Experts and Doctors on multiprotein complexes in Chapel Hill, North Carolina, United States


Locale: Chapel Hill, North Carolina, United States
Topic: multiprotein complexes

Top Publications

  1. Kishton R, Barnes C, Nichols A, Cohen S, Gerriets V, Siska P, et al. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metab. 2016;23:649-62 pubmed publisher
    ..Thus, AMPK simultaneously inhibits anabolic growth signaling and is essential to promote mitochondrial pathways that mitigate metabolic stress and apoptosis in T-ALL. ..
  2. Lawrimore J, Aicher J, Hahn P, Fulp A, Kompa B, Vicci L, et al. ChromoShake: a chromosome dynamics simulator reveals that chromatin loops stiffen centromeric chromatin. Mol Biol Cell. 2016;27:153-66 pubmed publisher
    ..The consequences of radial loops and cohesin and condensin binding are to stiffen the DNA along the spindle axis, imparting an active function to the centromere in mitosis. ..
  3. Bergstralh D, Conti B, Moore C, Brickey W, Taxman D, Ting J. Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription. Exp Cell Res. 2007;313:65-76 pubmed
    ..These results demonstrate multi-faceted functions of NPM that can affect cancer cells. ..
  4. Kaur P, Wu D, Lin J, Countryman P, Bradford K, Erie D, et al. Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2. Sci Rep. 2016;6:20513 pubmed publisher
    ..Revealing DNA paths in TRF2 complexes provides new mechanistic insights into structure-function relationships underlying telomere maintenance pathways. ..
  5. Gentry L, Martin T, Der C. Mechanisms of targeted therapy resistance take a de-TOR. Cancer Cell. 2013;24:284-6 pubmed publisher
    ..Two recent studies identify mTOR activation as a point of convergence of mechanisms that cause resistance to inhibitors of the Raf-MEK-ERK and PI3K signaling. ..
  6. Duncan M, Peifer M. Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from crumblin' aPart. J Cell Biol. 2008;183:971-4 pubmed publisher
    ..2008. J. Cell. Biol. 183:1129-1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins. ..
  7. Weerasinghe R, Swanson S, Okada S, Garrett M, Kim S, Stacey G, et al. Touch induces ATP release in Arabidopsis roots that is modulated by the heterotrimeric G-protein complex. FEBS Lett. 2009;583:2521-6 pubmed publisher
    ..We propose that ATP acts as an extracellular signal released by mechano-stimulation and that the G-protein complex is needed for fine-tuning this response. ..
  8. Nakamura K, Uhlik M, Johnson N, Hahn K, Johnson G. PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol Cell Biol. 2006;26:2065-79 pubmed
    ..The MEK5 PB1 domain confers stringent MAP3K regulation of ERK5 relative to more promiscuous MAP3K control of ERK1/2, JNK, and p38. ..
  9. Pazy Y, Motaleb M, Guarnieri M, Charon N, Zhao R, Silversmith R. Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate. Proc Natl Acad Sci U S A. 2010;107:1924-9 pubmed publisher
    ..Thus, evolution has found two structural solutions to achieve the same catalytic mechanism through different helical spacing and side chain lengths of the conserved acid/amide residues in CheX and CheZ. ..

More Information


  1. Campbell R, Overmyer K, Selzman C, Sheridan B, Wolberg A. Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability. Blood. 2009;114:4886-96 pubmed publisher
    ..Together, these findings indicate fibrin structure and stability reflect the procoagulant phenotype of the endogenous cells, and suggest abnormal fibrin structure is a novel link between inflammation and thrombosis. ..
  2. Bai S, Wilson E. Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor. Mol Cell Biol. 2008;28:1947-63 pubmed publisher
    ..Sequence conservation of the MAGE-11 phosphorylation and ubiquitinylation sites throughout the MAGE gene family suggests common regulatory mechanisms for this group of cancer-testis antigens. ..
  3. Su S, Blackwelder A, Grossman G, Minges J, Yuan L, Young S, et al. Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. J Biol Chem. 2012;287:34809-24 pubmed publisher
    ..We conclude that the coregulator function of MAGE-11 extends to isoform-specific regulation of PR-B during the cyclic development of the human endometrium. ..
  4. Compton S, Ozgur S, Griffith J. Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy. J Biol Chem. 2010;285:13349-56 pubmed publisher
    ..This work provides the first EM visualization of BCDX2 and CX3 binding to Holliday junctions and forked DNAs and suggests the complexes form ring-shaped structures. ..
  5. Wang Z, Widgren E, Sivashanmugam P, O Rand M, Richardson R. Association of eppin with semenogelin on human spermatozoa. Biol Reprod. 2005;72:1064-70 pubmed
  6. Kumar R, Whitehurst C, Pagano J. The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity. J Virol. 2014;88:6411-22 pubmed publisher
    ..Our findings demonstrate that EBV can co-opt Rad18 as a novel accessory factor in the production of infectious virus. ..
  7. Griffin C, Trejo J, Magnuson T. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005;102:15173-7 pubmed
    ..Moreover, we find that mammalian retromer complexes containing SNX1 and SNX2 have an essential role in embryonic development that is independent of cation-independent mannose 6-phosphate receptor trafficking. ..
  8. Dial J, Petrotchenko E, Borchers C. Inhibition of APCCdh1 activity by Cdh1/Acm1/Bmh1 ternary complex formation. J Biol Chem. 2007;282:5237-48 pubmed
    ..Taken together, our results suggest an additional inactivation mechanism exists for APC(Cdh1) that is independent of Cdh1 phosphorylation. ..
  9. Sullivan K, Steiniger M, Marzluff W. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Mol Cell. 2009;34:322-32 pubmed publisher
    ..These results suggest that a common core cleavage factor is required for processing of histone and polyadenylated pre-mRNAs. ..
  10. Tang R, Zheng X, Callis T, Stansfield W, He J, Baldwin A, et al. Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression. Proc Natl Acad Sci U S A. 2008;105:3362-7 pubmed publisher
  11. Wang H, Wang L, Erdjument Bromage H, Vidal M, Tempst P, Jones R, et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature. 2004;431:873-8 pubmed
    ..Thus, our studies identify the H2A ubiquitin ligase, and link H2A ubiquitination to Polycomb silencing. ..
  12. Gates J, Peifer M. Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions. Cell. 2005;123:769-72 pubmed
    ..In this issue of Cell, the Weis and Nelson groups call this static model into question, showing that alpha-catenin can directly regulate actin dynamics (Drees et al., 2005 and Yamada et al., 2005). ..
  13. Matera A, Wang Z. A day in the life of the spliceosome. Nat Rev Mol Cell Biol. 2014;15:108-21 pubmed publisher
    ..This assembly process can also affect the regulation of alternative splicing and has implications for human disease. ..
  14. Stephens A, Snider C, Haase J, Haggerty R, Vasquez P, Forest M, et al. Individual pericentromeres display coordinated motion and stretching in the yeast spindle. J Cell Biol. 2013;203:407-16 pubmed publisher
    ..Linking of pericentric chromatin through cohesin, condensin, and kinetochore microtubules functions to coordinate dynamics across multiple attachment sites. ..
  15. Romes E, Tripathy A, Slep K. Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction. J Biol Chem. 2012;287:15862-73 pubmed publisher
    ..Our data highlight the determinants that mediate oligomerization of the Nup82 complex and promote a directed, elongated cytoplasmic fibril architecture. ..
  16. Roberts D, Pronobis M, Alexandre K, Rogers G, Poulton J, Schneider D, et al. Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. PLoS ONE. 2012;7:e31284 pubmed publisher
    ..We use these data to refine our model for how Wnt signaling is regulated during normal development. ..
  17. Giguère P, Laroche G, Oestreich E, Siderovski D. G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with G? and G?i protein subunits. J Biol Chem. 2012;287:4863-74 pubmed publisher
    ..Discovery of a G?/GPSM3 interaction, independent of G?·GDP and G? involvement, adds to the combinatorial complexity of the role of GPSM3 in heterotrimeric G-protein regulation. ..
  18. Lindström M, Zhang Y. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. J Biol Chem. 2008;283:15568-76 pubmed publisher
    ..Our results suggest that B23 selectively stores, and protects ribosomal protein S9 in nucleoli and therefore could facilitate ribosome biogenesis. ..
  19. Banerjee S, Blauth K, Peters K, Rogers S, Fanning A, Bhat M. Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance. J Neurosci. 2010;30:5653-67 pubmed publisher
    ..Together, our studies establish that Nrx IV is essential for proper Robo localization and identify Nrx IV as a novel interacting partner of the Slit/Robo signaling pathway. ..
  20. Van Itallie C, Mitic L, Anderson J. Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. J Biol Chem. 2011;286:3442-50 pubmed publisher
    ..Our results suggest that BN-PAGE may be a useful tool in understanding tight junction structure. ..
  21. Stephens A, Haase J, Vicci L, Taylor R, Bloom K. Cohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring. J Cell Biol. 2011;193:1167-80 pubmed publisher
    ..Together with the intramolecular centromere loop, these SMC complexes constitute a molecular spring that balances spindle microtubule force in metaphase. ..
  22. Kapur P, Peña Llopis S, Christie A, Zhrebker L, Pavía Jiménez A, Rathmell W, et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation. Lancet Oncol. 2013;14:159-167 pubmed publisher
    ..The existence of different molecular subtypes with disparate outcomes should be considered in the design and assessment of clinical studies. Cancer Prevention and Research Institution of Texas and National Cancer Institute. ..
  23. Lei Y, Wen H, Yu Y, Taxman D, Zhang L, Widman D, et al. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity. 2012;36:933-46 pubmed publisher
    ..This study establishes a link between an NLR protein and the viral-induced autophagic machinery via an intermediary partner, TUFM. ..
  24. Garcia Mata R, Boulter E, Burridge K. The 'invisible hand': regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol. 2011;12:493-504 pubmed publisher
    ..The same metaphor can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the RHO GTPase cycle. ..
  25. Li Z, Pei X, Yan J, Yan F, Cappell K, Whitehurst A, et al. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell. 2014;54:805-19 pubmed publisher
    ..We propose a 3M-CUL9-survivin pathway in maintaining microtubule and genome integrity, normal development, and tumor suppression. ..
  26. Guo X, Snider W, Chen B. GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. elife. 2016;5:e11903 pubmed publisher
    ..Constitutive activation of eIF2Bε is sufficient to promote axon regeneration. Our results reveal a key role of the AKT-GSK3β-eIF2Bε signaling module in regulating axon regeneration in the adult mammalian CNS. ..
  27. Martin T, Chen X, Kaplan R, Saltiel A, Walker C, Reiner D, et al. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014;53:209-20 pubmed publisher
    ..Finally, RalGAP suppression caused mTORC1-dependent pancreatic tumor cell invasion. Our findings identify an unexpected crosstalk and integration of the Ral and mTOR signaling networks...
  28. Ercan S, Lieb J. C. elegans dosage compensation: a window into mechanisms of domain-scale gene regulation. Chromosome Res. 2009;17:215-27 pubmed publisher
    ..We discuss how condensin-like complexes may be targeted to specific chromosomal locations for performance of their functions. ..
  29. Bultman S, Gebuhr T, Magnuson T. A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005;19:2849-61 pubmed
    ..Not only does this mutation establish a role for Brg1 during organogenesis, it also demonstrates that ATPase activity can be uncoupled from chromatin remodeling. ..
  30. Xi G, Shen X, Clemmons D. p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation. J Biol Chem. 2010;285:6937-51 pubmed publisher
    ..These findings demonstrate that p66(shc) utilizes a novel mechanism for modulating Src kinase activation and that this interaction is mediated through both its collagen homologous region 2 and Src homology 2 domains. ..
  31. Arat N, Griffith J. Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere. J Biol Chem. 2012;287:41583-94 pubmed publisher
    ..Moreover, the TRF2-Rap1 complex has higher ability to re-model telomeric DNA than either component alone. This finding underlies the importance of complex formation between hRap1 and hTRF2 for telomere function and end protection. ..
  32. Sen B, Xie Z, Case N, Thompson W, Uzer G, Styner M, et al. mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow-derived mesenchymal stem cells. J Bone Miner Res. 2014;29:78-89 pubmed publisher
    ..As such, mechanical activation of mTORC2 signaling participates in mesenchymal stem cell lineage selection, preventing adipogenesis by preserving ?-catenin and stimulating osteogenesis by generating a stiffer cytoskeleton. ..
  33. Ding F, Furukawa Y, Nukina N, Dokholyan N. Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates. J Mol Biol. 2012;421:548-60 pubmed publisher
  34. Willard F, Willard M, Kimple A, Soundararajan M, Oestreich E, Li X, et al. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS ONE. 2009;4:e4884 pubmed publisher
    ..This cellular function for RGS14 is similar but distinct from that recently described for its closely-related paralogue, RGS12, which shares the tandem Ras-binding domain architecture with RGS14. ..