Experts and Doctors on animals in Philadelphia, Pennsylvania, United States

Summary

Locale: Philadelphia, Pennsylvania, United States
Topic: animals

Top Publications

  1. George A, Komisarof J, Kallen R, Barchi R. Primary structure of the adult human skeletal muscle voltage-dependent sodium channel. Ann Neurol. 1992;31:131-7 pubmed
    ..This structural information should provide the necessary backdrop for identifying and evaluating mutations affecting the function of this channel in the periodic paralyses...
  2. Hsu J, Laz T, Mohn K, Taub R. Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver. Proc Natl Acad Sci U S A. 1991;88:3511-5 pubmed
    ..As such, LRF-1 may have a unique and critical role in growth regulation of regenerating liver and mitogen-stimulated cells. ..
  3. Calvert R, Klurfeld D, Subramaniam S, Vahouny G, Kritchevsky D. Reduction of colonic carcinogenesis by wheat bran independent of fecal bile acid concentration. J Natl Cancer Inst. 1987;79:875-80 pubmed
    ..Although the fecal bile acid concentrations of the FF and WB + bile salts groups were equal, the latter showed a significant reduction in tumor yield. ..
  4. Olds Clarke P, Pilder S, Visconti P, Moss S, Orth J, Kopf G. Sperm from mice carrying two t haplotypes do not possess a tyrosine phosphorylated form of hexokinase. Mol Reprod Dev. 1996;43:94-104 pubmed
    ..Since the mutant sperm are unable to complete fertilization, there could be a relationship between sterility and the lack of tyrosine phosphorylation of HK1 in these mutant sperm. ..
  5. Fernandes M, Finnegan A, Siracusa L, Brenner C, Iscove N, Calabretta B. Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 1999;59:2709-17 pubmed
    ..Moreover, its expression is not restricted to natural killer cells, as reported for the majority of group V lectins. Nkcl is expressed in pluripotent myeloid precursors, precursor and mature macrophages, and neutrophils. ..
  6. Caloca M, Wang H, Delemos A, Wang S, Kazanietz M. Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. J Biol Chem. 2001;276:18303-12 pubmed
    ..The identification of selective ligands for each phorbol ester receptor class represents an important step in dissecting their specific cellular functions. ..
  7. Chatah N, Abrams C. G-protein-coupled receptor activation induces the membrane translocation and activation of phosphatidylinositol-4-phosphate 5-kinase I alpha by a Rac- and Rho-dependent pathway. J Biol Chem. 2001;276:34059-65 pubmed
    ..Once activated and translocated to the cell membrane, PIP5K I alpha becomes available to phosphorylate PI4P to generate PI4,5P(2) on the plasma membrane. ..
  8. Bullrich F, Fujii H, Calin G, Mabuchi H, Negrini M, Pekarsky Y, et al. Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene. Cancer Res. 2001;61:6640-8 pubmed
    ..This feature of the sequence may favor the occurrence of chromosomal rearrangements and may confer instability to the region, resulting in deletions that may inactivate an as yet unidentified tumor suppressor. ..
  9. Mulugeta S, Gray J, Notarfrancesco K, Gonzales L, Koval M, Feinstein S, et al. Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3. J Biol Chem. 2002;277:22147-55 pubmed

More Information

Publications1248 found, 100 shown here

  1. Shinohara T, Orwig K, Avarbock M, Brinster R. Germ line stem cell competition in postnatal mouse testes. Biol Reprod. 2002;66:1491-7 pubmed
    ..Thus, a dynamic relationship between stem cell and niche exists in the testis, as has been suggested for hematopoiesis. Therefore, similar competitive properties of donor stem cells may be characteristic of all self-renewing systems. ..
  2. Cryan J, O Leary O, Jin S, Friedland J, Ouyang M, Hirsch B, et al. Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Proc Natl Acad Sci U S A. 2004;101:8186-91 pubmed
    ..These data show that NE plays an important role in mediating acute behavioral and neurochemical actions of many antidepressants, including most SSRIs. ..
  3. Kritchevsky D, Tepper S, Wright S, Czarnecki S, Wilson T, Nicolosi R. Conjugated linoleic acid isomer effects in atherosclerosis: growth and regression of lesions. Lipids. 2004;39:611-6 pubmed
    ..2% cholesterol; and when fed as part of a cholesterol-free diet, they reduce established lesions by 26%. Reduction of atheromata to the observed extent by dietary means alone is noteworthy. ..
  4. Kushner J, Ciemerych M, Sicinska E, Wartschow L, Teta M, Long S, et al. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol. 2005;25:3752-62 pubmed
    ..Thus, cyclins D2 and D1 were essential for beta-cell expansion in adult mice. Strategies to tightly regulate D-type cyclin activity in beta cells could prevent or cure diabetes. ..
  5. Wallenfang M, Nayak R, Dinardo S. Dynamics of the male germline stem cell population during aging of Drosophila melanogaster. Aging Cell. 2006;5:297-304 pubmed
    ..Second, at any given time not all stem cells actively cycle, leading to 'clonal succession' from the reserve pool of initially quiescent stem cells. We find that neither of these mechanisms is used in Drosophila male GSCs. ..
  6. Filone C, Heise M, Doms R, Bertolotti Ciarlet A. Development and characterization of a Rift Valley fever virus cell-cell fusion assay using alphavirus replicon vectors. Virology. 2006;356:155-64 pubmed
  7. Galioto A, Hess J, Nolan T, Schad G, Lee J, Abraham D. Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice. Infect Immun. 2006;74:5730-8 pubmed
    ..stercoralis in mice...
  8. Song J, Aswad R, Kanaan R, Rico M, Owen T, Barbe M, et al. Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF-beta1 to induce mesenchymal cell condensation. J Cell Physiol. 2007;210:398-410 pubmed
    ..CTGF is also involved in up-regulating FN and suppressing Sox9 expression during TGF-beta1 induced MC condensation. ..
  9. Korutla L, Degnan R, Wang P, Mackler S. NAC1, a cocaine-regulated POZ/BTB protein interacts with CoREST. J Neurochem. 2007;101:611-8 pubmed
    ..This is the first report to demonstrate that a POZ/BTB protein interacts with CoREST. Taken together, the results indicate that CoREST may be part of the NAC1 repressor mechanism. ..
  10. Markowitz S, Mendoza Paredes A, Liu H, Pastuszko P, Schultz S, Schears G, et al. Response of brain oxygenation and metabolism to deep hypothermic circulatory arrest in newborn piglets: comparison of pH-stat and alpha-stat strategies. Ann Thorac Surg. 2007;84:170-6 pubmed
    ..The increase in p-CREB, p-Akt, Bcl-2, Bcl-2/Bax, and delay in increase of dopamine indicated that pH-stat, in the piglet model, prolongs "safe" time of DHCA and provides some brain protection against ischemic injury. ..
  11. Xu M, You Y, Hunsicker P, Hori T, Small C, Griswold M, et al. Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control. Biol Reprod. 2008;79:51-7 pubmed publisher
    ..These findings indicate that piRNAs from a cluster on chromosome 2 are necessary to maintain transposon silencing. ..
  12. Gudima S, He Y, Chai N, Bruss V, Urban S, Mason W, et al. Primary human hepatocytes are susceptible to infection by hepatitis delta virus assembled with envelope proteins of woodchuck hepatitis virus. J Virol. 2008;82:7276-83 pubmed publisher
    ..One interpretation of these data is that host range specificity of HDV is determined entirely by pre-S1 and that the WHV and HBV pre-S1 proteins recognize different receptors on PHH...
  13. Sewell D, Pan Z, Paterson Y. Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors. Vaccine. 2008;26:5315-20 pubmed publisher
    ..This study shows that Listeria-based vaccines are able to slow autochthonous tumor growth and break immunological tolerance...
  14. Danielyan K, Ganguly K, Ding B, Atochin D, Zaitsev S, Murciano J, et al. Cerebrovascular thromboprophylaxis in mice by erythrocyte-coupled tissue-type plasminogen activator. Circulation. 2008;118:1442-9 pubmed publisher
    ..These results suggest a potential RBC/tPA utility as thromboprophylaxis in patients who are at risk for acute cerebrovascular thromboembolism. ..
  15. Brutus N, Hanley S, Ashraf Q, Mishra O, Delivoria Papadopoulos M. Effect of hyperoxia on serine phosphorylation of apoptotic proteins in mitochondrial membranes of the cerebral cortex of newborn piglets. Neurochem Res. 2009;34:1219-25 pubmed publisher
    ..We speculate that phosphorylation of Bcl-2 and Bcl-xl will result in loss of their anti-apoptotic potential by preventing their dimerization with Bax leading to activation of the caspase cascade of neuronal death. ..
  16. Müller M, Cheung K, Foskett J. Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling. Antioxid Redox Signal. 2011;14:1225-35 pubmed publisher
    ..Exaggerated Ca(2+) signaling through InsP(3)R-PS interaction is a disease specific and robust proximal mechanism in AD that may contribute to the pathology of AD by enhanced generation of reactive oxygen species. ..
  17. Lee R, Foskett J. cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways. J Clin Invest. 2010;120:3137-48 pubmed publisher
    ..These results identify important molecular mechanisms of cAMP-dependent secretion, including a requirement for Ca2+ signaling, and suggest new therapeutic approaches to correct defective submucosal gland secretion in CF...
  18. Zhu H, Li J, Nolan T, Schad G, Lok J. Sensory neuroanatomy of Parastrongyloides trichosuri, a nematode parasite of mammals: Amphidial neurons of the first-stage larva. J Comp Neurol. 2011;519:2493-507 pubmed publisher
    ..elegans was adopted. A map of cell bodies within the lateral ganglion of P. trichosuri was prepared to facilitate functional study of these neurons. ..
  19. Heydendael W, Sharma K, Iyer V, Luz S, Piel D, Beck S, et al. Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress. Endocrinology. 2011;152:4738-52 pubmed publisher
    ..Together, the results suggest that orexin actions in the pPVT, mediated by orexin1 receptors, are important for the ability to adapt to repeated stress. ..
  20. Sagar D, Lamontagne A, Foss C, Khan Z, Pomper M, Jain P. Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation. J Neuroinflammation. 2012;9:245 pubmed publisher
    ..Overall, these comprehensive studies provide a state-of-the-art view of DCs within the CNS, elucidate their path across the BBB, and highlight potential mechanisms involved in CCL2-mediated DC trafficking. ..
  21. Schoenhaut D, Curtis P. Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites. Nucleic Acids Res. 1989;17:7013-28 pubmed
    ..Thus, these sites are specific for erythroid chromatin but appear to be established at an earlier stage of differentiation than represented by the uninduced MEL cell. ..
  22. Offord S, Ordway G, Frazer A. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. J Pharmacol Exp Ther. 1988;244:144-53 pubmed
  23. Zhou E, Favor J, Silvers W, Stambolian D. Exclusion of three candidate genes, Grpr, Cxn33, and Pdha1, for the X-linked cataract gene on the distal region of the mouse chromosome X. Mamm Genome. 1995;6:357-9 pubmed
  24. Shaw M. The same but different: the biology of Theileria sporozoite entry into bovine cells. Int J Parasitol. 1997;27:457-74 pubmed
    ..These processes in turn regulate the invasive capacity of the sporozoite although the identity of these parasite molecules and how they contribute to the invasion process remain to be determined...
  25. Clevenger C, Kline J. Prolactin receptor signal transduction. Lupus. 2001;10:706-18 pubmed
    ..Differential activation of these pathways may contribute to the pleiotropism of PRL action in tissues of the immune system. ..
  26. Graves L, Dalvi A, Lucki I, Blendy J, Abel T. Behavioral analysis of CREB alphadelta mutation on a B6/129 F1 hybrid background. Hippocampus. 2002;12:18-26 pubmed
    ..These studies underscore the importance of controlling for genetic background in the behavioral analysis of knockout and transgenic mice. ..
  27. Wagner D, Mullins M. Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev Biol. 2002;245:109-23 pubmed
    ..As has been proposed for the fly orthologue of chordin, short gastrulation, our paradoxical results can be explained by a model whereby Chordin both antagonizes and promotes BMP activity. ..
  28. Kim S, Foster C, Lecchi A, Quinton T, Prosser D, Jin J, et al. Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling. Blood. 2002;99:3629-36 pubmed
  29. Mutai H, Kenyon L, Locke E, Kikuchi N, Oberholtzer J. Characterization of the chicken inward rectifier K+ channel IRK1/Kir2.1 gene. BMC Genomics. 2004;5:90 pubmed
    ..These results provide fundamental data to analyze cIRK1 transcriptional mechanisms. The control elements identified here may provide clues to the tissue-specific expression of this K+ channel. ..
  30. Theos A, Truschel S, Raposo G, Marks M. The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function. Pigment Cell Res. 2005;18:322-36 pubmed
    ..As such, we will refer to the protein in this review simply as pre-melanosomal protein (Pmel). This review will summarize the structural and functional aspects of Pmel and its role in melanosome biogenesis...
  31. Chen Roetling J, Regan R. Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin. Biochem Biophys Res Commun. 2006;350:233-7 pubmed
    ..These results suggest that HO-1 induction protects astrocytes from the oxidative toxicity of Hb, but has no effect on neuronal injury. ..
  32. Marzec M, Kasprzycka M, Liu X, El Salem M, Halasa K, Raghunath P, et al. Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway. Oncogene. 2007;26:5606-14 pubmed
    ..These findings identify mTOR as a novel key target of NPM/ALK and suggest that mTOR inhibitors may prove effective in therapy of ALK-induced malignancies. ..
  33. Vedhachalam C, Duong P, Nickel M, Nguyen D, Dhanasekaran P, Saito H, et al. Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles. J Biol Chem. 2007;282:25123-30 pubmed
    ..Overall, this mechanism is consistent with the known properties of ABCA1 and apo A-I and reconciles many of the apparently discrepant findings in the literature...
  34. Wu M, Li J, Engleka K, Zhou B, Lu M, Plotkin J, et al. Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. J Clin Invest. 2008;118:2076-87 pubmed publisher
    ..These studies provide in vivo evidence for the importance of Pax3 downregulation during differentiation of multipotent neural crest precursors and cranial development. ..
  35. Ertel A, Tozeren A. Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality. BMC Genomics. 2008;9:628 pubmed publisher
  36. Rough J, Engdahl R, Opperman K, Yerrum S, Monroy M, Daly J. beta2 Adrenoreceptor blockade attenuates the hyperinflammatory response induced by traumatic injury. Surgery. 2009;145:235-42 pubmed publisher
    ..05). This study demonstrates that beta(2)-receptor blockade reduces macrophage cytokine production and improves survival showing the critical importance of catecholamines to the immunologic response in surgery. ..
  37. Merianos D, Tiblad E, Santore M, Todorow C, Laje P, Endo M, et al. Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice. J Clin Invest. 2009;119:2590-600 pubmed publisher
    ..This study resolves the apparent contradiction of induction of an adaptive immune response in the pre-immune fetus and confirms the potential of actively acquired tolerance to facilitate prenatal therapeutic applications. ..
  38. Yasuda T, Ishida T, Rader D. Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis. Circ J. 2010;74:2263-70 pubmed
    ..The available data regarding the impact of EL expression and activity on HDL metabolism, reverse cholesterol transport, and atherosclerosis are reviewed. ..
  39. Lu B, Zhang Q, Wang H, Wang Y, Nakayama M, Ren D. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron. 2010;68:488-99 pubmed publisher
    ..Therefore, extracellular Ca(2+) influences neuronal excitability through the UNC79-UNC80-NALCN complex in a G protein-dependent fashion. ..
  40. Ramanan V, Agrawal N, Liu J, Engles S, Toy R, Radhakrishnan R. Systems biology and physical biology of clathrin-mediated endocytosis. Integr Biol (Camb). 2011;3:803-15 pubmed publisher
  41. Genda E, Jackson J, Sheldon A, Locke S, Greco T, O Donnell J, et al. Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci. 2011;31:18275-88 pubmed publisher
  42. Sitaram A, Dennis M, Chaudhuri R, De Jesus Rojas W, Tenza D, Setty S, et al. Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes. Mol Biol Cell. 2012;23:3178-92 pubmed
    ..These data provide evidence for distinct roles of AP-1 and AP-3 in OCA2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo sorting to LROs...
  43. Liu M, Scalia R, Mehta J, Williams K. Cholesterol-induced membrane microvesicles as novel carriers of damage-associated molecular patterns: mechanisms of formation, action, and detoxification. Arterioscler Thromb Vasc Biol. 2012;32:2113-21 pubmed publisher
    ..By promoting maladaptive immunologic and thrombotic responses, these particles may contribute to atherothrombosis and other conditions in vivo. ..
  44. Elrod J, Molkentin J. Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circ J. 2013;77:1111-22 pubmed
  45. Kepler C, Markova D, Dibra F, Yadla S, Vaccaro A, Risbud M, et al. Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1? in painful human intervertebral discs. Spine (Phila Pa 1976). 2013;38:873-80 pubmed publisher
    ..Laboratory study...
  46. Albenberg L, Wu G. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology. 2014;146:1564-72 pubmed publisher
    ..We review how diet affects the structure and metabolome of the human intestinal microbiome and may contribute to health or the pathogenesis of disorders such as coronary vascular disease and inflammatory bowel disease. ..
  47. Li C, Kirby L. Effects of cocaine history on postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats. Eur Neuropsychopharmacol. 2016;26:45-54 pubmed publisher
    ..Such mechanisms may result in serotonergic hypofunction and consequent dysphoric mood states which confer vulnerability to stress-induced drug reinstatement. ..
  48. Beltran W, Wen R, Acland G, Aguirre G. Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina. Exp Eye Res. 2007;84:753-71 pubmed
    ..Our findings suggest that some inherited forms of retinal degeneration may not respond to CNTF's neuroprotective effects. ..
  49. Faul E, Wanjalla C, McGettigan J, Schnell M. Interferon-beta expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity. Virology. 2008;382:226-38 pubmed publisher
    ..The increased CD8+ T cell activation in the presence of IFN-beta, even with greatly reduced viral replication, indicates the beneficial effect of IFN-beta for the host. ..
  50. Mennella J, Forestell C, Morgan L, Beauchamp G. Early milk feeding influences taste acceptance and liking during infancy. Am J Clin Nutr. 2009;90:780S-788S pubmed publisher
    ..This model system of research investigation sheds light on sources of individual differences in taste and perhaps cultural food preferences. ..
  51. Onder O, Shao W, Kemps B, Lam H, Brisson D. Identifying sources of tick blood meals using unidentified tandem mass spectral libraries. Nat Commun. 2013;4:1746 pubmed publisher
    ..This biological fingerprinting methodology is sensitive, fast, cost-effective and can potentially be adapted for other biological and medical applications when existing genome-based methods are impractical or ineffective. ..
  52. Bi L, Sarkar R, Naas T, Lawler A, Pain J, Shumaker S, et al. Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies. Blood. 1996;88:3446-50 pubmed
    ..Assay of cryoprecipitate from the plasma of affected mice failed to show factor VIII light chain. ..
  53. Bucher E, Dhoot G, Emerson M, Ober M, Emerson C. Structure and evolution of the alternatively spliced fast troponin T isoform gene. J Biol Chem. 1999;274:17661-70 pubmed
  54. Atkins G, Hu X, Guenther M, Rachez C, Freedman L, Lazar M. Coactivators for the orphan nuclear receptor RORalpha. Mol Endocrinol. 1999;13:1550-7 pubmed
    ..GRIP-1 functioned as a coactivator for the RORalpha both in yeast and in mammalian cells. Thus, GRIP-1 is the first proven coactivator for RORalpha. ..
  55. Karpinich N, Tafani M, Rothman R, Russo M, Farber J. The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J Biol Chem. 2002;277:16547-52 pubmed
    ..The activation of p53 increases Bax synthesis. The translocation of Bax to the mitochondria induces the MPT, the event that releases cytochrome c and culminates in the death of the cells. ..
  56. Newbrough S, Mocsai A, Clemens R, Wu J, Silverman M, Singer A, et al. SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity. 2003;19:761-9 pubmed
    ..These results provide genetic evidence for a critical role of SLP-76 in the regulation of neutrophil function. ..
  57. Little S, Mullins M. Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development. 2004;131:5825-35 pubmed
    ..Our results support a model in which zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning. ..
  58. Do C, Lu W, Mitchell C, Civan M. Inhibition of swelling-activated Cl- currents by functional anti-ClC-3 antibody in native bovine non-pigmented ciliary epithelial cells. Invest Ophthalmol Vis Sci. 2005;46:948-55 pubmed
    ..This information will be useful in understanding the mechanisms controlling aqueous humor formation and thereby intraocular pressure. ..
  59. Sambandam A, Maillard I, Zediak V, Xu L, Gerstein R, Aster J, et al. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nat Immunol. 2005;6:663-70 pubmed
    ..In contrast, multipotent hematopoietic progenitors circulated in the blood even in the absence of Notch signaling, suggesting that critical Notch signals during early T lineage development are delivered early after thymic entry. ..
  60. Kumar R, Ha J, Radhakrishnan R, Dhanasekaran D. Transactivation of platelet-derived growth factor receptor alpha by the GTPase-deficient activated mutant of Galpha12. Mol Cell Biol. 2006;26:50-62 pubmed
    ..Consistent with this view, we demonstrate that the expression of a dominant negative mutant of PDGFRalpha attenuated Galpha12-mediated neoplastic transformation of NIH 3T3 cells. ..
  61. Volgin D, Kubin L. Regionally selective effects of GABA on hypothalamic GABAA receptor mRNA in vitro. Biochem Biophys Res Commun. 2007;353:726-32 pubmed
    ..We conclude that, in the PF region where GABA facilitates sleep, increased GABA release may limit GABAAR-mediated inhibition, whereas in the DM region, GABA-induced changes are mainly mediated by non-GABAA receptors. ..
  62. Carmody R, Ruan Q, Palmer S, Hilliard B, Chen Y. Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade. Science. 2007;317:675-8 pubmed
    ..These findings indicate that the p50 ubiquitination pathway can be selectively targeted to control deleterious inflammatory diseases. ..
  63. HUANG A, Stein A, Tuan R, Mauck R. Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner. Tissue Eng Part A. 2009;15:3461-72 pubmed publisher
  64. Horn C. Electrophysiology of vagal afferents: amino acid detection in the gut. Ann N Y Acad Sci. 2009;1170:69-76 pubmed publisher
    ..Several problems with recording the electrophysiological signals of vagal afferents are discussed, with particular reference to sampling the afferent signals from the duodenum and liver region. ..
  65. Hayashi Y, Jacob Vadakot S, Dugan E, McBride S, Olexa R, Simansky K, et al. 5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats. Exp Neurol. 2010;221:68-78 pubmed publisher
    ..While no side effects were observed in normal or MOD rats, SEV rats displayed hindlimb tremors and 33% mortality, indicating hypersensitivity to the precursor. ..
  66. Zou S, Scarfo K, Nantz M, Hecker J. Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells. Int J Pharm. 2010;389:232-43 pubmed publisher
    ..Higher mean levels of expression per cell obtained following DNA delivery and the longer duration of expression confirm a continuing role for DNA gene delivery in clinical applications that require longer term transient gene expression. ..
  67. Oca P, Zaka R, Dion A, Freeman T, Williams C. Phosphate and calcium are required for TGFbeta-mediated stimulation of ANK expression and function during chondrogenesis. J Cell Physiol. 2010;224:540-8 pubmed publisher
    ..Our findings indicate that TGFbeta stimulation of ANK expression is dependent upon the influx of phosphate and calcium into ATDC5 cells at all stages of differentiation. ..
  68. Galván E, Nair M, Chen H, Del Piero F, Schifferli D. Biosafety level 2 model of pneumonic plague and protection studies with F1 and Psa. Infect Immun. 2010;78:3443-53 pubmed publisher
    ..Therefore, further investigations to fully characterize the protective properties of the Psa fimbriae are warranted. ..
  69. Wesolowski J, Paumet F. SNARE motif: a common motif used by pathogens to manipulate membrane fusion. Virulence. 2010;1:319-24 pubmed publisher
    ..Such a recurrence across pathogenic organisms suggests that this architectural motif was evolutionarily selected because it most effectively ensures the survival of pathogens within the eukaryotic environment. ..
  70. Zediak V, Johnnidis J, Wherry E, Berger S. Cutting edge: persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status. J Immunol. 2011;186:2705-9 pubmed publisher
    ..We propose that these chromatin changes poise effector genes for rapid upregulation, but are insufficient for PolII recruitment and transcription. ..
  71. Kao C, Oestreich K, Paley M, Crawford A, Angelosanto J, Ali M, et al. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol. 2011;12:663-71 pubmed publisher
    ..Persistent antigenic stimulation caused downregulation of T-bet, which resulted in more severe exhaustion of CD8(+) T cells. Our observations suggest therapeutic opportunities involving higher T-bet expression during chronic infection...
  72. Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, et al. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia. 2011;59:1719-31 pubmed publisher
  73. Penton A, Leonard L, Spinner N. Notch signaling in human development and disease. Semin Cell Dev Biol. 2012;23:450-7 pubmed publisher
    ..Studies of these human disorders and their inheritance patterns and types of mutations reveal insights into the mechanisms of Notch signaling. ..
  74. Wilhelm M, Ong H, Wehrli S, Li C, Tsai P, Hackney D, et al. Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density. Proc Natl Acad Sci U S A. 2012;109:9605-10 pubmed publisher
    ..Last, the integrated signal from myelin suspensions is shown, both spectroscopically and by imaging, to scale with concentration, suggesting the potential for quantitative determination of myelin density. ..
  75. Huang C, Tong J, Bi F, Wu Q, Huang B, Zhou H, et al. Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats. Hum Mol Genet. 2012;21:4602-14 pubmed publisher
    ..As rosiglitazone is clinically used to treat diabetes, our results would encourage immediate application of PPAR-? agonists in treating patients with cortical dementia. ..
  76. Jolly A, Luan C, Dusel B, Dunne S, Winding M, Dixit V, et al. A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells. Cell Rep. 2016;14:611-620 pubmed publisher
    ..We identify innate immunity genes, ion channels, and signaling proteins having a role in lysosome motility regulation and find an unexpected relationship between the dynein motor, Rab7a, and lysosome motility regulation. ..
  77. Penning T, Abrams W, Pawlowski J. Affinity labeling of 3 alpha-hydroxysteroid dehydrogenase with 3 alpha-bromoacetoxyandrosterone and 11 alpha-bromoacetoxyprogesterone. Isolation and sequence of active site peptides containing reactive cysteines; sequence confirmation using nucleotid. J Biol Chem. 1991;266:8826-34 pubmed
    ..By contrast the 11 alpha-bromoacetoxy group in Br11P labeled several reactive cysteines which may be involved in the binding of glucocorticoids and NSAIDs. ..
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