Experts and Doctors on sodium channels in Durham, North Carolina, United States


Locale: Durham, North Carolina, United States
Topic: sodium channels

Top Publications

  1. Bennett V, Healy J. Being there: cellular targeting of voltage-gated sodium channels in the heart. J Cell Biol. 2008;180:13-5 pubmed publisher
    ..5 in an intracellular compartment in cardiomyocytes. Conclusive evidence is now provided that direct interaction between Na(v)1.5 and ankyrin-G is necessary for the expression of Na(v)1.5 at the cardiomyocyte cell surface. ..
  2. Liu L, Zhu W, Zhang Z, Yang T, Grant A, Oxford G, et al. Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. J Neurophysiol. 2004;91:1482-91 pubmed
    ..These studies document several new effects of nicotine on channels involved in nociception and indicate how they may impact physiological processes involving pain and gustation. ..
  3. Grant A, Chandra R, Keller C, Carboni M, Starmer C. Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. Biophys J. 2000;79:3019-35 pubmed
    ..The qualitative differences in use-dependent block appear to be the result of differences in drug dissociation rate. The inactivation gate may play a trapping role during exposure to some sodium channel blocking drugs. ..
  4. Wang C, Chung B, Yan H, Lee S, Pitt G. Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. Structure. 2012;20:1167-76 pubmed publisher
    ..Furthermore, we identify a critical interaction that contributes to the specificity of individual Na(V) CTD isoforms for distinctive FHFs. ..
  5. Liu L, Simon S. Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. Brain Res. 2001;923:58-70 pubmed
    ..TRCs that exhibit Type II responses could also be activated by quinine (which increased Ca(2+)(I)) thus suggesting a mechanism by which the addition of acid may be suppressive to other chemical stimuli. ..
  6. Zhou D, Lambert S, Malen P, Carpenter S, Boland L, Bennett V. AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J Cell Biol. 1998;143:1295-304 pubmed
    ..These results demonstrate that ankyrinG is essential for clustering NaCh and neurofascin at axon initial segments and is required for physiological levels of sodium channel activity. ..
  7. Pablo J, Wang C, Presby M, Pitt G. Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action. Proc Natl Acad Sci U S A. 2016;113:E2665-74 pubmed publisher
    ..Thus, our data show how the concerted actions of FGF13 and FGF14 regulate the polarized localization of VGSCs that supports efficient action potential initiation. ..
  8. Hunter G, Crawford J, Genkins J, Kiehart D. Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. Development. 2014;141:325-34 pubmed publisher
    ..Our results point to a key role for ion channels in closure, and suggest a mechanism for the coordination of force-producing cell behaviors across the embryo. ..
  9. Wang C, Hennessey J, Kirkton R, Wang C, Graham V, Puranam R, et al. Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circ Res. 2011;109:775-82 pubmed publisher
    ..5 loss-of-function mutations. ..

More Information


  1. Sun A, Koontz J, Shah S, Piccini J, Nilsson K, Craig D, et al. The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction. Circ Cardiovasc Genet. 2011;4:163-8 pubmed publisher
    ..This is the first report that the S1103Y variant is associated with a higher incidence of ventricular arrhythmias in blacks with heart failure and reduced ejection fraction. ..
  2. Heinzen E, Yoon W, Tate S, Sen A, Wood N, Sisodiya S, et al. Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A. Am J Hum Genet. 2007;80:876-83 pubmed
  3. Somjen G. Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev. 2001;81:1065-96 pubmed
    ..Short bouts of SD and HSD are well tolerated, but prolonged depolarization results in lasting loss of neuron function. Irreversible damage can, however, be avoided if Ca(2+) influx into neurons is prevented...
  4. Davis J, Lambert S, Bennett V. Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. J Cell Biol. 1996;135:1355-67 pubmed
    ..This is the first characterization of defined neuronal cell adhesion molecules localized to axonal membranes at the node of Ranvier of myelinated axons. ..
  5. Zhang Z, Tranquillo J, Neplioueva V, Bursac N, Grant A. Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease. Am J Physiol Heart Circ Physiol. 2007;292:H399-407 pubmed
    ..The findings also suggest how Brugada syndrome and PCCD which both result from loss of sodium channel function are sometimes present alone and at other times in combination. ..
  6. Zhan R, Nadler J, Schwartz Bloom R. Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. J Cereb Blood Flow Metab. 2007;27:1444-52 pubmed
    ..1 subunit. These changes may promote interneuron survival, but might also contribute to pyramidal cell death. ..
  7. Mohler P, Rivolta I, Napolitano C, LeMaillet G, Lambert S, Priori S, et al. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci U S A. 2004;101:17533-8 pubmed
    ..Together with previous work in neurons, these results in cardiomyocytes suggest that ankyrin-G participates in a common pathway for localization of voltage-gated Na(v) channels at sites of function in multiple excitable cell types. ..
  8. Jenkins S, Bennett V. Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. Proc Natl Acad Sci U S A. 2002;99:2303-8 pubmed
    ..Recruitment of Na(v)1.2, Na(v)1.6, beta IV spectrin, and neurofascin to sites of ankyrin-G clustering is unimpaired in jimpy mice, indicating that node formation occurs independent of intact paranodal axoglial contacts. ..
  9. Bennett V, Baines A. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev. 2001;81:1353-92 pubmed
    ..Exciting questions for the future relate to the molecular basis for these pathways and their roles in a clinical context, either as the basis for disease or more positively as therapeutic targets...
  10. Kanter R, Pfeiffer R, Hu D, Barajas Martinez H, Carboni M, Antzelevitch C. Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay. Circulation. 2012;125:14-22 pubmed publisher
    ..Infants having rapid ventricular tachycardia and conduction abnormalities in the absence of structural or metabolic abnormalities are likely to have disease-causing mutations in cardiac depolarizing channels. ..
  11. Tsubouchi A, Caldwell J, Tracey W. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Curr Biol. 2012;22:2124-34 pubmed publisher
    ..These cells show physiological responses to force. Ion channels in several force-sensing gene families are required for behavioral sensitivity to touch and for the formation of the actin-rich sensory filopodia. ..
  12. Kirkton R, Bursac N. Genetic engineering of somatic cells to study and improve cardiac function. Europace. 2012;14 Suppl 5:v40-v49 pubmed publisher
  13. Chauhan V, Tuvia S, Buhusi M, Bennett V, Grant A. Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. Circ Res. 2000;86:441-7 pubmed
    ..In conclusion, Na(+) channels in ankyrin(B)(-/-) display reduced I(Na) density and abnormal kinetics at the whole-cell and single-channel level that contribute to prolonged APD(90) and abnormal QT-rate adaptation. ..
  14. Ho T, Zollinger D, Chang K, Xu M, Cooper E, Stankewich M, et al. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci. 2014;17:1664-72 pubmed publisher
  15. Chen G, Kim Y, Li H, Luo H, Liu D, Zhang Z, et al. PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. Nat Neurosci. 2017;20:917-926 pubmed publisher
    ..Notably, blocking PD-L1 or PD-1 elicited spontaneous pain and allodynia in melanoma-bearing mice. Our findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator. ..
  16. Zhong L, Hwang R, Tracey W. Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae. Curr Biol. 2010;20:429-34 pubmed publisher
    ..Our results suggest that neurons that detect harsh touch in Drosophila utilize similar mechanosensory molecules. ..
  17. Jenkins S, Bennett V. Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. J Cell Biol. 2001;155:739-46 pubmed
  18. Hennessey J, Wei E, Pitt G. Fibroblast growth factor homologous factors modulate cardiac calcium channels. Circ Res. 2013;113:381-8 pubmed publisher
    ..We predict that FHF loss-of-function mutations would adversely affect currents through both Na+ and Ca2+ channels, suggesting that FHFs may be arrhythmogenic loci, leading to arrhythmias through a novel, dual-ion channel mechanism. ..