Experts and Doctors on zebrafish proteins in Eugene, Oregon, United States

Summary

Locale: Eugene, Oregon, United States
Topic: zebrafish proteins

Top Publications

  1. Toro S, Wegner J, Muller M, Westerfield M, Varga Z. Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis. Gene Expr Patterns. 2009;9:200-8 pubmed publisher
    ..Expression at these stages makes these genes useful markers to study HP maturation and function. ..
  2. Simonson L, Ganz J, Melancon E, Eisen J. Characterization of enteric neurons in wild-type and mutant zebrafish using semi-automated cell counting and co-expression analysis. Zebrafish. 2013;10:147-53 pubmed publisher
    ..We also show that gutwrencher mutants have the same number of serotonin-positive enteroendocrine cells in the intestine as wild types. ..
  3. DeLaurier A, Huycke T, Nichols J, Swartz M, Larsen A, Walker C, et al. Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Dev Biol. 2014;385:189-99 pubmed publisher
    ..Hence, steps along the developmental trajectory appear differentially sensitive to the loss of buffering, providing focus for the future study. ..
  4. Morin Kensicki E, Melancon E, Eisen J. Segmental relationship between somites and vertebral column in zebrafish. Development. 2002;129:3851-60 pubmed
    ..Our results support co-localization of the anterior expression boundaries of zebrafish hoxc6 homologs with a cervical/thoracic transition and also suggest Hox-independent patterning of regionally specific posterior vertebrae. ..
  5. Seredick S, Van Ryswyk L, Hutchinson S, Eisen J. Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics. Neural Dev. 2012;7:35 pubmed publisher
    ..This is, to our knowledge, the first report of transcription factors that act to distinguish CaP and MiP subtype identities. Our results also suggest that MiP motoneurons are more similar to V2 interneurons than are CaP motoneurons. ..
  6. Maves L, Jackman W, Kimmel C. FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain. Development. 2002;129:3825-37 pubmed
    ..Taken together, our findings demonstrate a crucial role for FGF-mediated inter-rhombomere signaling in promoting early hindbrain patterning and underscore the significance of organizing centers in patterning the vertebrate neural plate. ..
  7. Phillips J, Blanco Sanchez B, Lentz J, Tallafuss A, Khanobdee K, Sampath S, et al. Harmonin (Ush1c) is required in zebrafish Müller glial cells for photoreceptor synaptic development and function. Dis Model Mech. 2011;4:786-800 pubmed publisher
    ..This study shows that visual defects associated with loss of ush1c function in zebrafish can be detected from the onset of vision, and thus could be applicable to early diagnosis for USH1C patients. ..
  8. Lewis K, Eisen J. Paraxial mesoderm specifies zebrafish primary motoneuron subtype identity. Development. 2004;131:891-902 pubmed
    ..Our findings suggest that in the absence of signals from paraxial mesoderm, primary motoneurons have a hybrid identity with respect to gene expression, and that under these conditions the CaP axon trajectory may be dominant. ..
  9. Kimmel C, Ullmann B, Walker M, Miller C, Crump J. Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish. Development. 2003;130:1339-51 pubmed
    ..Changes involving Edn1 may have occurred during actinopterygian evolution to produce the efficient gill-pumping opercular apparatus of teleosts. ..

More Information

Publications55

  1. Beattie C, Hatta K, Halpern M, Liu H, Eisen J, Kimmel C. Temporal separation in the specification of primary and secondary motoneurons in zebrafish. Dev Biol. 1997;187:171-82 pubmed
    ..These results suggest that both primary and secondary motoneurons are specified by signals from midline tissues, but at very different stages of embryonic development. ..
  2. Phillips J, Vastinsalo H, Wegner J, Clément A, Sankila E, Westerfield M. The cone-dominant retina and the inner ear of zebrafish express the ortholog of CLRN1, the causative gene of human Usher syndrome type 3A. Gene Expr Patterns. 2013;13:473-81 pubmed publisher
    ..Our data provide a foundation for exploring the role of Clarin-1 in retinal cell function and survival in a diurnal, cone-dominant species. ..
  3. He X, Yan Y, Eberhart J, Herpin A, Wagner T, Schartl M, et al. miR-196 regulates axial patterning and pectoral appendage initiation. Dev Biol. 2011;357:463-77 pubmed publisher
    ..These results show that a Hox cluster microRNA modulates development of axial patterning similar to nearby protein-coding Hox genes, and acts on appendicular patterning at least in part by modulating retinoic acid signaling. ..
  4. Walker M, Miller C, Coffin Talbot J, Stock D, Kimmel C. Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Dev Biol. 2006;295:194-205 pubmed
  5. Ochi H, Westerfield M. Lbx2 regulates formation of myofibrils. BMC Dev Biol. 2009;9:13 pubmed publisher
    ..Expression of myofilament genes, including actin and myosin, requires the engrailed repressor domain of Lbx2. Our results elucidate a new function of Lbx2 as a regulator of myofibril formation. ..
  6. Song H, Yan Y, Titus T, He X, Postlethwait J. The role of stat1b in zebrafish hematopoiesis. Mech Dev. 2011;128:442-56 pubmed publisher
    ..These results suggest that zebrafish Stat1b promotes myeloid development at the expense of erythroid development. ..
  7. DeLaurier A, Nakamura Y, Braasch I, Khanna V, Kato H, Wakitani S, et al. Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Dev Biol. 2012;12:16 pubmed publisher
    ..Cleft palate resulting from HDAC4 mutations in human patients may result from defects in a homologous CNC progenitor cell population. ..
  8. Muyskens J, Kimmel C. Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer. Mech Dev. 2007;124:35-42 pubmed
    ..Our findings thus reveal that Tbx16, in combination with Wnt11, are critical components not only in morphogenesis but also in initial assembly of the organizer. ..
  9. Eberhart J, Swartz M, Crump J, Kimmel C. Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development. 2006;133:1069-77 pubmed
  10. Hirsinger E, Stellabotte F, Devoto S, Westerfield M. Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors. Dev Biol. 2004;275:143-57 pubmed
  11. Kroeger P, Drummond B, Miceli R, McKernan M, Gerlach G, Marra A, et al. The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Dev Biol. 2017;428:148-163 pubmed publisher
  12. Yan Y, Talbot W, Egan E, Postlethwait J. Mutant rescue by BAC clone injection in zebrafish. Genomics. 1998;50:287-9 pubmed
    ..We conclude that the injection of large-insert genomic clones will speed the isolation of zebrafish genes disrupted by mutation and hence the identification of gene functions necessary for development of vertebrate embryos. ..
  13. Halpern M, Hatta K, Amacher S, Talbot W, Yan Y, Thisse B, et al. Genetic interactions in zebrafish midline development. Dev Biol. 1997;187:154-70 pubmed
    ..From these findings we propose that ntl+ plays an early role in cell fate choice at the dorsal midline, mediated by the Ntl protein acting to antagonize floor plate development as well as to promote notochord development. ..
  14. Peng G, Westerfield M. Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development. 2006;133:3191-200 pubmed
    ..Our results demonstrate that Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists. ..
  15. DeLaurier A, Eames B, Blanco Sanchez B, Peng G, He X, Swartz M, et al. Zebrafish sp7:EGFP: a transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration. Genesis. 2010;48:505-11 pubmed publisher
    ..This line provides an essential tool for the further study of zebrafish otic vesicle formation and the development and regeneration of the skeleton. ..
  16. Honjo Y, Kniss J, Eisen J. Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons. Development. 2008;135:2615-25 pubmed publisher
    ..Together, our results suggest that ErbB3 signaling is required for normal migration of trunk, but not cranial, neural crest cells. ..
  17. Hans S, Westerfield M. Changes in retinoic acid signaling alter otic patterning. Development. 2007;134:2449-58 pubmed
    ..Thus, excess RA expands otic competence, whereas the loss of RA impairs the expression of fgf3 and wnt8b in the hindbrain, compromising the induction and maintenance of otic fate. ..
  18. Huycke T, Eames B, Kimmel C. Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone. Development. 2012;139:2371-80 pubmed publisher
    ..Hence, patterning within a module may include adjacent regions of functionally related bones and might require that signaling pathways function over an extended period of development. ..
  19. Moens C, Cordes S, Giorgianni M, Barsh G, Kimmel C. Equivalence in the genetic control of hindbrain segmentation in fish and mouse. Development. 1998;125:381-91 pubmed
  20. Crump J, Swartz M, Eberhart J, Kimmel C. Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face. Development. 2006;133:2661-9 pubmed
    ..We present a model in which Moz-dependent Hox expression in CNC shapes the normal support skeleton by instructing second-segment CNC to undergo skeletogenesis in response to local extrinsic signals...
  21. Ochi H, Pearson B, Chuang P, Hammerschmidt M, Westerfield M. Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Dev Biol. 2006;297:127-40 pubmed
    ..These data support a model in which Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened. ..
  22. Moens C, Yan Y, Appel B, Force A, Kimmel C. valentino: a zebrafish gene required for normal hindbrain segmentation. Development. 1996;122:3981-90 pubmed
    ..These results provide genetic evidence for a two-segment periodicity in the hindbrain and suggest that this periodicity arises sequentially, through the specification and later subdivision of a two-rhombomere unit, or 'protosegment'. ..
  23. Thisse C, Thisse B, Halpern M, Postlethwait J. Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Dev Biol. 1994;164:420-9 pubmed
    ..We propose that in the gastrula head, goosecoid may be important in organizing the ventral neurectoderm. ..
  24. Jensen A, Westerfield M. Zebrafish mosaic eyes is a novel FERM protein required for retinal lamination and retinal pigmented epithelial tight junction formation. Curr Biol. 2004;14:711-7 pubmed
    ..We suggest that moe may be a necessary component of the crumbs pathway that regulates apical cell polarity and also may play a role in photoreceptor morphogenesis. ..
  25. Hans S, Liu D, Westerfield M. Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development. 2004;131:5091-102 pubmed
    ..Combined loss of both factors eliminates all indications of otic specification. We suggest that the Foxi1-Pax8 pathway provides an early 'jumpstart' of otic specification that is maintained by the Dlx3b-Pax2a pathway. ..
  26. Miller C, Maves L, Kimmel C. moz regulates Hox expression and pharyngeal segmental identity in zebrafish. Development. 2004;131:2443-61 pubmed
  27. Talbot W, Trevarrow B, Halpern M, Melby A, Farr G, Postlethwait J, et al. A homeobox gene essential for zebrafish notochord development. Nature. 1995;378:150-7 pubmed
    ..We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate. ..
  28. Neal J, Peterson T, Kent M, Guillemin K. H. pylori virulence factor CagA increases intestinal cell proliferation by Wnt pathway activation in a transgenic zebrafish model. Dis Model Mech. 2013;6:802-10 pubmed publisher
  29. Miller C, Schilling T, Lee K, Parker J, Kimmel C. sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development. Development. 2000;127:3815-28 pubmed
    ..Collectively our results support a model for dorsoventral patterning of the gnathostome pharyngeal arches in which Et-1 in the environment of the postmigratory cranial neural crest specifies the lower jaw and other ventral arch fates. ..
  30. Lewis K, Eisen J. Hedgehog signaling is required for primary motoneuron induction in zebrafish. Development. 2001;128:3485-95 pubmed
    ..Our results also suggest that Twhh and Shh are more important for motoneuron development than Ehh. ..
  31. Talbot J, Johnson S, Kimmel C. hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches. Development. 2010;137:2507-17 pubmed publisher
    ..Collectively, our work indicates that the expression and function of hand2 and Dlx genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches...
  32. Varga Z, Amores A, Lewis K, Yan Y, Postlethwait J, Eisen J, et al. Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development. 2001;128:3497-509 pubmed
    ..We propose that smoothened is required for induction of lateral floor plate and a subpopulation of hypothalamic cells and for maintenance of medial floor plate and hypothalamic cells. ..
  33. Cornell R, Eisen J. Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function. Development. 2002;129:2639-48 pubmed
    ..We propose that temporally distinct episodes of Ngn1 activity in the same precursor population specify these two different types of sensory neurons. ..
  34. Miller C, Swartz M, Khuu P, Walker M, Eberhart J, Kimmel C. mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish. Dev Biol. 2007;308:144-57 pubmed
    ..Together our results support a model in which CNC cells require mef2ca downstream of edn1 signaling for proper craniofacial development...
  35. Walker M, Miller C, Swartz M, Eberhart J, Kimmel C. phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish. Dev Biol. 2007;304:194-207 pubmed
  36. Miller C, Yelon D, Stainier D, Kimmel C. Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development. 2003;130:1353-65 pubmed
    ..Together our results reveal two critical edn1 effectors that pattern the vertebrate jaw: hand2 specifies ventral pharyngeal cartilage of the lower jaw and bapx1 specifies the jaw joint. ..
  37. Puschel A, Westerfield M, Dressler G. Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish. Mech Dev. 1992;38:197-208 pubmed
    ..Our results confirm that Pax genes are highly conserved both in sequences and in expression patterns, indicating that they may have a function during early development that has been conserved during vertebrate evolution. ..
  38. Liu D, Chu H, Maves L, Yan Y, Morcos P, Postlethwait J, et al. Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development. 2003;130:2213-24 pubmed
  39. Cheesman S, Eisen J. gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish. Gene Expr Patterns. 2004;5:107-12 pubmed
    ..These data suggest gsh1 may play a role in patterning cell types generated in these domains. ..
  40. Draper B, Stock D, Kimmel C. Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. Development. 2003;130:4639-54 pubmed
    ..Last, we show that fgf24 is expressed in early fin bud mesenchyme and that inhibiting fgf24 function results in viable fish that lack pectoral fins. ..
  41. Meneghini M, Ishitani T, Carter J, Hisamoto N, Ninomiya Tsuji J, Thorpe C, et al. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature. 1999;399:793-7 pubmed
    ..These functions are likely to be conserved in vertebrates, as TAK1 and NLK can downregulate HMG-domain-containing proteins related to POP-1. ..
  42. Tallafuss A, Gibson D, Morcos P, Li Y, Seredick S, Eisen J, et al. Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish. Development. 2012;139:1691-9 pubmed publisher
    ..Our results suggest that sox10 function might not be critical during neural crest formation. ..
  43. Hans S, Christison J, Liu D, Westerfield M. Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Dev Biol. 2007;7:5 pubmed
    ..These results provide further support for the hypothesis that Foxi1 and Dlx3b provide competence for cells to respond to Fgf and form an otic placode. ..
  44. Talbot J, Walker M, Carney T, Huycke T, Yan Y, Bremiller R, et al. fras1 shapes endodermal pouch 1 and stabilizes zebrafish pharyngeal skeletal development. Development. 2012;139:2804-13 pubmed publisher
    ..Similar mechanisms of stochastic developmental instability might also account for the high phenotypic variation observed in human FRAS1 patients. ..
  45. Nichols J, Pan L, Moens C, Kimmel C. barx1 represses joints and promotes cartilage in the craniofacial skeleton. Development. 2013;140:2765-75 pubmed publisher
    ..We further show that hand2 feeds back to negatively regulate barx1 expression. We consider the possibility that changes in barx1 function in early vertebrates were among the key innovations fostering the evolution of skeletal joints...
  46. Crump J, Maves L, Lawson N, Weinstein B, Kimmel C. An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development. 2004;131:5703-16 pubmed
    ..Moreover, we argue that the Fgf-dependent morphogenesis of the pharyngeal endoderm into pouches is critical for the later patterning of pharyngeal cartilages. ..