Genomes and Genes
Experts and Doctors on adenosine triphosphate in Philadelphia, Pennsylvania, United States
Locale: Philadelphia, Pennsylvania, United States
Topic: adenosine triphosphate
Publications126 found, 100 shown here
- Hu H, Lu W, Zhang M, Zhang X, Argall A, Patel S, et al. Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo. Exp Eye Res. 2010;91:425-32 pubmed publisher..This implies that the balance between extracellular ATP and its protective metabolite adenosine can influence ganglion cell survival in the living eye. ..
- Lim M, Selak M, Xiang Z, Krainc D, Neve R, Kraemer B, et al. Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease. J Neurosci. 2012;32:1123-41 pubmed publisher..Altogether, these data suggest that bioenergetic abnormalities are likely to be pathophysiologically relevant to motor neuron disease...
- Anastassiadis T, Duong Ly K, Deacon S, Lafontant A, Ma H, Devarajan K, et al. A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor. J Biol Chem. 2013;288:28068-77 pubmed publisher..These findings suggest a novel approach to polypharmacology in which two or more unrelated kinases are inhibited by a single compound that targets different conformations of each target kinase. ..
- Spillane M, Ketschek A, Merianda T, Twiss J, Gallo G. Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis. Cell Rep. 2013;5:1564-75 pubmed publisher..This study reveals a local role for axonal mitochondria in the regulation of the actin cytoskeleton and axonal mRNA translation underlying branching. ..
- Schneiderman R, Kubin J, Mishra O, Delivoria Papadopoulos M. Brain cell membrane modification following hypercapnia and recovery in newborn piglets. Pediatr Pulmonol. 1994;18:81-8 pubmed..The data demonstrate that hypercapnia followed by restoration of normal PaCO2 in healthy term newborn piglets is associated with mild modification of brain cell membrane Na+,K(+)-ATPase, possibly due to lipid peroxidation. ..
- Armstead W. Superoxide generation links protein kinase C activation to impaired ATP-sensitive K+ channel function after brain injury. Stroke. 1999;30:153-9 pubmed..These data suggest, therefore, that O2- generation links PKC activation to impaired KATP channel function after FPI. ..
- Fleischhauer J, Mitchell C, Peterson Yantorno K, Coca Prados M, Civan M. PGE(2), Ca(2+), and cAMP mediate ATP activation of Cl(-) channels in pigmented ciliary epithelial cells. Am J Physiol Cell Physiol. 2001;281:C1614-23 pubmed..cAMP acts directly on Cl(-) channels of PE cells, increasing stromal release and potentially reducing net aqueous humor formation and intraocular pressure. ..
- Edwards S, Buffone M, Knee G, Rossato M, Bonanni G, Masiero S, et al. Effects of extracellular adenosine 5'-triphosphate on human sperm motility. Reprod Sci. 2007;14:655-66 pubmed..These results suggest that ATPe could constitute a new therapeutic modality in the treatment of male infertility. ..
- Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, et al. CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature. 2013;495:223-6 pubmed publisher..Thus, CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception. ..
- Lee J, Lake R, Kirk J, Bohr V, Fan H, Hohng S. NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB. Nucleic Acids Res. 2017;45:4696-4707 pubmed publisher..Additionally, NAP1L1 increases CSB processivity by decreasing the pausing probability during translocation. Our study, therefore, uncovers the different steps of CSB-mediated chromatin remodeling that can be regulated by NAP1L1. ..
- Duda T, Goraczniak R, Sitaramayya A, Sharma R. Cloning and expression of an ATP-regulated human retina C-type natriuretic factor receptor guanylate cyclase. Biochemistry. 1993;32:1391-5 pubmed..We now report the molecular cloning and expression of CNP-RGC from human retina and show that ATP is obligatory in CNP signaling also.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Gumireddy K, Reddy M, Cosenza S, Boominathan R, Boomi Nathan R, Baker S, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005;7:275-86 pubmed..ON01910 showed strong synergy with several chemotherapeutic agents, often inducing complete regression of tumors. ..
- Shim K, Schmutte C, Tombline G, Heinen C, Fishel R. hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51. J Biol Chem. 2004;279:30385-94 pubmed..These observations begin to elucidate the separate and specialized functions of the human mitotic RecA homologs that enable an efficient nucleoprotein filament required for HRR. ..
- Mazurek A, Berardini M, Fishel R. Activation of human MutS homologs by 8-oxo-guanine DNA damage. J Biol Chem. 2002;277:8260-6 pubmed..These results suggest that only hMSH2-hMSH6 is activated by recognition of 8-oxo-G lesions. Our data are consistent with the notion that post-replication MMR only participates in the repair of mismatched 8-oxo-G lesions. ..
- Yanase K, Madaio M. Nuclear localizing anti-DNA antibodies enter cells via caveoli and modulate expression of caveolin and p53. J Autoimmun. 2005;24:145-51 pubmed..The novel mechanism of cellular perturbation is indirect and dependent on apoptotic stimuli, and it may account for the presence of intranuclear antibodies in inflammatory and normal tissues of individuals with lupus. ..
- Mishra O, Ashraf Q, Delivoria Papadopoulos M. Tyrosine phosphorylation of neuronal nitric oxide synthase (nNOS) during hypoxia in the cerebral cortex of newborn piglets: the role of nitric oxide. Neurosci Lett. 2009;462:64-7 pubmed publisher..We conclude that the mechanism of hypoxia-induced increased tyrosine phosphorylation of nNOS is mediated by nNOS-derived NO. ..
- Cole A, Kmiec E. ATP-independent DNA renaturation catalyzed by a protein from Ustilago maydis. Eur J Biochem. 1994;220:75-82 pubmed..These latter reactions are dependent on the presence of DNA sequence similarity between the pairing partners. ..
- Amuthan G, Biswas G, Ananadatheerthavarada H, Vijayasarathy C, Shephard H, Avadhani N. Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene. 2002;21:7839-49 pubmed..Our results suggest that the mitochondria-to-nucleus signaling pathway operating through increased [Ca(2+)](c) plays an important role in cancer progression and metastasis. ..
- Woulfe D, Lilliendahl J, August S, Rauova L, Kowalska M, Abrink M, et al. Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Blood. 2008;111:3458-67 pubmed..We propose that SG-/- platelet function deficiencies are related to inadequate packaging and secretion of selected alpha-granule proteins and reduced secretion of dense granule contents critical for platelet activation. ..
- Balasubramanian K, Stitt B. Evidence for amino acid roles in the chemistry of ATP hydrolysis in Escherichia coli Rho. J Mol Biol. 2010;404:587-99 pubmed publisher..All four mutant proteins behaved as expected for Rhos lacking the proposed mechanistic roles. The results provide firm biochemical evidence in support of the proposed model for hydrolysis chemistry. ..
- Chancellor M, Kaplan S, Blaivas J. The cholinergic and purinergic components of detrusor contractility in a whole rabbit bladder model. J Urol. 1992;148:906-9 pubmed..Since ATP generated pressure is more rapid than with bethanechol alone, we support the hypothesis that ATP may be important in the initiation of micturition...
- Yengo C, Sweeney H. Functional role of loop 2 in myosin V. Biochemistry. 2004;43:2605-12 pubmed..The ability to maintain a high affinity for actin in the weak binding states may prevent diffusion away from the actin filament and increase the degree of processive motion of myosin V. ..
- Demeshkina N, Hirokawa G, Kaji A, Kaji H. Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP. Nucleic Acids Res. 2007;35:4597-607 pubmed..Upon dissociation of the 80S ribosome, eEF2 was found on the subunits. We propose that the dissociation activity of eEF2/ATP plays a role in mobilizing 80S ribosomes for protein synthesis during the shift up of physiological conditions. ..
- Crumm S, Cofan M, Juskeviciute E, Hoek J. Adenine nucleotide changes in the remnant liver: An early signal for regeneration after partial hepatectomy. Hepatology. 2008;48:898-908 pubmed publisher..The rapid loss of adenine nucleotides after PHx generates early stress signals that contribute to the onset of liver regeneration. ..
- Ferrucci A, Nonnemacher M, Cohen E, Wigdahl B. Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir. Virus Res. 2012;167:358-69 pubmed publisher..Studies are underway to better understand the intricate correlation between reductions in ATP and GSH metabolites and how they affect neuronal survival in end-stage disease. ..
- Hou Y. Unusual synthesis by the Escherichia coli CCA-adding enzyme. RNA. 2000;6:1031-43 pubmed
- Elefant F, Palter K. Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality. Mol Biol Cell. 1999;10:2101-17 pubmed..We believe that the amino acid substitutions in Hsc3p interfere with the structural coupling of ATP binding to substrate release, and this defect is the basis for the mutant proteins' dominant negative effects in vivo. ..
- Yang F, Lu G, Rubin H. Isolation of ribonucleotide reductase from Mycobacterium tuberculosis and cloning, expression, and purification of the large subunit. J Bacteriol. 1994;176:6738-43 pubmed..The predicted molecular mass of R1 from the DNA sequence is 82,244 Da. Recombinant M. tuberculosis R1, purified to homogeneity, was biochemically active when assayed with extracts of M. tuberculosis enriched for R2. ..
- Reigada D, Lu W, Zhang M, Mitchell C. Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels. Neuroscience. 2008;157:396-404 pubmed publisher..This excess extracellular ATP may link increased pressure to the death of ganglion cells in acute glaucoma, and suggests a possible role for ATP in the neuronal damage accompanying increased intracranial pressure. ..
- Hawkins B, Levin M, Doonan P, Petrenko N, Davis C, Patel V, et al. Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential loss. J Biol Chem. 2010;285:26494-505 pubmed publisher..This finding is important as it sets the stage for complex II functional preservation as an attractive therapy to maintain mitochondrial function during hypoxia. ..
- Gradia S, Acharya S, Fishel R. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell. 1997;91:995-1005 pubmed..These results suggest a new model for the function of MutS proteins during mismatch repair in which the switch determines the timing of downstream events. ..
- Guo Y, Kotova E, Chen Z, Lee K, Hopper Borge E, Belinsky M, et al. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J Biol Chem. 2003;278:29509-14 pubmed..We conclude that MRP8 is an amphipathic anion transporter that is able to efflux cAMP and cGMP and to function as a resistance factor for commonly employed purine and pyrimidine nucleotide analogs...
- Battle D, Kasim M, Wang J, Dreyfuss G. SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate. J Biol Chem. 2007;282:27953-9 pubmed..These findings demonstrate a modular nature of the SMN complex and identify a new intermediate in the snRNP assembly process. ..
- Ostrovsky O, Makarewich C, Snapp E, Argon Y. An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells. Proc Natl Acad Sci U S A. 2009;106:11600-5 pubmed publisher..This mutational analysis suggests that the ATPase activity of GRP94 is essential for chaperone activity in vivo and that the essential protein-binding domain of GRP94 is distinct from the N-terminal domain...
- Rossi M, Mazina O, Bugreev D, Mazin A. The RecA/RAD51 protein drives migration of Holliday junctions via polymerization on DNA. Proc Natl Acad Sci U S A. 2011;108:6432-7 pubmed publisher..The mechanism of BM promoted by RecA/RAD51 is unknown. Here, we demonstrate that cycles of RecA/Rad51 polymerization and dissociation coupled with ATP hydrolysis drives the BM of HJs. ..
- Uribe S, Devlin T. Tri-Calciphor (16,16-dimethyl-15-dehydroprostaglandin B1 trimer)-mediated mitochondrial Ca2+ movements: modulation by phosphate. Biochim Biophys Acta. 1994;1225:144-8 pubmed..Thus, depending on the assay conditions, two different effects involving Ca2+ movements and mitochondria are observed with tri-Calciphor. ..
- Stitt B, Kempner E. Structure-function relationships in Escherichia coli transcription termination protein Rho revealed by radiation target analysis. Arch Biochem Biophys. 1996;334:268-76 pubmed
- Muralidharan V, Tretiakova A, Steplewski A, Haas S, Amini S, Johnson E, et al. Evidence for inhibition of MyEF-2 binding to MBP promoter by MEF-1/Pur alpha. J Cell Biochem. 1997;66:524-31 pubmed
- Lim J, Mitchell C. Inflammation, pain, and pressure--purinergic signaling in oral tissues. J Dent Res. 2012;91:1103-9 pubmed publisher..The intricacies of the purinergic signaling system make it well-suited for the unique concerns of dental research, and future findings will doubtless confirm this importance. ..
- Saleh A, Srinivasula S, Balkir L, Robbins P, Alnemri E. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000;2:476-83 pubmed..On the basis of these results, we propose that resistance to apoptosis exhibited by stressed cells and some tumours, which constitutively express high levels of Hsp70, may be due in part to modulation of Apaf-1 function by Hsp70. ..
- Laakso J, Lewis J, Shuman H, Ostap E. Myosin I can act as a molecular force sensor. Science. 2008;321:133-6 pubmed publisher..2) to a high (>0.9) duty-ratio motor. This impressive tension sensitivity supports a role for myosin I as a molecular force sensor. ..
- Su Z, Klein J, Du J, Franch H, Zhang L, Hassounah F, et al. Chronic kidney disease induces autophagy leading to dysfunction of mitochondria in skeletal muscle. Am J Physiol Renal Physiol. 2017;312:F1128-F1140 pubmed publisher..However, myofibrillar protein is not directly broken down through autophagy. Instead, CKD-induced upregulation of autophagy leads to dysfunction of mitochondria and decrease of ATP production. ..
- Kruse C, Holden K, Pritchard M, Feild J, Rieman D, Greig R, et al. Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 1. J Med Chem. 1988;31:1762-7 pubmed..This interpretation is strengthened by the finding that the inhibitors lack specificity, inhibiting a serine kinase at comparable concentrations...
- Saito M, Longhurst P, Tammela T, Wein A, Levin R. Effects of partial outlet obstruction of the rat urinary bladder on micturition characteristics, DNA synthesis and the contractile response to field stimulation and pharmacological agents. J Urol. 1993;150:1045-51 pubmed
- McCully K, Chance B, Giger U. In vivo determination of altered hemoglobin saturation in dogs with M-type phosphofructokinase deficiency. Muscle Nerve. 1999;22:621-7 pubmed..NIRS appears to be a useful noninvasive method of monitoring tissue oxygen saturation in normal or disease conditions...
- Xia J, Reigada D, Mitchell C, Ren D. CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation. Biol Reprod. 2007;77:551-9 pubmed
- Greenberg M, Lin T, Goldman Y, Shuman H, Ostap E. Myosin IC generates power over a range of loads via a new tension-sensing mechanism. Proc Natl Acad Sci U S A. 2012;109:E2433-40 pubmed publisher..Based on these results, we propose that myo1c functions as a slow transporter rather than a tension-sensitive anchor. ..
- Ramamurthy B, Yengo C, Straight A, Mitchison T, Sweeney H. Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry. 2004;43:14832-9 pubmed..These effects are likely mediated by binding of blebbistatin within the myosin cleft that progressively closes in forming the acto-myosin rigor state. ..
- Hao L, Giasson B, Bonini N. DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc Natl Acad Sci U S A. 2010;107:9747-52 pubmed publisher..These findings link DJ-1, pink1, and parkin to mitochondrial integrity and provide the foundation for therapeutics that link bioenergetics and parkinsonism. ..
- Lounsbury K, Casey P, Brass L, Manning D. Phosphorylation of Gz in human platelets. Selectivity and site of modification. J Biol Chem. 1991;266:22051-6 pubmed..Results obtained with 6354 also suggest that phorbol ester-promoted phosphorylation of Gz alpha approaches 1 mol of phosphate per mol of subunit in permeabilized platelets. ..
- Jones R, Bui T, White C, Madesh M, Krawczyk C, Lindsten T, et al. The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity. 2007;27:268-80 pubmed..Together, the data establish that Bax and Bak play an essential role in the control of T cell proliferation by modulating ER Ca(2+) release. ..
- Goraczniak R, Duda T, Sitaramayya A, Sharma R. Structural and functional characterization of the rod outer segment membrane guanylate cyclase. Biochem J. 1994;302 ( Pt 2):455-61 pubmed..The identity of the granylate cyclase (ROS-GC) that synthesizes this pool of cyclic GMP is unknown. We now report the cloning, expression and functional characterization of a DNA from bovine retina that encodes ROS-GC. ..
- McCully K, Fielding R, Evans W, Leigh J, Posner J. Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles. J Appl Physiol (1985). 1993;75:813-9 pubmed..These results support studies that showed decreases in muscle metabolism with age in healthy humans and show a good correlation between in vivo and in vitro measurements of oxidative metabolism. ..
- Sund N, Vatamaniuk M, Casey M, Ang S, Magnuson M, Stoffers D, et al. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev. 2001;15:1706-15 pubmed..The Foxa2(loxP/loxP); Ins.Cre mice will serve as a unique model to investigate the regulation of insulin secretion by the beta cell and suggest the human FOXA2 as a candidate gene for familial hyperinsulinism. ..
- Madesh M, Antonsson B, Srinivasula S, Alnemri E, Hajnoczky G. Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J Biol Chem. 2002;277:5651-9 pubmed..The tBid-induced loss of DeltaPsi(m) occurs after cytochrome c release and reflects impairment of oxidative metabolism. ..
- Yengo C, De La Cruz E, Safer D, Ostap E, Sweeney H. Kinetic characterization of the weak binding states of myosin V. Biochemistry. 2002;41:8508-17 pubmed
- Ostap E, Lin T, Rosenfeld S, Tang N. Mechanism of regulation of Acanthamoeba myosin-IC by heavy-chain phosphorylation. Biochemistry. 2002;41:12450-6 pubmed..We propose that the TEDS-containing actin-binding loop plays a direct role in regulating phosphate release and the force-generating (A-to-R) transition of myosin-IC. ..
- Guenther M, Yu J, Kao G, Yen T, Lazar M. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev. 2002;16:3130-5 pubmed..The strict control of HDAC3 activity underscores the cellular imperative that histone deacetylation occur only in targeted regions of the genome. ..
- Bates S, Tao J, Notarfrancesco K, DeBolt K, Shuman H, Fisher A. Effect of surfactant protein A on granular pneumocyte surfactant secretion in vitro. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1055-65 pubmed..Finally, there was no evidence of a large PL pool retained on the cell surface through interaction with SP-A. Thus SP-A exposure does not affect these stages in the surfactant secretory pathway of type II cells. ..
- Acharya S, Foster P, Brooks P, Fishel R. The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair. Mol Cell. 2003;12:233-46 pubmed..Additionally, MutL promotes ATP binding-independent turnover of idle MutS sliding clamps. These results support a model of MMR that relies on two dynamic and redundant ATP-regulated molecular switches. ..
- Browne R, Stitt B. Active site occupancy required for catalytic cooperativity by Escherichia coli transcription termination factor Rho. J Biol Chem. 2005;280:13300-3 pubmed..They further suggest that, once the enzyme is saturated with ATP, a V(max) enzyme conformation is achieved that is stable for at least three catalytic cycles. ..
- Funakoshi H, Zacharia L, Tang Z, Zhang J, Lee L, Good J, et al. A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007;115:2307-15 pubmed..Modulation of the myocardial adenosine system and its signaling pathways may be a novel therapeutic target in patients with heart failure. ..
- Pimkin M, Markham G. The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover. Mol Microbiol. 2008;68:342-59 pubmed publisher..We conclude that the CBS subdomain of IMPDH may coordinate the activities of the enzymes of purine nucleotide metabolism and is essential for maintaining the normal ATP and GTP pool sizes in E. coli...
- Li A, Banerjee J, Leung C, Peterson Yantorno K, Stamer W, Civan M. Mechanisms of ATP release, the enabling step in purinergic dynamics. Cell Physiol Biochem. 2011;28:1135-44 pubmed publisher..However, vesicular release and P2X(7) release pathways were functionally limited to inflow and outflow cells, respectively, suggesting that blocking exocytosis might selectively inhibit inflow, lowering IOP. ..
- Agrawal A, Guttapalli A, Narayan S, Albert T, Shapiro I, Risbud M. Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. Am J Physiol Cell Physiol. 2007;293:C621-31 pubmed..Results of this study indicate that oxygen-independent stabilization of HIF-1alpha in nucleus pulposus cells is a metabolic adaptation that drives glycolysis and aggrecan expression. ..
- Kurata S, Nielsen K, Mitchell S, Lorsch J, Kaji A, Kaji H. Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP. Proc Natl Acad Sci U S A. 2010;107:10854-9 pubmed publisher..No 40S*mRNA complex was observed, indicating that eEF3 action promotes ribosome recycling, not reinitiation. ..
- Robert Cooperman C, Carnegie J, Wilson C, Yang J, Cook J, Wu J, et al. Targeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell function. Diabetes. 2010;59:2209-18 pubmed publisher..These results support a potential role of PANDER in the pancreatic beta-cell for regulation or facilitation of insulin secretion. ..
- Li A, Leung C, Peterson Yantorno K, Mitchell C, Civan M. Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow. Am J Physiol Cell Physiol. 2010;299:C1308-17 pubmed publisher..The relatively large response to dithiothreitol raises the possibility that the oxidation-reduction state is a substantial regulator of PX1-mediated ATP release from bovine ciliary epithelial cells...
- Kruse C, Holden K, Offen P, Pritchard M, Feild J, Rieman D, et al. Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 2. J Med Chem. 1988;31:1768-72 pubmed..It is therefore concluded that the ATP moiety is largely responsible for binding and that the enzyme requires additional structural features for recognition of the tyrosine-containing substrate...
- Jin J, Daniel J, Kunapuli S. Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem. 1998;273:2030-4 pubmed
- Kasinathan R, Goronga T, Messerli S, Webb T, Greenberg R. Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel. FASEB J. 2010;24:128-35 pubmed publisher..The interaction of praziquantel with SMDR2 may offer new strategies for potentiating the action of praziquantel and possibly overcoming drug resistance...
- Shorter J. The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system. PLoS ONE. 2011;6:e26319 pubmed publisher..Taken together, these findings suggest that Hsp110 fulfils a subset of Hsp104 activities in mammals. Moreover, they suggest that Hsp104 can collaborate with the mammalian disaggregase machinery to rapidly remodel amyloid conformers. ..
- Rajavel M, Lalo D, Gross J, Grubmeyer C. Conversion of a cosubstrate to an inhibitor: phosphorylation mutants of nicotinic acid phosphoribosyltransferase. Biochemistry. 1998;37:4181-8 pubmed..We have cloned, overexpressed, and purified the yeast enzyme and report its kinetic properties, which are similar to those of the bacterial enzyme. ..
- Rome L, Cook C, Syme D, Connaughton M, Ashley Ross M, Klimov A, et al. Trading force for speed: why superfast crossbridge kinetics leads to superlow forces. Proc Natl Acad Sci U S A. 1999;96:5826-31 pubmed..This imbalance between attachment and detachment rates is likely to be a general mechanism that imposes a tradeoff of force for speed in all superfast fibers. ..
- Fang J, Hsu B, MacMullen C, Poncz M, Smith T, Stanley C. Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. Biochem J. 2002;363:81-7 pubmed
- Baylor S, Hollingworth S. Simulation of Ca2+ movements within the sarcomere of fast-twitch mouse fibers stimulated by action potentials. J Gen Physiol. 2007;130:283-302 pubmed..Overall, the simulations indicate that this reaction-diffusion model, which was originally developed for Ca(2+) sparks in frog fibers, works well when adapted to mouse fast-twitch fibers stimulated by APs. ..
- Ibrahim M, Razmara M, Nguyen D, Donahue R, Wubah J, Knudsen T. Altered expression of mitochondrial 16S ribosomal RNA in p53-deficient mouse embryos revealed by differential display. Biochim Biophys Acta. 1998;1403:254-64 pubmed..The preliminary results of the present study suggest that p53 may be involved, directly or indirectly, in this transition. ..
- Reczkowski R, Markham G. Slow binding inhibition of S-adenosylmethionine synthetase by imidophosphate analogues of an intermediate and product. Biochemistry. 1999;38:9063-8 pubmed..A model based on ionization of the bridging -NH- moiety is presented which could account for the potent inhibition by PNP and PNPNP. ..
- Suarez T, Biswas S, Biswas E. Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration. J Biol Chem. 2002;277:21759-67 pubmed..We have correlated the dissociation constant (K(D)) and the rates of nucleotide hydrolysis (V(max)) of NBD1 and its mutants with the available genetic data for these mutations...
- Zelent B, Buettger C, Grimsby J, Sarabu R, Vanderkooi J, Wand A, et al. Thermal stability of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea. Biochim Biophys Acta. 2012;1824:769-84 pubmed publisher..This study establishes the foundation for exploring numerous instability mutants among the more than 600 variant GKs causing diabetes in animals and humans...
- Guha S, Baltazar G, Coffey E, Tu L, Lim J, Beckel J, et al. Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor. FASEB J. 2013;27:4500-9 pubmed publisher..In summary, P2X7R stimulation raises lysosomal pH and impedes lysosomal function, suggesting a possible role for overstimulation in diseases of accumulation...
- Margulis A, Goraczniak R, Duda T, Sharma R, Sitaramayya A. Structural and biochemical identity of retinal rod outer segment membrane guanylate cyclase. Biochem Biophys Res Commun. 1993;194:855-61 pubmed..These results suggest that ROS-GC represents a new subtype of the membrane guanylate cyclase family that is structurally and biochemically distinct from the other retinal cyclases. ..
- Kashlan O, Scott C, Lear J, Cooperman B. A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit. Biochemistry. 2002;41:462-74 pubmed..The similar specific activities of R1(2)R2(2) and R1(6)R2(6) are inconsistent with a proposed model for R2(2) docking with R1(2) [Uhlin, U., and Eklund, H. (1994) Nature 370, 533-539], and an alternative is suggested. ..
- Biswas Fiss E. Functional analysis of genetic mutations in nucleotide binding domain 2 of the human retina specific ABC transporter. Biochemistry. 2003;42:10683-96 pubmed..The ABCR dysfunctions, associated with various retinopathies, are multifaceted in nature and include alterations in protein structure as well as the attenuation of ATPase activity and nucleotide binding...