Experts and Doctors on caenorhabditis elegans proteins in Eugene, Oregon, United States


Locale: Eugene, Oregon, United States
Topic: caenorhabditis elegans proteins

Top Publications

  1. Severson A, Bowerman B. Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans. J Cell Biol. 2003;161:21-6 pubmed
    ..This in turn produces asymmetry in the forces applied to MTs at each pole and allows PAR-2 to accumulate in the posterior cortex of a one-cell zygote and maintain asymmetry. ..
  2. GOULDING M, Canman J, Senning E, Marcus A, Bowerman B. Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II. J Cell Biol. 2007;178:1177-91 pubmed
    ..These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction...
  3. Canman J, Lewellyn L, Laband K, Smerdon S, Desai A, Bowerman B, et al. Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science. 2008;322:1543-6 pubmed publisher
    ..Thus, inactivation of Rac by centralspindlin functions in parallel with RhoA activation to drive contractile ring constriction during cytokinesis. ..
  4. Thorpe C, Schlesinger A, Carter J, Bowerman B. Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm. Cell. 1997;90:695-705 pubmed
    ..Defective mitotic spindle orientations in mom mutant embryos indicate that Wnt signaling influences cytoskeletal polarity in blastomeres throughout the early embryo. ..
  5. Rupert P, Daughdrill G, Bowerman B, Matthews B. A new DNA-binding motif in the Skn-1 binding domain-DNA complex. Nat Struct Biol. 1998;5:484-91 pubmed
    ..Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'. ..
  6. Swan K, Severson A, Carter J, Martin P, Schnabel H, Schnabel R, et al. cyk-1: a C. elegans FH gene required for a late step in embryonic cytokinesis. J Cell Sci. 1998;111 ( Pt 14):2017-27 pubmed
    ..We discuss our findings in the context of other studies suggesting that FH genes in yeast and insects function early in cytokinesis to assemble a cleavage furrow. ..
  7. Meneghini M, Ishitani T, Carter J, Hisamoto N, Ninomiya Tsuji J, Thorpe C, et al. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature. 1999;399:793-7 pubmed
    ..These functions are likely to be conserved in vertebrates, as TAK1 and NLK can downregulate HMG-domain-containing proteins related to POP-1. ..
  8. Hamill D, Severson A, Carter J, Bowerman B. Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains. Dev Cell. 2002;3:673-84 pubmed
    ..Furthermore, SPD-5 interacts genetically with a dynein heavy chain. We propose that SPD-5, along with dynein, is required for centrosome maturation and mitotic spindle assembly. ..
  9. Ellis G, Phillips J, O Rourke S, Lyczak R, Bowerman B. Maternally expressed and partially redundant beta-tubulins in Caenorhabditis elegans are autoregulated. J Cell Sci. 2004;117:457-64 pubmed
    ..We conclude that feedback regulation influences maternal beta-tubulin expression in C. elegans, but cannot fully restore normal microtubule function in the absence of one beta-tubulin isoform. ..

More Information


  1. Siller K, Serr M, Steward R, Hays T, Doe C. Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control. Mol Biol Cell. 2005;16:5127-40 pubmed
    ..We conclude that Lis1/dynactin act together to regulate multiple, independent functions in mitotic cells, including spindle formation and cell cycle checkpoint release. ..
  2. Willis J, Munro E, Lyczak R, Bowerman B. Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform. Mol Biol Cell. 2006;17:1051-64 pubmed
    ..Furthermore, one of the dominant act-2 mutations resulted in uncoordinated adult movement. We conclude that redundant C. elegans actin isoforms function in both muscle and nonmuscle contractile processes. ..
  3. Dorfman M, Gomes J, O Rourke S, Bowerman B. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Genetics. 2009;182:1035-49 pubmed publisher
    ..Thus, when controlled properly for specificity, modifier screens using conditionally lethal C. elegans mutants can identify roles for nonessential but conserved genes in essential processes. ..
  4. Gaertner B, Parmenter M, Rockman M, Kruglyak L, Phillips P. More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics. 2012;192:1533-42 pubmed publisher