Experts and Doctors on plant gene expression regulation in Chapel Hill, North Carolina, United States


Locale: Chapel Hill, North Carolina, United States
Topic: plant gene expression regulation

Top Publications

  1. Dietrich R, Richberg M, Schmidt R, Dean C, Dangl J. A novel zinc finger protein is encoded by the Arabidopsis LSD1 gene and functions as a negative regulator of plant cell death. Cell. 1997;88:685-94 pubmed
    ..We propose that LSD1 regulates transcription, via either repression of a prodeath pathway or activation of an antideath pathway, in response to signals emanating from cells undergoing pathogen-induced hypersensitive cell death. ..
  2. Mudgil Y, Uhrig J, Zhou J, Temple B, Jiang K, Jones A. Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin transport in a G protein-mediated pathway. Plant Cell. 2009;21:3591-609 pubmed publisher
    ..AGB1, auxin, and sugars are required for NDL1 protein stability in regions of the root where auxin gradients are established; thus, the signaling mechanism contains feedback loops. ..
  3. Xu S, Rahman A, Baskin T, Kieber J. Two leucine-rich repeat receptor kinases mediate signaling, linking cell wall biosynthesis and ACC synthase in Arabidopsis. Plant Cell. 2008;20:3065-79 pubmed publisher
    ..Furthermore, the FEI proteins interact directly with ACC synthase. These results suggest that the FEI proteins define a novel signaling pathway that regulates cell wall function, likely via an ACC-mediated signal. ..
  4. Francis K, Lam S, Copenhaver G. Separation of Arabidopsis pollen tetrads is regulated by QUARTET1, a pectin methylesterase gene. Plant Physiol. 2006;142:1004-13 pubmed
    ..The identification of QRT1 as a PME contributes to our understanding of pollen development and may help to provide valuable genetic tools in other plant species. ..
  5. Chen Z, Noir S, Kwaaitaal M, Hartmann H, Wu M, Mudgil Y, et al. Two seven-transmembrane domain MILDEW RESISTANCE LOCUS O proteins cofunction in Arabidopsis root thigmomorphogenesis. Plant Cell. 2009;21:1972-91 pubmed publisher
    ..These results demonstrate that the exaggerated root curling phenotypes of the mlo4 and mlo11 mutants depend on auxin gradients and suggest that MLO4 and MLO11 cofunction as modulators of touch-induced root tropism. ..
  6. Ploense S, Wu M, Nagpal P, Reed J. A gain-of-function mutation in IAA18 alters Arabidopsis embryonic apical patterning. Development. 2009;136:1509-17 pubmed publisher
    ..These results indicate that apical patterning requires Aux/IAA protein turnover, and that apical domain auxin response also influences root formation. ..
  7. Siefers N, Dang K, Kumimoto R, Bynum W, Tayrose G, Holt B. Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity. Plant Physiol. 2009;149:625-41 pubmed publisher
    ..The results are discussed with a special emphasis on potential roles for NF-Y subunits in photoperiod-controlled flowering time. ..
  8. Chen Z, Hartmann H, Wu M, Friedman E, Chen J, Pulley M, et al. Expression analysis of the AtMLO gene family encoding plant-specific seven-transmembrane domain proteins. Plant Mol Biol. 2006;60:583-97 pubmed
  9. Ellis C, Nagpal P, Young J, Hagen G, Guilfoyle T, Reed J. AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana. Development. 2005;132:4563-74 pubmed
    ..NPH4/ARF7 and ARF19 function as transcriptional activators, suggesting that auxin may control senescence in part by activating gene expression. ..

More Information


  1. Kawasaki T, Nam J, Boyes D, Holt B, Hubert D, Wiig A, et al. A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response. Plant J. 2005;44:258-70 pubmed
    ..Thus, the RIN2/RIN3 RING E3 ligases apparently act on a substrate that regulates RPM1- and RPS2-dependent HR. ..
  2. Jones A, Im K, Savka M, Wu M, DeWitt N, Shillito R, et al. Auxin-dependent cell expansion mediated by overexpressed auxin-binding protein 1. Science. 1998;282:1114-7 pubmed
    ..Similarly, constitutive expression of maize ABP1 in maize cell lines conferred on them the capacity to respond to auxin by increasing cell size. These results support a role of ABP1 as an auxin receptor controlling plant growth. ..
  3. Wu M, Tian Q, Reed J. Arabidopsis microRNA167 controls patterns of ARF6 and ARF8 expression, and regulates both female and male reproduction. Development. 2006;133:4211-8 pubmed
    ..The essential patterning function of miR167 contrasts with cases from animals in which miRNAs reinforce or maintain transcriptionally established gene expression patterns. ..
  4. To J, Deruère J, Maxwell B, Morris V, Hutchison C, Ferreira F, et al. Cytokinin regulates type-A Arabidopsis Response Regulator activity and protein stability via two-component phosphorelay. Plant Cell. 2007;19:3901-14 pubmed
    ..These studies shed light on the mechanism by which type-A ARRs act to negatively regulate cytokinin signaling and reveal a novel mechanism by which cytokinin controls type-A ARR function. ..
  5. Lewis M, Leslie M, Fulcher E, Darnielle L, Healy P, Youn J, et al. The SERK1 receptor-like kinase regulates organ separation in Arabidopsis flowers. Plant J. 2010;62:817-28 pubmed publisher
    ..Our studies indicate that in addition to its previously characterized roles in stamen development and brassinosteroid perception, SERK1 plays a unique role in modulating the loss of cell adhesion that occurs during organ abscission. ..
  6. Nagpal P, Ellis C, Weber H, Ploense S, Barkawi L, Guilfoyle T, et al. Auxin response factors ARF6 and ARF8 promote jasmonic acid production and flower maturation. Development. 2005;132:4107-18 pubmed
  7. Tian Q, Nagpal P, Reed J. Regulation of Arabidopsis SHY2/IAA3 protein turnover. Plant J. 2003;36:643-51 pubmed
    ..The chemical juglone (5-hydroxy-1,4-naphthoquinone) inhibited the interaction, suggesting that peptidyl-prolyl isomerization may mediate auxin-induced SHY2/IAA3 protein turnover. ..
  8. Eitas T, NIMCHUK Z, Dangl J. Arabidopsis TAO1 is a TIR-NB-LRR protein that contributes to disease resistance induced by the Pseudomonas syringae effector AvrB. Proc Natl Acad Sci U S A. 2008;105:6475-80 pubmed publisher
    ..AvrB activates both RPM1, a CC-NB-LRR protein, and TAO1, a TIR-NB-LRR protein. These NB-LRR proteins then act additively to generate a full disease resistance response to P. syringae expressing this type III effector. ..
  9. Berchowitz L, Francis K, Bey A, Copenhaver G. The role of AtMUS81 in interference-insensitive crossovers in A. thaliana. PLoS Genet. 2007;3:e132 pubmed
    ..These data are consistent with the hypothesis that AtMUS81 is involved in a secondary subset of meiotic crossovers that are interference insensitive. ..
  10. Desveaux D, Singer A, Wu A, McNulty B, Musselwhite L, Nimchuk Z, et al. Type III effector activation via nucleotide binding, phosphorylation, and host target interaction. PLoS Pathog. 2007;3:e48 pubmed publisher
    ..Our data suggest that activated AvrB, bound to RIN4, is indirectly recognized by RPM1 to initiate plant immune system function...
  11. McDowell J, An Y, Huang S, McKinney E, Meagher R. The arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli. Plant Physiol. 1996;111:699-711 pubmed
    ..The ACT7 promoter sequence contains a remarkable number of motifs with sequence similarity to putative phytohormone response elements. ..
  12. Rashotte A, Mason M, Hutchison C, Ferreira F, Schaller G, Kieber J. A subset of Arabidopsis AP2 transcription factors mediates cytokinin responses in concert with a two-component pathway. Proc Natl Acad Sci U S A. 2006;103:11081-5 pubmed
    ..Thus, the evolutionarily ancient two-component system that is used by cytokinin branches to incorporate a unique family of plant-specific transcription factors. ..
  13. Wilmoth J, Wang S, Tiwari S, Joshi A, Hagen G, Guilfoyle T, et al. NPH4/ARF7 and ARF19 promote leaf expansion and auxin-induced lateral root formation. Plant J. 2005;43:118-30 pubmed
    ..Auxin induces the ARF19 gene, and NPH4/ARF7 and ARF19 together are required for expression of one of the arf19 mutant alleles, suggesting that a positive feedback loop regulates leaf expansion and/or lateral root induction. ..
  14. Grigston J, Osuna D, Scheible W, Liu C, Stitt M, Jones A. D-Glucose sensing by a plasma membrane regulator of G signaling protein, AtRGS1. FEBS Lett. 2008;582:3577-84 pubmed publisher
    ..This interaction between AtRGS1 and AtGPA1 involves, in part, the seven-transmembrane domain of AtRGS1. ..
  15. Hansen M, Chae H, Kieber J. Regulation of ACS protein stability by cytokinin and brassinosteroid. Plant J. 2009;57:606-14 pubmed publisher
    ..These data suggest that ACS is regulated by phytohormones through regulatory inputs that probably act together to continuously adjust ethylene biosynthesis in various tissues and in response to various environmental conditions. ..
  16. Ullah H, Chen J, Temple B, Boyes D, Alonso J, Davis K, et al. The beta-subunit of the Arabidopsis G protein negatively regulates auxin-induced cell division and affects multiple developmental processes. Plant Cell. 2003;15:393-409 pubmed
    ..These results suggest that although auxin-regulated cell division is not coupled directly by a G protein, the Gbeta-subunit attenuates this auxin pathway upstream of the control of mRNA steady state levels. ..
  17. Mackey D, Holt B, Wiig A, Dangl J. RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Cell. 2002;108:743-54 pubmed
    ..This may enhance RIN4 activity as a negative regulator of plant defense, facilitating pathogen growth. RPM1 may "guard" against pathogens that use AvrRpm1 and AvrB to manipulate RIN4 activity...
  18. Desveaux D, Mar chal A, Brisson N. Whirly transcription factors: defense gene regulation and beyond. Trends Plant Sci. 2005;10:95-102 pubmed publisher
    ..There is evidence to suggest that Whirly proteins might play roles in processes other than defense responses and could function in the chloroplast as well as in the nucleus...
  19. Eulgem T, Weigman V, Chang H, McDowell J, Holub E, Glazebrook J, et al. Gene expression signatures from three genetically separable resistance gene signaling pathways for downy mildew resistance. Plant Physiol. 2004;135:1129-44 pubmed
    ..Previously defined and novel sequence motifs were found to be enriched in the promoters of genes coregulated by the local defense-signaling network. These putative promoter elements may operate downstream from signal convergence points...