Experts and Doctors on multigene family in Chapel Hill, North Carolina, United States


Locale: Chapel Hill, North Carolina, United States
Topic: multigene family

Top Publications

  1. Fulcher N, Holliday P, Klem E, Cann M, Wolfgang M. The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity. Mol Microbiol. 2010;76:889-904 pubmed publisher
    ..Overall, our data define a novel function for a chemotaxis-like system in controlling cAMP production and establish a regulatory link between the Chp system, TFP and other cAMP-dependent virulence systems. ..
  2. Benders G, Powell B, Hutchison C. Transcriptional analysis of the conserved ftsZ gene cluster in Mycoplasma genitalium and Mycoplasma pneumoniae. J Bacteriol. 2005;187:4542-51 pubmed
    ..genitalium and M. pneumoniae are often preceded by promoters but rarely followed by terminators. This causes functionally unrelated genes to be commonly cotranscribed in these organisms. ..
  3. O Rand M, Widgren E, Wang Z, Richardson R. Eppin: an effective target for male contraception. Mol Cell Endocrinol. 2006;250:157-62 pubmed
    ..We can hypothesize from our analysis of anti-Eppin epitopes on Eppin that when anti-Eppin antibodies are bound to Eppin on the sperm surface they block the binding site for semenogelin. ..
  4. Peifer M, McCrea P, Green K, Wieschaus E, Gumbiner B. The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J Cell Biol. 1992;118:681-91 pubmed
    ..The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed. ..
  5. Yamburenko M, Kieber J, Schaller G. Dynamic patterns of expression for genes regulating cytokinin metabolism and signaling during rice inflorescence development. PLoS ONE. 2017;12:e0176060 pubmed publisher
    ..The identification of subnetworks of genes expressed at different stages of early panicle development suggests that manipulation of their expression could have substantial effects on inflorescence architecture. ..
  6. Lever M, Rouxel O, Alt J, Shimizu N, Ono S, Coggon R, et al. Evidence for microbial carbon and sulfur cycling in deeply buried ridge flank basalt. Science. 2013;339:1305-8 pubmed publisher
    ..Downcore changes in carbon and sulfur cycling show discrete geochemical intervals with chemoautotrophic ?(13)C signatures locally attenuated by heterotrophic metabolism...
  7. Radhakrishnan Y, Hamil K, Yenugu S, Young S, French F, Hall S. Identification, characterization, and evolution of a primate beta-defensin gene cluster. Genes Immun. 2005;6:203-10 pubmed publisher
    ..The evolutionary forces driving the proliferation and diversification of these defensins may be related to reproductive specialization and/or the host-parasite coevolutionary process...
  8. Conti B, Davis B, Zhang J, O Connor W, Williams K, Ting J. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J Biol Chem. 2005;280:18375-85 pubmed
    ..We propose that CLR16.2 serves to attenuate T cell activation via TCR and co-stimulatory molecules, and its reduction during T cell stimulation allows the ensuing cellular activation. ..
  9. Greene S, Stamm L. Molecular characterization of a chemotaxis operon in the oral spirochete, Treponema denticola. Gene. 1999;232:59-68 pubmed
    ..denticola CheA and CheY proteins are highly conserved with those of the Escherichia coli (Ec) CheA and CheY proteins. Phylogenetic analysis of Td CheY indicated that it is closely related to Tp CheY and Bb CheY3...

More Information


  1. Elkins C, Totten P, Olsen B, Thomas C. Role of the Haemophilus ducreyi Ton system in internalization of heme from hemoglobin. Infect Immun. 1998;66:151-60 pubmed
    ..This arrangement, as well as the DNA and deduced amino acid sequences of these H. ducreyi genes, was most similar to those from other pasteurellae. ..
  2. Erickson L, Kim H, Maeda N. Junctions between genes in the haptoglobin gene cluster of primates. Genomics. 1992;14:948-58 pubmed
    ..The observation that Alu sequences define the junctions between genes in the haptoglobin gene cluster emphasizes the importance of Alu sequences in the evolution of multigene families. ..
  3. Henrich V, Sliter T, Lubahn D, MacIntyre A, Gilbert L. A steroid/thyroid hormone receptor superfamily member in Drosophila melanogaster that shares extensive sequence similarity with a mammalian homologue. Nucleic Acids Res. 1990;18:4143-8 pubmed
    ..The high degree of similarity in the hormone-binding domain between the 2C protein and the H2RII binding protein outside regions II-IV suggests specific functional roles which are not shared by other members of the superfamily. ..
  4. Yashar B, Kelley C, Yee K, Errede B, Zon L. Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. Mol Cell Biol. 1993;13:5738-48 pubmed
    ..Discovery of this family suggests that multiple MAP kinase activation pathways similar to those in yeast cells exist in vertebrates. ..
  5. Sivashanmugam P, Hall S, Hamil K, French F, O Rand M, Richardson R. Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2. Gene. 2003;312:125-34 pubmed
    ..Our results demonstrate that mouse chromosome 2 contains a conserved linkage of Eppin-like protease inhibitor genes that are expressed in the epididymis. ..
  6. Ting J, Davis B. CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu Rev Immunol. 2005;23:387-414 pubmed
    ..We also discuss implied roles of these proteins in diversifying immune detection and in providing a check-and-balance during inflammation. ..
  7. Gentry H, Singer A, Betts L, Yang C, Ferrara J, Sondek J, et al. Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. J Biol Chem. 2005;280:8407-15 pubmed
    ..Differences in structure, oligomeric state, and phylogeny define a new family of CIB1-related proteins that extends from arthropods to humans. ..
  8. Wilson V, Conlon F. The T-box family. Genome Biol. 2002;3:REVIEWS3008 pubmed
  9. Kim H, Smithies O, Maeda N. A physical map of the human salivary proline-rich protein gene cluster covers over 700 kbp of DNA. Genomics. 1990;6:260-7 pubmed
    ..The PRP gene cluster spans at least 700 kbp on chromosome 12 at p13.2. A scheme for the evolution of the cluster that requires an initial gene duplication followed by three unequal but homologous crossovers is given. ..
  10. O Bryan J, Songyang Z, Cantley L, Der C, Pawson T. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996;93:2729-34 pubmed
    ..These results suggest that ShcC may mediate signaling from tyrosine kinases in the nervous system, such as receptors for neurotrophins. ..
  11. Siefers N, Dang K, Kumimoto R, Bynum W, Tayrose G, Holt B. Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity. Plant Physiol. 2009;149:625-41 pubmed publisher
    ..The results are discussed with a special emphasis on potential roles for NF-Y subunits in photoperiod-controlled flowering time. ..
  12. Chen Z, Hartmann H, Wu M, Friedman E, Chen J, Pulley M, et al. Expression analysis of the AtMLO gene family encoding plant-specific seven-transmembrane domain proteins. Plant Mol Biol. 2006;60:583-97 pubmed
  13. Stamm L, Bergen H. Molecular characterization of the Treponema denticola fliQ region. DNA Seq. 2001;12:463-7 pubmed
    ..The location of the T. denticola fliQ-flhA' genes differs from that of the corresponding T. pallidum and Borrelia burgdorferi genes which are present in the large fla or flgB flagellar operons, respectively. ..
  14. Wang J, Mager J, Chen Y, Schneider E, Cross J, Nagy A, et al. Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat Genet. 2001;28:371-5 pubmed
    ..Based on the recent finding that the Eed protein interacts with histone deacetylases, we suggest that this maintenance activity involves hypoacetylation of the inactivated paternal X chromosome in the extra-embryonic tissues. ..
  15. Fares H, Goetsch L, Pringle J. Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiae. J Cell Biol. 1996;132:399-411 pubmed
    ..Taken together, the results suggest that the septins play important but partially redundant roles during the process of spore formation. ..
  16. Beltran A, Russo A, Lara H, Fan C, Lizardi P, Blancafort P. Suppression of breast tumor growth and metastasis by an engineered transcription factor. PLoS ONE. 2011;6:e24595 pubmed publisher
    ..Our results describe for the first time an ATF able to reduce tumor growth and metastatic colonization by epigenetic reactivation of a dormant, normal-like, and more differentiated gene program. ..
  17. Shehee W, Loeb D, Adey N, Burton F, Casavant N, Cole P, et al. Nucleotide sequence of the BALB/c mouse beta-globin complex. J Mol Biol. 1989;205:41-62 pubmed
    ..The significance of these homologies is unclear, but these regions are candidates for further study in functional assays in erythroid cell lines or transgenic animals. ..
  18. Swinnen J, Joseph D, Conti M. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Proc Natl Acad Sci U S A. 1989;86:5325-9 pubmed
    ..These findings provide a molecular basis for the observed heterogeneity of cAMP PDEs. ..
  19. Haskill S, Peace A, Morris J, Sporn S, Anisowicz A, Lee S, et al. Identification of three related human GRO genes encoding cytokine functions. Proc Natl Acad Sci U S A. 1990;87:7732-6 pubmed
    ..Expression studies reveal tissue-specific regulation as well as regulation by specific inducing agents, including interleukin 1, tumor necrosis factor, phorbol 12-myristate 13-acetate, and lipopolysaccharide. ..
  20. Crayton M, Powell B, Vision T, Giddings M. Tracking the evolution of alternatively spliced exons within the Dscam family. BMC Evol Biol. 2006;6:16 pubmed
    ..The different patterns of conservation and turnover among the Dscam exon arrays provide a striking example of how a gene can evolve in a modular fashion rather than as a single unit. ..
  21. Guo J, Jin J, Cooper L. Dissection of sets of genes that control the character of wnt5a-deficient mouse calvarial cells. Bone. 2008;43:961-71 pubmed publisher
    ..Its function during mesenchymal stem cell differentiation as well as cell growth was suggested by comparing the gene expression profile of calvarial cells from the Wnt5a(-/-) and wild type mice. ..
  22. Montague M, Hutchison C. Gene content phylogeny of herpesviruses. Proc Natl Acad Sci U S A. 2000;97:5334-9 pubmed
    ..This clustering may give clues to genes with related functions or with related histories of acquisition and loss during herpesvirus evolution...
  23. Stamm L, Greene S, Bergen H, Hardham J, Barnes N. Identification and sequence analysis of Treponema pallidum tprJ, a member of a polymorphic multigene family. FEMS Microbiol Lett. 1998;169:155-63 pubmed
    ..The deduced amino acid sequence of T. pertenue TprJ is 87.3% identical to that of T. pallidum TprJ. This is the first report of significant sequence differences within homologous genes of T. pallidum and T. pertenue...
  24. Schisler J, Rubel C, Zhang C, Lockyer P, Cyr D, Patterson C. CHIP protects against cardiac pressure overload through regulation of AMPK. J Clin Invest. 2013;123:3588-99 pubmed publisher
  25. Sawyer J, Glass S, Li T, Shemer G, White N, Starostina N, et al. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Genetics. 2011;188:549-64 pubmed publisher
    ..Our results implicate new genes in C. elegans gastrulation, and they show that an RNAi-based enhancer screen in C. elegans can be used as an efficient means to identify important but redundant or partially redundant developmental genes. ..
  26. Ye Z, Ting J. NLR, the nucleotide-binding domain leucine-rich repeat containing gene family. Curr Opin Immunol. 2008;20:3-9 pubmed publisher
    ..Its role in inflammation is linked to the formation of biochemical complexes such as the inflammasome, and its roles in cell death might be linked to the proposed formation of pyroptosome and necrosome. ..
  27. Wang H, Peng M, Chen Y, Geng J, Robinson H, Houslay M, et al. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem J. 2007;408:193-201 pubmed
    ..PDE4C appears to be more distal from other PDE4 subfamilies, with certain key residues being disordered. Our analyses provide the first structural basis for the development of PDE4 subfamily-selective inhibitors. ..
  28. Smithies O, Kim H. Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc Natl Acad Sci U S A. 1994;91:3612-5 pubmed
    ..Varying gene copy numbers by targeting consequently offers a promising approach to quantitative genetics. ..
  29. Kim H, Lyons K, Saitoh E, Azen E, Smithies O, Maeda N. The structure and evolution of the human salivary proline-rich protein gene family. Mamm Genome. 1993;4:3-14 pubmed
    ..During this evolutionary process, multiple rearrangements and gene conversion occurred mainly in the region from the 3' end of IVS2 and the 3' end of exon 3. ..
  30. Nelson D, Kamataki T, Waxman D, Guengerich F, Estabrook R, Feyereisen R, et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993;12:1-51 pubmed
    ..Finally, we describe P450 genes that have been detected by expressed sequence tags (ESTs), as well as the relationship between the P450 and the nitric oxide synthase gene superfamilies, as a likely example of convergent evolution. ..
  31. McDowell J, An Y, Huang S, McKinney E, Meagher R. The arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli. Plant Physiol. 1996;111:699-711 pubmed
    ..The ACT7 promoter sequence contains a remarkable number of motifs with sequence similarity to putative phytohormone response elements. ..
  32. Mashek D, Bornfeldt K, Coleman R, Berger J, Bernlohr D, Black P, et al. Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res. 2004;45:1958-61 pubmed
    ..Splice variants of ACSL3, -4, -5, and -6 are cataloged. Suggestions for naming other family members and for the nonmammalian acyl-CoA synthetases are made. ..
  33. Judd B. Genes and chromomeres: A puzzle in three dimensions. Genetics. 1998;150:1-9 pubmed