidant defense systems. ..
  10. Gaidarov I, Keen J. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits. J Cell Biol. 1999;146:755-64 pubmed
    ..1999. EMBO (Eur. Mol. Biol. Organ.) J. 18:871-881), suggest that phosphoinositides play a critical and general role in adaptor incorporation into plasma membrane clathrin-coated pits...
  11. Levitan I, Christian A, Tulenko T, Rothblat G. Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells. J Gen Physiol. 2000;115:405-16 pubmed
    ..We hypothesize that changes in membrane cholesterol modulate VRAC activity by affecting the membrane deformation energy associated with channel opening. ..
  12. Eckenhoff R, Knoll F, Greenblatt E, Dailey W. Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics. J Med Chem. 2002;45:1879-86 pubmed
    ..When tagged with radioactivity, this compound should serve as a reasonable probe of haloalkane anesthetic binding targets and sites. ..
  13. Yu W, Ling C, Baas P. Microtubule reconfiguration during axogenesis. J Neurocytol. 2001;30:861-75 pubmed
    ..These observations demonstrate a complexity of microtubule behaviors, some of which can be explained by interactions with actin and/or by forces generated by molecular motor proteins. ..
  14. Wheaton A, Casey F, Gougoutas A, Dodge G, Borthakur A, Lonner J, et al. Correlation of T1rho with fixed charge density in cartilage. J Magn Reson Imaging. 2004;20:519-25 pubmed
    ..This work is a first step in establishing T1rho as a method of quantifying PG changes in early-stage OA. ..
  15. Ombelli M, Composto R, Meng Q, Eckmann D. A quantitative and selective chromatography method for determining coverages of multiple proteins on surfaces. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;826:198-205 pubmed
    ..Relative to silicon, the dextranized surfaces were found to strongly inhibit protein adsorption, decreasing BSA and Fg coverages by 76 and 60%, respectively. ..
  16. Huang A, Yeger McKeever M, Stein A, Mauck R. Tensile properties of engineered cartilage formed from chondrocyte- and MSC-laden hydrogels. Osteoarthritis Cartilage. 2008;16:1074-82 pubmed publisher
  17. Bucki R, Leszczynska K, Byfield F, Fein D, Won E, Cruz K, et al. Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Antimicrob Agents Chemother. 2010;54:2525-33 pubmed publisher
    ..The combined antibacterial and anti-inflammatory activities of D2S suggest its potential as an alternative to natural CAPs in the prevention and treatment of some bacterial infections. ..
  18. Farrell M, Comeau E, Mauck R. Mesenchymal stem cells produce functional cartilage matrix in three-dimensional culture in regions of optimal nutrient supply. Eur Cell Mater. 2012;23:425-40 pubmed
  19. Doulias P, Tenopoulou M, Raju K, Spruce L, Seeholzer S, Ischiropoulos H. Site specific identification of endogenous S-nitrosocysteine proteomes. J Proteomics. 2013;92:195-203 pubmed publisher
    ..This article is part of a Special Issue entitled: Posttranslational Protein modifications in biology and Medicine. ..
  20. Liu C, Stonestrom A, Christian T, Yong J, Takase R, Hou Y, et al. Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. J Biol Chem. 2016;291:10426-36 pubmed publisher
    ..Together, these findings provide new insights into the cytochrome c-tRNA interaction and apoptotic regulation. ..
  21. Zimmerman U, Schlaepfer W. Two-stage autolysis of the catalytic subunit initiates activation of calpain I. Biochim Biophys Acta. 1991;1078:192-8 pubmed
    ..Both intramolecular and intermolecular proteolysis of the catalytic subunit appear to yield the same products. ..
  22. Engisch K, Nowycky M. Calcium dependence of large dense-cored vesicle exocytosis evoked by calcium influx in bovine adrenal chromaffin cells. J Neurosci. 1996;16:1359-69 pubmed
  23. Kumar V, Hidaka H, Okazaki K, Vijay Kumar S. Crystallization and preliminary X-ray crystallographic studies of recombinant bovine neurocalcin delta. Proteins. 1996;25:261-4 pubmed
    ..696 A, and beta = 98.37 degrees. The asymmetric unit contains two molecules, with corresponding crystal volume per protein mass (Vm) of 2.29 A3/Da and solvent fraction of 45% by volume, exhibiting an approximate 222 point symmetry. ..
  24. Bashir M, Abrams W, Rosenbloom J. Molecular cloning and characterization of the bovine tuftelin gene. Arch Oral Biol. 1997;42:489-96 pubmed
    ..Codons are generally not divided at exon/intron borders. Several alternatively spliced transcripts were identified by DNA sequence analysis of the isolated products produced by reverse transcriptase/polymerase chain reaction. ..
  25. Wool Lewis R, Bates P. Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines. J Virol. 1998;72:3155-60 pubmed
  26. Sun L, Sun T, Lavker R. Identification of a cytosolic NADP+-dependent isocitrate dehydrogenase that is preferentially expressed in bovine corneal epithelium. A corneal epithelial crystallin. J Biol Chem. 1999;274:17334-41 pubmed
    ..Taken together, these data indicate that bovine cytosolic ICDH fulfills the criteria for a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. ..
  27. Giangiacomo K, Fremont V, Mullmann T, Hanner M, Cox R, Garcia M. Interaction of charybdotoxin S10A with single maxi-K channels: kinetics of blockade depend on the presence of the beta 1 subunit. Biochemistry. 2000;39:6115-22 pubmed
    ..Taken together, these data suggest that studies of ChTX block of single maxi-K channels provide an approach for characterizing structural and functional features of the alpha/beta 1 interaction. ..
  28. Koyama E, Wu C, Shimo T, Iwamoto M, Ohmori T, Kurisu K, et al. Development of stratum intermedium and its role as a Sonic hedgehog-signaling structure during odontogenesis. Dev Dyn. 2001;222:178-91 pubmed
    ..Given its dynamic and apparently interactive properties, stratum intermedium may help orchestrate progression of odontogenesis from cusp to cervix. ..
  29. Shapiro E, Borthakur A, Gougoutas A, Reddy R. 23Na MRI accurately measures fixed charge density in articular cartilage. Magn Reson Med. 2002;47:284-91 pubmed
    ..Both methodologies gave similar results, with the average sodium concentration of normal human patellar cartilage ranging from approximately 240 to 260 mM. This corresponds to FCDs of -158 mM to -182 mM. ..
  30. Stokes D, Liu G, Coimbra I, Piera Velazquez S, Crowl R, Jimenez S. Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum. 2002;46:404-19 pubmed
    ..At least 3 of the genes that were regulated in response to dedifferentiation were also found to be expressed in adult normal and OA articular cartilage and chondrocytes. ..
  31. Fang J, Hsu B, MacMullen C, Poncz M, Smith T, Stanley C. Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. Biochem J. 2002;363:81-7 pubmed
  32. Hakimi M, Speicher D, Shiekhattar R. The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis. J Biol Chem. 2002;277:36909-12 pubmed
    ..Importantly, although NF1 and NF2 are not in a stable association, NF2 is also a component of a distinct kinesin-1-containing complex. These results point to kinesin-1 as a common denominator between NF1 and NF2. ..
  33. Borthakur A, Wheaton A, Charagundla S, Shapiro E, Regatte R, Akella S, et al. Three-dimensional T1rho-weighted MRI at 1.5 Tesla. J Magn Reson Imaging. 2003;17:730-6 pubmed
    ..Images of the human knee joint in vivo demonstrate a clear delineation of cartilage from surrounding tissues. We developed and implemented a three-dimensional T(1rho)-weighted pulse sequence on a 1.5-T clinical scanner. ..
  34. Kamel I, Wendling W, Chen D, Wendling K, Harakal C, Carlsson C. N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries. J Neurosurg Anesthesiol. 2008;20:241-8 pubmed publisher
  35. Reigada D, Lu W, Zhang M, Mitchell C. Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels. Neuroscience. 2008;157:396-404 pubmed publisher
    ..This excess extracellular ATP may link increased pressure to the death of ganglion cells in acute glaucoma, and suggests a possible role for ATP in the neuronal damage accompanying increased intracranial pressure. ..
  36. Suzuki H, Motley E, Eguchi K, Hinoki A, Shirai H, Watts V, et al. Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase. Hypertension. 2009;53:182-8 pubmed publisher
  37. Shankar H, Michal A, Kern R, Kang D, Gurevich V, Benovic J. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. J Biol Chem. 2010;285:8316-29 pubmed publisher
    ..Taken together, our data reveal that non-visual arrestins are novel centrosomal components and regulate normal centrosome function. ..
  38. Zhou R, Pesant S, Cohn H, Soltys S, Koch W, Eckhart A. Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5. Clin Transl Sci. 2009;2:57-61 pubmed publisher
  39. Ohnishi S, Shinzawa Itoh K, Ohta K, Yoshikawa S, Ohnishi T. New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals. Biochim Biophys Acta. 2010;1797:1901-9 pubmed publisher
    ..This suggests that if electron transfer was inhibited under pathological conditions, superoxide generation from the SF would be increased. ..
  40. Uttayarat P, Perets A, Li M, Pimton P, Stachelek S, Alferiev I, et al. Micropatterning of three-dimensional electrospun polyurethane vascular grafts. Acta Biomater. 2010;6:4229-37 pubmed publisher
  41. Li A, Leung C, Peterson Yantorno K, Mitchell C, Civan M. Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow. Am J Physiol Cell Physiol. 2010;299:C1308-17 pubmed publisher
    ..The relatively large response to dithiothreitol raises the possibility that the oxidation-reduction state is a substantial regulator of PX1-mediated ATP release from bovine ciliary epithelial cells...
  42. Ombelli M, Costello L, Postle C, Anantharaman V, Meng Q, Composto R, et al. Competitive protein adsorption on polysaccharide and hyaluronate modified surfaces. Biofouling. 2011;27:505-18 pubmed publisher
    ..With changing bulk protein concentration from 20 to 40 ?g ml(-1) for each species, Fg coverage on silicon increased by 4x, whereas both BSA and Fg adsorption on dextran and HA were far less dependent on protein bulk concentration...
  43. HUANG A, Baker B, Ateshian G, Mauck R. Sliding contact loading enhances the tensile properties of mesenchymal stem cell-seeded hydrogels. Eur Cell Mater. 2012;24:29-45 pubmed
    ..These findings point to the potential of sliding contact to produce engineered cartilage constructs that begin to recapitulate the complex mechanical features of the native tissue. ..
  44. Bashir M, Abrams W, Kucich U, Bacarra M, Han M, Brown Augsberger P, et al. Microfibril-associated glycoprotein: characterization of the bovine gene and of the recombinantly expressed protein. Biochemistry. 1994;33:593-600 pubmed
  45. Storey B. Mammalian sperm metabolism: oxygen and sugar, friend and foe. Int J Dev Biol. 2008;52:427-37 pubmed publisher
  46. Kang D, Kern R, Puthenveedu M, von Zastrow M, Williams J, Benovic J. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J Biol Chem. 2009;284:29860-72 pubmed publisher
    ..Taken together, these data provide a framework for understanding the dynamic interactions between arrestin2 and clathrin and reveal an essential role for this interaction in arrestin-mediated endocytosis. ..
  47. Bakhshi M, Myers J, Howard P, Soprano D, Kirby E. Sequencing of the primary adhesion domain of bovine von Willebrand factor. Biochim Biophys Acta. 1992;1132:325-8 pubmed
    ..Both the nucleotide sequence and the deduced amino acid sequence are 82% homologous to those of human vWF. Cysteine residues #471, 474, 509 and 695, which form intrachain bonds in human vWF, are also present in the bovine vWF sequence. ..
  48. Stokes D, Liu G, Dharmavaram R, Hawkins D, Piera Velazquez S, Jimenez S. Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors. Biochem J. 2001;360:461-70 pubmed
    ..These results underscore the overt change in phenotype that occurs when chondrocytes are cultured as monolayers on tissue-culture plastic substrata. ..
  49. Solt K, Johansson J. Binding of the active metabolite of chloral hydrate, 2,2,2-trichloroethanol, to serum albumin demonstrated using tryptophan fluorescence quenching. Pharmacology. 2002;64:152-9 pubmed
  50. Boczkowska M, Rebowski G, Petoukhov M, Hayes D, Svergun D, Dominguez R. X-ray scattering study of activated Arp2/3 complex with bound actin-WCA. Structure. 2008;16:695-704 pubmed publisher
    ..The results support a model of activation that is consistent with most of the biochemical observations. ..
  51. Nakamaru Ogiso E, Matsuno Yagi A, Yoshikawa S, Yagi T, Ohnishi T. Iron-sulfur cluster N5 is coordinated by an HXXXCXXCXXXXXC motif in the NuoG subunit of Escherichia coli NADH:quinone oxidoreductase (complex I). J Biol Chem. 2008;283:25979-87 pubmed publisher
    ..These data confirmed that, contrary to the misassignment claim, cluster N5 has a unique coordination with His(Cys)(3) ligands in NuoG. ..
  52. Laksari K, Shafieian M, Darvish K. Constitutive model for brain tissue under finite compression. J Biomech. 2012;45:642-6 pubmed publisher
    ..Viscoelastic relaxation was characterized at five decay rates (100, 10, 1, 0.1, 0 s(-1)) and the results in compression and their extrapolation to tension were compared against previous models. ..
  53. Sinha D, Yang X, Emig F, Kirby E. Isolation and characterization of two protease inhibitors from bovine plasma. J Biochem. 1994;115:387-91 pubmed
    ..Inh2, on the other hand, has some structural homology to human alpha 1-antichymotrypsin, but its specificity does not correspond to that of either human alpha 1-antitrypsin or human alpha 1-antichymotrypsin. ..
  54. Margulis A, Goraczniak R, Duda T, Sharma R, Sitaramayya A. Structural and biochemical identity of retinal rod outer segment membrane guanylate cyclase. Biochem Biophys Res Commun. 1993;194:855-61 pubmed
    ..These results suggest that ROS-GC represents a new subtype of the membrane guanylate cyclase family that is structurally and biochemically distinct from the other retinal cyclases. ..
  55. Xu Y, Liu Y, Yu Q. Angiopoietin-3 is tethered on the cell surface via heparan sulfate proteoglycans. J Biol Chem. 2004;279:41179-88 pubmed
  56. Wang L, Oriol Sunyer J, Bello L. Immunogenicity of a bovine viral diarrhea virus E2-C3d fusion protein containing a bovine homolog of C3d. Dev Comp Immunol. 2005;29:907-15 pubmed
    ..The ability of boC3d to function in mice provides a less costly and more convenient animal model than cattle for the preliminary evaluation of E2-boC3d and other bovine antigen-boC3d fusion proteins. ..
  57. Hadziahmetovic M, Song Y, Ponnuru P, Iacovelli J, Hunter A, Haddad N, et al. Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci. 2011;52:109-18 pubmed publisher
  58. Kepler C, Markova D, Dibra F, Yadla S, Vaccaro A, Risbud M, et al. Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1? in painful human intervertebral discs. Spine (Phila Pa 1976). 2013;38:873-80 pubmed publisher
    ..Laboratory study...
  59. Lee V, Otvos L, Carden M, Hollosi M, Dietzschold B, Lazzarini R. Identification of the major multiphosphorylation site in mammalian neurofilaments. Proc Natl Acad Sci U S A. 1988;85:1998-2002 pubmed
    ..e., MAP2 and tau. ..
  60. Yuan Z, Collier P, Rosenbloom J, Gibson C. Analysis of amelogenin mRNA during bovine tooth development. Arch Oral Biol. 1996;41:205-13 pubmed
    ..This new exon-4 sequence is unusual in that it is not highly conserved between species. ..
  61. Bulman A, Nelson H. Role of trehalose and heat in the structure of the C-terminal activation domain of the heat shock transcription factor. Proteins. 2005;58:826-35 pubmed
    ..cerevisiae HSF1 transcriptional activity in response to stress might be linked to the combined effects of trehalose and elevated temperatures in modifying the overall structure of HSF1's C-terminal activation domain. ..
  62. Xu W, Campillo M, Pardo L, Kim de Riel J, Liu Chen L. The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions. Biochemistry. 2005;44:16014-25 pubmed
    ..iv) The NPxxY motif in TM7 interacts with TM2, TM6, and helix 8 to maintain receptors in inactive states. To the best of our knowledge, this represents the first such comparison of the structures of two highly homologous GPCRs. ..
  63. Caviston J, Ross J, Antony S, Tokito M, Holzbaur E. Huntingtin facilitates dynein/dynactin-mediated vesicle transport. Proc Natl Acad Sci U S A. 2007;104:10045-50 pubmed
    ..Together these findings indicate that Htt binds to dynein and acts in a complex along with dynactin and Htt-associated protein-1 to facilitate vesicular transport. ..
  64. Guha S, Baltazar G, Coffey E, Tu L, Lim J, Beckel J, et al. Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor. FASEB J. 2013;27:4500-9 pubmed publisher
    ..In summary, P2X7R stimulation raises lysosomal pH and impedes lysosomal function, suggesting a possible role for overstimulation in diseases of accumulation...
  65. Redding L, Cubas Delgado F, Sammel M, Smith G, Galligan D, Levy M, et al. The use of antibiotics on small dairy farms in rural Peru. Prev Vet Med. 2014;113:88-95 pubmed publisher
    ..The results of this study are useful for understanding the patterns of antibiotic use and associated management, demographic and knowledge factors of farmers on small dairy farms in rural Peru. ..
  66. Davydov D, Davydova N, Rodgers J, Rushmore T, Jones J. Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences. Biochem J. 2017;474:3523-3542 pubmed publisher
  67. Benovic J, Onorato J, Arriza J, Stone W, Lohse M, Jenkins N, et al. Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. J Biol Chem. 1991;266:14939-46 pubmed
    ..These data suggest the existence of a "family" of receptor kinases which may serve broadly to regulate receptor function. ..
  68. Yuan Z, Golub E, Collier P, Gibson C. Bovine enamel organ cells express tissue non-specific alkaline phosphatase mRNA. J Dent Res. 1995;74:1886-90 pubmed
    ..The extended 3' untranslated region of the cDNA has considerable homology to human TNS-AP, and the conservation of sequence suggests that the 3' end may have a role in post-transcriptional regulation of expression...
  69. Anandatheerthavarada H, Amuthan G, Biswas G, Robin M, Murali R, Waterman M, et al. Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. EMBO J. 2001;20:2394-403 pubmed
    ..We demonstrate that evolutionarily divergent electron donor proteins interact with the same domain but subtly different contact points of P450MT2. ..
  70. Kim Y, Benovic J. Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking. J Biol Chem. 2002;277:30760-8 pubmed
    ..These mutants should prove useful in better defining the role of arrestins in mediating receptor trafficking. ..
  71. Isken O, Grassmann C, Yu H, Behrens S. Complex signals in the genomic 3' nontranslated region of bovine viral diarrhea virus coordinate translation and replication of the viral RNA. RNA. 2004;10:1637-52 pubmed
    ..Our data suggest the accuracy of translation termination as a sophisticated device determining viral adaptation to the host. ..
  72. Ren S, Bolton E, Mohi M, Morrione A, Neel B, Skorski T. Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences. Mol Cell Biol. 2005;25:8001-8 pubmed
    ..In conclusion, we have identified the domains of p85alpha responsible for the interaction with the FTK protein network and transduction of leukemogenic signaling. ..
  73. Luo J, Taylor P, Losen M, De Baets M, Shelton G, Lindstrom J. Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity. J Neurosci. 2009;29:13898-908 pubmed publisher
    ..This reveals a structural and functional, as well as antigenic, significance of the MIR. ..
  74. Coleman N, Shagiakhmetova G, Lebedeva I, Kuzmina T, Golubev A. In vitro maturation and early developmental capacity of bovine oocytes cultured in pure follicular fluid and supplementation with follicular wall. Theriogenology. 2007;67:1053-9 pubmed
    ..We also inferred that bovine FF constituents affecting bovine oocyte maturation and the meiosis-promoting ability of the FW were heat-labile. ..
  75. Bhadriraju K, Yang M, Alom Ruiz S, Pirone D, Tan J, Chen C. Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res. 2007;313:3616-23 pubmed
    ..These results suggest the existence of a feedback loop between cytoskeletal tension, adhesion maturation, and ROCK signaling that likely contributes to numerous mechanochemical processes. ..
  76. Showalter B, Beckstein J, Martin J, Beattie E, Espinoza OrĂ­as A, Schaer T, et al. Comparison of animal discs used in disc research to human lumbar disc: torsion mechanics and collagen content. Spine (Phila Pa 1976). 2012;37:E900-7 pubmed publisher
    ..Experimental measurement and normalization of in vitro disc torsion mechanics and collagen content for several animal species used in intervertebral disc research and comparing these with the human disc...
  77. Ferrari G, Terushkin V, Wolff M, Zhang X, Valacca C, Poggio P, et al. TGF-?1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38? to proapoptotic p38?. Mol Cancer Res. 2012;10:605-14 pubmed publisher
    ..Therefore, these results show that TGF-?1 induces endothelial cell apoptosis by shifting VEGF signaling from the prosurvival p38? to the proapoptotic p38?. ..
  78. Baltazar G, Guha S, Lu W, Lim J, Boesze Battaglia K, Laties A, et al. Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells. PLoS ONE. 2012;7:e49635 pubmed publisher
    ..These observations suggest the acidification produced by the nanoparticles was functionally effective. In summary, acid nanoparticles lead to a rapid and sustained lowering of lysosomal pH and improved degradative activity...
  79. Gibson C, Golub E, Herold R, Risser M, Ding W, Shimokawa H, et al. Structure and expression of the bovine amelogenin gene. Biochemistry. 1991;30:1075-9 pubmed
    ..Furthermore, the results are consistent with alternative splicing of the class I primary transcript as a potential mechanism for generating amelogenin heterogeneity. ..
  80. Matunis M, Xing J, Dreyfuss G. The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. Nucleic Acids Res. 1994;22:1059-67 pubmed
  81. Goraczniak R, Duda T, Sitaramayya A, Sharma R. Structural and functional characterization of the rod outer segment membrane guanylate cyclase. Biochem J. 1994;302 ( Pt 2):455-61 pubmed
    ..The identity of the granylate cyclase (ROS-GC) that synthesizes this pool of cyclic GMP is unknown. We now report the cloning, expression and functional characterization of a DNA from bovine retina that encodes ROS-GC. ..
  82. Goodman O, Krupnick J, Gurevich V, Benovic J, Keen J. Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain. J Biol Chem. 1997;272:15017-22 pubmed
    ..The terminal domain is oriented toward the plasma membrane in coated pits, and its binding of both arrestins and AP-2 suggests that this domain is the anchor responsible for adaptor-receptor recruitment to the coated pit. ..
  83. Loudon R, Benovic J. Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6. J Biol Chem. 1997;272:27422-7 pubmed
    ..These data demonstrate an important functional link between the ability of GRK6 to bind to the plasma membrane, a process that appears to be regulated by palmitoylation, and its activity toward receptor substrates. ..
  84. Ishikawa H, Li K, Tamai K, Sawamura D, Uitto J. Cloning of the mouse desmoglein 3 gene (Dsg3): interspecies conservation within the cadherin superfamily. Exp Dermatol. 2000;9:229-39 pubmed
    ..This relatively high level of conservation both at the protein and genomic level suggests that desmoglein 3 plays an important role in keratinocyte cell-cell adhesion. ..
  85. Tamura I, Rosenbloom J, Macarak E, Chaqour B. Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways. Am J Physiol Cell Physiol. 2001;281:C1524-32 pubmed
    ..These results establish the regulation of Cyr61 gene by mechanical stretch and provide clues to the key signaling molecules involved in this process...
  86. Eckmann D, Zhang J, Lampe J, Ayyaswamy P. Gas embolism and surfactant-based intervention: implications for long-duration space-based activity. Ann N Y Acad Sci. 2006;1077:256-69 pubmed
    ..Special consideration is given to modeling the transport and hydrodynamic interactions associated with surfactant-based intervention. ..
  87. Suzuki H, Kimura K, Shirai H, Eguchi K, Higuchi S, Hinoki A, et al. Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration. Arterioscler Thromb Vasc Biol. 2009;29:217-24 pubmed publisher
    ..The eNOS/NO cascade specifically targets the Rho/Rho-kinase system via inhibition of G(12/13) to prevent vascular migration induced by AngII, representing a novel signal cross-talk in cardiovascular protection by NO. ..
  88. Saxena V, Kim M, Keah N, Neuwirth A, Stoeckl B, Bickard K, et al. Anatomic Mesenchymal Stem Cell-Based Engineered Cartilage Constructs for Biologic Total Joint Replacement. Tissue Eng Part A. 2016;22:386-95 pubmed publisher
  89. Sinha D, Bakhshi M, Kirby E. Complete cDNA sequence of bovine alpha 1-antitrypsin. Biochim Biophys Acta. 1992;1130:209-12 pubmed
    ..The bovine and the sheep molecules have a sequence homology of 94% and both the molecules contain four cysteine residues; there is only one cysteine in the others. ..
  90. Rappaport J, Cho K, Saltzman A, Prenger J, Golomb M, Weinmann R. Transcription elongation factor SII interacts with a domain of the large subunit of human RNA polymerase II. Mol Cell Biol. 1988;8:3136-42 pubmed
    ..Thus, this suggests that an SII-binding contact required for specific RNA elongation resides within the fifth exon region of the largest RNA polymerase II subunit. ..
  91. Scholzen T, Solursh M, Suzuki S, Reiter R, Morgan J, Buchberg A, et al. The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. J Biol Chem. 1994;269:28270-81 pubmed
    ..In contrast, the major parenchymal organs were only weakly positive for decorin mRNA. These findings suggest that decorin may play a role in epithelial/mesenchymal interactions during organ development and shaping. ..
  92. Sterne Marr R, Gurevich V, Goldsmith P, Bodine R, Sanders C, Donoso L, et al. Polypeptide variants of beta-arrestin and arrestin3. J Biol Chem. 1993;268:15640-8 pubmed
    ..These observations suggest that in some tissues, as many as four arrestin homolog variants may play a role in the regulation of G protein-coupled receptors. ..