Genomes and Genes
Experts and Doctors on zebrafish in Durham, North Carolina, United States
Locale: Durham, North Carolina, United States
- Powers C, Slotkin T, Seidler F, Badireddy A, Padilla S. Silver nanoparticles alter zebrafish development and larval behavior: distinct roles for particle size, coating and composition. Neurotoxicol Teratol. 2011;33:708-14 pubmed publisher..Different AgNP formulations are thus likely to produce distinct patterns of developmental neurotoxicity. ..
- Qiao T, Maddox B, Erickson H. A novel alternative splice domain in zebrafish tenascin-C. Gene. 1995;156:307-8 pubmed..The alternative splice domain, designated TNfnQ, is not closely identified to any of the domains in other species, and may represent a novel descendent of the alternative splice-domain precursor. ..
- Wills A, Kidd A, Lepilina A, Poss K. Fgfs control homeostatic regeneration in adult zebrafish fins. Development. 2008;135:3063-70 pubmed publisher..Our experiments reveal that the facultative machinery that regenerates amputated teleost fins also has a surprisingly vigorous role in homeostatic regeneration. ..
- Bailey J, Oliveri A, Karbhari N, Brooks R, De La Rocha A, Janardhan S, et al. Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. Neurotoxicology. 2016;52:23-33 pubmed publisher..Social behavior and some aspects of motor function were altered in exposed fish; the importance of examining emotional or psychological consequences of early life exposure to retinoid acting chemicals is discussed. ..
- Shakes L, Malcolm T, Allen K, De S, Harewood K, Chatterjee P. Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish. Nucleic Acids Res. 2008;36:6237-48 pubmed publisher..The methodology should help functionally map multiple noncontiguous regulatory elements in BACs with or without gene-coding sequences. ..
- Yin V, Poss K. New regulators of vertebrate appendage regeneration. Curr Opin Genet Dev. 2008;18:381-6 pubmed publisher..These discoveries establish research avenues that may impact the regenerative capacity of mammalian tissues. ..
- Fleming C, Di Giulio R. The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio). Ecotoxicology. 2011;20:1300-14 pubmed publisher..The enhanced toxicity of environmental mixtures of PAHs under hypoxia suggests that risk assessments that do not take into account potential interactions with hypoxia may underestimate the threat of PAHs to fish in contaminated sites. ..
- Bone A, Colman B, Gondikas A, Newton K, Harrold K, Cory R, et al. Biotic and abiotic interactions in aquatic microcosms determine fate and toxicity of Ag nanoparticles: part 2-toxicity and Ag speciation. Environ Sci Technol. 2012;46:6925-33 pubmed publisher..Reductions in toxicity may have been related to decreased water column concentrations as well as changes in the surface chemistry of the particles induced by organic substances released from the plants. ..
- Choi W, Gemberling M, Wang J, Holdway J, Shen M, Karlstrom R, et al. In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 2013;140:660-6 pubmed publisher..Our findings describe a new screening system that identifies molecules and pathways with the potential to modify heart regeneration. ..
- Hutson M, Kirby M. Neural crest and cardiovascular development: a 20-year perspective. Birth Defects Res C Embryo Today. 2003;69:2-13 pubmed..We propose that the cardiac neural crest exists as part of a larger cardiocraniofacial morphogenetic field and describe several human syndromes that result from abnormal development of this field. ..
- Evron T, Philipp M, Lu J, Meloni A, Burkhalter M, Chen W, et al. Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. J Biol Chem. 2011;286:27676-86 pubmed publisher..This is in contrast to cells stably expressing both GRK2 and Smo, in which cilia are significantly elongated. These results identify Gas8 as a positive regulator of Hh signaling that cooperates with GRK2 to control Smo signaling. ..
- Gupta V, Poss K. Clonally dominant cardiomyocytes direct heart morphogenesis. Nature. 2012;484:479-84 pubmed publisher..Our results illuminate the dynamic proliferative behaviours that generate adult cardiac structure, revealing clonal dominance as a key mechanism that shapes a vertebrate organ. ..
- ..The current challenge is to integrate these details into a systematic view of metal content, speciation, localization and use within organisms and ecosystems. ..
- Levin E, Sledge D, Roach S, Petro A, Donerly S, Linney E. Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicol Teratol. 2011;33:668-73 pubmed publisher..The identification of these functional deficits in zebrafish enables further studies with this model to determine how molecular and cellular mechanisms are disturbed to arrive at this compromised state. ..
- Lee J, Anholt R, Cole G. Olfactomedin-2 mediates development of the anterior central nervous system and head structures in zebrafish. Mech Dev. 2008;125:167-81 pubmed..Our studies show that this member of the olfactomedin protein family is an important regulator of development of the anterior nervous system. ..
- Lassiter C, Linney E. Embryonic expression and steroid regulation of brain aromatase cyp19a1b in zebrafish (Danio rerio). Zebrafish. 2007;4:49-57 pubmed..The expression pattern of aromatase in the brain and its control by steroid hormones is well conserved among the vertebrate lineage. ..
- Li Y, Zdanowicz M, Young L, Kumiski D, Leatherbury L, Kirby M. Cardiac neural crest in zebrafish embryos contributes to myocardial cell lineage and early heart function. Dev Dyn. 2003;226:540-50 pubmed..These results suggest a new role for cardiac neural crest cells in vertebrate cardiac development and are the first report of a myocardial cell lineage for neural crest derivatives. ..
- Eddins D, Cerutti D, Williams P, Linney E, Levin E. Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. Neurotoxicol Teratol. 2010;32:99-108 pubmed publisher..This may be helpful in screening for persisting neurobehavioral defects from a variety of toxicants. ..
- Cao J, Navis A, Cox B, Dickson A, Gemberling M, Karra R, et al. Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. Development. 2016;143:232-43 pubmed publisher..Our study defines a new platform for the discovery of epicardial lineage markers, genetic tools, and mechanisms of heart regeneration. ..
- Arnold M, Badireddy A, Wiesner M, Di Giulio R, Meyer J. Cerium oxide nanoparticles are more toxic than equimolar bulk cerium oxide in Caenorhabditis elegans. Arch Environ Contam Toxicol. 2013;65:224-33 pubmed publisher..elegans. Growth inhibition observed in C. elegans may be explained at least in part by a non-specific inhibition of feeding caused by CeO2 NPs aggregating around bacterial food and/or inside the gut tract...
- Garner L, Brown D, Di Giulio R. Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Aquat Toxicol. 2013;142-143:336-46 pubmed publisher..These results suggest that AHR1A is not a nonfunctional receptor as previously thought and may play a role in the normal physiology of zebrafish during development and/or the toxicity of environmental contaminants in early life stages. ..
- Nachtrab G, Czerwinski M, Poss K. Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. Curr Biol. 2011;21:1912-7 pubmed publisher..Our findings identify a natural sex bias in appendage regenerative capacity and indicate an underlying regulatory circuit in which androgen locally restricts key morphogenetic programs after amputation. ..
- Hu B, Chen H, Liu X, Zhang C, Cole G, Lee J, et al. Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium. Zebrafish. 2013;10:218-27 pubmed publisher..However, cdx1b failed to induce histological IM, or to modulate cell proliferation and apoptosis in the squamous epithelium of adult transgenic zebrafish. ..
- Gemberling M, Bailey T, Hyde D, Poss K. The zebrafish as a model for complex tissue regeneration. Trends Genet. 2013;29:611-20 pubmed publisher..Here, we review the recent history of zebrafish as a genetic model system for understanding how and why tissue regeneration occurs. ..
- Wang J, Karra R, Dickson A, Poss K. Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. Dev Biol. 2013;382:427-35 pubmed publisher..These findings reveal a new role for the epicardium in establishing an extracellular environment that supports heart regeneration...
- Lee Y, Hami D, De Val S, Kagermeier Schenk B, Wills A, Black B, et al. Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Dev Biol. 2009;331:270-80 pubmed publisher..Thus, the fin wound epidermis spatially confines Hh signaling through the activity of Fgf and Wnt pathways, impacting blastemal proliferation during regenerative outgrowth. ..
- Philipp M, Fralish G, Meloni A, Chen W, MacInnes A, BARAK L, et al. Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. Mol Biol Cell. 2008;19:5478-89 pubmed publisher..Together, these data suggest that a GRK functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development. ..
- Cao J, Wang J, Jackman C, Cox A, Trembley M, Balowski J, et al. Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue. Dev Cell. 2017;42:600-615.e4 pubmed publisher..Our findings provide evidence that mechanical tension can regulate cell-cycle dynamics in regenerating tissue, stratifying the source cell features to improve repair. ..
- Arnold M, Forte J, Osterberg J, Di Giulio R. Antioxidant Rescue of Selenomethionine-Induced Teratogenesis in Zebrafish Embryos. Arch Environ Contam Toxicol. 2016;70:311-20 pubmed publisher..These results suggest that aqueous exposure to SeMet can induce significant embryonic teratogenesis in zebrafish that are at least partially attributed to oxidative stress. ..
- Ramachandran K, Hennessey J, Barnett A, Yin X, Stadt H, Foster E, et al. Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. J Clin Invest. 2013;123:1638-46 pubmed publisher..2, including those that activated the calcineurin signaling pathway. Together, these results provide new insights into the role of voltage-gated Ca2+ channels in nonexcitable cells during development. ..
- Ellis K, Bagwell J, Bagnat M. Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. J Cell Biol. 2013;200:667-79 pubmed publisher..Thus, the vertebrate notochord plays important structural roles beyond early development...
- Billiard S, Timme Laragy A, Wassenberg D, Cockman C, Di Giulio R. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicol Sci. 2006;92:526-36 pubmed..Identifying the pathways involved in PAH toxicity will provide for more robust, mechanistic-based tools for risk assessment of single compounds and complex environmental mixtures. ..
- Timme Laragy A, Van Tiem L, Linney E, Di Giulio R. Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicol Sci. 2009;109:217-27 pubmed publisher..Collectively, these findings demonstrate that antioxidant responses are a component of PAH synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development. ..
- Wang J, Panàkovà D, Kikuchi K, Holdway J, Gemberling M, Burris J, et al. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development. 2011;138:3421-30 pubmed publisher..Our study indicates that genetic depletion of cardiomyocytes, even at levels so extreme as to elicit signs of cardiac failure, can be reversed by natural regenerative capacity in lower vertebrates such as zebrafish. ..
- Lepilina A, Coon A, Kikuchi K, Holdway J, Roberts R, Burns C, et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell. 2006;127:607-19 pubmed..Our findings reveal injury responses by myocardial and epicardial tissues that collaborate in an Fgf-dependent manner to achieve cardiac regeneration...
- Navis A, Marjoram L, Bagnat M. Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish. Development. 2013;140:1703-12 pubmed publisher..These findings uncover a new role for cftr in KV morphogenesis and function during zebrafish development. ..
- Golzio C, Willer J, Talkowski M, Oh E, Taniguchi Y, Jacquemont S, et al. KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature. 2012;485:363-7 pubmed publisher..2 CNV, reinforce the idea that one or a small number of transcripts within a CNV can underpin clinical phenotypes, and offer an efficient route to identifying dosage-sensitive loci. ..
- Liu I, Zhang C, Kim M, Cole G. Retina development in zebrafish requires the heparan sulfate proteoglycan agrin. Dev Neurobiol. 2008;68:877-98 pubmed publisher..Collectively, these agrin morphant phenotypes provide support for a crucial role of agrin in retina development and formation of an ordered retinotectal topographic map in the optic tectum of zebrafish. ..
- Zhang C, Turton Q, Mackinnon S, Sulik K, Cole G. Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. Birth Defects Res A Clin Mol Teratol. 2011;91:129-41 pubmed publisher..The results of this work suggest that agrin expression and function may be a target of ethanol exposure during embryogenesis. ..
- Yen J, Donerly S, Levin E, Linney E. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicol Teratol. 2011;33:735-41 pubmed publisher..Because of its availability outside the mother at the time of fertilization, zebrafish provides a complementary model for studying the neurotoxicity of very early developmental exposures. ..
- Wilbanks A, Fralish G, Kirby M, Barak L, Li Y, Caron M. Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science. 2004;306:2264-7 pubmed..These results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate Hh signaling in zebrafish development. ..
- Timme Laragy A, Noyes P, Buhler D, Di Giulio R. CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). Mar Environ Res. 2008;66:85-7 pubmed publisher..These data suggest that CYP1B1 is not a significant factor in causing synergistic toxicity of PAHs, nor, in contrast to CYP1A, in providing protection. ..
- Linney E, Perz Edwards A, Kelley B. Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Gene. 2011;486:31-6 pubmed publisher..We suggest that this rar-corepressor complex may be part of an embryonic, epigenetic switch that keeps retinoic acid responsive genes off before retinoic becomes available to the embryo. ..
- Lindstrand A, Davis E, Carvalho C, Pehlivan D, Willer J, Tsai I, et al. Recurrent CNVs and SNVs at the NPHP1 locus contribute pathogenic alleles to Bardet-Biedl syndrome. Am J Hum Genet. 2014;94:745-54 pubmed publisher..These results suggest that NPHP1 mutations are probably rare primary causes of BBS that contribute to the mutational burden of the disorder. ..
- Ryan S, Willer J, Marjoram L, Bagwell J, Mankiewicz J, Leshchiner I, et al. Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Development. 2013;140:4445-51 pubmed publisher..This methodology should thus help facilitate genetic screens and expedite the identification of mutants that can inform basic biological processes and the causality of genetic disorders in humans...
- Van Tiem L, Di Giulio R. AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio). Toxicol Appl Pharmacol. 2011;254:280-7 pubmed publisher..These results further show the protective role of AHR2 knockdown against cardiotoxic PAHs and the role of AHR2 as a mediator of redox-responsive gene induction. ..
- Bagnat M, Navis A, Herbstreith S, Brand Arzamendi K, Curado S, Gabriel S, et al. Cse1l is a negative regulator of CFTR-dependent fluid secretion. Curr Biol. 2010;20:1840-5 pubmed publisher..This work demonstrates the importance of fluid homeostasis in development and establishes the zebrafish as a much-needed model system to study CFTR regulation in vivo. ..
- Ravanelli A, Klingensmith J. The actin nucleator Cordon-bleu is required for development of motile cilia in zebrafish. Dev Biol. 2011;350:101-11 pubmed publisher..Thus, Cobl represents a molecular activity that couples developmental patterning signals with local intracellular cytoskeletal dynamics to support morphogenesis of motile cilia. ..
- Nachtrab G, Kikuchi K, Tornini V, Poss K. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development. 2013;140:3754-64 pubmed publisher..These findings have implications for mechanisms of positional memory in vertebrate tissues. ..
- Reijnders M, Ansor N, Kousi M, Yue W, Tan P, Clarkson K, et al. RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes. Am J Hum Genet. 2017;101:466-477 pubmed publisher..We show that ultra-rare disorders caused by private, non-recurrent missense mutations that result in varying phenotypes are challenging to dissect, but can be delineated through focused international collaboration. ..
- Alvers A, Ryan S, Scherz P, Huisken J, Bagnat M. Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. Development. 2014;141:1110-9 pubmed publisher..Thus, lumen resolution is a distinct genetically controlled process crucial for single, continuous lumen formation in the zebrafish gut. ..
- Kang J, Nachtrab G, Poss K. Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. Dev Cell. 2013;27:19-31 pubmed publisher..Our findings help explain sexually dimorphic fin regeneration in zebrafish and have implications for how regenerative potential might decline as development progresses or during species evolution. ..
- Yin V, Lepilina A, Smith A, Poss K. Regulation of zebrafish heart regeneration by miR-133. Dev Biol. 2012;365:319-27 pubmed publisher..Our results reveal dynamic regulation of miRNAs during heart regeneration, and indicate that miR-133 restricts injury-induced cardiomyocyte proliferation. ..
- Gupta V, Gemberling M, Karra R, Rosenfeld G, Evans T, Poss K. An injury-responsive gata4 program shapes the zebrafish cardiac ventricle. Curr Biol. 2013;23:1221-7 pubmed publisher..Our experiments uncover an injury-responsive program that prevents heart failure in juveniles by fortifying the ventricular wall, one that is reiterated in adults to promote regeneration after cardiac damage. ..
- Garner L, Di Giulio R. Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2012;155:573-9 pubmed publisher..However, GSTp2 knockdown did not affect PCB-126 toxicity. These results further suggest that pi class GSTs serve a protective function against the synergistic toxicity caused by PAHs in developing zebrafish. ..
- Kikuchi K, Gupta V, Wang J, Holdway J, Wills A, Fang Y, et al. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development. 2011;138:2895-902 pubmed publisher..Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish. ..
- Fang Y, Gupta V, Karra R, Holdway J, Kikuchi K, Poss K. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2013;110:13416-21 pubmed publisher..Our results identify an injury-specific cardiomyocyte program essential for heart regeneration. ..
- Tornini V, Thompson J, Allen R, Poss K. Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration. Development. 2017;144:2889-2895 pubmed publisher..Our experiments visualize and quantify how incorporation into an appendage blastema broadens the progeny contributions of a cellular subpopulation that normally has proximodistal restrictions. ..
- Bencan Z, Sledge D, Levin E. Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety. Pharmacol Biochem Behav. 2009;94:75-80 pubmed publisher..The zebrafish novel tank diving task can be useful in discriminating anxiolytic drugs of several classes (serotonergic, benzodiazepines and nicotinic). ..
- Singh S, Holdway J, Poss K. Regeneration of amputated zebrafish fin rays from de novo osteoblasts. Dev Cell. 2012;22:879-86 pubmed publisher..Our findings demonstrate diversity in the cellular origins of appendage bone and reveal that de novo osteoblasts can fully support the regeneration of amputated zebrafish fins. ..
- Timme Laragy A, Cockman C, Matson C, Di Giulio R. Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. Aquat Toxicol. 2007;85:241-50 pubmed..This study furthers a mechanistic understanding of interactions underlying PAH synergistic toxicity. ..
- Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Létourneau L, Dzamba M, et al. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat Genet. 2014;46:451-6 pubmed publisher..Our results highlight distinct molecular subgroups and novel therapeutic targets for this incurable pediatric cancer. ..
- Li C, Wang L, Zhang J, Huang M, Wong F, Liu X, et al. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014;1842:1121-9 pubmed publisher..Our results show that CERKL interacts with TRX2 and plays a novel key role in the regulation of the TRX2 antioxidant pathway and, for the first time, provides an explanation of how mutations in CERKL may lead to retinal cell death. ..
- Minchin J, Rawls J. A classification system for zebrafish adipose tissues. Dis Model Mech. 2017;10:797-809 pubmed publisher..Altogether, this resource provides foundational information on the identity, dynamics and expected quantities of zebrafish ATs for use as a reference for future studies. ..
- Lee N, Golzio C, Gatza C, Sharma A, Katsanis N, Blobe G. Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis. Mol Biol Cell. 2012;23:2412-23 pubmed publisher..These studies define a novel non-Smad function for endoglin and GIPC in regulating endothelial cell function during angiogenesis. ..
- Sledge D, Yen J, Morton T, Dishaw L, Petro A, Donerly S, et al. Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicol Teratol. 2011;33:742-51 pubmed publisher..The zebrafish model can facilitate the determination of the molecular mechanisms underlying long-term neurobehavioral impairment after developmental toxicant exposure. ..
- Chen C, Durand E, Wang J, Zon L, Poss K. zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. Development. 2013;140:4988-97 pubmed publisher..Our findings present a versatile resource for monitoring and dissecting vertebrate stem cell and regeneration biology...
- Stankiewicz P, Khan T, Szafranski P, Slattery L, Streff H, Vetrini F, et al. Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. Am J Hum Genet. 2017;101:503-515 pubmed publisher..Taken together, our data demonstrate the pathogenic role of BPTF haploinsufficiency in syndromic neurodevelopmental anomalies and extend the clinical spectrum of human disorders caused by ablation of chromatin remodeling complexes. ..
- Perz Edwards A, Hardison N, Linney E. Retinoic acid-mediated gene expression in transgenic reporter zebrafish. Dev Biol. 2001;229:89-101 pubmed..Together these data suggest that the reporter expression we see in zebrafish is dependent upon conserved vertebrate pathways of RA synthesis. ..
- Bencan Z, Levin E. The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. Physiol Behav. 2008;95:408-12 pubmed publisher..This nicotine-induced anxiolytic effect was reversed by both MLA and DHbetaE, indicating that both nicotinic alpha7 and alpha4beta2 receptors are involved in the nicotinic effect on anxiety in zebrafish. ..
- Powers C, Yen J, Linney E, Seidler F, Slotkin T. Silver exposure in developing zebrafish (Danio rerio): persistent effects on larval behavior and survival. Neurotoxicol Teratol. 2010;32:391-7 pubmed publisher..Ag(+) is a developmental toxicant at concentrations only slightly above allowable levels. At low concentrations, Ag(+) acts as a neurobehavioral toxicant even in the absence of dysmorphology. ..
- Lee Y, Grill S, Sanchez A, Murphy Ryan M, Poss K. Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Development. 2005;132:5173-83 pubmed..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage. ..
- Dong W, Macaulay L, Kwok K, Hinton D, Stapleton H. Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. Aquat Toxicol. 2013;132-133:190-9 pubmed publisher..Our results demonstrate effects of OH-BDEs on thyroid regulating gene expression and provide more insight into potential sites of injury during early life stages. ..
- Wills A, Holdway J, Major R, Poss K. Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. Development. 2008;135:183-92 pubmed..Our results demonstrate that the adult zebrafish ventricle grows and is maintained by cardiomyocyte hyperplasia, and that epicardial cells are added to the ventricle in an Fgf-dependent fashion to support homeostasis. ..