Genomes and Genes
Experts and Doctors on animals in Eugene, Oregon, United States
Locale: Eugene, Oregon, United States
Publications200 found, 100 shown here
- Wakamatsu Y, Maynard T, Jones S, Weston J. NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1. Neuron. 1999;23:71-81 pubmed
- Kimmel C, Ullmann B, Walker M, Miller C, Crump J. Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish. Development. 2003;130:1339-51 pubmed..Changes involving Edn1 may have occurred during actinopterygian evolution to produce the efficient gill-pumping opercular apparatus of teleosts. ..
- Lib M, Rodriguez Mari A, Marusich M, Capaldi R. Immunocapture and microplate-based activity measurement of mammalian pyruvate dehydrogenase complex. Anal Biochem. 2003;314:121-7 pubmed
- Cannon M, Remington S. Re-engineering redox-sensitive green fluorescent protein for improved response rate. Protein Sci. 2006;15:45-57 pubmed..roGFP1-R12 is most suitable for use in live cells, due to significantly increased reaction rate and increased pI. ..
- Muyskens J, Kimmel C. Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer. Mech Dev. 2007;124:35-42 pubmed..Our findings thus reveal that Tbx16, in combination with Wnt11, are critical components not only in morphogenesis but also in initial assembly of the organizer. ..
- Nadanaciva S, Bernal A, Aggeler R, Capaldi R, Will Y. Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays. Toxicol In Vitro. 2007;21:902-11 pubmed..A major advantage of the immunocapture approach is that it can be used throughout drug screening from early compound evaluation to clinical trials. ..
- Tran K, Miller M, Doe C. Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity. Development. 2010;137:1421-30 pubmed publisher..We propose that Hunchback maintains early neuroblast competence by silencing a suite of late-expressed genes. ..
- He X, Yan Y, Eberhart J, Herpin A, Wagner T, Schartl M, et al. miR-196 regulates axial patterning and pectoral appendage initiation. Dev Biol. 2011;357:463-77 pubmed publisher..These results show that a Hox cluster microRNA modulates development of axial patterning similar to nearby protein-coding Hox genes, and acts on appendicular patterning at least in part by modulating retinoic acid signaling. ..
- Wee B, Johnston C, Prehoda K, Doe C. Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation. J Cell Biol. 2011;195:369-76 pubmed publisher..We show that the Canoe Ras-association (RA) domains directly bind RanGTP and that both the Canoe(RA) domains and RanGTP are required to recruit Mud to the cortex and activate the Pins/Mud/dynein spindle orientation pathway. ..
- Faumont S, Lindsay T, Lockery S. Neuronal microcircuits for decision making in C. elegans. Curr Opin Neurobiol. 2012;22:580-91 pubmed..Peptide signaling seems to play a prominent role in all three motifs, and it may be a general rule that concentrations of various peptides encode the internal states that influence behavioral decisions in C. elegans. ..
- Henderson J, Ai H, Campbell R, Remington S. Structural basis for reversible photobleaching of a green fluorescent protein homologue. Proc Natl Acad Sci U S A. 2007;104:6672-7 pubmed..The fundamental mechanism appears to be common to all of the photoactivatable and reversibly photoswitchable FPs reported to date. ..
- Morin Kensicki E, Eisen J. Sclerotome development and peripheral nervous system segmentation in embryonic zebrafish. Development. 1997;124:159-67 pubmed..We propose that peripheral nervous system segmentation is established through interactions with adjacent paraxial mesoderm which develops as sclerotome in some vertebrate species and myotome in others. ..
- Melby A, Kimelman D, Kimmel C. Spatial regulation of floating head expression in the developing notochord. Dev Dyn. 1997;209:156-65 pubmed..In ntl mutants the spatial pattern of flh expression is altered as early as the late gastrula stage, becoming broad and diffuse. We hypothesize that ntl+ is required for the proper convergence movements of flh-expressing cells. ..
- Halpern M, Hatta K, Amacher S, Talbot W, Yan Y, Thisse B, et al. Genetic interactions in zebrafish midline development. Dev Biol. 1997;187:154-70 pubmed..From these findings we propose that ntl+ plays an early role in cell fate choice at the dorsal midline, mediated by the Ntl protein acting to antagonize floor plate development as well as to promote notochord development. ..
- Yan Y, Talbot W, Egan E, Postlethwait J. Mutant rescue by BAC clone injection in zebrafish. Genomics. 1998;50:287-9 pubmed..We conclude that the injection of large-insert genomic clones will speed the isolation of zebrafish genes disrupted by mutation and hence the identification of gene functions necessary for development of vertebrate embryos. ..
- Maves L, Jackman W, Kimmel C. FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain. Development. 2002;129:3825-37 pubmed..Taken together, our findings demonstrate a crucial role for FGF-mediated inter-rhombomere signaling in promoting early hindbrain patterning and underscore the significance of organizing centers in patterning the vertebrate neural plate. ..
- Severson A, Bowerman B. Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans. J Cell Biol. 2003;161:21-6 pubmed..This in turn produces asymmetry in the forces applied to MTs at each pole and allows PAR-2 to accumulate in the posterior cortex of a one-cell zygote and maintain asymmetry. ..
- Lewis K, Eisen J. Paraxial mesoderm specifies zebrafish primary motoneuron subtype identity. Development. 2004;131:891-902 pubmed..Our findings suggest that in the absence of signals from paraxial mesoderm, primary motoneurons have a hybrid identity with respect to gene expression, and that under these conditions the CaP axon trajectory may be dominant. ..
- Walker M, Miller C, Coffin Talbot J, Stock D, Kimmel C. Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Dev Biol. 2006;295:194-205 pubmed
- Jovelin R, He X, Amores A, Yan Y, Shi R, Qin B, et al. Duplication and divergence of fgf8 functions in teleost development and evolution. J Exp Zool B Mol Dev Evol. 2007;308:730-43 pubmed
- Talbot J, Johnson S, Kimmel C. hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches. Development. 2010;137:2507-17 pubmed publisher..Collectively, our work indicates that the expression and function of hand2 and Dlx genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches...
- Simonson L, Ganz J, Melancon E, Eisen J. Characterization of enteric neurons in wild-type and mutant zebrafish using semi-automated cell counting and co-expression analysis. Zebrafish. 2013;10:147-53 pubmed publisher..We also show that gutwrencher mutants have the same number of serotonin-positive enteroendocrine cells in the intestine as wild types. ..
- Keana J, McBurney R, Scherz M, Fischer J, Hamilton P, Smith S, et al. Synthesis and characterization of a series of diarylguanidines that are noncompetitive N-methyl-D-aspartate receptor antagonists with neuroprotective properties. Proc Natl Acad Sci U S A. 1989;86:5631-5 pubmed
- Sepich D, Ho R, Westerfield M. Autonomous expression of the nic1 acetylcholine receptor mutation in zebrafish muscle cells. Dev Biol. 1994;161:84-90 pubmed..We conclude that the nic1 mutation acts autonomously in muscle cells rather than by affecting signaling between motoneurons and muscle. The wild-type nic1 gene is necessary in muscle for expression and clustering of AChRs. ..
- Halpern M, Thisse C, Ho R, Thisse B, Riggleman B, Trevarrow B, et al. Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants. Development. 1995;121:4257-64 pubmed..Our results suggest that wild-type floating head provides an essential step in maintaining, rather than initiating, development of notochord-forming axial mesoderm. ..
- Paragas V, Zhang Y, Haugland R, Singer V. The ELF-97 alkaline phosphatase substrate provides a bright, photostable, fluorescent signal amplification method for FISH. J Histochem Cytochem. 1997;45:345-57 pubmed..Finally, Southern blot hybridization using singly labeled oligonucleotide probes yielded a sensitivity similar to that obtained with radioactivity. ..
- Wakamatsu Y, Weston J. Sequential expression and role of Hu RNA-binding proteins during neurogenesis. Development. 1997;124:3449-60 pubmed..These data confirm that cHuD protein is involved in regulating neuronal differentiation. ..
- Jenkins B, Pullen C, Darimont B. Novel glucocorticoid receptor coactivator effector mechanisms. Trends Endocrinol Metab. 2001;12:122-6 pubmed..The emerging picture shows coactivators as flexible, but precise, coordinators of complex and dynamic networks, in which transcriptional regulation by GR and other NRs is linked to other signaling pathways. ..
- Hausrath A, Capaldi R, Matthews B. The conformation of the epsilon- and gamma-subunits within the Escherichia coli F(1) ATPase. J Biol Chem. 2001;276:47227-32 pubmed..It is argued that these large-scale changes in conformation reflect distinct functional states that occur during the rotation of the gamma-subunit within the alpha(3)beta(3) hexamer. ..
- Zelhof A, Bao H, Hardy R, Razzaq A, Zhang B, Doe C. Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis. Development. 2001;128:5005-15 pubmed..The strong misexpression phenotype coupled with the mild mutant and lack of phenotypes suggests that Amphiphysin acts redundantly with other proteins to organize specialized membrane domains within a diverse array of cell types. ..
- Gillis W, Bowerman B, Schneider S. Ectoderm- and endomesoderm-specific GATA transcription factors in the marine annelid Platynereis dumerilli. Evol Dev. 2007;9:39-50 pubmed..Moreover, our results indicate that the GATA gene duplication and the functional divergence that led to these two ancestral GATA factor genes occurred after the split of the bilaterian stem group from the cnidarians. ..
- Chabu C, Doe C. Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal. Dev Biol. 2009;330:399-405 pubmed publisher..We conclude that Twins/PP2A is required to maintain aPKC at the apical cortex of mitotic neuroblasts, keeping it out of the differentiating GMC, and thereby maintaining neuroblast homeostasis. ..
- Eick G, Thornton J. Evolution of steroid receptors from an estrogen-sensitive ancestral receptor. Mol Cell Endocrinol. 2011;334:31-8 pubmed publisher..The primordial interaction between the ancestral steroid receptor and estrogens may itself have evolved due to an early molecular exploitation event. ..
- Kohwi M, Hiebert L, Doe C. The pipsqueak-domain proteins Distal antenna and Distal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity. Development. 2011;138:1727-35 pubmed publisher..We conclude that Dan/Danr and Svp act in parallel pathways to limit Hb expression and allow neuroblasts to transition from making early-born neurons to late-born neurons at the proper time. ..
- Murray K, Bauer J, Tallen A, Matthews J, Westerfield M, Varga Z. Characterization and management of asymptomatic Mycobacterium infections at the Zebrafish International Resource Center. J Am Assoc Lab Anim Sci. 2011;50:675-9 pubmed..Application of these findings has allowed us to decrease mycobacteriosis in TU zebrafish and resume shipment of TU adults to the research community...
- Anderson D, Whitney D, Hanson Smith V, Woznica A, Campodonico Burnett W, Volkman B, et al. Evolution of an ancient protein function involved in organized multicellularity in animals. elife. 2016;5:e10147 pubmed publisher..We show how the physical simplicity of this binding interface enabled the evolution of a new protein function now essential to the biological complexity of many animals. ..
- Puschel A, Westerfield M, Dressler G. Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish. Mech Dev. 1992;38:197-208 pubmed..Our results confirm that Pax genes are highly conserved both in sequences and in expression patterns, indicating that they may have a function during early development that has been conserved during vertebrate evolution. ..
- Keller C, Kawasaki M, Heiligenberg W. The control of pacemaker modulations for social communication in the weakly electric fish Sternopygus. J Comp Physiol A. 1991;169:441-50 pubmed..Application to the Pn of an antagonist to NMDA-type glutamate receptors blocked EOD-frequency rises and EOD-interruptions. Antagonists to quisqualate/kainate receptor-types were ineffective...
- Taanman J, Burton M, Marusich M, Kennaway N, Capaldi R. Subunit specific monoclonal antibodies show different steady-state levels of various cytochrome-c oxidase subunits in chronic progressive external ophthalmoplegia. Biochim Biophys Acta. 1996;1315:199-207 pubmed..The data presented in this paper demonstrate that the battery of monoclonal antibodies can be employed for diagnostic purposes to analyze steady-state levels of mitochondrially and nuclear-encoded subunits of cytochrome-c oxidase...
- Kingston R, Olson N, Vogt V. The organization of mature Rous sarcoma virus as studied by cryoelectron microscopy. J Struct Biol. 2001;136:67-80 pubmed..From estimates of RNA packing density we conclude that either the RNA within the core is loosely packed or, more probably, that it does not fill the core. ..
- Ellis G, Phillips J, O Rourke S, Lyczak R, Bowerman B. Maternally expressed and partially redundant beta-tubulins in Caenorhabditis elegans are autoregulated. J Cell Sci. 2004;117:457-64 pubmed..We conclude that feedback regulation influences maternal beta-tubulin expression in C. elegans, but cannot fully restore normal microtubule function in the absence of one beta-tubulin isoform. ..
- Peng G, Westerfield M. Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development. 2006;133:3191-200 pubmed..Our results demonstrate that Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists. ..
- GOULDING M, Canman J, Senning E, Marcus A, Bowerman B. Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II. J Cell Biol. 2007;178:1177-91 pubmed..These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction...
- Scholl B, Gao X, Wehr M. Nonoverlapping sets of synapses drive on responses and off responses in auditory cortex. Neuron. 2010;65:412-21 pubmed publisher..Furthermore, an on-on sequence causes complete forward suppression, whereas an off-on sequence causes no suppression at all. We conclude that on and off responses are driven by largely nonoverlapping sets of synaptic inputs. ..
- Carroll C, NALEWAY J, Haley M, Johnson D. Arylethynyl receptors for neutral molecules and anions: emerging applications in cellular imaging. Chem Soc Rev. 2010;39:3875-88 pubmed publisher..We will also examine briefly how the "chemistry in the cuvet" translates into biological media (125 references). ..
- Coonrod E, Graham L, Carpp L, Carr T, Stirrat L, Bowers K, et al. Homotypic vacuole fusion in yeast requires organelle acidification and not the V-ATPase membrane domain. Dev Cell. 2013;27:462-8 pubmed publisher..Furthermore, we show that acidification of the yeast vacuole in the absence of the V-ATPase rescues vacuole-fusion defects. Our results clarify the in vivo requirements of acidification for membrane fusion. ..
- Talbot W, Trevarrow B, Halpern M, Melby A, Farr G, Postlethwait J, et al. A homeobox gene essential for zebrafish notochord development. Nature. 1995;378:150-7 pubmed..We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate. ..
- Kimmel C, Sidlauskas B, Clack J. Linked morphological changes during palate evolution in early tetrapods. J Anat. 2009;215:91-109 pubmed publisher..Further work is needed to learn whether such correlated evolution might be due to adaptation and/or to developmental bias, and particularly to learn how correlations and allometries themselves evolve. ..
- Yan Y, Postlethwait J. Vitellogenesis in Drosophila: sequestration of a yolk polypeptide/invertase fusion protein into developing oocytes. Dev Biol. 1990;140:281-90 pubmed..This work provides a means of identifying the features of yolk polypeptides that are responsible for their deposition into yolk during oogenesis. ..
- Bauerle C, Ho M, Lindorfer M, Stevens T. The Saccharomyces cerevisiae VMA6 gene encodes the 36-kDa subunit of the vacuolar H(+)-ATPase membrane sector. J Biol Chem. 1993;268:12749-57 pubmed..These results are discussed in the context of a developing model for V-ATPase assembly in yeast. ..
- Lynch M. Mutation accumulation in nuclear, organelle, and prokaryotic transfer RNA genes. Mol Biol Evol. 1997;14:914-25 pubmed
- Hagedorn M, Mack A, Evans B, Fernald R. The embryogenesis of rod photoreceptors in the teleost fish retina, Haplochromis burtoni. Brain Res Dev Brain Res. 1998;108:217-27 pubmed..Moreover, the wave of GABAergic staining in the horizontal cells parallels the wave of rod differentiation across the embryonic retina of H. burtoni. Thus, GABA may play a role in the development of rod photoreceptors. ..
- Amores A, Force A, Yan Y, Joly L, Amemiya C, Fritz A, et al. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998;282:1711-4 pubmed..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis. ..
- Chen C, Chen W, Zhou M, Arttamangkul S, Haugland R. Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy. J Biochem Biophys Methods. 2000;42:137-51 pubmed..These properties, along with the good photostability of the BODIPY FL fluorophore, make this probe a novel tool for the study of the secretion and trafficking of cathepsin D. ..
- Henion P, Blyss G, Luo R, An M, Maynard T, Cole G, et al. Avian transitin expression mirrors glial cell fate restrictions during neural crest development. Dev Dyn. 2000;218:150-9 pubmed
- Freeman M, Doe C. Moving muscle. Jeb signaling in Drosophila. Dev Cell. 2001;1:587-8 pubmed..A recent study identifies a novel nonautonomous signaling pathway that regulates cell migration and differentiation in early Drosophila mesodermal tissues. ..
- Matthews M, Trevarrow B, Matthews J. A virtual tour of the Guide for zebrafish users. Lab Anim (NY). 2002;31:34-40 pubmed..PHS-funded and AAALAC-accredited facilities are required to use the Guide as the basis for setting up a zebrafish care and use program. The authors describe how they accomplished this task at the University of Oregon Zebrafish Facility. ..
- Miller C, Yelon D, Stainier D, Kimmel C. Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development. 2003;130:1353-65 pubmed..Together our results reveal two critical edn1 effectors that pattern the vertebrate jaw: hand2 specifies ventral pharyngeal cartilage of the lower jaw and bapx1 specifies the jaw joint. ..
- Martin K, Hart C, Liu J, Leung W, Patton W. Simultaneous trichromatic fluorescence detection of proteins on Western blots using an amine-reactive dye in combination with alkaline phosphatase- and horseradish peroxidase-antibody conjugates. Proteomics. 2003;3:1215-27 pubmed
- Henderson J, Remington S. Crystal structures and mutational analysis of amFP486, a cyan fluorescent protein from Anemonia majano. Proc Natl Acad Sci U S A. 2005;102:12712-7 pubmed
- Liu S, Fewkes N, Ricketson D, Penkert R, Prehoda K. Filament-dependent and -independent localization modes of Drosophila non-muscle myosin II. J Biol Chem. 2008;283:380-7 pubmed..These results delineate the requirements for zipper filament assembly and indicate that the ability to form filaments is necessary for targeting to the cleavage furrow but not to the interphase cortex. ..
- Clausen R, York R. Economic growth and marine biodiversity: influence of human social structure on decline of marine trophic levels. Conserv Biol. 2008;22:458-66 pubmed publisher..The challenge is to utilize the socioeconomic and ecological research in the service of a comprehensive marine-conservation movement. ..
- Schofield R, Niedbala J, Nesson M, Tao Y, Shokes J, Scott R, et al. Br-rich tips of calcified crab claws are less hard but more fracture resistant: a comparison of mineralized and heavy-element biological materials. J Struct Biol. 2009;166:272-87 pubmed
- Stice E, Dagher A. Genetic variation in dopaminergic reward in humans. Forum Nutr. 2010;63:176-85 pubmed publisher..Improved understanding of the role of dopamine-based reward circuitry and genotypes that influence the functioning of this circuitry may inform the design of more effective preventive and treatment interventions for obesity. ..
- Ricketson D, Johnston C, Prehoda K. Multiple tail domain interactions stabilize nonmuscle myosin II bipolar filaments. Proc Natl Acad Sci U S A. 2010;107:20964-9 pubmed publisher..Together these results explain the relationship between the charge repeat and assembly domain in stabilizing myosin bipolar filaments. ..
- O Brien C, Bourdo R, Bradshaw W, Holzapfel C, Cresko W. Conservation of the photoperiodic neuroendocrine axis among vertebrates: evidence from the teleost fish, Gasterosteus aculeatus. Gen Comp Endocrinol. 2012;178:19-27 pubmed publisher..However, additional endocrinology, cell biology and molecular research will be required to define precisely which aspects of the pathway are conserved across vertebrates...
- Huycke T, Eames B, Kimmel C. Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone. Development. 2012;139:2371-80 pubmed publisher..Hence, patterning within a module may include adjacent regions of functionally related bones and might require that signaling pathways function over an extended period of development. ..
- Hetrick B, Han M, Helgeson L, Nolen B. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013;20:701-12 pubmed publisher..These results provide key insights into the relationship between conformation and activity in Arp2/3 complex and will be critical for interpreting the influence of the inhibitors on actin filament networks in vivo. ..
- Capaldi R, Marusich M, Taanman J. Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells. Methods Enzymol. 1995;260:117-32 pubmed
- Hans S, Christison J, Liu D, Westerfield M. Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Dev Biol. 2007;7:5 pubmed..These results provide further support for the hypothesis that Foxi1 and Dlx3b provide competence for cells to respond to Fgf and form an otic placode. ..
- Eisen J, Smith J. Controlling morpholino experiments: don't stop making antisense. Development. 2008;135:1735-43 pubmed publisher..We also discuss how the use of morpholinos can lead to misleading results, including off-target effects, and we suggest controls that will allow researchers to interpret morpholino experiments correctly. ..
- Kohwi M, Lupton J, Lai S, Miller M, Doe C. Developmentally regulated subnuclear genome reorganization restricts neural progenitor competence in Drosophila. Cell. 2013;152:97-108 pubmed publisher..We propose that neuroblasts undergo a developmentally regulated subnuclear genome reorganization to permanently silence Hunchback target genes that results in loss of progenitor competence. ..
- Hanson G, McAnaney T, Park E, Rendell M, Yarbrough D, Chu S, et al. Green fluorescent protein variants as ratiometric dual emission pH sensors. 1. Structural characterization and preliminary application. Biochemistry. 2002;41:15477-88 pubmed..Given their favorable optical characteristics, suitable pK(a)'s for the physiological pH range, and suitability for ratiometric measurements, dual emission GFPs should make excellent probes for studying pH in vivo. ..
- Rolls M, Albertson R, Shih H, Lee C, Doe C. Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. J Cell Biol. 2003;163:1089-98 pubmed
- Tran K, Doe C. Pdm and Castor close successive temporal identity windows in the NB3-1 lineage. Development. 2008;135:3491-9 pubmed publisher..Our results provide a new neuroblast lineage for investigating temporal identity and reveal the importance of Pdm and Cas as timing factors that close temporal identity windows. ..
- Moore A, Wehr M. Parvalbumin-expressing inhibitory interneurons in auditory cortex are well-tuned for frequency. J Neurosci. 2013;33:13713-23 pubmed publisher..PV+ neurons also had markedly faster response latencies than PV- neurons, consistent with a computational role in enhancing the temporal precision of cortical responses. ..
- JONES T, Hernandez D, Wong Z, Wandler A, Guillemin K. The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut. PLoS Pathog. 2017;13:e1006631 pubmed publisher..pylori infection. This work provides valuable new insights into the mechanisms by which interactions between a specific virulence factor and the resident microbiota can contribute to the development and progression of disease...
- Lightowlers R, Ewart G, Aggeler R, Zhang Y, Calavetta L, Capaldi R. Isolation and characterization of the cDNAs encoding two isoforms of subunit CIX of bovine cytochrome c oxidase. J Biol Chem. 1990;265:2677-81 pubmed..These results indicate that the synthesis of the H isoform of CIX is controlled transcriptionally while the L form is under post-transcriptional regulation at least in heart and muscle tissue. ..
- Moens C, Yan Y, Appel B, Force A, Kimmel C. valentino: a zebrafish gene required for normal hindbrain segmentation. Development. 1996;122:3981-90 pubmed..These results provide genetic evidence for a two-segment periodicity in the hindbrain and suggest that this periodicity arises sequentially, through the specification and later subdivision of a two-rhombomere unit, or 'protosegment'. ..
- Postlethwait J, Yan Y, Gates M, Horne S, Amores A, Brownlie A, et al. Vertebrate genome evolution and the zebrafish gene map. Nat Genet. 1998;18:345-9 pubmed..This zebrafish gene map will facilitate molecular identification of mutated zebrafish genes, which can suggest functions for human genes known only by sequence. ..
- Bridgham J, Carroll S, Thornton J. Evolution of hormone-receptor complexity by molecular exploitation. Science. 2006;312:97-101 pubmed..Our results indicate that tight interactions can evolve by molecular exploitation-recruitment of an older molecule, previously constrained for a different role, into a new functional complex. ..
- Lockery S, Hulme S, Roberts W, Robinson K, Laromaine A, Lindsay T, et al. A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans. Lab Chip. 2012;12:2211-20 pubmed publisher..It is also applicable in toxicology and drug discovery programs for human metabolic and degenerative diseases for which C. elegans is used as a model. ..
- De Carolis G, Paroli M, Tollapi L, Doust M, Burgher A, Yu C, et al. Paresthesia-Independence: An Assessment of Technical Factors Related to 10 kHz Paresthesia-Free Spinal Cord Stimulation. Pain Physician. 2017;20:331-341 pubmed..These results suggest that HF10 therapy is not only paresthesia-free, but may be paresthesia-independent. ..