Experts and Doctors on amino acid sequence in Philadelphia, Pennsylvania, United States

Summary

Locale: Philadelphia, Pennsylvania, United States
Topic: amino acid sequence

Top Publications

  1. Kumar V, Weber I. Molecular model of the cyclic GMP-binding domain of the cyclic GMP-gated ion channel. Biochemistry. 1992;31:4643-9 pubmed
    ..This model is in agreement with both the analogue binding experiments and the mutational analysis of Thr 560. ..
  2. Bennett V, Adams S. Identification of a cartilage-specific promoter within intron 2 of the chick alpha 2(I) collagen gene. J Biol Chem. 1990;265:2223-30 pubmed
  3. Yeh H, Anderson N, Ornstein Goldstein N, Bashir M, Rosenbloom J, Abrams W, et al. Structure of the bovine elastin gene and S1 nuclease analysis of alternative splicing of elastin mRNA in the bovine nuchal ligament. Biochemistry. 1989;28:2365-70 pubmed
    ..The results also suggest that such limited splicing is increased in the adult tissue relative to fetal and neonate tissues. ..
  4. Vogel B, Minor R, Freund M, Prockop D. A point mutation in a type I procollagen gene converts glycine 748 of the alpha 1 chain to cysteine and destabilizes the triple helix in a lethal variant of osteogenesis imperfecta. J Biol Chem. 1987;262:14737-44 pubmed
    ..Therefore, the mutation in the proband was a sporadic one and is very likely to have caused the connective tissue fragility that produced the lethal phenotype. ..
  5. Pan T, Sasaki T, Zhang R, Fassler R, Timpl R, Chu M. Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. J Cell Biol. 1993;123:1269-77 pubmed
    ..The latter studies also demonstrated an extracellular localization for fibulin-2 in basement membranes and other connective tissue compartments. ..
  6. Kong A, Ma M, Tao D, Yang L. Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p). Pharm Res. 1993;10:461-5 pubmed
  7. Li S, Sieron A, Fertala A, Hojima Y, Arnold W, Prockop D. The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. Proc Natl Acad Sci U S A. 1996;93:5127-30 pubmed
    ..4.24.19), an enzyme that is essential for the processing of procollagens to fibrillar collagens. The results demonstrate that procollagen C-proteinase is identical to BMP-1. ..
  8. Stokes D, Tartof K, Perry R. CHD1 is concentrated in interbands and puffed regions of Drosophila polytene chromosomes. Proc Natl Acad Sci U S A. 1996;93:7137-42 pubmed
    ..These observations strongly support the idea that CHD1 functions to alter chromatin structure in a way that facilitates gene expression. ..
  9. Srinivasula S, Fernandes Alnemri T, Zangrilli J, Robertson N, Armstrong R, Wang L, et al. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem. 1996;271:27099-106 pubmed
    ..This is the first demonstration of a protease cascade involving granzyme B, CPP32, Mch2alpha, and Mch6 and evidence that the lamin-cleaving enzyme Mch2 is a target of mature CPP32. ..

More Information

Publications492 found, 100 shown here

  1. Yusibov V, Modelska A, Steplewski K, Agadjanyan M, Weiner D, Hooper D, et al. Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1. Proc Natl Acad Sci U S A. 1997;94:5784-8 pubmed
    ..The plant-produced protein (virus particles) was purified and used for immunization of mice. Both antigens elicited specific virus-neutralizing antibodies in immunized mice...
  2. Thompson R, Bouwer H, Portnoy D, Frankel F. Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth. Infect Immun. 1998;66:3552-61 pubmed
    ..monocytogenes equivalent to that induced by the wild-type organism...
  3. Bellacosa A, Cicchillitti L, Schepis F, Riccio A, Yeung A, Matsumoto Y, et al. MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. Proc Natl Acad Sci U S A. 1999;96:3969-74 pubmed
    ..In addition, these results suggest that cytosine methylation may play a role in human DNA repair. ..
  4. Kline J, Roehrs H, Clevenger C. Functional characterization of the intermediate isoform of the human prolactin receptor. J Biol Chem. 1999;274:35461-8 pubmed
    ..Taken together, differences in signaling and tissue expression suggest that the human intermediate PRLr differs from the long PRLr in physiological function. ..
  5. Johnson A, Braidotti P, Pietra G, Russo S, Kabore A, Wang W, et al. Post-translational processing of surfactant protein-C proprotein: targeting motifs in the NH(2)-terminal flanking domain are cleaved in late compartments. Am J Respir Cell Mol Biol. 2001;24:253-63 pubmed
  6. Bray J, Chennathukuzhi V, Hecht N. Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. Genomics. 2002;79:799-808 pubmed
    ..The data suggest that TRAX may have a function associated with perinuclear organelles during spermatogenesis. ..
  7. Magira E, Papaioakim M, Nachamkin I, Asbury A, Li C, Ho T, et al. Differential distribution of HLA-DQ beta/DR beta epitopes in the two forms of Guillain-Barré syndrome, acute motor axonal neuropathy and acute inflammatory demyelinating polyneuropathy (AIDP): identification of DQ beta epitopes associated with suscep. J Immunol. 2003;170:3074-80 pubmed
  8. May M, Larsen S, Shim J, Madge L, Ghosh S. A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase. J Biol Chem. 2004;279:45528-39 pubmed
    ..Our findings therefore establish the ULD as a critical functional domain specific for IKKbeta that might play a role in dissociating IKKbeta from p65. ..
  9. Maza J, Das Sarma J, Koval M. Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J Biol Chem. 2005;280:21115-21 pubmed
    ..We propose that charged residues present in Cx43 and related connexins help prevent ER oligomerization by stabilizing the third transmembrane domain in the membrane bilayer. ..
  10. Zhang Z, Jones B, Tang W, Moss S, Wei Z, Ho C, et al. Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16. Mol Cell Proteomics. 2005;4:914-23 pubmed
    ..Thus, PF6, SPAG6, and PF20 form a newly identified network that links together components of the axoneme central apparatus and presumably participates in its dynamic regulation of ciliary and flagellar beat. ..
  11. Bai Y, Srinivasan L, Perkins L, Atchison M. Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. J Immunol. 2005;175:5160-9 pubmed
    ..Using chromatin immunoprecipitation assays we found that TSA caused preferential acetylation of histone H3 at the 3' enhancer. The relevance of these studies for PU.1 function in transcription and hemopoietic development is discussed. ..
  12. MARTIN GARCIA J, Cao W, Varela Rohena A, Plassmeyer M, Gonzalez Scarano F. HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor. Virology. 2006;346:169-79 pubmed
    ..Interestingly, we note the presence of envelopes more resistant to a fusion inhibitor in the brain of an untreated, HIV-1-infected individual. ..
  13. Xu L, Benson S, Burnett R. Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon. J Struct Biol. 2007;157:424-31 pubmed
    ..Structural studies on CELO will elucidate the differences between avian and human adenoviruses and contribute to a better understanding of adenoviruses with non-human hosts...
  14. Wan L, Ottinger E, Cho S, Dreyfuss G. Inactivation of the SMN complex by oxidative stress. Mol Cell. 2008;31:244-54 pubmed publisher
    ..Thus, the SMN complex is a redox-sensitive assemblyosome and an ROS target, suggesting that it may play a role in oxidative stress pathophysiology, which is associated with many degenerative diseases. ..
  15. Yan J, Hokey D, Morrow M, Corbitt N, Harris K, Harris D, et al. Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques. Vaccine. 2009;27:3260-6 pubmed publisher
    ..These data suggest that such DNA immunogens deserve further examination for their potential to control viral replication. ..
  16. Oh Y, Chang K, Orlean P, Wloka C, Deshaies R, Bi E. Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast. Mol Biol Cell. 2012;23:2445-56 pubmed publisher
    ..Our study establishes a mechanism for direct cell cycle control of ECM remodeling during cytokinesis. ..
  17. Eguchi Y, Ewert D, Tsujimoto Y. Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo. Nucleic Acids Res. 1992;20:4187-92 pubmed
    ..Our findings indicate that a homologue of the human bcl-2 gene does exist in the chicken and that its expression is developmentally regulated in some tissues. ..
  18. Page J, You J, Harris R, Colman R. Localization of the binding site on plasma kallikrein for high-molecular-weight kininogen to both apple 1 and apple 4 domains of the heavy chain. Arch Biochem Biophys. 1994;314:159-64 pubmed
    ..We conclude that the binding site for kininogen within prekallikrein is composed of discontinuous linear segments that form a contiguous surface in the folded protein. ..
  19. Carrera A, Gerton G, Moss S. The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins. Dev Biol. 1994;165:272-84 pubmed
    ..These results suggest that p82 acts as a scaffolding protein for the subcellular localization of regulatory proteins in the flagellum. ..
  20. Zhang R, Pan T, Timpl R, Chu M. Cloning and sequence analysis of cDNAs encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI. Biochem J. 1993;291 ( Pt 3):787-92 pubmed
  21. Chen X, Harrison E, Fisher E. Molecular cloning of the cDNA for rat hepatic, bile salt-dependent cholesteryl ester/retinyl ester hydrolase demonstrates identity with pancreatic carboxylester lipase. Proc Soc Exp Biol Med. 1997;215:186-91 pubmed
    ..1.1.13). In individual animals the hepatic and pancreatic cDNA sequences were identical. However, among rats there were sequence variations, suggesting a polymorphic nature for this rat gene. ..
  22. Dutta S, Gerhold D, Rice M, Germann M, Kmiec E. The cloning and overexpression of a cruciform binding protein from Ustilago maydis. Biochim Biophys Acta. 1997;1352:258-66 pubmed
    ..It is plausible that HMP1 represents a novel class of proteins that recognize such secondary structures. ..
  23. Monaco C, Negrini M, Sozzi G, Veronese M, Vorechovsky I, Godwin A, et al. Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23. Genomics. 1997;46:217-22 pubmed
    ..However, a role for these amino acid changes in the tumorigenic process could not established. ..
  24. Orsini M, Parent J, Mundell S, Marchese A, Benovic J. Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J Biol Chem. 1999;274:31076-86 pubmed
  25. Tolkunova E, Park H, Xia J, King M, Davidson E. The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript. J Biol Chem. 2000;275:35063-9 pubmed
  26. Bouyac Bertoia M, Dvorin J, Fouchier R, Jenkins Y, Meyer B, Wu L, et al. HIV-1 infection requires a functional integrase NLS. Mol Cell. 2001;7:1025-35 pubmed
  27. Wang H, Kazanietz M. Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J Biol Chem. 2002;277:4541-50 pubmed
    ..In this setting, Tmp21-I serves as an anchoring protein that determines the intracellular localization of these novel phorbol ester receptors. ..
  28. Zhan Y, Hegde R, Srinivasula S, Fernandes Alnemri T, Alnemri E. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. 2002;9:439-47 pubmed
    ..Our data provide the first direct evidence for the involvement of DED-containing proteins in the regulation of components of the general transcription machinery in the nucleus. ..
  29. Mohan M, Seaton T, Mitchell J, Howe A, Blackburn K, Burkhart W, et al. The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. Biochemistry. 2002;41:9462-9 pubmed
    ..All of these results indicate that TACE is unique in terms of its specificity requirements for substrate cleavage. ..
  30. Robin M, Anandatheerthavarada H, Biswas G, Sepuri N, Gordon D, Pain D, et al. Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem. 2002;277:40583-93 pubmed
    ..Our results provide new insights on the mechanism of cAMP-mediated activation of a cryptic mitochondrial targeting signal and regulation of P450MT5 targeting to mitochondria. ..
  31. Johnstone C, Castellvi Bel S, Chang L, Sung R, Bowser M, Pique J, et al. PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas. Genomics. 2005;85:338-51 pubmed
    ..Thus, PRR5 may represent a potential candidate tumor suppressor gene in breast cancer. ..
  32. Greco T, Hodara R, Parastatidis I, Heijnen H, Dennehy M, Liebler D, et al. Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells. Proc Natl Acad Sci U S A. 2006;103:7420-5 pubmed
    ..Interestingly, seven of the 18 proteins identified are localized within the ER/Golgi complex, suggesting a role for S-nitrosylation in membrane trafficking and ER stress response in vascular smooth muscle. ..
  33. Shenker B, Dlakic M, Walker L, Besack D, Jaffe E, LaBelle E, et al. A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity. J Immunol. 2007;178:5099-108 pubmed
    ..Collectively, these studies show that the CdtB not only exhibits PI-3,4,5-P(3) phosphatase activity, but also that toxicity in lymphocytes is related to this activity. ..
  34. Biswas C, Ostrovsky O, Makarewich C, Wanderling S, Gidalevitz T, Argon Y. The peptide-binding activity of GRP94 is regulated by calcium. Biochem J. 2007;405:233-41 pubmed
    ..We further show that grp94-/- cells are hypersensitive to perturbation of intracellular calcium and thus GRP94 is important for cellular Ca2+ storage. ..
  35. Del Prete G, Leslie G, Haggarty B, Jordan A, Romano J, Hoxie J. Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a CXCR4 antagonist. J Virol. 2010;84:8777-89 pubmed publisher
    ..The cooperative contributions of CXCR4 NT and ECL interactions with gp120 in acquiring X4 tropism likely impart flexibility on pathways for viral evolution and suggest novel approaches to isolate these interactions for drug discovery. ..
  36. Acharya R, Carnevale V, Fiorin G, Levine B, Polishchuk A, Balannik V, et al. Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc Natl Acad Sci U S A. 2010;107:15075-80 pubmed publisher
    ..Thus, the new crystal structure provides a possible unification of the discrete site versus continuum conduction models. ..
  37. Rao J, Madasu Y, Dominguez R. Mechanism of actin filament pointed-end capping by tropomodulin. Science. 2014;345:463-7 pubmed publisher
    ..We found that Tmod achieves high-affinity binding through several discrete low-affinity interactions, which suggests a mechanism for controlled subunit exchange at the pointed end...
  38. Bauer R, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, et al. Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation. 2015;131:1202-1213 pubmed publisher
  39. Walters J, Ferraro B, Duperret E, Kraynyak K, Chu J, Saint Fleur A, et al. A Novel DNA Vaccine Platform Enhances Neo-antigen-like T Cell Responses against WT1 to Break Tolerance and Induce Anti-tumor Immunity. Mol Ther. 2017;25:976-988 pubmed publisher
    ..These data support the further study of synthetic consensus DNA vaccines for breaking tolerance to important germline antigens. ..
  40. Chu M, Zhang R, Pan T, Stokes D, Conway D, Kuo H, et al. Mosaic structure of globular domains in the human type VI collagen alpha 3 chain: similarity to von Willebrand factor, fibronectin, actin, salivary proteins and aprotinin type protease inhibitors. EMBO J. 1990;9:385-93 pubmed
    ..Five putative Arg-Gly-Asp cell-binding sequences are exclusively localized in the triple helical segment.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  41. Gomez M, Cutting S. BofC encodes a putative forespore regulator of the Bacillus subtilis sigma K checkpoint. Microbiology. 1997;143 ( Pt 1):157-70 pubmed
    ..BofC acts negatively on SpoIVB and the results described suggest that BofC regulates SpoIVB activity and its intercompartmental signalling role in the sigma K checkpoint. ..
  42. Abdollahi A, Godwin A, Miller P, Getts L, Schultz D, Taguchi T, et al. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Cancer Res. 1997;57:2029-34 pubmed
    ..Lot1 shows a limited distribution of expression in normal rat tissues, including ovary, which shows abundant expression. Furthermore, examination of DNA derived from multiple species indicates that the gene is widely conserved. ..
  43. Evans J, Kopf G, Schultz R. Characterization of the binding of recombinant mouse sperm fertilin beta subunit to mouse eggs: evidence for adhesive activity via an egg beta1 integrin-mediated interaction. Dev Biol. 1997;187:79-93 pubmed
    ..These results suggest that a beta1-containing integrin participates in the binding of recombinant fertilin beta-EC to mouse eggs. ..
  44. Guo J, Liu C, Mason W, Pugh J. Cloning and expression of a cDNA encoding the large subunit of duck replication factor C. Biochim Biophys Acta. 1998;1395:293-300 pubmed
    ..The duck RFC-L amino acid sequence shares 66.4% and 68.4% identity with mouse and human RFC-L proteins, respectively. We identified a 4kb RFC-L mRNA expressed in most duck tissues. ..
  45. Lenka N, Vijayasarathy C, Mullick J, Avadhani N. Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex. Prog Nucleic Acid Res Mol Biol. 1998;61:309-44 pubmed
  46. Huebner K, Garrison P, Barnes L, Croce C. The role of the FHIT/FRA3B locus in cancer. Annu Rev Genet. 1998;32:7-31 pubmed
    ..FRA3B thus fulfills the prophecy that fragile site alterations contribute to the neoplastic process through inactivation of a tumor suppressor gene...
  47. Weston W, LeClair E, Trzyna W, McHugh K, Nugent P, Lafferty C, et al. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem. 1999;274:13698-703 pubmed
    ..Based on these observations, we propose that we have identified a new gene, which we call plunc (for palate, lung, and nasal epithelium clone; GenBankTM accession number U69172). ..
  48. Travis A, Sui D, Riedel K, Hofmann N, Moss S, Wilson J, et al. A novel NH(2)-terminal, nonhydrophobic motif targets a male germ cell-specific hexokinase to the endoplasmic reticulum and plasma membrane. J Biol Chem. 1999;274:34467-75 pubmed
    ..Such processing might constitute a regulatory mechanism governing the spatial and/or temporal expression of the protein. ..
  49. Santra M, Reed C, Iozzo R. Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. J Biol Chem. 2002;277:35671-81 pubmed
    ..Thus, decorin binds to a discrete region of the EGFR, partially overlapping with but distinct from the EGF-binding domain. These findings could lead to the generation of protein mimetics capable of suppressing EGFR function. ..
  50. Christian T, Evilia C, Williams S, Hou Y. Distinct origins of tRNA(m1G37) methyltransferase. J Mol Biol. 2004;339:707-19 pubmed
  51. Zhang J, Lefebvre J, Zhao S, Granato M. Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice. Nat Neurosci. 2004;7:1303-9 pubmed
    ..Our results demonstrate a new role for MuSK homologs in axonal pathway selection. ..
  52. Bagella L, Giacinti C, Simone C, Giordano A. Identification of murine cdk10: association with Ets2 transcription factor and effects on the cell cycle. J Cell Biochem. 2006;99:978-85 pubmed
    ..Murine cdk10 binds Ets2 transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed. ..
  53. Smirnova E, Collingwood T, Bisbal C, Tsygankova O, Bogush M, Meinkoth J, et al. TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion. Virology. 2008;372:10-23 pubmed
  54. Ren S, Uversky V, Chen Z, Dunker A, Obradovic Z. Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions. BMC Genomics. 2008;9 Suppl 2:S26 pubmed publisher
    ..The correlation between SLiM conservation with disorder prediction demonstrates that functional SLiMs recognized by each domain occur more often in disordered as compared to structured regions of proteins. ..
  55. Waxman E, Giasson B. Molecular mechanisms of alpha-synuclein neurodegeneration. Biochim Biophys Acta. 2009;1792:616-24 pubmed publisher
    ..In this review, some of the evidence for the different mechanisms of alpha-synuclein toxicity is presented and discussed. ..
  56. Hill A, Nishino A, Nakajo K, Zhang G, Fineman J, Selzer M, et al. Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet. 2008;4:e1000317 pubmed publisher
    ..The early chordate refinements in action potential mechanisms we have elucidated appear essential to the complex neural signaling, active behavior, and evolutionary success of vertebrates...
  57. Li H, Nourbakhsh B, Cullimore M, Zhang G, Rostami A. IL-9 is important for T-cell activation and differentiation in autoimmune inflammation of the central nervous system. Eur J Immunol. 2011;41:2197-206 pubmed publisher
    ..Interestingly, IL-10 was significantly increased in IL-9(-/-) mice compared with WT littermates. Importantly, we found that IL-9-mediated Th17-cell differentiation triggers complex STAT signaling pathways. ..
  58. Liszczak G, Goldberg J, Foyn H, Petersson E, Arnesen T, Marmorstein R. Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nat Struct Mol Biol. 2013;20:1098-105 pubmed publisher
    ..These studies have implications for understanding the mechanistic details of other NAT complexes and how regulatory subunits modulate the activity of the broader family of protein acetyltransferases. ..
  59. Geisheker M, Heymann G, Wang T, Coe B, Turner T, Stessman H, et al. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat Neurosci. 2017;20:1043-1051 pubmed publisher
    ..Overall, we find significant clustering of de novo mutations in 200 genes, highlighting specific functional domains and synaptic candidate genes important in NDD pathology. ..
  60. Mohn K, Melby A, Tewari D, Laz T, Taub R. The gene encoding rat insulinlike growth factor-binding protein 1 is rapidly and highly induced in regenerating liver. Mol Cell Biol. 1991;11:1393-401 pubmed
    ..In this way, IGFBP-I and IGF-I could act in a paracrine and/or autocrine fashion in maintaining normal liver architecture during regeneration. ..
  61. Pleasure I, Black M, Keen J. Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein. Nature. 1993;365:459-62 pubmed
    ..The association with clathrin and the morphological and catalytic similarity to the chaperonin proteins indicate that VCP may modulate protein-protein interactions in membrane transport processes. ..
  62. Sahu A, Soulika A, Morikis D, Spruce L, Moore W, Lambris J. Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin. J Immunol. 2000;165:2491-9 pubmed
  63. Matunis M, Xing J, Dreyfuss G. The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. Nucleic Acids Res. 1994;22:1059-67 pubmed
  64. Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M, et al. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest. 1998;102:874-80 pubmed
    ..These data suggest the existence of a family of beta-defensin molecules on mucosal surfaces that in the aggregate contributes to normal host defense. ..
  65. Schmutte C, Marinescu R, Sadoff M, Guerrette S, Overhauser J, Fishel R. Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res. 1998;58:4537-42 pubmed
    ..hExoI was found to interact strongly with the human MMR protein hMSH2, suggesting its involvement in the MMR process and/or DNA recombination. ..
  66. Wang M, Hu Y, Stearns M. A novel IL-10 signalling mechanism regulates TIMP-1 expression in human prostate tumour cells. Br J Cancer. 2003;88:1605-14 pubmed
    ..The data demonstrate, for the first time, that IL-10 receptor signalling of TIMP-1 expression is regulated by tyrosine phosphorylation of a novel gene, IL-10E1, in human prostate cells. ..
  67. Kotula L, Laury Kleintop L, Showe L, Sahr K, Linnenbach A, Forget B, et al. The exon-intron organization of the human erythrocyte alpha-spectrin gene. Genomics. 1991;9:131-40 pubmed
  68. Park K, Atchison M. Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. Proc Natl Acad Sci U S A. 1991;88:9804-8 pubmed
    ..Cotransfection studies with this cDNA indicate that it can repress basal promoter activity. The apparent dual function of this protein is discussed. ..
  69. Liebhaber S, Emery J, Urbanek M, Wang X, Cooke N. Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. Nucleic Acids Res. 1990;18:3871-9 pubmed
    ..The characteristics of this protein suggest that it serves a fundamental role in cellular function. ..
  70. Burch J, Davis D. Alternative promoter usage and splicing options result in the differential expression of mRNAs encoding four isoforms of chicken VBP, a member of the PAR subfamily of bZIP transcription factors. Nucleic Acids Res. 1994;22:4733-41 pubmed
  71. Liao C, Gaffney T, Bradley S, Wong L. Cloning of a pectate lyase gene from Xanthomonas campestris pv. malvacearum and comparison of its sequence relationship with pel genes of soft-rot Erwinia and Pseudomonas. Mol Plant Microbe Interact. 1996;9:14-21 pubmed
    ..Homologous pel sequences were detected in various pathovars or strains of X. campestris. All of these xanthomonads produced an alkaline Pel and were capable of causing soft-rot in potato tuber slices and green pepper fruits. ..
  72. Mysliwiec T, Perego R, Kruh G. Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain. Oncogene. 1996;12:631-40 pubmed
    ..These observations indicate that the C-terminal domain regulates Arg biological activity in a manner distinct from c-Abl and suggest that this effect may be mediated in part by SH3 domain-binding sites...
  73. Liao C, McCallus D, Wells J, Tzean S, Kang G. The repB gene required for production of extracellular enzymes and fluorescent siderophores in Pseudomonas viridiflava is an analog of the gacA gene of Pseudomonas syringae. Can J Microbiol. 1996;42:177-82 pubmed
    ..fluorescens, and P. syringae included in the study. The data presented here and earlier indicate that the repA/repB gene regulatory system of P. viridiflava is analogous to the lemA/gacA system of P. syringae and P. fluorescens...
  74. Loudon R, Benovic J. Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6. J Biol Chem. 1997;272:27422-7 pubmed
    ..These data demonstrate an important functional link between the ability of GRK6 to bind to the plasma membrane, a process that appears to be regulated by palmitoylation, and its activity toward receptor substrates. ..
  75. Ayoob J, Turnacioglu K, Mittal B, Sanger J, Sanger J. Targeting of cardiac muscle titin fragments to the Z-bands and dense bodies of living muscle and non-muscle cells. Cell Motil Cytoskeleton. 2000;45:67-82 pubmed
  76. Peng H, Begg G, Harper S, Friedman J, Speicher D, Rauscher F. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. J Biol Chem. 2000;275:18000-10 pubmed
    ..These structural and dynamic parameters of the KRAB/KAP-1 interaction have implications for identifying downstream effectors of KAP-1 silencing and the de novo design of new repression domains. ..
  77. Srinivasula S, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, et al. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 2001;410:112-6 pubmed
    ..Our studies reveal a mechanism in which binding to the BIR3 domain by two conserved peptides, one from Smac and the other one from caspase-9, has opposing effects on caspase activity and apoptosis. ..
  78. Jin Y, Stayrook S, Albert R, Palackal N, Penning T, Lewis M. Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. Biochemistry. 2001;40:10161-8 pubmed
  79. Hui Y, Yang G, Galczenski H, Figueroa D, Austin C, Copeland N, et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. J Biol Chem. 2001;276:47489-95 pubmed
    ..The identification of mCysLT(2)R will be useful for establishing CysLT(2)R-deficient mice and determining novel leukotriene functions. ..
  80. Gubitz A, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G. Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. J Biol Chem. 2002;277:5631-6 pubmed
    ..The presence of 13 WD repeat domains in the amino-terminal half of Gemin5 and a coiled-coil motif near its carboxyl terminus indicate that it may form a large heteromeric complex and engage in multiple interactions. ..
  81. Kim K, Lawrence S, Park J, Pitts L, Vann W, Betenbaugh M, et al. Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects. Glycobiology. 2002;12:73-83 pubmed
    ..Homology searches of the Drosophila genome identified putative orthologues of other genes required for sialylation of glycoconjugates. ..
  82. Grosser T, Yusuff S, Cheskis E, Pack M, Fitzgerald G. Developmental expression of functional cyclooxygenases in zebrafish. Proc Natl Acad Sci U S A. 2002;99:8418-23 pubmed
    ..Both zCOX isoforms are genetically and functionally homologous to their mammalian orthologs. The zebrafish affords a tractable model system for the study of COX biology and development. ..
  83. Liu Y, Xu Y, Yu Q. Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. Oncogene. 2006;25:2452-67 pubmed
  84. Ghosh A, Qiu J, Degrado W, Hochstrasser R. Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy. Proc Natl Acad Sci U S A. 2011;108:6115-20 pubmed publisher
    ..1.3 ps at pH 6.2. Thus, protonation of His37 at low pH causes liquid-like water molecules to flow into the neighborhood of the Gly34. ..
  85. Siglin A, Sun S, Moore J, Tan S, Poenie M, Lear J, et al. Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. PLoS ONE. 2013;8:e59453 pubmed publisher
    ..Taken together, the data indicate that the dynein-dynactin interaction proceeds through a disorder-to-order transition, leveraging its bivalent-bivalent character to form a high affinity, but readily reversible interaction. ..
  86. Yan H, Opachaloemphan C, Mancini G, Yang H, Gallitto M, Mlejnek J, et al. An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants. Cell. 2017;170:736-747.e9 pubmed publisher
    ..Therefore, the development of genetics in Harpegnathos establishes this ant species as a model organism to study the complexity of eusociality. ..
  87. Olsen D, Nagayoshi T, Fazio M, Mattei M, Passage E, Weil D, et al. Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome Iq43. Am J Hum Genet. 1989;44:876-85 pubmed
    ..Finally, one of the nidogen cDNAs was used to map the nidogen gene onto locus q43 of chromosome 1. ..
  88. Schechter N, Wang Z, Blacher R, Lessin S, Lazarus G, Rubin H. Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. J Immunol. 1994;152:4062-9 pubmed
    ..These studies provide further evidence that human skin mast cells contain two different chymotrypsin-like proteinases...
  89. Bagyan I, Hobot J, Cutting S. A compartmentalized regulator of developmental gene expression in Bacillus subtilis. J Bacteriol. 1996;178:4500-7 pubmed
    ..SpoVT acts both positively and negatively in controlling sigmaG-dependent gene expression, providing an additional level of refinement to forespore gene regulation and feedback control of spoIIIG expression. ..
  90. Bedian V, Adams T, Geiger E, Bailey L, Gasser D. A gene belonging to the Sm family of snRNP core proteins maps within the mouse MHC. Immunogenetics. 1997;46:427-30 pubmed
  91. Yang F, Curran S, Li L, Avarbock D, Graf J, Chua M, et al. Characterization of two genes encoding the Mycobacterium tuberculosis ribonucleotide reductase small subunit. J Bacteriol. 1997;179:6408-15 pubmed
    ..M. tuberculosis is a species in which a nrdEF system appears to encode the biologically active species of RR and also the only bacterial species identified so far in which class I RR subunits are not arranged on an operon. ..
  92. Metjian A, Roll R, Ma A, Abrams C. Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. J Biol Chem. 1999;274:27943-7 pubmed
    ..This finding implies that the intracellular localization of p110gamma is regulated by p101 as well as Gbetagamma. The effect of PI3Kgamma in the nucleus is an area of active investigation. ..