Experts and Doctors on sodium in Durham, North Carolina, United States


Locale: Durham, North Carolina, United States
Topic: sodium

Top Publications

  1. Breuder T, Hemenway C, Movva N, Cardenas M, Heitman J. Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. Proc Natl Acad Sci U S A. 1994;91:5372-6 pubmed
    ..In yeast strains in which calcineurin is not essential, calcineurin inhibition or mutation of calcineurin confers hypersensitivity to LiCl or NaCl, suggesting that calcineurin regulates cation transport. ..
  2. Schulthess C, Ndu U. Modeling the adsorption of hydrogen, sodium, chloride and phthalate on goethite using a strict charge-neutral ion-exchange theory. PLoS ONE. 2017;12:e0176743 pubmed publisher
  3. Turner M, Saint Criq V, Patel W, Ibrahim S, Verdon B, Ward C, et al. Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia. J Physiol. 2016;594:1643-61 pubmed publisher
    ..Based on current models of airways biology, a reduction in fluid secretion, associated with hypercapnia, would be predicted to have important consequences for airways hydration and the innate defence mechanisms of the lungs...
  4. Greenberg A, Verbalis J. Vasopressin receptor antagonists. Kidney Int. 2006;69:2124-30 pubmed
    ..Results of long-term trials to determine the ability of VRAs to reduce morbidity or mortality in congestive heart failure or to slow the progression of polycystic kidney disease are awaited with great interest. ..
  5. Winn M, Conlon P, Lynn K, Farrington M, Creazzo T, Hawkins A, et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science. 2005;308:1801-4 pubmed
    ..Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease. ..
  6. Payne M, Hybels C, Bales C, Steffens D. Vascular nutritional correlates of late-life depression. Am J Geriatr Psychiatry. 2006;14:787-95 pubmed
    ..The authors sought to examine the association of vascular nutritional factors and depression in an elderly cohort of depression (currently and recently depressed) and comparison (never depressed) subjects...
  7. Crowley S, Gurley S, Herrera M, Ruiz P, Griffiths R, Kumar A, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006;103:17985-90 pubmed
    ..Further, they suggest that the major mechanism of action of RAS inhibitors in hypertension is attenuation of angiotensin II effects in the kidney. ..
  8. Lu C, Stricker J, Erickson H. FtsZ from Escherichia coli, Azotobacter vinelandii, and Thermotoga maritima--quantitation, GTP hydrolysis, and assembly. Cell Motil Cytoskeleton. 1998;40:71-86 pubmed publisher
    ..Using this standard and quantitative Western blotting, we determined that the average E. coli cell has 15,000 molecules of FtsZ, at a concentration of 400 microg/ml. This is just above the plateau for full GTPase activity in vitro...
  9. Shafqat S, Tamarappoo B, Kilberg M, Puranam R, McNamara J, Guadaño Ferraz A, et al. Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. J Biol Chem. 1993;268:15351-5 pubmed
    ..SATT may represent one of multiple activities that exhibit System ASC-like transport characteristics in diverse tissues and cell lines. ..

More Information


  1. Grodin J, Gallup D, Anstrom K, Felker G, Chen H, Tang W. Implications of Alternative Hepatorenal Prognostic Scoring Systems in Acute Heart Failure (from DOSE-AHF and ROSE-AHF). Am J Cardiol. 2017;119:2003-2009 pubmed publisher
    ..However, MELD-Na and MELD-XI were not predictive of 60-day clinical events. ..
  2. Hall R, Premont R, Chow C, Blitzer J, Pitcher J, Claing A, et al. The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature. 1998;392:626-30 pubmed
    ..Our findings indicate that agonist-dependent beta2-adrenergic receptor binding of NHERF plays a role in beta2-adrenergic receptor-mediated regulation of Na+/H+ exchange. ..
  3. Gurley S, Riquier Brison A, Schnermann J, Sparks M, Allen A, Haase V, et al. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011;13:469-475 pubmed publisher
    ..Thus, effectively targeting epithelial functions of the proximal tubule of the kidney should be a useful therapeutic strategy in hypertension. ..
  4. McNulty A, Vail T, Kraus V. Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. Biochim Biophys Acta. 2005;1712:212-21 pubmed
    ..Thus, we provide the first evidence that SVCT2 mediates the secondary active and concentrative transport of ascorbic acid in human chondrocytes. ..
  5. Cann M. A subset of GAF domains are evolutionarily conserved sodium sensors. Mol Microbiol. 2007;64:461-72 pubmed
    ..CyaB1 and CyaB2 are the first identified directly Na(+)-responsive signalling molecules that function in sodium homeostasis and we propose a subset of GAF domains underpin an evolutionarily conserved Na(+) signalling mechanism. ..
  6. Lowry D, Hall M, Salt D, Willis J. Genetic and physiological basis of adaptive salt tolerance divergence between coastal and inland Mimulus guttatus. New Phytol. 2009;183:776-88 pubmed publisher
    ..Physiological results are consistent with adaptation of coastal populations to salt spray and soil salinity. Field results suggest that there may not be trade-offs across habitats for alleles involved in local salt spray adaptations...
  7. Johnson Z, Cheong C, Lee S. Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4?Å. Nature. 2012;483:489-93 pubmed publisher
  8. Fremeau R, Caron M, Blakely R. Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain. Neuron. 1992;8:915-26 pubmed
    ..These findings support a synaptic role for L-proline in specific excitatory pathways in the CNS. ..
  9. Buckley B, Whorton A. Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells. Am J Physiol Cell Physiol. 2000;279:C1168-76 pubmed
    ..In summary, vascular cells respond to chronic peroxynitrite exposure with adaptive increases in cellular glutathione and cystine transport...
  10. Wang C, Hennessey J, Kirkton R, Wang C, Graham V, Puranam R, et al. Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circ Res. 2011;109:775-82 pubmed publisher
    ..5 loss-of-function mutations. ..
  11. Pablo J, Wang C, Presby M, Pitt G. Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action. Proc Natl Acad Sci U S A. 2016;113:E2665-74 pubmed publisher
    ..Thus, our data show how the concerted actions of FGF13 and FGF14 regulate the polarized localization of VGSCs that supports efficient action potential initiation. ..