Experts and Doctors on suprachiasmatic nucleus in Chapel Hill, North Carolina, United States
Locale: Chapel Hill, North Carolina, United States
Topic: suprachiasmatic nucleus
Thresher R, Vitaterna M, Miyamoto Y, Kazantsev A, Hsu D, Petit C, et al
. Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science. 1998;282:1490-4 pubmed
..These data are consistent with the hypothesis that CRY2 protein modulates circadian responses in mice and suggest that cryptochromes have a role in circadian photoreception in mammals. ..
Thompson C, Blaner W, Van Gelder R, Lai K, Quadro L, Colantuoni V, et al
. Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice. Proc Natl Acad Sci U S A. 2001;98:11708-13 pubmed
..The data suggest that a non-opsin pigment is the primary circadian photoreceptor in the mouse. ..
Thompson C, Selby C, Partch C, Plante D, Thresher R, Araujo F, et al
. Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction. Brain Res Mol Brain Res. 2004;122:158-66 pubmed
Thompson C, Selby C, Van Gelder R, Blaner W, Lee J, Quadro L, et al
. Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice. J Biol Rhythms. 2004;19:504-17 pubmed
..These data demonstrate that both cryptochromes and opsins regulate nonvisual photoresponses. ..
Partch C, Shields K, Thompson C, Selby C, Sancar A. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. Proc Natl Acad Sci U S A. 2006;103:10467-10472 pubmed publisher
..Collectively, these findings indicate that PP5, CKIepsilon, and cryptochrome dynamically regulate the mammalian circadian clock. ..
Miyamoto Y, Sancar A. Circadian regulation of cryptochrome genes in the mouse. Brain Res Mol Brain Res. 1999;71:238-43 pubmed
..Third, mutation in Cry2 causes a phase delay in Cry1 and mPer1 expression both in the SCN and internal organs relative to wild-type animals. Finally, no obvious periodicity in mCry2 expression was seen in all tissues tested. ..