Genomes and Genes
Experts and Doctors on animals in Cincinnati, Ohio, United States
Locale: Cincinnati, Ohio, United States
Publications709 found, 100 shown here
- Wansapura J, Millay D, Dunn R, Molkentin J, Benson D. Magnetic resonance imaging assessment of cardiac dysfunction in ?-sarcoglycan null mice. Neuromuscul Disord. 2011;21:68-73 pubmed publisher..Our results demonstrate severe cardiac dysfunction in Scgd(-/-) mice at 8 months. The study identifies a set of non-invasive markers that could be used to study efficacy of novel therapeutic agents in dystrophic mice. ..
- Franz D. Everolimus: an mTOR inhibitor for the treatment of tuberous sclerosis. Expert Rev Anticancer Ther. 2011;11:1181-92 pubmed publisher..In time, the use of mTOR inhibitors in patients with TSC will likely be very well established. ..
- Wang J, Chen L, Ko C, Zhang L, Puga A, Xia Y. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. J Biol Chem. 2012;287:2787-97 pubmed publisher..Our results uncover complementary and interdependent roles of MKK4 and MKK7 in development, and identify the essential requirement for MKK4 in p38 activation and cardiomyocyte differentiation. ..
- Littleton R, Miller M, Hove J. Whole plant based treatment of hypercholesterolemia with Crataegus laevigata in a zebrafish model. BMC Complement Altern Med. 2012;12:105 pubmed publisher..Here we develop the larval zebrafish (4-30 days post fertilization) as a vertebrate model of dietary plant-based treatment of hypercholesterolemia and test the effects of Crataegus laevigata in this model...
- Hofacer R, Deng M, Ward C, Joseph B, Hughes E, Jiang C, et al. Cell age-specific vulnerability of neurons to anesthetic toxicity. Ann Neurol. 2013;73:695-704 pubmed publisher..This knowledge may help guide neurocognitive testing of specific neurological domains in humans following exposure to anesthesia, dependent on the individual's age during exposure. ..
- Lowrie D, Stickney J, Ip W. Properties of the nonhelical end domains of vimentin suggest a role in maintaining intermediate filament network structure. J Struct Biol. 2000;132:83-94 pubmed..The head domains exert a nuclear-directed force while the tail domains extend the IF network toward the cell periphery via a microtubule-dependent mechanism. ..
- Houston D, Wylie C. Cloning and expression of Xenopus Lrp5 and Lrp6 genes. Mech Dev. 2002;117:337-42 pubmed..Both genes are also expressed at the intersomitic boundary. These results suggest roles for Wnt signaling via LRP proteins in these tissues. ..
- Dou H, Finberg K, Cardell E, Lifton R, Choo D. Mice lacking the B1 subunit of H+ -ATPase have normal hearing. Hear Res. 2003;180:76-84 pubmed
- Addis Lieser E, Köhl J, Chiaramonte M. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. J Immunol. 2005;175:1894-902 pubmed..Furthermore, these findings provide insight into the development of new therapeutic strategies for idiopathic pulmonary fibrosis patients...
- Chance W, Dayal R, Friend L, Sheriff S. Possible role of CRF peptides in burn-induced hypermetabolism. Life Sci. 2006;78:694-703 pubmed..Although these results suggest a role of CRF receptors in mediating burn-induced hypermetabolism, CRF itself may not be the principle ligand, as suggested by the significant elevation of hypothalamic urocortin 15 days after burn injury. ..
- Reichard J, Puga A. Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics. 2010;2:87-104 pubmed publisher..Here, we discuss the evidence supporting changes in DNA methylation as a cause of arsenic carcinogenesis and highlight the strengths and limitations of these studies, as well as areas where consistencies and inconsistencies exist. ..
- Linares J, Amanchy R, Greis K, Diaz Meco M, Moscat J. Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation. Mol Cell Biol. 2011;31:105-17 pubmed publisher..Therefore, p62 emerges as a node for the control of not only cell survival but also cell transit through mitosis. ..
- Liu C, Aschbacher Smith L, Barthelery N, Dyment N, Butler D, Wylie C. What we should know before using tissue engineering techniques to repair injured tendons: a developmental biology perspective. Tissue Eng Part B Rev. 2011;17:165-76 pubmed publisher..Here we review studies focusing on the developmental mechanisms of tendon development, and discuss the potential applications of a molecular understanding of tendon development to the treatment of tendon injuries. ..
- Sroga J, Ma X, Das S. Developmental regulation of decidual cell polyploidy at the site of implantation. Front Biosci (Schol Ed). 2012;4:1475-86 pubmed..Here we review the mechanisms involved in polyploidy cell formation in normal developmental processes, with focus on known regulatory aspects in decidual cells. ..
- Wang P, Swain H, Kunkler A, Chen C, Hutzen B, Arnold M, et al. Neuroblastomas vary widely in their sensitivities to herpes simplex virotherapy unrelated to virus receptors and susceptibility. Gene Ther. 2016;23:135-43 pubmed publisher..Our results also suggest that profiling the expression of known viral entry receptors on neuroblastoma cells may not be entirely predictive of their susceptibility to Seprehvir therapy. ..
- Degen S, Gilbert D, Jenkins N, Copeland N. Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9. Genomics. 1992;13:1368-9 pubmed..The likely gene order in this region is centromere-Trf-Gnai-2-Hgfl-Cck. The region surrounding the Hgfl locus shows homology of syntenty to band p21 on human chromosome 3. ..
- Brown C, McHugh K, Lessard J. A cDNA sequence encoding cytoskeletal gamma-actin from rat. Nucleic Acids Res. 1990;18:5312 pubmed
- Weisbrod A, Shea D, Moore M, Stegeman J. Species, tissue and gender-related organochlorine bioaccumulation in white-sided dolphins, pilot whales and their common prey in the northwest Atlantic. Mar Environ Res. 2001;51:29-50 pubmed
- Huang F, Kemp C, Williams J, Erwin C, Warner B. Role of epidermal growth factor and its receptor in chemotherapy-induced intestinal injury. Am J Physiol Gastrointest Liver Physiol. 2002;282:G432-42 pubmed..These findings do not support a critical role for EGF or its receptor in chemotherapy-induced intestinal injury. ..
- O Brien D, Nelson L, Kemp C, Williams J, Wang Q, Erwin C, et al. Intestinal permeability and bacterial translocation are uncoupled after small bowel resection. J Pediatr Surg. 2002;37:390-4 pubmed..This suggests that the mechanism for bacterial translocation after SBR does not involve alterations in gut permeability. ..
- Yuan Y, Hilliard G, Ferguson T, Millhorn D. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J Biol Chem. 2003;278:15911-6 pubmed..These findings show that cobalt mimics hypoxia, at least in part, by occupying the VHL-binding domain of HIF-alpha and thereby preventing the degradation of HIF-alpha. ..
- Wang X, Klevitsky R, Huang W, Glasford J, Li F, Robbins J. AlphaB-crystallin modulates protein aggregation of abnormal desmin. Circ Res. 2003;93:998-1005 pubmed..Significantly less aberrant desmin aggregation was observed in the WT-CryAB-overexpressing cells than in the HEK cells. The results suggest that CryAB modulates abnormal desmin aggregation and can serve a cardioprotective role. ..
- Tschop M, Castaneda T, Joost H, Thone Reineke C, Ortmann S, Klaus S, et al. Physiology: does gut hormone PYY3-36 decrease food intake in rodents?. Nature. 2004;430:1 p following 165; discussion 2 p following 165 pubmed..The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36. ..
- Kuzmenko A, Wu H, Wan S, McCormack F. Surfactant protein A is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid. J Biol Chem. 2005;280:25913-9 pubmed
- Morris S, Orekhova T, Meadows M, Heidorn S, Yang J, Finkelman F. IL-4 induces in vivo production of IFN-gamma by NK and NKT cells. J Immunol. 2006;176:5299-305 pubmed..This explains how IL-4 can contribute to Th1 cytokine-associated immune effector functions and suggests how IL-13 can have stronger proallergic effects than IL-4. ..
- Allen H, Deepe G. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol. 2006;177:1763-71 pubmed..The data reveal the complex control by the host to prevent reactivation of this fungus. ..
- Wardle R, Gu M, Ishida Y, Paul R. Rho kinase is an effector underlying Ca2+-desensitizing hypoxic relaxation in porcine coronary artery. Am J Physiol Heart Circ Physiol. 2007;293:H23-9 pubmed..Our evidence strongly implicates that hypoxia directly inhibits Rho kinase-dependent phosphorylation of MYPT1. This underlies the decreases in both p-MYPT1 and p-MRLC and thereby leads to the Ca(2+)-desensitizing hypoxic relaxation. ..
- Wang I, Meliton L, Tretiakova M, Costa R, Kalinichenko V, Kalin T. Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors. Oncogene. 2008;27:4137-49 pubmed publisher..In co-transfection experiments, Foxm1 protein-induced Cox-2 promoter activity and directly bound to the -2566/-2580 bp region of human Cox-2 promoter. ..
- Menconi F, Monti M, Greenberg D, Oashi T, Osman R, Davies T, et al. Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. Proc Natl Acad Sci U S A. 2008;105:14034-9 pubmed publisher..Because the HT- and EAT-associated pockets are structurally different, it is likely that distinct antigenic peptides are associated with HT and EAT. ..
- Zhang X, Lewkowich I, Köhl G, Clark J, Wills Karp M, Köhl J. A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J Immunol. 2009;182:5123-30 pubmed publisher..Ex vivo targeting of B7-H1 and B7-DC increased Th2 cytokine production from T cells of wild-type but not of C5aR-targeted mice, suggesting a protective role for C5a through regulation of B7 molecule expression on plasmacytoid DCs. ..
- Yan D, Wu Y, Feng Y, Lin S, Lin X. The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling. Dev Cell. 2009;17:470-81 pubmed publisher..Based on these data, we propose that the principal function of Dlp is to retain Wg on the cell surface. As such, it can either compete with the receptor or provide ligands to the receptor, depending on the ratios of Wg, Fz2, and Dlp. ..
- Wyder M, Johnston L, Kaneshiro E. Evidence for DNA synthesis in Pneumocystis carinii trophozoites treated with the beta-1,3-glucan synthesis inhibitor pneumocandin L-693,989. J Eukaryot Microbiol. 2010;57:447-8 pubmed publisher..Fluorescence intensities of trophozoite nuclei from drug-treated rats were greater than those of untreated controls, suggesting that DNA replication was not inhibited but that cytokinesis and perhaps karyokinesis were blocked...
- Liu H, Zhang J, Liu C, Hayashi Y, Kao W. Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype. J Cell Mol Med. 2012;16:1114-24 pubmed publisher..These observations suggest that corneal intrastromal transplantation of BM-MSC may be an effective treatment regimen for corneal diseases involving dysfunction of keratocytes. ..
- Lewkowich I, Day S, Ledford J, Zhou P, Dienger K, Wills Karp M, et al. Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation. Respir Res. 2011;12:122 pubmed publisher..Together these data suggest an important role for allergen activation of PAR-2 on mDCs in mediating Th2/Th17 cytokine production and allergic airway responses. ..
- Li J, Bessho K, Shivakumar P, Mourya R, Mohanty S, Dos Santos J, et al. Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype. J Clin Invest. 2011;121:4244-56 pubmed publisher..These findings demonstrate compatibility between Th2 commitment and the pathogenesis of BA, and suggest that patient subgrouping in future clinical trials should account for differences in Th2 status. ..
- Cai W, Pritchard T, Florea S, Lam C, Han P, Zhou X, et al. Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovasc Res. 2012;94:333-41 pubmed publisher..These findings indicate that deficiency of either junctin or triadin impairs the contractile recovery in post-ischaemic hearts, which appears to be primarily attributed to increased ER stress and activation of calpain. ..
- Kim S, Ezhilarasan R, Phillips E, Gallego Perez D, Sparks A, Taylor D, et al. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-?B-dependent Manner. Cancer Cell. 2016;29:201-13 pubmed publisher..Collectively, our results uncover MLK4 as an upstream regulator of NF-?B signaling and a potential molecular target for the MES subtype of glioblastomas. ..
- Mizukawa B, O Brien E, Moreira D, Wunderlich M, Hochstetler C, Duan X, et al. The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood. 2017;130:1336-1346 pubmed publisher..Thus, CDC42 loss suppresses AML cell polarity and division asymmetry, and CDC42 constitutes a useful target to alter leukemia-initiating cell fate for differentiation therapy. ..
- Gerhardt B, Leesman L, Burra K, Snowball J, Rosenzweig R, Guzman N, et al. Notum attenuates Wnt/β-catenin signaling to promote tracheal cartilage patterning. Dev Biol. 2018;436:14-27 pubmed publisher..We propose that Notum influences mesenchymal cell differentiation by generating a barrier for Wnt ligands produced and secreted by airway epithelial cells to attenuate Wnt signaling. ..
- Nelson D, Setser E, Hall D, Schwartz S, Hewitt T, Klevitsky R, et al. Proinflammatory consequences of transgenic fas ligand expression in the heart. J Clin Invest. 2000;105:1199-208 pubmed..The data suggest that the FasL expression level and other tissue-specific microenvironmental factors can modulate the proinflammatory consequences of FasL. ..
- Du H, Heur M, Duanmu M, Grabowski G, Hui D, Witte D, et al. Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span. J Lipid Res. 2001;42:489-500 pubmed..The involvement of macrophages throughout the body of lal-/- mice provide evidence for a critical nonappreciated role of LAL in cellular cholesterol and fatty acid metabolism, adipocyte differentiation, and fat mobilization. ..
- Tarapore P, Horn H, Tokuyama Y, Fukasawa K. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene. 2001;20:3173-84 pubmed
- Krane C, Fortner C, Hand A, McGraw D, Lorenz J, Wert S, et al. Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. Proc Natl Acad Sci U S A. 2001;98:14114-9 pubmed
- Yang H, Lin C, Ma G, Orr M, Baffi M, Wathelet M. Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions. Eur J Biochem. 2002;269:6142-51 pubmed..Interference with any of these interactions leads to a complete loss of transcriptional activity, suggesting that a bivalent interaction is essential for coactivator recruitment by IRF-3. ..
- Sun Y, Qi X, Grabowski G. Saposin C is required for normal resistance of acid beta-glucosidase to proteolytic degradation. J Biol Chem. 2003;278:31918-23 pubmed..Thus, diminished in vivo GCase activity would be greater than expected only from the lack of GCase activation by saposin C. These results indicate a new property for saposin C, an anti-proteolytic protective function toward GCase. ..
- Zhang L, Deng M, Parthasarathy R, Wang L, Mongan M, Molkentin J, et al. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Mol Cell Biol. 2005;25:60-5 pubmed..Together, these pathways lead to the control of actin cytoskeleton reorganization and epithelial cell migration, contributing to the physiologic and pathological effects of activins on epithelial morphogenesis. ..
- Warner B, Warner B. Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis. Semin Pediatr Surg. 2005;14:175-80 pubmed..The relevant evidence for the role of EGF in intestinal development and mucosal repair, as well as its potential involvement in the genesis of NEC will be reviewed. ..
- Oka T, Xu J, Molkentin J. Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol. 2007;18:117-31 pubmed..This review will discuss the transcription factors that regulate the hypertrophic growth response of the adult heart, with a special emphasis on those regulators that participate in cardiac development. ..
- Runyan C, Gu Y, Shoemaker A, Looijenga L, Wylie C. The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors. Int J Dev Biol. 2008;52:333-44 pubmed publisher..This hypothesis is supported, but not proved, by the finding of cells expressing the germ cell marker Oct4 associated with a coccygeal germ cell tumor in a human infant. ..
- Xu J, Song P, Miller M, Borgese F, Barone S, Riederer B, et al. Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc Natl Acad Sci U S A. 2008;105:17955-60 pubmed publisher..We propose that Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells. ..
- Wang M, Bridges J, Na C, Xu Y, Weaver T. Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C. J Biol Chem. 2009;284:33377-83 pubmed publisher..These results support a model in which MKS3 links the ER lumenal quality control machinery with the cytosolic degradation apparatus. ..
- Kroetz D, Deepe G. CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection. J Immunol. 2010;184:5224-31 pubmed publisher..Thus, CCR5 dictates pathogen persistence by tightly regulating the balance between Treg and Th17 cells in H. capsulatum infection. ..
- Kazanjian A, Noah T, Brown D, Burkart J, Shroyer N. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology. 2010;139:918-28, 928.e1-6 pubmed publisher..Among gastrointestinal malignancies, ATOH1 mediates the effects of GSIs, so ATOH1 expression levels might predict responses to these inhibitors. We propose that only the subset of CRCs that retain ATOH1 expression will respond to GSIs. ..
- Shah T, Hillman N, Nitsos I, Polglase G, Pillow J, Newnham J, et al. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res. 2010;68:210-5 pubmed publisher..LPS or IL-1 can induce robust expression of MCP-1 or MCP-2 in the fetal lung. LPS induction of MCP-1 is not IL-1 dependent in fetal sheep. MCP-1 and MCP-2 may be significant contributors to fetal inflammation...
- Flick M, Chauhan A, Frederick M, Talmage K, Kombrinck K, Miller W, et al. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 2011;117:6326-37 pubmed publisher..These studies provide a proof-of-principle that pro/thrombin variants engineered with altered substrate specificity may offer therapeutic opportunities for limiting inflammatory disease processes. ..
- Ryan K, Li B, Grayson B, Matter E, Woods S, Seeley R. A role for central nervous system PPAR-? in the regulation of energy balance. Nat Med. 2011;17:623-6 pubmed publisher..These findings have implications for the widespread clinical use of TZD drugs and for understanding the etiology of diet-induced obesity. ..
- Krawczewski Carhuatanta K, Demuro G, Tschop M, Pfluger P, Benoit S, Obici S. Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. Endocrinology. 2011;152:2655-64 pubmed publisher..These results support the notion that physical exercise directly influences the responsiveness of the CNS circuits involved in energy homeostasis by allowing the defense of a lowered BW. ..
- Pasha Z, Haider H, Ashraf M. Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells. PLoS ONE. 2011;6:e23667 pubmed publisher..Cardiac progenitors derived from iPS cells propagated extensively in the infarcted myocardium without tumorgenesis and improved cardiac function. ..
- Noel G, DeKoter R, Wang Q, Hexley P, Ogle C. Optimization and application of a flow cytometric PU.1 assay for murine immune cells. J Immunol Methods. 2012;382:81-92 pubmed publisher..1 than did unburned, but proliferating cells from burn or sham mice showed no difference in their levels of PU.1. This assay should be a useful addition to the tools used to study the function of PU.1 in health and disease. ..
- Sorrell M, Dohn T, D Aniello E, Waxman J. Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish. Dev Biol. 2013;380:199-210 pubmed publisher..This study expands our understanding of the in vivo developmental requirements of Tcf7l1 proteins and the mechanisms directing CM development in vertebrates. ..
- Gieske T, Doherty N, Raddatz R, Stephens D. S-adenosylhomocysteine levels are not involved in the spasmolytic activity of 3-deazaadenosine in guinea-pig lung parenchyma. Pharmacology. 1991;42:151-5 pubmed..These data indicate that SHA levels do not regulate the contractile response of guinea-pig lung parenchyma. ..
- Sciaky D, Jenkins N, Gilbert D, Copeland N, Sonoda G, Testa J, et al. Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35. Genomics. 1995;26:427-9 pubmed
- Jiang H, Monaco J. Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Immunogenetics. 1997;46:93-8 pubmed..Southern blot analysis suggests that both PA28a and PA28b are multiple-copy genes, while Ki is a single-copy gene. ..
- Ikegami M, Jobe A. Surfactant protein metabolism in vivo. Biochim Biophys Acta. 1998;1408:218-25 pubmed..The relative importance of type II cells or macrophages to the catabolism of the protein components of surfactant remains to be characterized, as do regulators of surfactant homeostasis. ..
- Puga A, Barnes S, Dalton T, Chang C, Knudsen E, Maier M. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J Biol Chem. 2000;275:2943-50 pubmed
- Gurel O, Ikegami M, Chroneos Z, Jobe A. Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2001;280:L1266-72 pubmed..Eighty percent of the macrophage-associated radiolabel was recovered from lung digest macrophages. We conclude that macrophages and type II cells contribute equally to saturated phosphatidylcholine and SP-A catabolism in mice...
- Bueno O, Wilkins B, Tymitz K, Glascock B, Kimball T, Lorenz J, et al. Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proc Natl Acad Sci U S A. 2002;99:4586-91 pubmed..Collectively, these data solidify the hypothesis that calcineurin functions as a central regulator of the cardiac hypertrophic growth response in vivo. ..
- Sliwowska J, Billings H, Goodman R, Coolen L, Lehman M. The premammillary hypothalamic area of the ewe: anatomical characterization of a melatonin target area mediating seasonal reproduction. Biol Reprod. 2004;70:1768-75 pubmed..This anatomical map of the PMH provides a basis for future studies to determine the functional contribution of each component to the influence of melatonin on seasonal reproduction. ..
- Baines C, Kaiser R, Purcell N, Blair N, Osinska H, Hambleton M, et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature. 2005;434:658-62 pubmed..Thus, cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death. ..
- Andrade R, Portillo J, Wessendarp M, Subauste C. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun. 2005;73:3115-23 pubmed
- Lincoln J, Alfieri C, Yutzey K. BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells. Dev Biol. 2006;292:292-302 pubmed..Together, these studies define regulatory pathways of AV valve progenitor cell diversification into leaflets and chordae tendineae that share inductive interactions and differentiation phenotypes with cartilage and tendon cell lineages. ..
- Dominguez J, Balfour M, Lee H, Brown J, Davis B, Coolen L. Mating activates NMDA receptors in the medial preoptic area of male rats. Behav Neurosci. 2007;121:1023-31 pubmed..These results provide evidence that mating activates NMDA receptors in the MPOA and that this activation is important for the expression of male sexual behavior. ..
- Mishra A, Wang M, Pemmaraju V, Collins M, Fulkerson P, Abonia J, et al. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology. 2008;134:204-14 pubmed publisher..These findings provide evidence that local IL-5-mediated eosinophilia is essential in the induction of esophageal remodeling. ..
- Spight D, Trapnell B, Zhao B, Berclaz P, Shanley T. Granulocyte-macrophage-colony-stimulating factor-dependent peritoneal macrophage responses determine survival in experimentally induced peritonitis and sepsis in mice. Shock. 2008;30:434-42 pubmed publisher..1-dependent peritoneal macrophage responses are a critical determinant of survival after experimentally induced peritonitis/sepsis or exposure to LPS and have implications for therapies to treat such infections. ..
- Blanchard C, Rothenberg M. Chemotactic factors associated with eosinophilic gastrointestinal diseases. Immunol Allergy Clin North Am. 2009;29:141-8, xi pubmed publisher..Eosinophilic GI diseases are characterized by an increased number of eosinophil infiltrates with no identified cause. This article describes the past and present knowledge regarding the chemotactic factors involved in GI eosinophilia. ..
- Cardin R, Bravo F, Sewell A, Cummins J, Flamand L, Juteau J, et al. Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection. Virol J. 2009;6:214 pubmed publisher..These studies indicate that APs exhibit potent, well tolerated antiviral activity against CMV infection in vivo and represent a new class of broad spectrum anti-herpetic agents. ..
- Lu G, Haider H, Porollo A, Ashraf M. Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells. Cardiovasc Res. 2010;88:277-86 pubmed publisher..Expression of mito-Cx-43 simulated the cytoprotective effects of preconditioning in stem cells. Structural features of Cx-43 were shared with the Bcl-2 family as determined by computational analysis. ..
- Basford J, Wancata L, Hofmann S, Silva R, Davidson W, Howles P, et al. Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice. J Biol Chem. 2011;286:13079-87 pubmed publisher..Taken together, these results documented that hepatic LRP1 participates in cellular activation of lysosomal enzymes and through this mechanism, indirectly modulates the production and plasma levels of HDL. ..
- Murphy B, Danzer S. Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersion. J Neurosci. 2011;31:2959-64 pubmed publisher..Together, these findings identify novel forms of neuronal plasticity that contribute to granule cell dysmorphogenesis in the epileptic brain. ..
- Pan D, Kalfa T, Wang D, Risinger M, Crable S, Ottlinger A, et al. K-Cl cotransporter gene expression during human and murine erythroid differentiation. J Biol Chem. 2011;286:30492-503 pubmed publisher..The results suggest that KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 among individuals that could result in modulation of KCC activity. ..
- Noah T, Donahue B, Shroyer N. Intestinal development and differentiation. Exp Cell Res. 2011;317:2702-10 pubmed publisher..Section two reviews cell fate specification and differentiation of each cell type within the intestinal epithelium. Growth factor and transcriptional networks that regulate these developmental processes are summarized. ..
- Kattamuri C, Luedeke D, Nolan K, Rankin S, Greis K, Zorn A, et al. Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers. J Mol Biol. 2012;424:313-27 pubmed publisher..These results demonstrate that certain DAN family members can form both monomers and noncovalent dimers, implying that biological activity of DAN family members might be linked to their oligomeric state. ..
- Istaphanous G, Ward C, Nan X, Hughes E, McCann J, McAuliffe J, et al. Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex. Anesth Analg. 2013;116:845-54 pubmed publisher..Conversely, at this age, only a minority of degenerating cells were identified as astrocytes. The clinical relevance of these findings in animals remains to be determined. ..
- Bouffi C, Rochman M, Zust C, Stucke E, Kartashov A, Fulkerson P, et al. IL-33 markedly activates murine eosinophils by an NF-?B-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop. J Immunol. 2013;191:4317-25 pubmed publisher..In conclusion, we have identified a novel activation pathway in murine eosinophils that is induced by IL-33 and differentially dependent upon an IL-4 auto-amplification loop. ..
- Xu Y, Khoury J, Sucharew H, Dietrich K, Yolton K. Low-level gestational exposure to mercury and maternal fish consumption: Associations with neurobehavior in early infancy. Neurotoxicol Teratol. 2016;54:61-7 pubmed publisher..In contrast, infants with higher prenatal mercury exposure and those whose mothers consumed more fish had better attention and needed less special handling, which likely reflect the beneficial nutritional effects of fish consumption. ..