Experts and Doctors on signal transduction in Durham, North Carolina, United States

Summary

Locale: Durham, North Carolina, United States
Topic: signal transduction

Top Publications

  1. Hu L, Chen W, Martin N, Whalen E, Premont R, Lefkowitz R. GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. J Biol Chem. 2003;278:26295-301 pubmed
    ..These data suggest that GIPC can regulate beta1-adrenergic receptor-stimulated, Gi-mediated, ERK activation while having no effect on receptor internalization or Gs-mediated cAMP signaling. ..
  2. Koonpaew S, Shen S, Flowers L, Zhang W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med. 2006;203:119-29 pubmed
    ..Our data indicate that the LAT-PLC-gamma1 interaction plays a critical role in Foxp3 expression and the development of CD4+CD25+ T reg cells. ..
  3. Smith J, Evans E, Murakami M, Moyer M, Moseley M, Vande Woude G, et al. Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. J Cell Biol. 2000;151:1391-400 pubmed
  4. D Souza C, Heitman J. Conserved cAMP signaling cascades regulate fungal development and virulence. FEMS Microbiol Rev. 2001;25:349-64 pubmed
    ..We also present examples of interaction between the cAMP and MAP kinase signaling cascades in the regulation of fungal development and virulence. ..
  5. Li S, Whorton A. Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols. Arch Biochem Biophys. 2003;410:269-79 pubmed
    ..These findings suggest an important role for NO in modulating signaling pathways since inhibition of PTPases could potentially enhance or prolong activity of phosphoproteins. ..
  6. Wilbanks A, Fralish G, Kirby M, Barak L, Li Y, Caron M. Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science. 2004;306:2264-7 pubmed
    ..These results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate Hh signaling in zebrafish development. ..
  7. Zhao C, Chen W, Yang L, Chen L, Stimpson S, Diehl A. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun. 2006;350:385-91 pubmed
    ..Thus, the anti-fibrotic actions of PPARgamma agonists reflect their ability to inhibit TGFbeta1-TGFbetaR1 signaling that initiates ECM gene expression in quiescent HSC. ..
  8. Zhu J, Huang X, Yang Y. Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways. J Virol. 2007;81:3170-80 pubmed
    ..Our results that suggest strategies to interfere with type I IFN pathway may improve the outcome of adenovirus-mediated gene therapy, whereas approaches to activate the type I IFN pathway may enhance vaccine potency. ..
  9. Hjelmeland A, Lattimore K, Fee B, Shi Q, Wickman S, Keir S, et al. The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. Mol Cancer Ther. 2007;6:2449-57 pubmed
    ..These data suggest that the combination of LBT613 and RAD001 reduces glioma cell proliferation and invasion and support examination of the combination of RAF and TOR inhibitors for the treatment of human glioblastoma patients. ..

More Information

Publications337 found, 100 shown here

  1. Cohen T, Mallory M, Strich R, Yao T. Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway. Eukaryot Cell. 2008;7:1191-9 pubmed publisher
  2. Shenoy S, Modi A, Shukla A, Xiao K, Berthouze M, Ahn S, et al. Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A. 2009;106:6650-5 pubmed publisher
    ..Thus, USP33-beta-arrestin interaction is a key regulatory step in 7TMR trafficking and signal transmission from the activated receptors to downstream effectors. ..
  3. Grasfeder L, Gaillard S, Hammes S, Ilkayeva O, Newgard C, Hochberg R, et al. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Mol Endocrinol. 2009;23:1171-82 pubmed publisher
    ..These data suggest that DHEA could be playing a role as an intracellular signaling molecule involved in modulating hepatic activity in response to fasting conditions. ..
  4. Kunder C, St John A, Li G, Leong K, Berwin B, Staats H, et al. Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med. 2009;206:2455-67 pubmed publisher
    ..These complexes enter lymphatic vessels and rapidly traffic to the DLNs. This physiological drug delivery system facilitates communication between peripheral sites of inflammation and remote secondary lymphoid tissues. ..
  5. Pisetsky D, Vrabie I. Antibodies to DNA: infection or genetics?. Lupus. 2009;18:1176-80 pubmed publisher
    ..Given the universal expression of DNA, this model suggests that many different kinds of infections could trigger pathogenic autoantibody responses in SLE, as well as induce flare. ..
  6. Muramoto G, Russell J, Safi R, Salter A, Himburg H, Daher P, et al. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells. 2010;28:523-34 pubmed publisher
    ..Pharmacologic inhibition of ALDH has therapeutic potential as a means to amplify ST-HSCs for transplantation purposes...
  7. Shertz C, Bastidas R, Li W, Heitman J, Cardenas M. Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. BMC Genomics. 2010;11:510 pubmed publisher
    ..These comparative genomic analyses illustrate the evolutionary trajectory of a central nutrient-sensing cascade that enables diverse eukaryotic organisms to respond to their natural environments. ..
  8. Duncan C, Killela P, Payne C, Lampson B, Chen W, Liu J, et al. Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. Oncotarget. 2010;1:265-77 pubmed
    ..Our multifaceted genomic evaluation of glioblastoma establishes ERRFI1 as a potential candidate tumor suppressor gene and TACC3 as a potential oncogene, and provides insight on targets for oncogenic pathway-based therapy. ..
  9. Zhang Z, Ogawa M, Fleet C, Zentella R, Hu J, Heo J, et al. Scarecrow-like 3 promotes gibberellin signaling by antagonizing master growth repressor DELLA in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:2160-5 pubmed publisher
    ..This work is beginning to shed light on how this complex regulatory network achieves GA homeostasis and controls GA-mediated growth and development in the plant. ..
  10. Philips G, Chan I, Swiderska M, Schroder V, Guy C, Karaca G, et al. Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. PLoS ONE. 2011;6:e23943 pubmed publisher
    ..We used Mdr2(-/-) mice to investigate the hypothesis that activation of the hedgehog (Hh) signaling pathway promotes development of both liver fibrosis and HCC...
  11. Risher W, Eroglu C. Thrombospondins as key regulators of synaptogenesis in the central nervous system. Matrix Biol. 2012;31:170-7 pubmed publisher
  12. Oancea E, Meyer T. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell. 1998;95:307-18 pubmed
    ..The properties of this molecular decoding machine make PKCgamma responsive to persistent diacylglycerol increases combined with high- but not low-frequency calcium spikes. ..
  13. Slotkin T, Pinkerton K, Garofolo M, Auman J, McCook E, Seidler F. Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase and alters receptor-mediated cell signaling in brain and heart of neonatal rats. Brain Res. 2001;898:73-81 pubmed
  14. Misra U, Gonzalez Gronow M, Gawdi G, Hart J, Johnson C, Pizzo S. The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction. J Biol Chem. 2002;277:42082-7 pubmed
  15. Fields R, Schoenecker J, Hart J, Hoffman M, Pizzo S, Lawson J. Protease-activated receptor-2 signaling triggers dendritic cell development. Am J Pathol. 2003;162:1817-22 pubmed
    ..These results suggest that endogenous serine proteases stimulate DC development in vitro. Thus, serine proteases may help trigger adaptive immune responses in vivo. ..
  16. Cohen T, Lee K, Rutkowski L, Strich R. Ask10p mediates the oxidative stress-induced destruction of the Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p. Eukaryot Cell. 2003;2:962-70 pubmed
  17. Kim J, Ahn S, Ren X, Whalen E, Reiter E, Wei H, et al. Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A. 2005;102:1442-7 pubmed
    ..These findings indicate distinct functional capabilities of beta-arrestins bound to receptors phosphorylated by different classes of GRKs. ..
  18. Datto M, Wang X. Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. Cell. 2005;121:2-4 pubmed
    ..The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005). ..
  19. Misra U, Deedwania R, Pizzo S. Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. J Biol Chem. 2005;280:26278-86 pubmed
    ..These studies suggest a mechanism by which alpha2M* enhances the metastatic potential of these cells. ..
  20. Gesty Palmer D, Chen M, Reiter E, Ahn S, Nelson C, Wang S, et al. Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J Biol Chem. 2006;281:10856-64 pubmed
    ..These findings imply the existence of distinct active conformations of the hPTH1R responsible for the two pathways, which can be stimulated by unique ligands. Such ligands may have distinct and valuable therapeutic properties. ..
  21. Hollingsworth J, Whitehead G, Lin K, Nakano H, Gunn M, Schwartz D, et al. TLR4 signaling attenuates ongoing allergic inflammation. J Immunol. 2006;176:5856-62 pubmed
    ..Together, these findings show that low doses of endotoxin can have regulatory effects on allergic inflammation, particularly in the setting of ongoing allergen exposure. ..
  22. Kerry S, TeKippe M, Gaddis N, Aballay A. GATA transcription factor required for immunity to bacterial and fungal pathogens. PLoS ONE. 2006;1:e77 pubmed
    ..Our results indicate that ELT-2 is part of a multi-pathogen defense pathway that regulates innate immunity independently of the DAF-2/DAF-16 signaling pathway. ..
  23. Witek R, Yang L, Liu R, Jung Y, Omenetti A, Syn W, et al. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 2009;136:320-330.e2 pubmed publisher
    ..Hh-containing exosome-enriched microparticles released from liver cells alter hepatic SEC gene expression, suggesting a novel mechanism for cirrhotic vasculopathy. ..
  24. Choi S, Syn W, Karaca G, Omenetti A, Moylan C, Witek R, et al. Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. J Biol Chem. 2010;285:36551-60 pubmed publisher
  25. Finberg K, Whittlesey R, Andrews N. Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. Blood. 2011;117:4590-9 pubmed publisher
  26. Zaremba A, Schmuecker U, Esche H. Sprouty is a cytoplasmic target of adenoviral E1A oncoproteins to regulate the receptor tyrosine kinase signalling pathway. Virol J. 2011;8:192 pubmed publisher
  27. Sha Y, Marshall H. S-nitrosylation in the regulation of gene transcription. Biochim Biophys Acta. 2012;1820:701-11 pubmed publisher
    ..This article is part of a Special Issue entitled Regulation of Cellular Processes by S-nitrosylation. ..
  28. Racioppi L, Noeldner P, Lin F, Arvai S, Means A. Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. J Biol Chem. 2012;287:11579-91 pubmed publisher
    ..Our findings uncover an important function for CaMKK2 in mediating mechanisms that control the amplitude of macrophage inflammatory responses to excess nutrients or pathogen derivatives. ..
  29. Ou Yang C, Zhu M, Fuller D, Sullivan S, Chuck M, Ogden S, et al. Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. Mol Cell Biol. 2012;32:2674-84 pubmed publisher
    ..Our data demonstrated that LAT-mediated signaling intricately regulates CTL cytotoxicity at multiple steps. ..
  30. Misra U, Pizzo S. Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways. PLoS ONE. 2013;8:e63150 pubmed publisher
    ..We show that Epac1, a downstream effector of cAMP, functions as a pro-inflammatory modulator in prostate cancer cells and promotes cell proliferation and survival by upregulating Ras-MAPK, and PI 3-kinase-Akt-mTOR signaling. ..
  31. Miriyala S, Thippakorn C, Chaiswing L, Xu Y, Noel T, Tovmasyan A, et al. Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. Free Radic Biol Med. 2016;91:68-80 pubmed publisher
    ..These results identify a previously unrecognized role of HNE with important consequences for mitochondrial stress signaling, heart failure, and the side effects of cancer therapy. ..
  32. Sato S, Steeber D, Tedder T. The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc Natl Acad Sci U S A. 1995;92:11558-62 pubmed
  33. Lee D, Patel D, Pendergast A, Haynes B. Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. Int Immunol. 1996;8:1195-203 pubmed
    ..The interaction of CD7 with the Pi3-kinase signal transduction pathway provides a mechanism for the previously observed functional responses attributed to CD7-mediated T and NK cell activation. ..
  34. Kontos C, Cha E, York J, Peters K. The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol. 2002;22:1704-13 pubmed
    ..These findings are the first biochemical demonstration of a signal transduction pathway and corresponding cellular function for Tie1, and the antiapoptotic effect of Tie1 is consistent with the results of previous genetic studies. ..
  35. Reya T, Duncan A, Ailles L, Domen J, Scherer D, Willert K, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423:409-14 pubmed
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development. ..
  36. Shenoy S, Drake M, Nelson C, Houtz D, Xiao K, Madabushi S, et al. beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem. 2006;281:1261-73 pubmed
    ..These findings demonstrate that the beta2AR can signal to ERK via a GRK5/6-beta-arrestin-dependent pathway, which is independent of G protein coupling...
  37. Sicklick J, Li Y, Melhem A, Schmelzer E, Zdanowicz M, Huang J, et al. Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol Gastrointest Liver Physiol. 2006;290:G859-70 pubmed
    ..Therefore, Hedgehog signaling is conserved in hepatic progenitors from fetal development through adulthood and may be a new therapeutic target in patients with liver damage. ..
  38. Choi M, Stottmann R, Yang Y, Meyers E, Klingensmith J. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res. 2007;100:220-8 pubmed
    ..These data indicate that antagonism of BMP signaling by Noggin plays a critical role in ensuring proper levels of cell proliferation and EMT during cardiac morphogenesis in the mouse. ..
  39. Payne H, Ives J, Sieghart W, Thompson C. AMPA and kainate receptors mediate mutually exclusive effects on GABA(A) receptor expression in cultured mouse cerebellar granule neurones. J Neurochem. 2008;104:173-86 pubmed
    ..Thus, we provide evidence that a KAR-mediated and at least three mutually exclusive AMPAR-mediated signalling mechanisms regulate neuronal GABAR expression. ..
  40. Kozubowski L, Lee S, Heitman J. Signalling pathways in the pathogenesis of Cryptococcus. Cell Microbiol. 2009;11:370-80 pubmed publisher
  41. Huang Y, McNamara J. Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. J Biol Chem. 2010;285:8207-17 pubmed publisher
    ..In sum, SFKs are activated by TrkB and, in turn, SFKs can promote TrkB activation. We propose models depicting the mutual regulation of SFKs and TrkB following activation of TrkB by zinc and BDNF. ..
  42. Rice J, Veal J, Barabasz A, Foley B, Fadden P, Scott A, et al. Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib. Oncol Res. 2009;18:229-42 pubmed
  43. Sun T. The molecular mechanism and evolution of the GA-GID1-DELLA signaling module in plants. Curr Biol. 2011;21:R338-45 pubmed publisher
    ..Interestingly, differentiation of the moss Physcomitrella patens is regulated by as yet unidentified ent-kaurene-derived diterpenes, which are distinct from the common active GAs in vascular plants. ..
  44. Rock J, Gao X, Xue Y, Randell S, Kong Y, Hogan B. Notch-dependent differentiation of adult airway basal stem cells. Cell Stem Cell. 2011;8:639-48 pubmed publisher
    ..Moreover, sustained Notch activation in BCs promotes their luminal differentiation, primarily toward secretory lineages. We also provide evidence that this function of Notch signaling is conserved in BCs from human airways. ..
  45. Evron T, Philipp M, Lu J, Meloni A, Burkhalter M, Chen W, et al. Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. J Biol Chem. 2011;286:27676-86 pubmed publisher
    ..This is in contrast to cells stably expressing both GRK2 and Smo, in which cilia are significantly elongated. These results identify Gas8 as a positive regulator of Hh signaling that cooperates with GRK2 to control Smo signaling. ..
  46. Anderson K, Lin F, Ribar T, Stevens R, Muehlbauer M, Newgard C, et al. Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. Mol Endocrinol. 2012;26:281-91 pubmed publisher
  47. Zhu M, Fuller D, Ou Yang C, Sullivan S, Zhang W. Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB. J Immunol. 2012;188:2733-41 pubmed publisher
    ..Our study suggested a novel mechanism by which LAB functions in the regulation of innate immunity. ..
  48. Babu R, Bagley J, Di C, Friedman A, Adamson C. Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage-induced secondary brain injury and as potential targets for intervention. Neurosurg Focus. 2012;32:E8 pubmed publisher
    ..This review will discuss the molecular mechanisms of brain injury as a result of intraparenchymal blood, potential targets for therapeutic intervention, and treatment strategies currently in development. ..
  49. Granek J, Murray D, Kayrkçi O, Magwene P. The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae. Genetics. 2013;193:587-600 pubmed publisher
    ..Based on these results, we propose a mechanistic model that relates genetic variation to gene network function and phenotypic outcomes. ..
  50. Noyes P, Lema S, Macaulay L, Douglas N, Stapleton H. Low level exposure to the flame retardant BDE-209 reduces thyroid hormone levels and disrupts thyroid signaling in fathead minnows. Environ Sci Technol. 2013;47:10012-21 pubmed publisher
    ..Declines in the gonadal-somatic index (GSI) and increased mortality were also measured. Effects at the low dose were consistent with the high dose, suggesting nonlinear relationships between BDE-209 exposures and thyroid dysfunction. ..
  51. Loviglio M, Arbogast T, Jønch A, Collins S, Popadin K, Bonnet C, et al. The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs. Am J Hum Genet. 2017;101:564-577 pubmed publisher
    ..Taken together, our results suggest that LAT, besides its well-recognized function in T cell development, is a major contributor of the 16p11.2 220 kb BP2-BP3 CNV-associated neurodevelopmental phenotypes. ..
  52. Silverstone A, Mak P, Martínez E, Sun T. The new RGA locus encodes a negative regulator of gibberellin response in Arabidopsis thaliana. Genetics. 1997;146:1087-99 pubmed
    ..Our studies indicate that RGA lies on a separate branch of the GA signal transduction pathway from SPY, which leads us to propose a modified model of the GA response pathway. ..
  53. Lorenz M, Heitman J. Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. EMBO J. 1997;16:7008-18 pubmed
    ..Our findings suggest that GPA2 is an element of the nitrogen sensing machinery that regulates pseudohyphal differentiation by modulating cAMP levels. ..
  54. Harrison J, Bardes E, Ohya Y, Lew D. A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint. Nat Cell Biol. 2001;3:417-20 pubmed
    ..The G2 delay involves stabilization of Swe1p in response to various actin perturbations, although this alone is insufficient to produce a long G2 delay. ..
  55. Szakmary A, Cox D, Wang Z, Lin H. Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation. Curr Biol. 2005;15:171-8 pubmed
  56. Lee Y, Haas K, Gor D, Ding X, Karp D, Greenspan N, et al. Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. J Immunol. 2005;175:8011-23 pubmed
    ..Therefore, C3d may enhance or inhibit Ag-specific humoral immune responses through both CD21-dependent and -independent mechanisms depending on the concentration and nature of the Ag-C3d complexes. ..
  57. Freamat M, Kawauchi H, Nozaki M, Sower S. Identification and cloning of a glycoprotein hormone receptor from sea lamprey, Petromyzon marinus. J Mol Endocrinol. 2006;37:135-46 pubmed
  58. Hollingsworth J, Maruoka S, Li Z, Potts E, Brass D, Garantziotis S, et al. Ambient ozone primes pulmonary innate immunity in mice. J Immunol. 2007;179:4367-75 pubmed
    ..These observations indicate that ozone exposure increases both the pulmonary and the systemic biologic response to inhaled LPS by priming the innate immune system. ..
  59. Gordon K, Blobe G. Role of transforming growth factor-beta superfamily signaling pathways in human disease. Biochim Biophys Acta. 2008;1782:197-228 pubmed publisher
    ..Ongoing studies will enable targeting of TGF-beta superfamily signaling pathways for the chemoprevention and treatment of human disease. ..
  60. Awumey E, Hill S, Diz D, Bukoski R. Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. Am J Physiol Heart Circ Physiol. 2008;294:H2363-70 pubmed publisher
  61. Croce J, McClay D. Evolution of the Wnt pathways. Methods Mol Biol. 2008;469:3-18 pubmed publisher
  62. Lee N, Haney J, Sogani J, Blobe G. Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling. FASEB J. 2009;23:3712-21 pubmed publisher
    ..Similarly, ALK-1 and CK2beta antagonized endothelial tubule formation in Matrigel. These studies support CK2beta as an important regulator of ALK-1 signaling and ALK-1-mediated functions in endothelial cells. ..
  63. Gao Y, Hubbert C, Yao T. The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem. 2010;285:11219-26 pubmed publisher
  64. Wang J, Lu J, Bond M, Chen M, Ren X, Lyerly H, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010;107:9323-8 pubmed publisher
    ..Halcinonide, fluticasone, clobetasol, and fluocinonide provide an unprecedented opportunity to develop unique clinical strategies to treat Hedgehog-dependent illnesses. ..
  65. Gurley S, Riquier Brison A, Schnermann J, Sparks M, Allen A, Haase V, et al. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011;13:469-475 pubmed publisher
    ..Thus, effectively targeting epithelial functions of the proximal tubule of the kidney should be a useful therapeutic strategy in hypertension. ..
  66. Wu J, Zhang L, Fanaroff A, Cai X, Sharma K, Brian L, et al. G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. Arterioscler Thromb Vasc Biol. 2012;32:308-16 pubmed publisher
  67. Shin J, Pan H, Zhong X. Regulation of mast cell survival and function by tuberous sclerosis complex 1. Blood. 2012;119:3306-14 pubmed publisher
    ..Together, these findings reveal that TSC1 is a critical regulator of mast cell activation and survival, suggesting the manipulation of the TSC1/2-mTOR pathway as a therapeutic strategy for mast cell-mediated diseases. ..
  68. de Ridder G, Ray R, Pizzo S. A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. Melanoma Res. 2012;22:225-35 pubmed publisher
    ..005) or after (P<0.05) tumor implantation. ..
  69. Poe J, Minard Colin V, Kountikov E, Haas K, Tedder T. A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. J Immunol. 2012;189:2318-25 pubmed publisher
    ..These findings define a new and novel c-Myc:CD19 regulatory loop that positively influences B cell transformation and lymphoma progression. ..
  70. Khatri A, Wang J, Pendergast A. Multifunctional Abl kinases in health and disease. J Cell Sci. 2016;129:9-16 pubmed publisher
  71. Rizzo N, Bejsovec A. SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila. Development. 2017;144:2248-2258 pubmed publisher
    ..We conclude that proper denticle morphogenesis requires transcriptional regulation by both SoxN and Svb. ..
  72. Shibata M, Breuer C, Kawamura A, Clark N, Rymen B, Braidwood L, et al. GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis. Development. 2018;145: pubmed publisher
    ..This study therefore uncovers a core regulatory module that fine-tunes the extent of root hair growth by the orchestrated actions of opposing transcription factors. ..
  73. Stiles G. Adenosine receptors. J Biol Chem. 1992;267:6451-4 pubmed
    ..We are likely to begin to see evidence for a whole group of adenosine receptors undetected by previous technology. One era of adenosine receptor research has just ended, and we now enter the new with anxious anticipation. ..
  74. Akhter S, Luttrell L, Rockman H, Iaccarino G, Lefkowitz R, Koch W. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science. 1998;280:574-7 pubmed
    ..The data demonstrate the role of myocardial Gq in the initiation of myocardial hypertrophy and indicate a possible strategy for preventing pathophysiological signaling by simultaneously blocking multiple receptors coupled to Gq. ..
  75. Lorenz M, Pan X, Harashima T, Cardenas M, Xue Y, Hirsch J, et al. The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics. 2000;154:609-22 pubmed
    ..In summary, our studies reveal a novel G protein-coupled receptor senses nutrients and regulates the dimorphic transition to filamentous growth via a Galpha protein-cAMP-PKA signal transduction cascade. ..
  76. Miller W, McDonald P, Cai S, Field M, Davis R, Lefkowitz R. Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. J Biol Chem. 2001;276:27770-7 pubmed
  77. Silverstone A, Jung H, Dill A, Kawaide H, Kamiya Y, Sun T. Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis. Plant Cell. 2001;13:1555-66 pubmed
    ..The effect of rga on GA4 gene expression and the effect of GA on RGA protein level allow us to identify part of the mechanism by which GA homeostasis is achieved. ..
  78. Zhu S, Goldschmidt Clermont P, Dong C. Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability. Circ Res. 2004;94:617-25 pubmed
  79. Keys J, Koch W. The adrenergic pathway and heart failure. Recent Prog Horm Res. 2004;59:13-30 pubmed
    ..Overall, genetically engineered mouse models pertaining to this critical myocardial signaling system have provided novel insight into heart function under normal conditions and during states of dysfunction and failure. ..
  80. Wu J, Goswami R, Kim L, Miller W, Peppel K, Freedman N. The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. J Biol Chem. 2005;280:31027-35 pubmed
    ..We conclude that the activated PDGFRbeta itself phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta. ..
  81. Tiruchinapalli D, Caron M, Keene J. Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. J Neurochem. 2008;107:1529-43 pubmed publisher
    ..Finally, our data suggest that HuR and HuD RBPs potentially interact directly with neuronal mRNAs important for differentiation and synaptic plasticity. ..
  82. Cui B, Johnson S, Bullock N, Ali Osman F, Bigner D, Friedman H. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol. 2009;75:1356-63 pubmed publisher
    ..This MMR-independent activation seems to be the result of DNA interstrand cross-link formation. ..
  83. Shen S, Zhu M, Lau J, Chuck M, Zhang W. The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J Immunol. 2009;182:5596-604 pubmed publisher
    ..Collectively, our data indicate that in addition to its role in pre-TCR signaling, LAT also plays an essential role in thymocyte development during transition from the double-positive to single-positive stage. ..
  84. Adigun A, Wrench N, Levin E, Seidler F, Slotkin T. Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum. Brain Res Bull. 2010;81:605-12 pubmed publisher
  85. Xie T, Liang J, Guo R, Liu N, Noble P, Jiang D. Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation. Physiol Genomics. 2011;43:479-87 pubmed publisher
    ..The miRNAs and their potential target genes identified may contribute to the understanding of the complex transcriptional program of lung fibrosis. ..
  86. Rogg L, Fortwendel J, Juvvadi P, Steinbach W. Regulation of expression, activity and localization of fungal chitin synthases. Med Mycol. 2012;50:2-17 pubmed publisher
    ..Thus, an in-depth understanding of the precise roles of each protein in cell wall maintenance and repair will be essential to identifying the most likely therapeutic targets. ..
  87. O Brien T, Gorentla B, Xie D, Srivatsan S, McLeod I, He Y, et al. Regulation of T-cell survival and mitochondrial homeostasis by TSC1. Eur J Immunol. 2011;41:3361-70 pubmed publisher
    ..Overall, our results demonstrate that TSC1 differentially regulates mTORC1 and mTORC2 activity, promotes T-cell survival, and is critical for normal mitochondrial homeostasis in T cells. ..
  88. Hunter C, Bond J, Kuo P, Selim M, Levinson H. The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity. J Surg Res. 2012;176:348-58 pubmed publisher
    ..R3 prevents OPN mediated activity. OPN may be useful for promoting closure of non-healing wounds and the OPN specific aptamer, R3, may be useful for preventing fibrosis. ..
  89. Jackson I, Zhang X, Hadley C, Rabbani Z, Zhang Y, Marks S, et al. Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. Free Radic Biol Med. 2012;53:337-46 pubmed publisher
    ..Genes identified herein could provide insight into the role of hypoxic signaling in radiation lung injury, suggesting novel therapeutic targets, as well as clues to the mechanism by which AEOL10150 confers pulmonary radioprotection. ..
  90. Fong A, Alam S, Imai T, Haribabu B, Patel D. CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. J Biol Chem. 2002;277:19418-23 pubmed
    ..Further, tyrosine sulfation may represent a general mechanism utilized by molecules that function in the rapid capture of circulating leukocytes. ..
  91. Zhao Y, Altman B, Coloff J, Herman C, Jacobs S, Wieman H, et al. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol. 2007;27:4328-39 pubmed
  92. Barske L, Capel B. Blurring the edges in vertebrate sex determination. Curr Opin Genet Dev. 2008;18:499-505 pubmed publisher
    ..This system would be highly responsive to changes in the upstream primary signal and may provide a basis for the rapid evolution of and transitions between different methods of sex determination. ..