Experts and Doctors on blastomeres in Philadelphia, Pennsylvania, United States
Locale: Philadelphia, Pennsylvania, United States
Hawes S, Gie Chung Y, Latham K. Genetic and epigenetic factors affecting blastomere fragmentation in two-cell stage mouse embryos. Biol Reprod. 2001;65:1050-6 pubmed
Han Z, Chung Y, Gao S, Latham K. Maternal factors controlling blastomere fragmentation in early mouse embryos. Biol Reprod. 2005;72:612-8 pubmed
..The results also indicate that clinical procedures seeking to define or manipulate oocyte quality in humans should take into account early effects of the embryonic genome, particularly the maternal genome. ..
Han Z, Mtango N, Zhong Z, Vassena R, Latham K. Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos. Am J Physiol Cell Physiol. 2010;298:C1235-44 pubmed publisher
..These results reveal novel mechanisms by which maternal genotype affects cytofragmentation, including a system of opposing signaling pathways that most likely operate by controlling cytoskeletal function. ..
Abrams E, Zhang H, Marlow F, KAPP L, Lu S, Mullins M. Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. Cell. 2012;150:521-32 pubmed publisher
..Our studies provide insight into the machinery required for karyomere fusion and suggest that specialized proteins are necessary for proper nuclear division in large dividing blastomeres...