Experts and Doctors on beta catenin in Philadelphia, Pennsylvania, United States


Locale: Philadelphia, Pennsylvania, United States
Topic: beta catenin

Top Publications

  1. Gaillard D, Bowles S, Salcedo E, Xu M, Millar S, Barlow L. β-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice. PLoS Genet. 2017;13:e1006990 pubmed publisher
  2. Ezaki T, Guo R, Li H, Reynolds A, Lynch J. The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation. Am J Physiol Gastrointest Liver Physiol. 2007;293:G54-65 pubmed
    ..Ascertaining the mechanism for this novel Cdx effect may improve our understanding of the regulation of cell-cell adhesion in the colonic epithelium. ..
  3. Rieske P, Krynska B, Azizi S. Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin. Differentiation. 2005;73:474-83 pubmed
    ..These data indicate that the cells commonly known as fibroblasts have some of the characteristics of stem cells, and can be induced to become neuroectodermal cells and perhaps even mature neurons. ..
  4. Yan J, Yang Y, Zhang H, King C, Kan H, Cai Y, et al. Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells. Oncogene. 2009;28:973-82 pubmed publisher
    ..Together, these results define a novel menin-IQGAP1 pathway that controls cell migration and cell-cell adhesion in endocrine cells. ..
  5. Crino P. Focal brain malformations: a spectrum of disorders along the mTOR cascade. Novartis Found Symp. 2007;288:260-72; discussion 272-81 pubmed
    ..Second, we are using gene and protein expression profile techniques to understand how mTOR activation affects the developing cortex. ..
  6. Yasuhara R, Yuasa T, Williams J, Byers S, Shah S, Pacifici M, et al. Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover. J Biol Chem. 2010;285:317-27 pubmed publisher
    ..Taken together, our data indicate that the Wnt and retinoid signaling pathways do interact in chondrocytes, and their cross-talks and cross-regulation play important roles in the regulation of cartilage matrix homeostasis. ..
  7. Bhattacharyya R, Noch E, Khalili K. A novel role of Rac1 GTPase in JCV T-antigen-mediated beta-catenin stabilization. Oncogene. 2007;26:7628-36 pubmed publisher
    ..These observations unravel the interplay between beta-catenin and Rac1 that is initiated by T-Ag and results in stabilization of beta-catenin and its presence in cell membrane ruffles...
  8. Yang J, Wu J, Tan C, Klein P. PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development. Development. 2003;130:5569-78 pubmed
    ..These data demonstrate a positive role for PP2A:B56epsilon in the Wnt pathway. ..
  9. Wortman B, Darbinian N, Sawaya B, Khalili K, Amini S. Evidence for regulation of long terminal repeat transcription by Wnt transcription factor TCF-4 in human astrocytic cells. J Virol. 2002;76:11159-65 pubmed

More Information


  1. Hedgepeth C, Deardorff M, Rankin K, Klein P. Regulation of glycogen synthase kinase 3beta and downstream Wnt signaling by axin. Mol Cell Biol. 1999;19:7147-57 pubmed
    ..These observations also demonstrate that alternative inhibitors of GSK-3beta can mimic the effect of lithium in developing Xenopus embryos. ..
  2. Ghiselli G, Coffee N, Munnery C, Koratkar R, Siracusa L. The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. J Biol Chem. 2003;278:20259-67 pubmed
    ..Altogether these results are consistent with the idea that the beta-catenin/TCF4 transactivation pathway contributes to SMC3 overexpression in intestinal tumorigenesis. ..
  3. Chang W, Everley L, Pfeiffer G, Cooper H, Barusevicius A, Clapper M. Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC. Ann N Y Acad Sci. 2005;1059:41-55 pubmed
    ..These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin. ..
  4. Katuri V, Tang Y, Li C, Jogunoori W, Deng C, Rashid A, et al. Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression. Oncogene. 2006;25:1871-86 pubmed publisher
    ..Our results identify a group of common lethal malignancies in which inactivation of TGF-beta signaling, which is essential for tumor suppression, is disrupted by inactivation of the ELF adaptor protein. ..
  5. Goss A, Tian Y, Cheng L, Yang J, Zhou D, Cohen E, et al. Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression. Dev Biol. 2011;356:541-52 pubmed publisher
    ..These studies place Wnt2 high in a hierarchy of signaling molecules that promote the earliest aspects of lung airway smooth muscle development. ..
  6. Daumer K, Tufan A, Tuan R. Long-term in vitro analysis of limb cartilage development: involvement of Wnt signaling. J Cell Biochem. 2004;93:526-41 pubmed
    ..Our findings implicate functional role(s) for Wnt signaling throughout embryonic cartilage development, and show the utility of the long-term in vitro limb mesenchyme culture system for such studies. ..
  7. Guo R, Funakoshi S, Lee H, Kong J, Lynch J. The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. Carcinogenesis. 2010;31:159-66 pubmed publisher
  8. Perreault N, Katz J, Sackett S, Kaestner K. Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut. J Biol Chem. 2001;276:43328-33 pubmed
    ..Moreover, we provide the first example implicating proteoglycans in the regulation of cellular proliferation in the gastrointestinal tract. ..
  9. Pan J, Lian Z, Wallett S, Wallet S, Feitelson M. The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin. J Gen Virol. 2007;88:3275-85 pubmed
    ..This suggests that URG7 helps to protect virus-infected hepatocytes during chronic hepatitis B virus infection. ..
  10. Huang J, Zhang Y, Bersenev A, O Brien W, Tong W, Emerson S, et al. Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin Invest. 2009;119:3519-29 pubmed publisher
  11. Blythe S, Reid C, Kessler D, Klein P. Chromatin immunoprecipitation in early Xenopus laevis embryos. Dev Dyn. 2009;238:1422-32 pubmed publisher
    ..Developmental Dynamics 238:1422-1432, 2009. (c) 2009 Wiley-Liss, Inc. ..
  12. Yuasa T, Kondo N, Yasuhara R, Shimono K, Mackem S, Pacifici M, et al. Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. Am J Pathol. 2009;175:1993-2003 pubmed publisher
  13. Sackett S, Gao Y, Shin S, Esterson Y, Tsingalia A, Hurtt R, et al. Foxl1 promotes liver repair following cholestatic injury in mice. Lab Invest. 2009;89:1387-96 pubmed publisher
    ..These results show that Foxl1 promotes liver repair after bile-duct-ligation-induced liver injury through activation of the canonical wnt/beta-catenin pathway...
  14. Li G, Fukunaga M, Herlyn M. Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding beta-catenin signaling. Exp Cell Res. 2004;297:142-51 pubmed
    ..The results indicate that E-cadherin-mediated cell adhesion is required for keratinocyte-mediated control of melanocytic cells, which can override proliferative activity of beta-catenin. ..
  15. Koyama E, Shibukawa Y, Nagayama M, Sugito H, Young B, Yuasa T, et al. A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev Biol. 2008;316:62-73 pubmed publisher
    ..The cells appear to be patterned along specific limb symmetry axes and rely on local signaling tools to make distinct contributions to joint formation. ..
  16. Arzumanyan A, Friedman T, Ng I, Clayton M, Lian Z, Feitelson M. Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?. Cancer Res. 2011;71:3701-8 pubmed publisher
  17. Tarapore R, Lim J, Tian C, Pacios S, Xiao W, Reid D, et al. NF-κB Has a Direct Role in Inhibiting Bmp- and Wnt-Induced Matrix Protein Expression. J Bone Miner Res. 2016;31:52-64 pubmed publisher
    ..This direct mechanism provides a new explanation for the rapid decrease in new bone formation after inflammation-related NF-κB activation. ..
  18. Liu X, Mazanek P, Dam V, Wang Q, Zhao H, Guo R, et al. Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification. Oncogene. 2008;27:1478-88 pubmed
    ..Thus, high-risk NBs without MYCN amplification may deregulate MYC and other oncogenic genes via altered beta-catenin signaling providing a potential candidate pathway for therapeutic inhibition. ..
  19. Hedgepeth C, Conrad L, Zhang J, Huang H, Lee V, Klein P. Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev Biol. 1997;185:82-91 pubmed
    ..The mechanism by which myo-inositol inhibits both dominant negative GSK-3 beta and lithium remains uncertain. ..
  20. Webster M, Weeraratna A. A Wnt-er migration: the confusing role of ?-catenin in melanoma metastasis. Sci Signal. 2013;6:pe11 pubmed publisher
    ..Here, we discuss this finding and how it may help us define different subpopulations of melanoma cells that could have different outcomes, as well as different responses to therapy. ..
  21. Guo R, Huang E, Ezaki T, Patel N, Sinclair K, Wu J, et al. Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. J Biol Chem. 2004;279:36865-75 pubmed
    ..We conclude that Cdx1 and Cdx2 inhibit colon cancer cell proliferation by blocking beta-catenin/TCF transcriptional activity. ..
  22. Gerhart J, Neely C, Stewart B, Perlman J, Beckmann D, Wallon M, et al. Epiblast cells that express MyoD recruit pluripotent cells to the skeletal muscle lineage. J Cell Biol. 2004;164:739-46 pubmed
    ..These results demonstrate that MyoD-positive epiblast cells recruit pluripotent cells to the skeletal muscle lineage. The mechanism of recruitment involves blocking the BMP signaling pathway. ..
  23. Valvezan A, Zhang F, Diehl J, Klein P. Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity. J Biol Chem. 2012;287:3823-32 pubmed publisher
    ..APC regulation of GSK-3 also provides a novel mechanism for Wnt regulation of multiple downstream effectors, including β-catenin and mTOR. ..
  24. Fischer L, Boland G, Tuan R. Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis. J Cell Biochem. 2002;84:816-31 pubmed
    ..We suggest that the chondro-inhibitory effect of lithium on BMP-2 induced chondrogenesis indicates antagonism between lithium-like Wnts and BMP-2 during mesenchymal condensation. ..
  25. Salem A, Bonuccelli G, Bevilacqua G, Arafat H, Pestell R, Sotgia F, et al. Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition. Cell Cycle. 2011;10:3692-700 pubmed publisher
    ..Thus, we provide evidence that Cav-1 functions as a crucial modulator of EMT and cell differentiation in pancreatic cancer. ..
  26. Liu F, Chu E, WATT B, Zhang Y, Gallant N, Andl T, et al. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008;313:210-24 pubmed
  27. Mizushima T, Nakagawa H, Kamberov Y, Wilder E, Klein P, Rustgi A. Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Cancer Res. 2002;62:277-82 pubmed
    ..A comparison of extracellular stimuli suggests that specific Wnt family members stabilize beta-catenin with resulting activation of TCF-dependent transcription in ESCC. ..
  28. Leonard M, Zhang L, Zhai N, Cader A, Chan Y, Nowak R, et al. Modulation of N-cadherin junctions and their role as epicenters of differentiation-specific actin regulation in the developing lens. Dev Biol. 2011;349:363-77 pubmed publisher
    ..These studies provide a molecular link between N-cadherin junctions and the organization of an actin cytoskeleton that governs lens fiber cell morphogenesis in vivo. ..
  29. Cohen E, Wang Z, Lepore J, Lu M, Taketo M, Epstein D, et al. Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest. 2007;117:1794-804 pubmed
    ..These data reveal what we believe to be a novel Wnt-FGF signaling axis required for expansion of Isl-1-positive AHF progenitors and suggest future therapies to increase the number and function of these cells for cardiac regeneration. ..
  30. Tsygankova O, Ma C, Tang W, Korch C, Feldman M, Lv Y, et al. Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Mol Cell Biol. 2010;30:3262-74 pubmed publisher
    ..The frequent downregulation of Rap1GAP in epithelial tumors where alterations in cell/cell and cell/matrix adhesion are early steps in tumor dissemination supports a role for Rap1GAP depletion in tumor progression. ..
  31. Alves Guerra M, Ronchini C, Capobianco A. Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. Cancer Res. 2007;67:8690-8 pubmed
    ..This is the first demonstration of a role for the Mastermind-like family in another signaling pathway and that the knockdown of Mastermind-like family function leads to tumor cell death. ..
  32. Lian Z, Liu J, Li L, Li X, Clayton M, Wu M, et al. Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. Hepatology. 2006;43:415-24 pubmed
    ..These observations also suggest that URG11 may be a regulatory element in the beta-catenin signaling pathway and may be a target for chemoprevention of HCC. ..
  33. Yuasa T, Otani T, Koike T, Iwamoto M, Enomoto Iwamoto M. Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration. Lab Invest. 2008;88:264-74 pubmed publisher
  34. Peng L, Li Y, Shusterman K, Kuehl M, Gibson C. Wnt-RhoA signaling is involved in dental enamel development. Eur J Oral Sci. 2011;119 Suppl 1:41-9 pubmed publisher
    ..The current results indicate that both Wnt and RhoA pathways are implicated in fluoride-induced signaling transductions in the ALC as well as in the development of enamel defects in RhoA(DN) transgenic mice. ..
  35. Menko A, Zhang L, Schiano F, Kreidberg J, Kukuruzinska M. Regulation of cadherin junctions during mouse submandibular gland development. Dev Dyn. 2002;224:321-33 pubmed
  36. Choi Y, Zhang Y, Xu M, Yang Y, Ito M, Peng T, et al. Distinct functions for Wnt/?-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013;13:720-33 pubmed publisher
    ..We further unexpectedly discovered a broader role for Wnt/?-catenin signaling in contributing to progenitor cell proliferation in nonhairy epithelia and interfollicular epidermis under homeostatic, but not inflammatory, conditions. ..
  37. Hanlon L, Avila J, Demarest R, Troutman S, Allen M, Ratti F, et al. Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res. 2010;70:4280-6 pubmed publisher
    ..Unexpectedly, the loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC. ..
  38. Rakowiecki S, Epstein D. Divergent roles for Wnt/?-catenin signaling in epithelial maintenance and breakdown during semicircular canal formation. Development. 2013;140:1730-9 pubmed publisher
    ..Together, these disparate functions of the Wnt/?-catenin pathway in epithelial maintenance and resorption help regulate the size, shape and number of SSCs...
  39. Zhang Y, Goss A, Cohen E, Kadzik R, Lepore J, Muthukumaraswamy K, et al. A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet. 2008;40:862-70 pubmed publisher
    ..Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration. ..
  40. Feigenson K, Reid M, See J, Crenshaw E, Grinspan J. Wnt signaling is sufficient to perturb oligodendrocyte maturation. Mol Cell Neurosci. 2009;42:255-65 pubmed publisher
    ..These results indicate that activating the Wnt/beta-catenin pathway delays the development of myelinating oligodendrocytes. ..
  41. Swope D, Cheng L, Gao E, Li J, Radice G. Loss of cadherin-binding proteins ?-catenin and plakoglobin in the heart leads to gap junction remodeling and arrhythmogenesis. Mol Cell Biol. 2012;32:1056-67 pubmed publisher
    ..In conclusion, these studies demonstrate that the N-cadherin-binding partners, PG and ?-catenin, are indispensable for maintaining mechanoelectrical coupling in the heart. ..
  42. Yuan K, Lian Z, Sun B, Clayton M, Ng I, Feitelson M. Role of miR-148a in hepatitis B associated hepatocellular carcinoma. PLoS ONE. 2012;7:e35331 pubmed publisher
    ..Thus, miR-148a may play a central role in HBx/URG11 mediated HCC, and may be an early diagnostic marker and/or therapeutic target associated with this tumor type. ..
  43. Ma L, Zhang G, Miao X, Deng X, Wu Y, Liu Y, et al. Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma. FEBS J. 2013;280:2027-41 pubmed publisher
    ..In addition, our results suggest that targeting β-catenin represents a rational clinical modality for patients whose tumors harbor activated EGFR or AKT. ..
  44. Balint K, Xiao M, Pinnix C, Soma A, Veres I, Juhasz I, et al. Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest. 2005;115:3166-76 pubmed
    ..Inhibiting beta-catenin expression reversed Notch1-enhanced tumor growth and metastasis. Our data therefore suggest a beta-catenin-dependent, stage-specific role for Notch1 signaling in promoting the progression of primary melanoma. ..
  45. Wu S, De Luca F. Inhibition of the proteasomal function in chondrocytes down-regulates growth plate chondrogenesis and longitudinal bone growth. Endocrinology. 2006;147:3761-8 pubmed
    ..In conclusion, our findings suggest that the proteasomal activity facilitates growth plate chondrogenesis and, in turn, longitudinal bone growth...
  46. Goldoni S, Humphries A, Nyström A, Sattar S, Owens R, McQuillan D, et al. Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol. 2009;185:743-54 pubmed publisher
    ..Thus, by antagonistically targeting multiple tyrosine kinase receptors, decorin contributes to reduction in primary tumor growth and metastastic spreading. ..
  47. Shu W, Guttentag S, Wang Z, Andl T, Ballard P, Lu M, et al. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol. 2005;283:226-39 pubmed
    ..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling. ..
  48. Reddy S, Andl T, Lu M, Morrisey E, Millar S. Expression of Frizzled genes in developing and postnatal hair follicles. J Invest Dermatol. 2004;123:275-82 pubmed
  49. Aho S, Rothenberger K, Uitto J. Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen. J Cell Biochem. 1999;73:390-9 pubmed
  50. Kong J, Crissey M, Stairs D, Sepulveda A, Lynch J. Cox2 and ?-catenin/T-cell factor signaling intestinalize human esophageal keratinocytes when cultured under organotypic conditions. Neoplasia. 2011;13:792-805 pubmed
    ..We conclude that in vitro modeling of BE pathogenesis can be improved by enhancing Wnt signaling and Cox2 activity and using three-dimensional organotypic culture conditions. ..
  51. Li J, Swope D, Raess N, Cheng L, Muller E, Radice G. Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol. 2011;31:1134-44 pubmed publisher
    ..This novel model of ARVC demonstrates for the first time how plakoglobin affects ?-catenin activity in the heart and its implications for disease pathogenesis. ..
  52. Mongroo P, Rustgi A. The role of the miR-200 family in epithelial-mesenchymal transition. Cancer Biol Ther. 2010;10:219-22 pubmed
  53. Liu F, Dangaria S, Andl T, Zhang Y, Wright A, Damek Poprawa M, et al. beta-Catenin initiates tooth neogenesis in adult rodent incisors. J Dent Res. 2010;89:909-14 pubmed publisher
    ..Thus, forced activation of beta-catenin signaling can initiate an embryonic-like program of tooth development in adult rodent incisor teeth. ..
  54. Rozan L, El Deiry W. Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target. Cancer Biol Ther. 2006;5:1228-35 pubmed
  55. Tetreault M, Yang Y, Travis J, Yu Q, Klein Szanto A, Tobias J, et al. Esophageal squamous cell dysplasia and delayed differentiation with deletion of krüppel-like factor 4 in murine esophagus. Gastroenterology. 2010;139:171-81.e9 pubmed publisher
    ..Klf4 is essential for squamous epithelial differentiation in vivo and interacts with Klf5 to maintain normal epithelial homeostasis. ..
  56. Liu F, Thirumangalathu S, Gallant N, Yang S, Stoick Cooper C, Reddy S, et al. Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet. 2007;39:106-12 pubmed
    ..Thus, Wnt-beta-catenin signaling is critical for fungiform papilla and taste bud development. Altered regulation of this pathway may underlie evolutionary changes in taste papilla patterning. ..
  57. Andl T, Reddy S, Gaddapara T, Millar S. WNT signals are required for the initiation of hair follicle development. Dev Cell. 2002;2:643-53 pubmed
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation. ..
  58. Grajales Esquivel E, Luz Madrigal A, Bierly J, Haynes T, Reis E, Han Z, et al. Complement component C3aR constitutes a novel regulator for chick eye morphogenesis. Dev Biol. 2017;428:88-100 pubmed publisher
    ..Together our results show that C3aR is necessary for the proper morphogenesis of the OC. This is the first report implicating C3aR in eye development, revealing an unsuspected hitherto regulator for proper chick eye morphogenesis. ..
  59. Nagayama M, Iwamoto M, Hargett A, Kamiya N, Tamamura Y, Young B, et al. Wnt/beta-catenin signaling regulates cranial base development and growth. J Dent Res. 2008;87:244-9 pubmed
    ..This pathway promotes chondrocyte maturation and ossification events, and may exert this important role by dampening the effects of Ihh-PTHrP together with sFRP-1. ..
  60. Chen J, Wu A, Sun H, Drakas R, Garofalo C, Cascio S, et al. Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin. J Biol Chem. 2005;280:29912-20 pubmed
    ..This possibility is supported by the demonstration that enforced nuclear localization of IRS-1 causes nuclear translocation of beta-catenin and transformation of normal mouse embryo fibroblasts (colony formation in soft agar). ..
  61. Tan X, Yuan Y, Zeng G, Apte U, Thompson M, Cieply B, et al. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology. 2008;47:1667-79 pubmed publisher
    ..Beta-catenin regulates multiple, critical events during the process of hepatic morphogenesis, including hepatoblast maturation, expansion, and survival, making it indispensable to survival. ..
  62. Proweller A, Tu L, Lepore J, Cheng L, Lu M, Seykora J, et al. Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res. 2006;66:7438-44 pubmed
  63. Ghiselli G, Agrawal A. The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. Biochem J. 2005;390:493-9 pubmed
    ..The data obtained are consistent with the idea that the beta-catenin-TCF4 transactivation pathway plays a major role in modulating GLCE expression, thus contributing to the regulation of HS biosynthesis and its structural organization. ..
  64. Varga M, Maegawa S, Bellipanni G, Weinberg E. Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo. Mech Dev. 2007;124:775-91 pubmed
  65. Kelly C, Chin A, Leatherman J, Kozlowski D, Weinberg E. Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish. Development. 2000;127:3899-911 pubmed
    ..This work demonstrates that a maternal gene controlling localization of (beta)-catenin in dorsal nuclei is necessary for dorsal yolk syncytial layer gene activity and formation of the organizer in the zebrafish. ..
  66. Swope D, Li J, Muller E, Radice G. Analysis of a Jup hypomorphic allele reveals a critical threshold for postnatal viability. Genesis. 2012;50:717-27 pubmed publisher
    ..These data suggest novel function(s) for PG beyond the heart and define a critical threshold of PG expression that is necessary for postnatal survival. ..
  67. Damek Poprawa M, Korostoff J, Gill R, DiRienzo J. Cell junction remodeling in gingival tissue exposed to a microbial toxin. J Dent Res. 2013;92:518-23 pubmed publisher
    ..These results indicate that the Cdt induced substantial remodeling of adherens junctions, with a potential impact on the barrier function of gingival epithelium...
  68. Li P, Schulz S, Bombonati A, Palazzo J, Hyslop T, Xu Y, et al. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology. 2007;133:599-607 pubmed
  69. Vuchak L, Tsygankova O, Meinkoth J. Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion. Cell Adh Migr. 2011;5:323-31 pubmed
    ..These data indicate that transient, modest expression of Rap1GAP is compatible with cell-cell adhesion and that the role of Rap1GAP in the regulation of cell-cell adhesion may be more complex than is currently appreciated. ..
  70. Yasuhara R, Ohta Y, Yuasa T, Kondo N, Hoang T, Addya S, et al. Roles of ?-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest. 2011;91:1739-52 pubmed publisher
    ..Together, the data reveal that Wnt/?-catenin signaling is a key regulator of SFZ cell phenotype and proliferation, and may be as important for articular cartilage long-term function. ..
  71. Kemeny S, Figueroa D, Clyne A. Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress. PLoS ONE. 2013;8:e66176 pubmed publisher
    ..These data suggest that low and high glucose alter endothelial cell alignment and nitric oxide production in response to shear stress through different mechanisms. ..
  72. Yang J, Tan C, Darken R, Wilson P, Klein P. Beta-catenin/Tcf-regulated transcription prior to the midblastula transition. Development. 2002;129:5743-52 pubmed
  73. Crissey M, Guo R, Funakoshi S, Kong J, Liu J, Lynch J. Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development. Gastroenterology. 2011;140:517-528.e8 pubmed publisher
    ..Cdx2 is a critical regulator not only of intestine-specific genes, but also processes that determine epithelial maturity and function. ..
  74. Buraschi S, Pal N, Tyler Rubinstein N, Owens R, Neill T, Iozzo R. Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. J Biol Chem. 2010;285:42075-85 pubmed publisher
    ..Collectively, our results indicate a role for a secreted proteoglycan in suppressing the expression of key oncogenic factors required for tumor progression...
  75. Brastianos P, Taylor Weiner A, Manley P, Jones R, Dias Santagata D, Thorner A, et al. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet. 2014;46:161-5 pubmed publisher
    ..Adamantinomatous and papillary craniopharyngiomas harbor mutations that are mutually exclusive and clonal. These findings have important implications for the diagnosis and treatment of these neoplasms. ..
  76. Ukropec J, Hollinger M, Salva S, Woolkalis M. SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin. J Biol Chem. 2000;275:5983-6 pubmed
    ..Such changes in adherens junction complex composition likely underlie thrombin-elicited alterations in endothelial monolayer permeability. ..
  77. Li J, Levin M, Xiong Y, Petrenko N, Patel V, Radice G. N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility. J Mol Cell Cardiol. 2008;44:597-606 pubmed publisher
  78. Cohen E, Ihida Stansbury K, Lu M, Panettieri R, Jones P, Morrisey E. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest. 2009;119:2538-49 pubmed publisher
    ..Together, these data define a Wnt/Tnc/Pdgfr signaling axis that is critical for smooth muscle development and disease progression in the lung. ..
  79. Goss A, Tian Y, Tsukiyama T, Cohen E, Zhou D, Lu M, et al. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell. 2009;17:290-8 pubmed publisher
    ..Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut...
  80. Zhang Y, Tomann P, Andl T, Gallant N, Huelsken J, Jerchow B, et al. Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell. 2009;17:49-61 pubmed publisher
    ..These data reveal a complex interplay and interdependence of Wnt/beta-catenin and EDA/EDAR/NF-kappaB signaling pathways in initiation and maintenance of primary hair follicle placodes...
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