Experts and Doctors on signal transduction in Chapel Hill, North Carolina, United States

Summary

Locale: Chapel Hill, North Carolina, United States
Topic: signal transduction

Top Publications

  1. O Bryan J, Lambert Q, Der C. The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor. J Biol Chem. 1998;273:20431-7 pubmed
    ..However, inhibition is not due to stable association with the receptor, suggesting that the SH2 domain is binding to a heretofore unknown protein(s) necessary for proper EGFR function. ..
  2. Alb J, Phillips S, Rostand K, Cui X, Pinxteren J, Cotlin L, et al. Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. Mol Biol Cell. 2002;13:739-54 pubmed
    ..We suggest that PITP beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals than that indicated by in vitro systems that show PITP dependence. ..
  3. Siler C, Raab Traub N. Rhesus lymphocryptovirus latent membrane protein 2A activates beta-catenin signaling and inhibits differentiation in epithelial cells. Virology. 2008;377:273-9 pubmed publisher
    ..These results underscore the similarity of LCV to EBV and the suitability of the macaque as an animal model for studying EBV pathogenesis...
  4. Ji J, Zheng X, Forgues M, Yamashita T, Wauthier E, Reid L, et al. Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma. Hepatology. 2015;62:829-40 pubmed publisher
    ..miR-155 is highly elevated in EpCAM(+) HCC cells and might serve as a molecular target to eradicate the EpCAM(+) CSC population in human HCCs. ..
  5. Arya R, Kedar V, Hwang J, McDonough H, Li H, Taylor J, et al. Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy. J Cell Biol. 2004;167:1147-59 pubmed
    ..These findings establish that MURF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy. ..
  6. Bogunovic M, DAVE S, Tilstra J, Chang D, Harpaz N, Xiong H, et al. Enteroendocrine cells express functional Toll-like receptors. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1770-83 pubmed
    ..Using a murine EEC model, a broad range of functional effects of TLR activation was demonstrated. This study suggests a potential role for EECs in innate immune responses. ..
  7. Weerasinghe R, Swanson S, Okada S, Garrett M, Kim S, Stacey G, et al. Touch induces ATP release in Arabidopsis roots that is modulated by the heterotrimeric G-protein complex. FEBS Lett. 2009;583:2521-6 pubmed publisher
    ..We propose that ATP acts as an extracellular signal released by mechano-stimulation and that the G-protein complex is needed for fine-tuning this response. ..
  8. Jones A, Fulcher N, Balzer G, Urbanowski M, Pritchett C, Schurr M, et al. Activation of the Pseudomonas aeruginosa AlgU regulon through mucA mutation inhibits cyclic AMP/Vfr signaling. J Bacteriol. 2010;192:5709-17 pubmed publisher
    ..These results suggest that mucoid conversion and inhibition of invasive virulence determinants may both confer a selective advantage to mucA mutant strains of P. aeruginosa in the CF lung. ..
  9. Wei Y, Kim T, Peng D, Duan D, Gibbons D, Yamauchi M, et al. Fibroblast-specific inhibition of TGF-?1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017;127:3675-3688 pubmed publisher
    ..These findings elucidate a therapeutic approach to attenuate fibrosis and the disease-promoting effects of tissue stiffness by specifically targeting T?RI kinase in LOXL2-expressing cells. ..

More Information

Publications450 found, 100 shown here

  1. Yavarone M, Shuey D, Tamir H, Sadler T, Lauder J. Serotonin and cardiac morphogenesis in the mouse embryo. Teratology. 1993;47:573-84 pubmed
    ..Dose-dependent effects of 5-HT on migration of outflow tract cells were also observed. Taken together, these results suggest that 5-HT may play a role in cardiac morphogenesis during endocardial cushion formation. ..
  2. Coffield V, Helms W, Jiang Q, Su L. Galpha13 mediates a signal that is essential for proliferation and survival of thymocyte progenitors. J Exp Med. 2004;200:1315-24 pubmed
    ..Overexpression of the antiapoptotic gene Bcl2 rescued the defect in DN3 cells and partially rescued T cell development. Therefore, Galpha13-mediated signaling is necessary in early thymocyte proliferation and survival. ..
  3. Chen Y, Yang B, Jacobson K. Transient confinement zones: a type of lipid raft?. Lipids. 2004;39:1115-9 pubmed
    ..Here we review transient confinement zones and some of their implications for membrane structure and function. ..
  4. Mainou B, Raab Traub N. LMP1 strain variants: biological and molecular properties. J Virol. 2006;80:6458-68 pubmed
    ..These findings indicate that the signature amino acid changes of the LMP1 variants do not hinder or enhance their in vitro transforming potentials or affect their signaling properties. ..
  5. Joo Y, Karrasch T, Muhlbauer M, Allard B, Narula A, Herfarth H, et al. Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS ONE. 2009;4:e4562 pubmed publisher
    ..These results indicate that TLE prevents LPS-induced proinflammatory gene expression by blocking of NF-kappaB signaling, but aggravates DSS-induced colitis by enhancing epithelial cell apoptosis. ..
  6. Bang D, Wilson W, Ryan M, Yeh J, Baldwin A. GSK-3? promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-?B. Cancer Discov. 2013;3:690-703 pubmed publisher
    ..These data identify GSK-3? as a key downstream effector of oncogenic KRAS via its ability to coordinately regulate distinct NF-?B signaling pathways. ..
  7. Peters K, Rogers S. Drosophila Ric-8 interacts with the G?12/13 subunit, Concertina, during activation of the Folded gastrulation pathway. Mol Biol Cell. 2013;24:3460-71 pubmed publisher
    ..We also use this system to conduct a structure-function analysis of Ric-8 and identify key residues required for both Cta interaction and cellular contractility. ..
  8. Lazarowski E, Shea D, Boucher R, Harden T. Release of cellular UDP-glucose as a potential extracellular signaling molecule. Mol Pharmacol. 2003;63:1190-7 pubmed
    ..Because cellular UDP-glucose is concentrated in the lumen of the endoplasmic reticulum, we speculate that UDP-glucose release may occur as a result of vesicle transport during trafficking of glycoproteins to the plasma membrane. ..
  9. Murphy G, Graham S, Morita S, Reks S, Rogers Graham K, Vojtek A, et al. Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. J Biol Chem. 2002;277:9966-75 pubmed
    ..Finally, unlike Ras, TC21 did not activate the Rac small GTPase, indicating that Ras may not activate Rac by PI3K. Taken together, these results suggest that PI3K, but not RalGDS, is an important mediator of cell proliferation by TC21. ..
  10. Ding J, Burette A, Nedvetsky P, Schmidt H, Weinberg R. Distribution of soluble guanylyl cyclase in the rat brain. J Comp Neurol. 2004;472:437-48 pubmed
    ..These data support a widespread role for the NO/sGC/cGMP pathway in the CNS and suggest that, in addition to its role as paracrine messenger, NO may also be an intracellular autocrine agent. ..
  11. Staus D, Blaker A, Taylor J, Mack C. Diaphanous 1 and 2 regulate smooth muscle cell differentiation by activating the myocardin-related transcription factors. Arterioscler Thromb Vasc Biol. 2007;27:478-86 pubmed
    ..These results indicate that RhoA-dependent signaling through mDia1/2 and the MRTFs is important for SMC-specific gene expression in SMCs. ..
  12. Li J, Niu X, Madamanchi N. Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis. J Biol Chem. 2008;283:34260-72 pubmed publisher
    ..Together, these data indicate that LAR regulates Fyn/JAK2/STAT3 and Fyn/p38 MAPK pathways involved in ROS-induced apoptosis. ..
  13. Lindsey Boltz L, Serçin O, Choi J, Sancar A. Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase. J Biol Chem. 2009;284:33107-14 pubmed publisher
    ..This in vitro system recapitulates essential components of the genetically defined ATR-signaling pathway. ..
  14. Harden T, Sesma J, Fricks I, Lazarowski E. Signalling and pharmacological properties of the P2Y receptor. Acta Physiol (Oxf). 2010;199:149-60 pubmed publisher
    ..This receptor historically was thought to be activated selectively by UDP-glucose and other UDP-sugars. However, UDP is also a very potent agonist of this receptor, and may prove to be one of its most important cognate activators. ..
  15. JHA S, Srivastava S, Brickey W, Iocca H, Toews A, Morrison J, et al. The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18. J Neurosci. 2010;30:15811-20 pubmed publisher
    ..Additionally, the therapeutic inhibition of IL-18 might decrease demyelination but enhance remyelination, which has broad implications for demyelinating diseases...
  16. Liu P, Wang X, Itano M, Neumann A, Jacobson K, Thompson N. The formation and stability of DC-SIGN microdomains require its extracellular moiety. Traffic. 2012;13:715-26 pubmed publisher
    ..By contrast, we propose that interactions between the CRD of DC-SIGN and the extracellular matrix and/or cis interactions with transmembrane scaffolding protein(s) play an essential role in organizing these microdomains. ..
  17. Rager J, Bailey K, Smeester L, Miller S, Parker J, Laine J, et al. Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen. 2014;55:196-208 pubmed publisher
    ..Results of this study highlight miRNAs as novel responders to prenatal arsenic exposure that may contribute to associated immune response perturbations. ..
  18. Miller W, Cheshire J, Raab Traub N. Interaction of tumor necrosis factor receptor-associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is essential for induction of epidermal growth factor receptor expression. Mol Cell Biol. 1998;18:2835-44 pubmed
    ..These data suggest that TRAF-mediated activation of EGFR expression requires assembly of a complex containing the appropriate stoichiometry of TRAF proteins clustered at the cell membrane with LMP1. ..
  19. Cho M, Rapacciuolo A, Koch W, Kobayashi Y, Jones L, Rockman H. Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. J Biol Chem. 1999;274:22251-6 pubmed
    ..Taken together, these data indicate that alterations in beta-adrenergic receptor signaling precede the development of overt heart failure in this mouse model of progressive cardiomyopathy. ..
  20. Coyne C, Ribeiro C, Boucher R, Johnson L. Acute mechanism of medium chain fatty acid-induced enhancement of airway epithelial permeability. J Pharmacol Exp Ther. 2003;305:440-50 pubmed
    ..These data suggest that C10 and C12 exert their acute effects on airway TJs via a Ca(2+)-independent mechanism of action and may alter junctional permeability via direct effects on the claudin family of TJ proteins. ..
  21. Abell A, Johnson G. MEKK4 is an effector of the embryonic TRAF4 for JNK activation. J Biol Chem. 2005;280:35793-6 pubmed
    ..The findings identify MEKK4 as the MAPK kinase kinase for TRAF4 regulation of the JNK pathway. ..
  22. Williams T, Brenman J. LKB1 and AMPK in cell polarity and division. Trends Cell Biol. 2008;18:193-8 pubmed publisher
    ..This review examines unanticipated AMPK functions for initiating and maintaining cell polarity and completing normal cell division. The ability of AMPK to sense energy status might be coupled with fundamental cell biological functions. ..
  23. Wang L, Damania B. Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Cancer Res. 2008;68:4640-8 pubmed publisher
    ..Collectively, these results suggest that KSHV infection of endothelial cells modulates cell signaling pathways and induces cell survival and angiogenesis, thereby contributing to the pathogenesis induced by KSHV...
  24. Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, et al. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol. 2009;184:597-609 pubmed publisher
    ..This dosage-dependent molecular switch resolves discordances among studies that examine how Bmper regulates Bmp activity and has broad implications for Bmp signal regulation by secreted mediators. ..
  25. Lee S, Chanoit G, McIntosh R, Zvara D, Xu Z. Molecular mechanism underlying Akt activation in zinc-induced cardioprotection. Am J Physiol Heart Circ Physiol. 2009;297:H569-75 pubmed publisher
    ..Taken together, these findings demonstrate that exogenous zinc activates Akt via IGF-1RTK and prevents the mPTP opening in cardiac cells. Inactivation of Ser/Thr protein phosphatases may also contribute to zinc-induced Akt activation...
  26. Dyer L, Patterson C. Development of the endothelium: an emphasis on heterogeneity. Semin Thromb Hemost. 2010;36:227-35 pubmed publisher
    ..This review details how endothelial cells arise and are directed to their specific fate, specifically targeting what differentiates endothelial populations...
  27. Serçin O, Kemp M. Characterization of functional domains in human Claspin. Cell Cycle. 2011;10:1599-606 pubmed
    ..We conclude that multiple protein-DNA and protein-protein interactions may be important for Claspin function during DNA replication and DNA replication checkpoint signaling. ..
  28. Shair K, Bendt K, Edwards R, Nielsen J, Moore D, Raab Traub N. Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model. J Virol. 2012;86:5352-65 pubmed publisher
    ..This study is the first to characterize the effects of LMP2 on tumor initiation and promotion and to identify an effect of the combined expression of LMP1 and LMP2 on the increase of carcinoma development. ..
  29. Serber D, Rogala A, Makarem M, Rosson G, Simin K, Godfrey V, et al. The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner. PLoS ONE. 2012;7:e31346 pubmed publisher
  30. Jiang K, Frick Cheng A, Trusov Y, Delgado Cerezo M, Rosenthal D, Lorek J, et al. Dissecting Arabidopsis G? signal transduction on the protein surface. Plant Physiol. 2012;159:975-83 pubmed publisher
    ..These findings provide promising new avenues to direct the finely tuned engineering of crop yield and traits. ..
  31. Crews F, Qin L, Sheedy D, Vetreno R, Zou J. High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. Biol Psychiatry. 2013;73:602-12 pubmed publisher
    ..Increased expression of HMGB1, TLR2, TLR3, and TLR4 in alcoholic brain and in mice treated with ethanol suggests that chronic alcohol-induced brain neuroimmune activation occurs through HMGB1/TLR signaling. ..
  32. Wen H, Miao E, Ting J. Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity. 2013;39:432-41 pubmed publisher
    ..This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs. ..
  33. Winchell C, Steele S, Kawula T, Voth D. Dining in: intracellular bacterial pathogen interplay with autophagy. Curr Opin Microbiol. 2016;29:9-14 pubmed publisher
    ..By understanding how intracellular pathogens manipulate autophagy, we gain insight not only into bacterial pathogenesis but also host cell signaling and autophagolysosome maturation. ..
  34. Siderovski D, Willard F. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci. 2005;1:51-66 pubmed
    ..Discovery of these novel GAP, GDI, and GEF activities have helped to illuminate a new role for Galpha subunit GDP/GTP cycling required for microtubule force generation and mitotic spindle function in chromosomal segregation. ..
  35. Lieskovska J, Ling Y, Badley Clarke J, Clemmons D. The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells. J Biol Chem. 2006;281:25041-53 pubmed
    ..Upon IGF-I stimulation, a complex assembles on SHPS-1 that contains SHP-2, c-Src, and Shc wherein Src phosphorylates Shc, a signaling step that is necessary for an optimal mitogenic response. ..
  36. Sundberg Smith L, DiMichele L, Sayers R, Mack C, Taylor J. The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. Circ Res. 2008;102:1502-11 pubmed publisher
    ..Thus, these studies indicate that modulation of the subcellular localization of serum response factor cofactors is 1 mechanism by which extracellular matrix-dependent signals may regulate phenotypic switching of smooth muscle cells. ..
  37. Sen B, Xie Z, Case N, Ma M, Rubin C, Rubin J. Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology. 2008;149:6065-75 pubmed publisher
    ..These data suggest that positive effects of exercise on both fat and bone may occur during mesenchymal lineage selection...
  38. Taylor S, Nevis K, Park H, Rogers G, Rogers S, Cook J, et al. Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels. Blood. 2010;116:3108-17 pubmed publisher
  39. Roberts D, Pronobis M, Poulton J, Waldmann J, Stephenson E, Hanna S, et al. Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol Biol Cell. 2011;22:1845-63 pubmed publisher
    ..Using these data, we suggest a new model for destruction complex action in development, which also provides new insights into functions of truncated APC proteins in cancer. ..
  40. Kendellen M, Bradford J, Lawrence C, Clark K, Baldwin A. Canonical and non-canonical NF-?B signaling promotes breast cancer tumor-initiating cells. Oncogene. 2014;33:1297-305 pubmed publisher
    ..The results suggest the use of NF-?B inhibitors for clinical therapy of certain breast cancers. ..
  41. Wells A, Xie X, Higginbotham J, Arguello A, Healey K, Blanton M, et al. Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats. Neuropsychopharmacology. 2016;41:675-85 pubmed publisher
    ..These findings suggest that hippocampal SFKs contribute to the long-term stability of cocaine-related memories that underlie contextual stimulus control over cocaine-seeking behavior. ..
  42. Solovey A, Somani A, Belcher J, Milbauer L, Vincent L, Pawlinski R, et al. A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. Am J Hematol. 2017;92:1119-1130 pubmed publisher
    ..Its presence, plus the many benefits of etanercept observed here, argue that pilot testing of TNF blockade should be considered for human sickle cell anemia, a challenging but achievable translational research goal...
  43. McCartney B, Dierick H, Kirkpatrick C, Moline M, Baas A, Peifer M, et al. Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J Cell Biol. 1999;146:1303-18 pubmed
    ..We discuss the implications of our results for Wg signaling, and suggest a role for dAPC2 as a mediator of Wg effects on the cytoskeleton. We also speculate on more general roles that APCs may play in cytoskeletal dynamics. ..
  44. Golubovskaya V, Beviglia L, Xu L, Earp H, Craven R, Cance W. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem. 2002;277:38978-87 pubmed
    ..The results of this study indicate that dual inhibition of FAK and EGFR signaling pathways can cooperatively enhance apoptosis in breast cancers. ..
  45. Gregory S, West J, Dillon P, Hilscher C, Dittmer D, Damania B. Toll-like receptor signaling controls reactivation of KSHV from latency. Proc Natl Acad Sci U S A. 2009;106:11725-30 pubmed publisher
    ..Our findings have broad implications for physiological triggers of latent viral infections, such as herpesviral reactivation and persistence in the host. ..
  46. Goldsmith J, Uronis J, Jobin C. Mu opioid signaling protects against acute murine intestinal injury in a manner involving Stat3 signaling. Am J Pathol. 2011;179:673-83 pubmed publisher
    ..Furthermore, Stat3 is required for DALDA-induced colonocyte migration. Consequently, manipulation of MOR signaling may represent a novel means to promote mucosal healing and to maintain intestinal homeostasis after intestinal injury. ..
  47. Roberts M, Tang S, Stallmann A, Dangl J, Bonardi V. Genetic requirements for signaling from an autoactive plant NB-LRR intracellular innate immune receptor. PLoS Genet. 2013;9:e1003465 pubmed publisher
    ..These data allows us to propose a genetic model that provides insight into an SA-dependent feedback regulation loop, which, surprisingly, includes ADR1-L2. ..
  48. Hassan B, Lindsey Boltz L, Kemp M, Sancar A. Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response. J Biol Chem. 2013;288:18903-10 pubmed publisher
    ..Overall, our results indicate that, like TopBP1, Treslin is a dual replication/checkpoint protein that directly participates in ATR-mediated checkpoint signaling. ..
  49. Cavallo R, Cox R, Moline M, Roose J, Polevoy G, Clevers H, et al. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 1998;395:604-8 pubmed
    ..Finally, mutations in the Drosophila groucho gene also suppress wingless and armadillo mutant phenotypes as Groucho physically interacts with dTcf and is required for its full repressor activity. ..
  50. Cox R, Pai L, Kirkpatrick C, Stein J, Peifer M. Roles of the C terminus of Armadillo in Wingless signaling in Drosophila. Genetics. 1999;153:319-32 pubmed
    ..These data suggest that the C-terminal domain plays a complex role in Wingless signaling and that Armadillo recruits the transcriptional machinery via multiple contact sites, which act in an additive fashion. ..
  51. Kimple R, Willard F, Siderovski D. The GoLoco motif: heralding a new tango between G protein signaling and cell division. Mol Interv. 2002;2:88-100 pubmed
    ..Such peptides could be exploited to help dissect the signals that underpin cell polarity and cell division processes. ..
  52. Chasse S, Flanary P, Parnell S, Hao N, Cha J, Siderovski D, et al. Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryot Cell. 2006;5:330-46 pubmed
    ..These findings suggest that Sst2 is the principal regulator of Gpa1-mediated signaling in vivo but that other proteins also contribute in distinct ways to pathway regulation. ..
  53. Bai F, Pei X, Pandolfi P, Xiong Y. p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Mol Cell Biol. 2006;26:4564-76 pubmed
    ..We suggest that p18 and Pten cooperate in tumor suppression by constraining a positive regulatory loop between cell growth and cell cycle control pathways. ..
  54. Hua X, Kovarova M, Chason K, Nguyen M, Koller B, Tilley S. Enhanced mast cell activation in mice deficient in the A2b adenosine receptor. J Exp Med. 2007;204:117-28 pubmed
  55. Bankaitis V, Vincent P, Merkulova M, Tyeryar K, Liu Y. Phosphatidylinositol transfer proteins and functional specification of lipid signaling pools. Adv Enzyme Regul. 2007;47:27-40 pubmed
  56. Lee M, Dohlman H. Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol. 2008;18:211-5 pubmed publisher
    ..Our data suggest that intracellular proteins function in cooperation with mating pheromones to amplify G protein signaling, thereby leading to full pathway activation. ..
  57. Itahana K, Zhang Y. Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell. 2008;13:542-53 pubmed publisher
    ..These findings provide a potential explanation for the frequent human cancer mutations targeting the ARF C terminus. ..
  58. Mathes W, Nehrenberg D, Gordon R, Hua K, Garland T, Pomp D. Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity. Behav Brain Res. 2010;210:155-63 pubmed publisher
  59. Xiong Q, Ancona N, Hauser E, Mukherjee S, Furey T. Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets. Genome Res. 2012;22:386-97 pubmed publisher
    ..These demonstrate that GSAA can help uncover biological pathways underlying human diseases and complex traits. ..
  60. Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, et al. Wnt1/?catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 2012;31:429-42 pubmed publisher
    ..These findings reveal that a pro-fibrotic Wnt1/?catenin injury response is critically required for preserving cardiac function after acute ischaemic cardiac injury. ..
  61. Zhang C, Wendel A, Keogh M, Harris T, Chen J, Coleman R. Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proc Natl Acad Sci U S A. 2012;109:1667-72 pubmed publisher
    ..These data demonstrate a critical link between nutrient excess, TAG synthesis, and hepatic insulin resistance. ..
  62. Reeves P, Ellis C, Ploense S, Wu M, Yadav V, Tholl D, et al. A regulatory network for coordinated flower maturation. PLoS Genet. 2012;8:e1002506 pubmed publisher
    ..These dynamic feedbacks may promote timely, coordinated, and transient growth of flower organs. ..
  63. Rager J, Fry R. The aryl hydrocarbon receptor pathway: a key component of the microRNA-mediated AML signalisome. Int J Environ Res Public Health. 2012;9:1939-53 pubmed publisher
    ..These findings provide important insight into miRNA-regulated pathways in leukemia, and may help to prioritize targets for disease prevention and treatment. ..
  64. Fotheringham J, Coalson N, Raab Traub N. Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through ?v-integrin membrane translocation. J Virol. 2012;86:10308-20 pubmed publisher
    ..The specific effects of LMP2A on an integrin with a diverse repertoire of ligand specificities could promote migration of different cell types and be initiated by multiple chemoattractants. ..
  65. Hoopes S, Willcockson H, Caron K. Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice. PLoS ONE. 2012;7:e45261 pubmed publisher
    ..Collectively, these studies reveal a spectrum of lymphatic defects in adult Calcrl(fl/fl)/CAGGCre-ER™ mice that closely recapitulate the clinical symptoms of patients with corneal, intestinal and peripheral lymphangiectasia. ..
  66. Divaris K, Monda K, North K, Olshan A, Reynolds L, Hsueh W, et al. Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Hum Mol Genet. 2013;22:2312-24 pubmed publisher
    ..These genome-wide association results provide information on multiple candidate regions and pathways for interrogation in future genetic studies of CP. ..
  67. Sen B, Xie Z, Case N, Thompson W, Uzer G, Styner M, et al. mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow-derived mesenchymal stem cells. J Bone Miner Res. 2014;29:78-89 pubmed publisher
    ..As such, mechanical activation of mTORC2 signaling participates in mesenchymal stem cell lineage selection, preventing adipogenesis by preserving ?-catenin and stimulating osteogenesis by generating a stiffer cytoskeleton. ..
  68. Nile A, Tripathi A, Yuan P, Mousley C, Suresh S, Wallace I, et al. PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nat Chem Biol. 2014;10:76-84 pubmed publisher
  69. Wood S, Long D, Reisz J, Yammani R, Burke E, Klomsiri C, et al. Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments. Arthritis Rheumatol. 2016;68:117-26 pubmed publisher
  70. Oladapo H, Tarpley M, Sauer S, Addo K, Ingram S, Strepay D, et al. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017;411:136-149 pubmed publisher
    ..Our results indicated that GLI1 activation in TN-IBC as in TNBC, plays a vital role in promoting cell proliferation, motility, tumor growth, and formation of tumor emboli. ..
  71. Yin H, Hu M, Liang X, Ajmo J, Li X, Bataller R, et al. Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology. 2014;146:801-11 pubmed publisher
    ..We compared mice with liver-specific deletion of Sirt1 (Sirt1LKO) mice with their LOX littermates (controls)...
  72. Houck S, Ren H, Madden V, Bonner J, Conlin M, Janovick J, et al. Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR. Mol Cell. 2014;54:166-179 pubmed publisher
    ..Interaction between ER-associated Hsp40s and the Vps34 complex permits the selective degradation of ERAD-resistant membrane proteins via ERQC autophagy. ..
  73. Lazarowski E, Boucher R, Harden T. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol. 2003;64:785-95 pubmed
  74. Tchivilev I, Madamanchi N, Vendrov A, Niu X, Runge M. Identification of a protective role for protein phosphatase 1cgamma1 against oxidative stress-induced vascular smooth muscle cell apoptosis. J Biol Chem. 2008;283:22193-205 pubmed publisher
    ..Together, these data indicate that PP1cgamma1 overexpression promotes VSMC survival by interfering with JNK1 and p53 phosphorylation cascades involved in apoptosis. ..
  75. Gris P, Cheng P, Pierson J, Maixner W, Diatchenko L. Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR). Methods Mol Biol. 2010;617:421-35 pubmed publisher
    ..In this review, we describe the methodologies used to assay key mediators of MOR activation including cellular assays for cAMP, free Ca(2+), and NO, all of which have been implicated in the pharmacological effects of MOR agonists. ..
  76. Zhang W, To J, Cheng C, Schaller G, Kieber J. Type-A response regulators are required for proper root apical meristem function through post-transcriptional regulation of PIN auxin efflux carriers. Plant J. 2011;68:1-10 pubmed publisher
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