Experts and Doctors on caenorhabditis elegans in Eugene, Oregon, United States


Locale: Eugene, Oregon, United States
Topic: caenorhabditis elegans

Top Publications

  1. Severson A, Bowerman B. Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans. J Cell Biol. 2003;161:21-6 pubmed
    ..This in turn produces asymmetry in the forces applied to MTs at each pole and allows PAR-2 to accumulate in the posterior cortex of a one-cell zygote and maintain asymmetry. ..
  2. Lockery S, Hulme S, Roberts W, Robinson K, Laromaine A, Lindsay T, et al. A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans. Lab Chip. 2012;12:2211-20 pubmed publisher
    ..It is also applicable in toxicology and drug discovery programs for human metabolic and degenerative diseases for which C. elegans is used as a model. ..
  3. Gaertner B, Parmenter M, Rockman M, Kruglyak L, Phillips P. More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics. 2012;192:1533-42 pubmed publisher
  4. Phillips P. One perfect worm. Trends Genet. 2006;22:405-7 pubmed
    ..This suggests either wide-ranging migration and intense natural selection or recent dispersal, perhaps by human association. Either way, the effective population size of this ubiquitous model organism is unexpectedly small. ..
  5. Phillips P. Self-fertilization sweeps up variation in the worm genome. Nat Genet. 2012;44:237-8 pubmed publisher
    ..Their analyses suggest that recent chromosome-scale selective sweeps have reduced C. elegans genetic diversity worldwide and strongly structured genetic variation across its genome. ..
  6. Anderson J, Albergotti L, Ellebracht B, Huey R, Phillips P. Does thermoregulatory behavior maximize reproductive fitness of natural isolates of Caenorhabditis elegans?. BMC Evol Biol. 2011;11:157 pubmed publisher
  7. Anderson J, Morran L, Phillips P. Outcrossing and the maintenance of males within C. elegans populations. J Hered. 2010;101 Suppl 1:S62-74 pubmed publisher
    ..Laboratory and field results still await full reconciliation, which may be facilitated by identifying the loci underlying among-strain differences in mating system dynamics. ..
  8. Dorfman M, Gomes J, O Rourke S, Bowerman B. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Genetics. 2009;182:1035-49 pubmed publisher
    ..Thus, when controlled properly for specificity, modifier screens using conditionally lethal C. elegans mutants can identify roles for nonessential but conserved genes in essential processes. ..
  9. Thorpe C, Schlesinger A, Carter J, Bowerman B. Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm. Cell. 1997;90:695-705 pubmed
    ..Defective mitotic spindle orientations in mom mutant embryos indicate that Wnt signaling influences cytoskeletal polarity in blastomeres throughout the early embryo. ..

More Information


  1. Ellis G, Phillips J, O Rourke S, Lyczak R, Bowerman B. Maternally expressed and partially redundant beta-tubulins in Caenorhabditis elegans are autoregulated. J Cell Sci. 2004;117:457-64 pubmed
    ..We conclude that feedback regulation influences maternal beta-tubulin expression in C. elegans, but cannot fully restore normal microtubule function in the absence of one beta-tubulin isoform. ..
  2. Hamill D, Severson A, Carter J, Bowerman B. Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains. Dev Cell. 2002;3:673-84 pubmed
    ..Furthermore, SPD-5 interacts genetically with a dynein heavy chain. We propose that SPD-5, along with dynein, is required for centrosome maturation and mitotic spindle assembly. ..
  3. Swan K, Severson A, Carter J, Martin P, Schnabel H, Schnabel R, et al. cyk-1: a C. elegans FH gene required for a late step in embryonic cytokinesis. J Cell Sci. 1998;111 ( Pt 14):2017-27 pubmed
    ..We discuss our findings in the context of other studies suggesting that FH genes in yeast and insects function early in cytokinesis to assemble a cleavage furrow. ..
  4. Willis J, Munro E, Lyczak R, Bowerman B. Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform. Mol Biol Cell. 2006;17:1051-64 pubmed
    ..Furthermore, one of the dominant act-2 mutations resulted in uncoordinated adult movement. We conclude that redundant C. elegans actin isoforms function in both muscle and nonmuscle contractile processes. ..
  5. GOULDING M, Canman J, Senning E, Marcus A, Bowerman B. Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II. J Cell Biol. 2007;178:1177-91 pubmed
    ..These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction...
  6. Canman J, Lewellyn L, Laband K, Smerdon S, Desai A, Bowerman B, et al. Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science. 2008;322:1543-6 pubmed publisher
    ..Thus, inactivation of Rac by centralspindlin functions in parallel with RhoA activation to drive contractile ring constriction during cytokinesis. ..
  7. Phillips J, Lyczak R, Ellis G, Bowerman B. Roles for two partially redundant alpha-tubulins during mitosis in early Caenorhabditis elegans embryos. Cell Motil Cytoskeleton. 2004;58:112-26 pubmed
    ..We conclude that microtubules in the early C. elegans embryo are composed of both TBA-1 and TBA-2, and that the dominant tba-1(or346ts) mutation disrupts MT assembly or stability. Cell Motil. ..
  8. Meneghini M, Ishitani T, Carter J, Hisamoto N, Ninomiya Tsuji J, Thorpe C, et al. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature. 1999;399:793-7 pubmed
    ..These functions are likely to be conserved in vertebrates, as TAK1 and NLK can downregulate HMG-domain-containing proteins related to POP-1. ..
  9. Rupert P, Daughdrill G, Bowerman B, Matthews B. A new DNA-binding motif in the Skn-1 binding domain-DNA complex. Nat Struct Biol. 1998;5:484-91 pubmed
    ..Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'. ..