Experts and Doctors on acute kidney injury in Pittsburgh, Pennsylvania, United States
Locale: Pittsburgh, Pennsylvania, United States
Topic: acute kidney injury
Balakumar V, Murugan R, Sileanu F, Palevsky P, Clermont G, Kellum J. Both Positive and Negative Fluid Balance May Be Associated With Reduced Long-Term Survival in the Critically Ill. Crit Care Med. 2017;45:e749-e757 pubmed publisher
..This mortality risk associated with positive fluid balance, however, was attenuated by use of renal replacement therapy. We found no association between fluid balance and renal recovery. ..
Amathieu R, Al Khafaji A, Sileanu F, Foldes E, DeSensi R, Hilmi I, et al
. Significance of oliguria in critically ill patients with chronic liver disease. Hepatology. 2017;66:1592-1600 pubmed publisher
..Compared with creatinine criteria alone, incorporating UO into the diagnostic criteria increased the measured incidence of AKI. Stage 2-3 AKI-UO has a high negative impact on hospital mortality. (Hepatology 2017;66:1592-1600). ..
Kellum J, Shaw A. Assessing Toxicity of Intravenous Crystalloids in Critically Ill Patients. JAMA. 2015;314:1695-7 pubmed publisher
Nadim M, Durand F, Kellum J, Levitsky J, O Leary J, Karvellas C, et al
. Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. J Hepatol. 2016;64:717-35 pubmed publisher
Bellomo R, Kellum J, Ronco C, Wald R, Martensson J, Maiden M, et al
. Acute kidney injury in sepsis. Intensive Care Med. 2017;43:816-828 pubmed publisher
..If sepsis resolves, the majority of patients recover renal function. Yet, even a single episode of septic AKI is associated with increased subsequent risk of chronic kidney disease. ..
Wenzel S, Tyurina Y, Zhao J, St Croix C, Dar H, Mao G, et al
. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 2017;171:628-641.e26 pubmed publisher
..As master regulators of ferroptotic cell death with profound implications for human disease, PEBP1/15LO complexes represent a new target for drug discovery. ..