Experts and Doctors on osteoblasts in Durham, North Carolina, United States


Locale: Durham, North Carolina, United States
Topic: osteoblasts

Top Publications

  1. Gesty Palmer D, Yuan L, Martin B, Wood W, Lee M, Janech M, et al. β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo. Mol Endocrinol. 2013;27:296-314 pubmed publisher
  2. Datto M, Wang X. Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. Cell. 2005;121:2-4 pubmed
    ..The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005). ..
  3. Quarles L, Hartle J, Siddhanti S, Guo R, Hinson T. A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor. J Bone Miner Res. 1997;12:393-402 pubmed
    ..These findings suggest that an extra-cellular cation-sensing mechanism is present in murine-derived osteoblasts that is functionally similar to but molecularly distinct from CaR. ..
  4. Pi M, Quarles L. A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium. J Bone Miner Res. 2004;19:862-9 pubmed
    ..These findings are consistent with strontium activation of a novel Galphaq-coupled extracellular cation-sensing receptor in osteoblasts with distinct cation specificity. ..
  5. Xiao Z, Crenshaw M, Guo R, Nesbitt T, Drezner M, Quarles L. Intrinsic mineralization defect in Hyp mouse osteoblasts. Am J Physiol. 1998;275:E700-8 pubmed
    ..Our findings indicate that abnormal PEX in osteoblasts is associated with the accumulation of a factor(s) that inhibits mineralization of extracellular matrix in vitro. ..
  6. DuSell C, Nelson E, Wang X, Abdo J, Mödder U, Umetani M, et al. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology. 2010;151:3675-85 pubmed publisher
    ..More studies are warranted to fully elucidate the mechanism of action of 27HC in bone and to identify ways to modulate this pathway therapeutically. ..
  7. Lin F, Chang J, McGuire M, Yee J, Brigman B. Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro. J Orthop Res. 2010;28:958-64 pubmed publisher
  8. Pi M, Garner S, Flannery P, Spurney R, Quarles L. Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem. 2000;275:3256-63 pubmed
    ..The presence of a cation-sensing response in osteoblasts from CasR(-/-) mice indicates the existence of a novel osteoblastic extracellular cation-sensing mechanism. ..
  9. Liu S, Guo R, Quarles L. Cloning and characterization of the proximal murine Phex promoter. Endocrinology. 2001;142:3987-95 pubmed
    ..Our findings are consistent with the predominant expression of Phex in bone and cartilage. Additional studies will be needed to confirm the regulatory regions in the Phex promoter that function in a cell-restricted manner. ..

More Information


  1. Tu Q, Pi M, Quarles L. Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism. J Bone Miner Res. 2003;18:1825-33 pubmed
    ..These results implicate calcyclin in the activation of SRE and establish a role for calcyclin as an accessory protein involved in the cation-sensing pathway in osteoblasts. ..
  2. Hjelmeland A, Schilling S, Guo X, Quarles D, Wang X. Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. Mol Cell Biol. 2005;25:9460-8 pubmed
    ..These data support the presence of a novel mechanism for controlling cell fate determination of mesenchymal lineages by preventing differentiation toward the osteoblastic lineage via negative regulation of Runx2 activity. ..
  3. Liu Z, Ren Y, Mirando A, Wang C, Zuscik M, O Keefe R, et al. Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. Osteoarthritis Cartilage. 2016;24:740-51 pubmed publisher
    ..RBPjκ-dependent Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. ..
  4. Im O, Li J, Wang M, Zhang L, Keidar M. Biomimetic three-dimensional nanocrystalline hydroxyapatite and magnetically synthesized single-walled carbon nanotube chitosan nanocomposite for bone regeneration. Int J Nanomedicine. 2012;7:2087-99 pubmed publisher
    ..Both nanocrystalline hydroxyapatite and SWCNT have a biomimetic nanostructure, excellent osteoconductivity, and high potential to improve the load-bearing capacity of hydrogels...
  5. Liu S, Guo R, Simpson L, Xiao Z, Burnham C, Quarles L. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem. 2003;278:37419-26 pubmed
  6. Liu S, Guo R, Tu Q, Quarles L. Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype. J Biol Chem. 2002;277:3686-97 pubmed
  7. Nelson E, DuSell C, Wang X, Howe M, Evans G, Michalek R, et al. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 2011;152:4691-705 pubmed publisher
  8. Singh S, Holdway J, Poss K. Regeneration of amputated zebrafish fin rays from de novo osteoblasts. Dev Cell. 2012;22:879-86 pubmed publisher
    ..Our findings demonstrate diversity in the cellular origins of appendage bone and reveal that de novo osteoblasts can fully support the regeneration of amputated zebrafish fins. ..
  9. Wang X, Liao S, Nelson E, Schmalzigaug R, Spurney R, Guilak F, et al. The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. Biochem Biophys Res Commun. 2012;425:407-12 pubmed publisher
  10. Borton A, Frederick J, Datto M, Wang X, Weinstein R. The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. J Bone Miner Res. 2001;16:1754-64 pubmed
    ..Together these data support a model that a loss of Smad3 increases the osteocyte fate of the osteoblast and decreases the duration of osteoblast function by shortening lifespan, ultimately resulting in osteopenia. ..
  11. Gray R, Wilm T, Smith J, Bagnat M, Dale R, Topczewski J, et al. Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. Dev Biol. 2014;386:72-85 pubmed publisher
    ..Our results afford a novel mechanism for the formation of VM, independent of defects of somitogenesis, resulting from aberrant bone deposition at regions of misshapen notochord tissue. ..
  12. Xiao Z, Thomas R, Hinson T, Quarles L. Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. Gene. 1998;214:187-97 pubmed
    ..Thus, the alternative use of transcription start sites and splicing leads to the genesis of CBFA1/Cbfa1 isoforms with possible differences in transactivation potentials. ..
  13. Nachtrab G, Kikuchi K, Tornini V, Poss K. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development. 2013;140:3754-64 pubmed publisher
    ..These findings have implications for mechanisms of positional memory in vertebrate tissues. ..