Experts and Doctors on body weight in Cincinnati, Ohio, United States


Locale: Cincinnati, Ohio, United States
Topic: body weight

Top Publications

  1. Kim D, Woods S, Seeley R. Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight. Diabetes. 2010;59:907-15 pubmed publisher
    ..These experiments provide compelling evidence for a previously unknown relationship between the status of adipose tissue vasculature and the regulation of food intake. ..
  2. Solomon M, Sakai R, Woods S, Foster M. Differential effects of glucocorticoids on energy homeostasis in Syrian hamsters. Am J Physiol Endocrinol Metab. 2011;301:E307-16 pubmed publisher
    ..However, the data suggest that cortisol alone does not mediate stress-induced increases in food intake or body mass in this species. ..
  3. Stefater M, Sandoval D, Chambers A, Wilson Perez H, Hofmann S, Jandacek R, et al. Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion. Gastroenterology. 2011;141:939-949.e1-4 pubmed publisher
    ..This resulted from reduced intestinal secretion of triglycerides following ingestion of a lipid meal and indicates that VSG has important effects on metabolism. ..
  4. Ledoussal C, Woo A, Miller M, Shull G. Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1385-96 pubmed
  5. Anderson J, Beekman R, Border W, Kalkwarf H, Khoury P, Uzark K, et al. Lower weight-for-age z score adversely affects hospital length of stay after the bidirectional Glenn procedure in 100 infants with a single ventricle. J Thorac Cardiovasc Surg. 2009;138:397-404.e1 pubmed publisher
    ..A lower weight-for-age z score and younger age at the time of the bidirectional Glenn procedure affects length of hospital stay independent of hemodynamic or echocardiographic variables. ..
  6. Melhorn S, Krause E, Scott K, Mooney M, Johnson J, Woods S, et al. Acute exposure to a high-fat diet alters meal patterns and body composition. Physiol Behav. 2010;99:33-9 pubmed publisher
    ..Together, these results suggest that consumption of a high-fat diet can rapidly alter meal patterns, which in turn contribute to the development of adiposity. ..
  7. Stefater M, MacLennan A, Lee N, Patterson C, Haller A, Sorrell J, et al. The anorectic effect of CNTF does not require action in leptin-responsive neurons. Endocrinology. 2012;153:2647-54 pubmed publisher
    ..These results indicate that despite anatomical overlap for CNTF and leptin action, CNTF appears to act within a distinct neuronal population to elicit its potent anorectic effect. ..
  8. Plair B, Reinhart P, Roth T. Neonatal milestones, behavior and growth rate of Sumatran rhinoceros (Dicerorhinus sumatrensis) calves born and bred in captivity. Zoo Biol. 2012;31:546-60 pubmed publisher
    ..Finally, footprint measurements proved valuable for estimating calf age. ..
  9. Glueck C, Khan N, Riaz M, Padda J, Khan Z, Wang P. Titrating lovaza from 4 to 8 to 12 grams/day in patients with primary hypertriglyceridemia who had triglyceride levels >500?mg/dl despite conventional triglyceride lowering therapy. Lipids Health Dis. 2012;11:143 pubmed publisher
    ..The 4, 8, and 12?g/d Lovaza doses were well tolerated. Titration of Lovaza from 4 to 8 to 12?g/d safely offers an effective way to lower TG beyond conventional 4?g therapy. ..

More Information

Publications105 found, 100 shown here

  1. Nogueiras R, Veyrat Durebex C, Suchanek P, Klein M, Tschop J, Caldwell C, et al. Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes. 2008;57:2977-91 pubmed publisher
    ..Several relevant metabolic processes appear to independently benefit from peripheral blockade of CB1, while CNS-CB1 blockade alone predominantly affects food intake and body weight. ..
  2. Zeller M, Inge T, Modi A, Jenkins T, Michalsky M, Helmrath M, et al. Severe obesity and comorbid condition impact on the weight-related quality of life of the adolescent patient. J Pediatr. 2015;166:651-9.e4 pubmed publisher
    ..Furthermore, they provide a comprehensive empirical base for understanding heterogeneity in adolescent WRQOL outcomes after WLS, as weight and comorbidity profiles change over time. ..
  3. Glueck C, Goldenberg N, Wang P, Loftspring M, Sherman A. Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout. Hum Reprod. 2004;19:510-21 pubmed
  4. Amlal H, Xu J, Barone S, Zahedi K, Soleimani M. The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion. J Mol Med (Berl). 2013;91:561-72 pubmed publisher
    ..We propose that impaired SLC26A9 activity in humans may interfere with the excretion of excess salt and result in hypertension. ..
  5. Sherwin C, Svahn S, van der Linden A, Broadbent R, Medlicott N, Reith D. Individualised dosing of amikacin in neonates: a pharmacokinetic/pharmacodynamic analysis. Eur J Clin Pharmacol. 2009;65:705-13 pubmed publisher
  6. Vorhees C, He E, Skelton M, Graham D, Schaefer T, Grace C, et al. Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze. Synapse. 2011;65:368-78 pubmed publisher
    ..Given that FEN selectively and MDMA preferentially affect serotonin whereas AMPH selectively and MA preferentially affect DA, the data suggest that egocentric learning may be predominantly dopaminergically mediated. ..
  7. Seeley R, Burklow M, Wilmer K, Matthews C, Reizes O, McOsker C, et al. The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity. Endocrinology. 2005;146:3732-8 pubmed
    ..These experiments support the hypothesis that melanocortin signaling primarily regulates total body adiposity and that food intake is adjusted as necessary to achieve a specific level of body adiposity. ..
  8. Choi D, Furay A, Evanson N, Ulrich Lai Y, Nguyen M, Ostrander M, et al. The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic-pituitary-adrenocortical axis responsiveness to acute and chronic stress. Psychoneuroendocrinology. 2008;33:659-69 pubmed publisher
    ..The data further suggest that acute versus chronic stress integration are subserved by different brain circuitry. ..
  9. Drazen D, Coolen L, Strader A, Wortman M, Woods S, Seeley R. Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A. Endocrinology. 2004;145:3404-12 pubmed
  10. Martin L, Woo J, Geraghty S, Altaye M, Davidson B, Banach W, et al. Adiponectin is present in human milk and is associated with maternal factors. Am J Clin Nutr. 2006;83:1106-11 pubmed
    ..Given the importance of adiponectin in inflammation, insulin sensitivity, and fatty acid metabolism, future studies should examine milk adiponectin's role in infant metabolic development. ..
  11. Flak J, Ostrander M, Tasker J, Herman J. Chronic stress-induced neurotransmitter plasticity in the PVN. J Comp Neurol. 2009;517:156-65 pubmed publisher
    ..These changes could lead to an enhanced capacity for excitation in these neurons, contributing to chronic stress-induced hyperreactivity of stress effector systems in the brain. ..
  12. Skelton M, Graham D, Schaefer T, Grace C, Braun A, Burns L, et al. Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats. Int J Neuropsychopharmacol. 2012;15:811-24 pubmed publisher
    ..Other effects, such as those upon MK-801-stimulated locomotion showed greatest effects after PD 1-10 MDMA exposure. Hence, each effect has a different window of developmental susceptibility. ..
  13. Glueck C, Bornovali S, Pranikoff J, Goldenberg N, Dharashivkar S, Wang P. Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome. Diabet Med. 2004;21:829-36 pubmed
    ..5 vs. 17.5%, P = 0.3) or > or = 4500 g (1.3 vs. 2.9%, P = 0.7). Metformin is not associated with pre-eclampsia in pregnancy in women with PCOS, and appears to be safe for mother and fetus. ..
  14. Paul R, Bowman P, Johnson J, Martin A. Effects of sex and estrogen on myosin COOH-terminal isoforms and contractility in rat aorta. Am J Physiol Regul Integr Comp Physiol. 2007;292:R751-7 pubmed
    ..An increase in the COOH-terminal myosin heavy chain isoform SM1-to-SM2 ratio with 17beta-estradiol treatment may underlie the changes observed in contractility. ..
  15. Glueck C, Golnik K, Aregawi D, Goldenberg N, Sieve L, Wang P. Changes in weight, papilledema, headache, visual field, and life status in response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia. Transl Res. 2006;148:215-22 pubmed
    ..04). As many women with IIH have PCOS, and because weight loss is central to IIH treatment, diet-MET is a novel approach to treat IIH in women with concurrent PCOS or hyperinsulinemia without PCOS. ..
  16. McElroy S, Suppes T, Frye M, Altshuler L, Stanford K, Martens B, et al. Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial. J Affect Disord. 2007;101:275-81 pubmed
    ..Double-blind, placebo-controlled studies are necessary to determine aripiprazole's efficacy, tolerability, and safety in bipolar depression. ..
  17. Vorhees C, Johnson H, Burns L, Williams M. Developmental treatment with the dopamine D2/3 agonist quinpirole selectively impairs spatial learning in the Morris water maze. Neurotoxicol Teratol. 2009;31:1-10 pubmed publisher
    ..The data suggest that caution is warranted concerning the developmental efficacy of quinpirole. ..
  18. Wilson Perez H, Chambers A, Ryan K, Li B, Sandoval D, Stoffers D, et al. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes. 2013;62:2380-5 pubmed publisher
    ..These data demonstrate that GLP-1 receptor activity is not necessary for the metabolic improvements induced by VSG surgery. ..
  19. Gao Y, Layritz C, Legutko B, Eichmann T, Laperrousaz E, Moullé V, et al. Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity. Diabetes. 2017;66:2555-2563 pubmed publisher
    ..We conclude that hypothalamic LPL functions in astrocytes to ensure appropriately balanced nutrient sensing, ceramide distribution, body weight regulation, and glucose metabolism. ..
  20. Davis J, Choi D, Schurdak J, Fitzgerald M, Clegg D, Lipton J, et al. Leptin regulates energy balance and motivation through action at distinct neural circuits. Biol Psychiatry. 2011;69:668-74 pubmed publisher
    ..These data highlight the ability of leptin to regulate overconsumption of palatable foods and food motivation through pathways that mediate energy homeostasis and reward, respectively. ..
  21. Shen L, Tso P, Woods S, Clegg D, Barber K, Carey K, et al. Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes. 2008;57:2092-8 pubmed publisher
    ..These data demonstrate that apoE suppresses food intake via a mechanism enhancing melanocortin signaling in the hypothalamus. ..
  22. McNamara R, Able J, Rider T, Tso P, Jandacek R. Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1317-21 pubmed publisher
    ..These preclinical findings do not support the hypothesis that chronic FLX treatment increases n-3 fatty acid biosynthesis or membrane composition. ..
  23. Chambers A, Wilson Perez H, McGrath S, Grayson B, Ryan K, D Alessio D, et al. Effect of vertical sleeve gastrectomy on food selection and satiation in rats. Am J Physiol Endocrinol Metab. 2012;303:E1076-84 pubmed publisher
    ..VSG alters nutrient sensing in a manner that lowers the threshold for satiety and reduces fat preference to induce and maintain weight loss. ..
  24. Krenz M, Robbins J. Impact of beta-myosin heavy chain expression on cardiac function during stress. J Am Coll Cardiol. 2004;44:2390-7 pubmed
    ..Expression of beta-MHC appears to be disadvantageous to the mice under severe cardiovascular stress, implying that the alpha-->beta-MHC isoform shift observed in cardiac disease may be a maladaptive response. ..
  25. Lu A, Kurosawa Y, Luskey K, Pyne Geithman G, Caudell D, Clark J. Hemorrhagic profile of the fibrinolytic alfimeprase after ischemia and reperfusion. Neurol Res. 2009;31:209-14 pubmed publisher
    ..1 mg/kg alfimeprase and recombinant tissue plasminogen activator. In this model, alfimeprase, a new fibrinolytic agent, exhibits a profile comparable to recombinant tissue plasminogen activator. ..
  26. Konikoff M, Noel R, Blanchard C, Kirby C, Jameson S, Buckmeier B, et al. A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology. 2006;131:1381-91 pubmed
    ..05). Swallowed FP is effective in inducing histologic remission in eosinophilic esophagitis, with a more pronounced effect in nonallergic and younger individuals, especially in the proximal esophagus. ..
  27. de Kloet A, Krause E, Woods S. The renin angiotensin system and the metabolic syndrome. Physiol Behav. 2010;100:525-34 pubmed publisher
    ..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. ..
  28. Davis J, Tracy A, Schurdak J, Magrisso I, Grayson B, Seeley R, et al. Roux en Y gastric bypass increases ethanol intake in the rat. Obes Surg. 2013;23:920-30 pubmed publisher
  29. Parsons S, Millay D, Sargent M, McNally E, Molkentin J. Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. Am J Pathol. 2006;168:1975-85 pubmed
    ..These findings suggest that MSTN inhibition may benefit muscular dystrophy when instituted early or if disease is relatively mild but that MSTN inhibition in severely affected or late-stage disease may be ineffective. ..
  30. Schaefer T, Ehrman L, Gudelsky G, Vorhees C, Williams M. Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. J Neurochem. 2006;98:1369-78 pubmed
  31. Reed J, Benoit S, Pfluger P, Tschop M, D Alessio D, Seeley R. Mice with chronically increased circulating ghrelin develop age-related glucose intolerance. Am J Physiol Endocrinol Metab. 2008;294:E752-60 pubmed publisher
    ..Despite the impaired glucose tolerance in L43 mice, insulin levels did not differ from those of wild-type mice. These findings suggest a role for ghrelin in age-associated impairments of glucose homeostasis. ..
  32. de Kloet A, Krause E, Kim D, Sakai R, Seeley R, Woods S. The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis. Endocrinology. 2009;150:4114-23 pubmed publisher
    ..These results suggest that angiotensin-converting enzyme inhibition protects against the development of diet-induced obesity and glucose intolerance. ..
  33. Meneton P, Schultheis P, Greeb J, Nieman M, Liu L, Clarke L, et al. Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice. J Clin Invest. 1998;101:536-42 pubmed
    ..In addition, cHKA-/- mice lost twice as much body weight as cHKA+/+ mice. These results demonstrate that, during K+ deprivation, cHKA plays a critical role in the maintenance of K+ homeostasis in vivo. ..
  34. Tschop M, Castaneda T, Joost H, Thone Reineke C, Ortmann S, Klaus S, et al. Physiology: does gut hormone PYY3-36 decrease food intake in rodents?. Nature. 2004;430:1 p following 165; discussion 2 p following 165 pubmed
    ..The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36. ..
  35. Reddy T, Olson G, Wiechman B, Reddy G, Torsella J, Daniel F, et al. Chronic toxicity of 1,3,5-trinitrobenzene in Fischer 344 rats. Int J Toxicol. 2001;20:59-67 pubmed
    ..We propose a chronic, oral no-observable-adverse-effect level (NOAEL) of 2.68 mg/kg BW/day for TNB in the rat, based on the hematological and renal changes. ..
  36. Huggins K, Camarota L, Howles P, Hui D. Pancreatic triglyceride lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice. J Biol Chem. 2003;278:42899-905 pubmed
  37. Morrison J, Gruppo R, Glueck C, Stroop D, Fontaine R, Wang P, et al. Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white children. Metabolism. 2004;53:465-8 pubmed
    ..However, the QQ genotype was population-specific, encompassing most black children versus 1% to 3% of white children. As such, K121Q genotyping should be useful in epidemiology, population genetics, and forensic anthropology. ..
  38. Yang Y, Dieter M, Chen Y, Shertzer H, Nebert D, Dalton T. Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. J Biol Chem. 2002;277:49446-52 pubmed
  39. Benoit S, Air E, Coolen L, Strauss R, Jackman A, Clegg D, et al. The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci. 2002;22:9048-52 pubmed
    ..These data suggest that the hypothalamic melanocortin system mediates the anorexic effects of central insulin, as well as of leptin. ..
  40. Tamashiro K, Nguyen M, Ostrander M, Gardner S, Ma L, Woods S, et al. Social stress and recovery: implications for body weight and body composition. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1864-74 pubmed
    ..Therefore, chronic social stress causes social status-dependent changes in BW, composition and endocrine measures that persist after repeated stress and recovery cycles and that may ultimately lead to metabolic disorders and obesity. ..
  41. Nogueiras R, Tschop M, Zigman J. Central nervous system regulation of energy metabolism: ghrelin versus leptin. Ann N Y Acad Sci. 2008;1126:14-9 pubmed publisher
    ..Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with the CNS. ..
  42. Kim D, Sandoval D, Reed J, Matter E, Tolod E, Woods S, et al. The role of GM-CSF in adipose tissue inflammation. Am J Physiol Endocrinol Metab. 2008;295:E1038-46 pubmed publisher
    ..Collectively, the data suggest that the GM-CSF knockout mutation ameliorates peripheral insulin resistance in spite of increased adiposity by reducing inflammation in adipose tissue in response to a HFD. ..
  43. Dusing M, Maier E, Aronow B, Wiginton D. Onecut-2 knockout mice fail to thrive during early postnatal period and have altered patterns of gene expression in small intestine. Physiol Genomics. 2010;42:115-25 pubmed publisher
    ..Many of the genes with altered patterns of expression in Onecut-2 knockout mouse duodenum displayed changes in the timing of gene expression...
  44. Melhorn S, Krause E, Scott K, Mooney M, Johnson J, Woods S, et al. Meal patterns and hypothalamic NPY expression during chronic social stress and recovery. Am J Physiol Regul Integr Comp Physiol. 2010;299:R813-22 pubmed publisher
  45. D Angelo D, Sakata Y, Lorenz J, Boivin G, Walsh R, Liggett S, et al. Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci U S A. 1997;94:8121-6 pubmed
    ..The Galphaq overexpressor exhibits a biochemical and physiologic phenotype resembling both the compensated and decompensated phases of human cardiac hypertrophy and suggests a common mechanism for their pathogenesis. ..
  46. Wang J, Niu W, Nikiforov Y, Naito S, Chernausek S, Witte D, et al. Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. J Clin Invest. 1997;100:1425-39 pubmed
    ..IGF-I stimulates SMC hyperplasia, leading to distinct patterns of organ remodeling in the different tissue environments. ..
  47. Bell S, Schreiner C, Schultheis P, Miller M, Evans R, Vorhees C, et al. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. Am J Physiol. 1999;276:C788-95 pubmed
    ..Histological analysis of adult tissues revealed a thickening of the lamina propria and a slightly atrophic glandular mucosa in the stomach. ..
  48. Hagan M, Rushing P, Pritchard L, Schwartz M, Strack A, Van der Ploeg L, et al. Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade. Am J Physiol Regul Integr Comp Physiol. 2000;279:R47-52 pubmed
  49. Barrera J, D Alessio D, Drucker D, Woods S, Seeley R. Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. Diabetes. 2009;58:2820-7 pubmed publisher
    ..A better understanding of these unique differences may lead to expansion and/or improvement of GLP-1-based therapies for type 2 diabetes and obesity. ..
  50. Lee N, Spearry R, Leahy K, Robitz R, Trinh D, Mason C, et al. Muscle ciliary neurotrophic factor receptor α promotes axonal regeneration and functional recovery following peripheral nerve lesion. J Comp Neurol. 2013;521:2947-65 pubmed publisher
    ..J. Comp. Neurol. 521: 2947-2965, 2013. © 2013 Wiley Periodicals, Inc. ..
  51. Clegg D, Riedy C, Smith K, Benoit S, Woods S. Differential sensitivity to central leptin and insulin in male and female rats. Diabetes. 2003;52:682-7 pubmed
    ..Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently. ..
  52. Strader A, Reizes O, Woods S, Benoit S, Seeley R. Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. J Clin Invest. 2004;114:1354-60 pubmed
    ..The data implicate syndecan-3 in the regulation of body weight and suggest that inhibition of syndecan-3 may provide a therapeutic approach for the treatment of obesity resulting from exposure to high-fat diets. ..
  53. Gotoh K, Liu M, Benoit S, Clegg D, Davidson W, D ALESSIO D, et al. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. Am J Physiol Regul Integr Comp Physiol. 2006;290:R202-7 pubmed
    ..In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate. ..
  54. Kramer E, Deutsch G, Sartor M, Hardie W, Ikegami M, Korfhagen T, et al. Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis. Am J Physiol Lung Cell Mol Physiol. 2007;293:L314-27 pubmed
    ..Pathological changes in TGF-alpha-overexpressing mice bore similarities to premature infants born in the saccular phase who develop BPD, including remodeling of the distal lung septae and arteries. ..
  55. Duncan E, Sorrell J, Adamantidis A, Rider T, Jandacek R, Seeley R, et al. Alcohol drinking in MCH receptor-1-deficient mice. Alcohol Clin Exp Res. 2007;31:1325-37 pubmed
    ..Changes in taste preference or alcohol metabolism do not appear to be important for the increased alcohol drinking in KO mice. ..
  56. Woo J, Guerrero M, Altaye M, Ruiz Palacios G, Martin L, Dubert Ferrandon A, et al. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeed Med. 2009;4:101-9 pubmed publisher
    ..We have previously shown that adiponectin is present in human milk. This study determined whether higher milk adiponectin is associated with infant growth and investigated milk adiponectin's oligomeric form...
  57. Huffman Reed J, Rice W, Zsengeller Z, Wert S, Dranoff G, Whitsett J. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997;273:L715-25 pubmed
  58. Bueno O, De Windt L, Tymitz K, Witt S, Kimball T, Klevitsky R, et al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J. 2000;19:6341-50 pubmed
    ..The results of the present study indicate that the MEK1-ERK1/2 signaling pathway stimulates a physiologic hypertrophy response associated with augmented cardiac function and partial resistance to apoptotsis. ..
  59. Vorhees C, Schaefer T, Skelton M, Grace C, Herring N, Williams M. (+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty. Dev Neurosci. 2009;31:107-20 pubmed publisher
    ..However, since no effects on egocentric learning were found, but were apparent after PD 11-20 treatment, the results show that these 2 forms of learning have different exposure-duration sensitivities. ..
  60. Gaitonde S, Kohli R, Seeley R. The role of the gut hormone GLP-1 in the metabolic improvements caused by ileal transposition. J Surg Res. 2012;178:33-9 pubmed publisher
    ..Such data support the notion that rather than restriction or malabsorption, the underling molecular mechanisms that mediate the potent improvements produced by bariatric procedures involve increased activation of GLP-1 signaling. ..
  61. Glueck C, Wang P, Bornovali S, Goldenberg N, Sieve L. Polycystic ovary syndrome, the G1691A factor V Leiden mutation, and plasminogen activator inhibitor activity: associations with recurrent pregnancy loss. Metabolism. 2003;52:1627-32 pubmed
    ..1 U/mL), 38% versus 8%, p(f) =. 004. The thrombophilic G1691A Factor V Leiden mutation is associated with RPL in women with and without PCOS; hypofibrinolysis (high PAI-Fx) is also associated with RPL in women with PCOS. ..
  62. Dorn L, Rose S, Rotenstein D, Susman E, Huang B, Loucks T, et al. Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche. J Pediatr Endocrinol Metab. 2008;21:439-48 pubmed
    ..PA girls may be more vulnerable to psychopathology than on-time adrenarche girls. The challenge of future studies is to determine which PA girls are at risk for psychopathology and which are more resilient. ..
  63. Lin A, Tripathi P, Sholl A, Jordan M, Hildeman D. Gamma interferon signaling in macrophage lineage cells regulates central nervous system inflammation and chemokine production. J Virol. 2009;83:8604-15 pubmed publisher
  64. Shi Z, Dragin N, Galvez Peralta M, Jorge Nebert L, Miller M, Wang B, et al. Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene. Mol Pharmacol. 2010;78:46-57 pubmed publisher
    ..We conclude that small intestine CYP1A1, and not liver CYP1A1, is critically important in oral BaP detoxication. ..
  65. Curran C, Vorhees C, Williams M, Genter M, Miller M, Nebert D. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicol Sci. 2011;119:189-208 pubmed publisher
  66. Lo Y, Ho P, Chen M, Hugo E, Ben Jonathan N, Wang S. Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet. Biochem Biophys Res Commun. 2013;430:43-8 pubmed publisher
    ..This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation. ..
  67. Lo C, Samuelson L, Chambers J, King A, Heiman J, Jandacek R, et al. Characterization of mice lacking the gene for cholecystokinin. Am J Physiol Regul Integr Comp Physiol. 2008;294:R803-10 pubmed
    ..We conclude that CCK is involved in metabolic rate and is important for memory and exploration. CCK is intimately involved in multiple processes related to cognitive function and food intake regulation. ..
  68. Lockie S, Czyzyk T, Chaudhary N, Perez Tilve D, Woods S, Oldfield B, et al. CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice. Endocrinology. 2011;152:3661-7 pubmed publisher
    ..These results indicate that the endogenous opioid system is involved in modulating both the metabolic and mood effects of rimonabant. ..
  69. Wang X, Klevitsky R, Huang W, Glasford J, Li F, Robbins J. AlphaB-crystallin modulates protein aggregation of abnormal desmin. Circ Res. 2003;93:998-1005 pubmed
    ..Significantly less aberrant desmin aggregation was observed in the WT-CryAB-overexpressing cells than in the HEK cells. The results suggest that CryAB modulates abnormal desmin aggregation and can serve a cardioprotective role. ..
  70. Pfluger P, Kampe J, Castaneda T, Vahl T, D Alessio D, Kruthaupt T, et al. Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J Clin Endocrinol Metab. 2007;92:583-8 pubmed
    ..We conclude that circulating PYY levels in humans are significantly elevated in anorexia nervosa and, given the controversially discussed anorectic effect of PYY, could theoretically contribute to that syndrome. ..
  71. Brown N, Belles C, Lindley S, Zimmer Nechemias L, Zhao X, Witte D, et al. The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer. Carcinogenesis. 2010;31:886-93 pubmed publisher
    ..In conclusion, the novel finding that the unnatural enantiomer, R-(+)equol, was potently chemopreventive warrants investigation of its potential for breast cancer prevention and treatment. ..
  72. Christiansen A, Dekloet A, Ulrich Lai Y, Herman J. "Snacking" causes long term attenuation of HPA axis stress responses and enhancement of brain FosB/deltaFosB expression in rats. Physiol Behav. 2011;103:111-6 pubmed publisher
    ..These data suggest that chronic palatable food intake causes lasting changes in stress/reward-modulatory circuitry and that the suppressed hormonal response to stress that can persist well beyond periods of palatable drink exposure. ..
  73. Leung D, Heltshe S, Borowitz D, Gelfond D, Kloster M, Heubi J, et al. Effects of Diagnosis by Newborn Screening for Cystic Fibrosis on Weight and Length in the First Year of Life. JAMA Pediatr. 2017;171:546-554 pubmed publisher
  74. Gear R, Kendziorski J, Belcher S. Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA study. Toxicol Lett. 2017;275:123-135 pubmed publisher
    ..In BPA or EE treated females cardiomyopathy incidence and severity was significantly increased compared to control females at PND21 with myocardial degeneration observed in both males and females at PND21 and PND90. ..
  75. Flynn J, Kaelber D, Baker Smith C, Blowey D, Carroll A, Daniels S, et al. Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Pediatrics. 2017;140: pubmed publisher
  76. Amlal H, Wilke C. Resistance of mTAL Na+-dependent transporters and collecting duct aquaporins to dehydration in 7-month-old rats. Kidney Int. 2003;64:544-54 pubmed
    ..This defect results from reduced responsiveness of cortical AQP2 and AQP3 and a blunted response of medullary AQP2 and mTAL BSC1, NHE3, and Na+ pump to dehydration in aging kidneys. ..
  77. Jandacek R, Tso P. Enterohepatic circulation of organochlorine compounds: a site for nutritional intervention. J Nutr Biochem. 2007;18:163-7 pubmed
    ..Data from animals and humans show that the presence of nonabsorbed lipid in the intestine can increase the rate of excretion in a clinically significant manner. ..
  78. Vahl T, Drazen D, Seeley R, D Alessio D, Woods S. Meal-anticipatory glucagon-like peptide-1 secretion in rats. Endocrinology. 2010;151:569-75 pubmed publisher
    ..These findings document for the first time a cephalic increase of plasma GLP-1 and suggest that it functions to facilitate consumption of a large meal. ..
  79. Wren T, Kalkwarf H, Zemel B, Lappe J, OBERFIELD S, Shepherd J, et al. Longitudinal tracking of dual-energy X-ray absorptiometry bone measures over 6 years in children and adolescents: persistence of low bone mass to maturity. J Pediatr. 2014;164:1280-5.e2 pubmed publisher
    ..This suggests that bone mass measurements in children and adolescents may be useful for early identification of individuals at risk for osteoporosis later in life. ..
  80. Kopec A, Abrahams S, Thornton S, Palumbo J, Mullins E, Divanovic S, et al. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. J Clin Invest. 2017;127:3152-3166 pubmed publisher
    ..Collectively, these data provide proof of concept that targeting thrombin or fibrin(ogen) may limit pathologies in obese patients. ..
  81. Toth G, Zenick H, Smith M. Effects of epichlorohydrin on male and female reproduction in Long-Evans rats. Fundam Appl Toxicol. 1989;13:16-25 pubmed
    ..5 mg/kg/day and above. All of the above sperm motion parameters showed dose-dependent trends. These effects are consistent with the spermatozoal metabolic lesions reported for alpha-chlorohydrin, a metabolite of ECH...
  82. Spicer Z, Clarke L, Gawenis L, Shull G. Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic Na(+) absorption during Na(+) restriction. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1369-77 pubmed
  83. Lorenz J, Baird N, Judd L, Noonan W, Andringa A, Doetschman T, et al. Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome. J Biol Chem. 2002;277:37871-80 pubmed
    ..These data show that the loss of ROMK in the mouse causes perturbations of electrolyte, acid-base, and fluid-volume homeostasis, reduced absorption of NaCl in the TALH, and impaired tubuloglomerular feedback. ..
  84. Tamashiro K, Hegeman M, Nguyen M, Melhorn S, Ma L, Woods S, et al. Dynamic body weight and body composition changes in response to subordination stress. Physiol Behav. 2007;91:440-8 pubmed
    ..The visible burrow system (VBS) model of social stress may be a potential laboratory model for studying stress-associated metabolic disease, including the metabolic syndrome. ..
  85. Solomon M, Jones K, Packard B, Herman J. The medial amygdala modulates body weight but not neuroendocrine responses to chronic stress. J Neuroendocrinol. 2010;22:13-23 pubmed publisher
    ..In addition, the data suggest that the MeA may be an important neural component for the control of body weight in the face of chronic stress...
  86. Perez Tilve D, Hofmann S, Basford J, Nogueiras R, Pfluger P, Patterson J, et al. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci. 2010;13:877-82 pubmed publisher
    ..Our data suggest that a neural circuit in the brain is directly involved in the control of cholesterol metabolism by the liver. ..
  87. Chambers A, Jessen L, Ryan K, Sisley S, Wilson Perez H, Stefater M, et al. Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology. 2011;141:950-8 pubmed publisher
    ..We investigated alterations in glucose metabolism in rats following RYGB or VSG...
  88. Saelens B, Sallis J, Black J, Chen D. Neighborhood-based differences in physical activity: an environment scale evaluation. Am J Public Health. 2003;93:1552-8 pubmed
    ..The reliability and validity of self-reported neighborhood environment subscales were supported. Neighborhood environment was associated with physical activity and overweight prevalence. ..
  89. Tamashiro K, Nguyen M, Sakai R. Social stress: from rodents to primates. Front Neuroendocrinol. 2005;26:27-40 pubmed
    ..The implications of the current findings on understanding of the development of stress-related disease will also be discussed. ..
  90. Williams M, Herring N, Schaefer T, Skelton M, Campbell N, Lipton J, et al. Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse. Neuropsychopharmacology. 2007;32:1404-20 pubmed
    ..5-MEO-DIPT may have the potential to induce untoward effects in humans...
  91. Karns R, Zhang G, Jeran N, Havas Augustin D, Missoni S, Niu W, et al. Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia. Eur J Hum Genet. 2011;19:341-6 pubmed publisher
    ..The estimated effect sizes of these variants were larger or comparable to published studies. This is likely attributable to the homogenous genetic background of the relatively isolated study population. ..
  92. Prabhakar R, Petrashevskaya N, Schwartz A, Aronow B, Boivin G, Molkentin J, et al. A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation. Mol Cell Biochem. 2003;251:33-42 pubmed
    ..This study demonstrates that mutations within tropomyosin can be severely disruptive of sarcomeric function, triggering a hypertrophic response coupled with a cascade of alterations in gene expression. ..